Haploinsufficiency in the mitochondrial protein CHCHD4 reduces brain injury in a mouse model of neonatal hypoxia-ischemia (scientific article published on 11 May 2017)

Apoptosis-inducing factor triggered by poly(ADP-ribose) polymerase and Bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia.

Q40355180

Protein import and oxidative folding in the mitochondrial intermembrane space of intact mammalian cells.

Q41783546

Different apoptotic mechanisms are activated in male and female brains after neonatal hypoxia-ischaemia

Q42164655

Loss of apoptosis-inducing factor results in cell-type-specific neurogenesis defects

Q42348594

Causal role of apoptosis-inducing factor for neuronal cell death following traumatic brain injury

Q43198609

Synergistic activation of caspase-3 by m-calpain after neonatal hypoxia-ischemia: a mechanism of "pathological apoptosis"?

Q43513153

Manganese Superoxide Dismutase Affects Cytochrome c Release and Caspase-9 Activation After Transient Focal Cerebral Ischemia in Mice

Q44844420

The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia-ischemia.

Q45183594

Mitochondrial translocation of p53 mediates release of cytochrome c and hippocampal CA1 neuronal death after transient global cerebral ischemia in rats.

Q46002885

Neuroprotective effect of Bax-inhibiting peptide on neonatal brain injury

Q48106824

Apoptosis-inducing factor is a major contributor to neuronal loss induced by neonatal cerebral hypoxia-ischemia.

Q48397448

Erythropoietin improved neurologic outcomes in newborns with hypoxic-ischemic encephalopathy

Q48495331

Effects of hypothermia for perinatal asphyxia on childhood outcomes

Q48669030

Regulation of autophagy by cytoplasmic p53

Q24651258

Oxidative folding in the mitochondrial intermembrane space: A regulated process important for cell physiology and disease

Q28076268

The Ca(2+)-Dependent Release of the Mia40-Induced MICU1-MICU2 Dimer from MCU Regulates Mitochondrial Ca(2+) Uptake

Q28118964

Life with or without AIF

Q28272615

Involvement of apoptosis-inducing factor in neuronal death after hypoxia-ischemia in the neonatal rat brain

Q28583382

Validation of housekeeping genes for quantitative real-time PCR in in-vivo and in-vitro models of cerebral ischaemia

Q33468639

Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress.

Q33694996

Which neuroprotective agents are ready for bench to bedside translation in the newborn infant?

Q33723452

Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations

Q33877979

The harlequin mouse mutation downregulates apoptosis-inducing factor

Q34152182

Lithium reduces apoptosis and autophagy after neonatal hypoxia-ischemia

Q34546517

Apoptosis-inducing factor deficiency decreases the proliferation rate and protects the subventricular zone against ionizing radiation

Q34561784

Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression

Q35698941

Cyclophilin A participates in the nuclear translocation of apoptosis-inducing factor in neurons after cerebral hypoxia-ischemia

Q36229578

Loss of apoptosis-inducing factor critically affects MIA40 function.

Q36293830

Apoptosis-inducing factor downregulation increased neuronal progenitor, but not stem cell, survival in the neonatal hippocampus after cerebral hypoxia-ischemia

Q36297305

Neuroprotection by selective neuronal deletion of Atg7 in neonatal brain injury

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Apoptotic mechanisms in the immature brain: involvement of mitochondria

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Regulation of Mn-superoxide dismutase activity and neuroprotection by STAT3 in mice after cerebral ischemia

Q37265505

Dichloroacetate treatment improves mitochondrial metabolism and reduces brain injury in neonatal mice

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Recombinant human erythropoietin improves neurological outcomes in very preterm infants

Q37375616

Mitochondrial membrane permeabilization in neuronal injury

Q37526353

AIF deficiency compromises oxidative phosphorylation

Q37671807

Neuronal cell death in neonatal hypoxia-ischemia

Q37724332

Mitochondrial fission/fusion dynamics and apoptosis

Q37781431

Mitochondrial control of cellular life, stress, and death

Q38052070

Mitochondria: hub of injury responses in the developing brain.

Q38181298

Effect of Early Prophylactic High-Dose Recombinant Human Erythropoietin in Very Preterm Infants on Neurodevelopmental Outcome at 2 Years: A Randomized Clinical Trial

Q38392485

p53 in survival, death and metabolic health: a lifeguard with a licence to kill

Q38540071

Mitochondrial Proteins Containing Coiled-Coil-Helix-Coiled-Coil-Helix (CHCH) Domains in Health and Disease

Q38702029

Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis

Q38871524

P275

Creative Commons Attribution 4.0 International

copyrighted

issue

main subject

haploinsufficiency

Q852654

P304

page(s)

e2781

P577

publication date

2017-05-11

P1433

published in

Cell Death and Disease

Q2197222

P1476

title

Haploinsufficiency in the mitochondrial protein CHCHD4 reduces brain injury in a mouse model of neonatal hypoxia-ischemia

P478

volume

Reverse relations

cites work (P2860)

Q92711687	A network analysis to identify mediators of germline-driven differences in breast cancer prognosis
Q64088603	Iron Metabolism and Brain Development in Premature Infants
Q60949510	Lack of the brain-specific isoform of apoptosis-inducing factor aggravates cerebral damage in a model of neonatal hypoxia-ischemia
Q47229517	Mitochondrial dynamics, mitophagy and biogenesis in neonatal hypoxic-ischaemic brain injury.
Q89454201	Overexpression of apoptosis inducing factor aggravates hypoxic-ischemic brain injury in neonatal mice
Q64262590	The Potential Role of Ferroptosis in Neonatal Brain Injury
Q90396259	Transfer of mitochondria from mesenchymal stem cells derived from induced pluripotent stem cells attenuates hypoxia-ischemia-induced mitochondrial dysfunction in PC12 cells