A tale of a tail: Structural insights into the conformational properties of the polyglutamine protein ataxin-3.

scientific article published on July 2013

A tale of a tail: Structural insights into the conformational properties of the polyglutamine protein ataxin-3. is …
instance of (P31):
scholarly articleQ13442814

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P6409CORE ID82077679
P6179Dimensions Publication ID1028080734
P356DOI10.1016/J.IJMS.2012.08.032
P953full work available at URLhttp://eprints.whiterose.ac.uk/76181/
https://doi.org/10.1016/j.ijms.2012.08.032
P6366Microsoft Academic ID2162497105
P932PMC publication ID4375668
P698PubMed publication ID25844046
P5875ResearchGate publication ID233758778
P1154Scopus EID2-s2.0-84878844824

P50authorSheena RadfordQ17011933
Sandra Macedo-RibeiroQ56422975
Alessandro SicorelloQ63345178
Alison E. AshcroftQ43156964
Charlotte A. ScarffQ39562846
P2093author name stringRicardo J L Tomé
P2860cites workTowards a structural understanding of the fibrillization pathway in Machado-Joseph's disease: trapping early oligomers of non-expanded ataxin-3.Q46728320
Structure validation of the Josephin domain of ataxin-3: conclusive evidence for an open conformation.Q51929028
Anhydrous Protein IonsQ56519907
Characterization of the structure and the amyloidogenic properties of the Josephin domain of the polyglutamine-containing protein ataxin-3Q81009813
Mass spectrometry of intact V-type ATPases reveals bound lipids and the effects of nucleotide bindingQ41961293
Collision cross sections of proteins and their complexes: a calibration framework and database for gas-phase structural biologyQ42846188
Calcium-induced structural transitions of the calmodulin-melittin system studied by electrospray mass spectrometry: conformational subpopulations and metal-unsaturated intermediatesQ43122240
Characterization of intrinsically disordered proteins with electrospray ionization mass spectrometry: conformational heterogeneity of alpha-synucleinQ43256880
Domain architecture of the polyglutamine protein ataxin-3: a globular domain followed by a flexible tailQ44546897
Gas-phase unfolding and disassembly reveals stability differences in ligand-bound multiprotein complexesQ44892400
Charge-surface correlation in electrospray ionization of folded and unfolded proteinsQ45774121
The role of the central flexible region on the aggregation and conformational properties of human ataxin-3Q24298707
CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1Q28235526
Aspects of native proteins are retained in vacuum.Q30356497
Integrating ion mobility mass spectrometry with molecular modelling to determine the architecture of multiprotein complexesQ33658957
Splice isoforms of the polyglutamine disease protein ataxin-3 exhibit similar enzymatic yet different aggregation propertiesQ33742179
Elongated oligomers in beta2-microglobulin amyloid assembly revealed by ion mobility spectrometry-mass spectrometryQ33859337
Fourteen and counting: unraveling trinucleotide repeat diseasesQ33892634
The solution structure of the Josephin domain of ataxin-3: structural determinants for molecular recognitionQ33906613
Deubiquitinating function of ataxin-3: insights from the solution structure of the Josephin domainQ33920788
Net charge per residue modulates conformational ensembles of intrinsically disordered proteinsQ33929602
Functional interactions as a survival strategy against abnormal aggregationQ34421847
The Josephin domain determines the morphological and mechanical properties of ataxin-3 fibrilsQ34800791
Toward understanding Machado-Joseph diseaseQ35837355
Quantitative characterization of intrinsic disorder in polyglutamine: insights from analysis based on polymer theoriesQ35963371
A combined approach to improving large-scale production of tobacco etch virus proteaseQ36101845
Recent developments in electrospray ionisation mass spectrometry: noncovalently bound protein complexesQ36208761
Machado-Joseph disease/spinocerebellar ataxia type 3.Q36599588
Protein complexes in the gas phase: technology for structural genomics and proteomicsQ36890557
Biomolecule analysis by ion mobility spectrometryQ37190550
Native mass spectrometry: a bridge between interactomics and structural biologyQ37313905
Stability and shape of hepatitis B virus capsids in vacuoQ37359983
Mass spectrometry of large complexesQ37603759
Polyglutamine diseases: where does toxicity come from? what is toxicity? where are we going?Q37735565
Ion mobility mass spectrometry of proteins and protein assemblies.Q37737098
Current understanding on the pathogenesis of polyglutamine diseasesQ37760791
Polyglutamine diseases: the special case of ataxin-3 and Machado-Joseph diseaseQ37899333
Modern biomolecular mass spectrometry and its role in studying virus structure, dynamics, and assembly.Q37906505
Physical chemistry of polyglutamine: intriguing tales of a monotonous sequenceQ37981477
Structure and dynamics of oligomeric intermediates in β2-microglobulin self-assemblyQ38272762
Unraveling lactococcal phage baseplate assembly by mass spectrometryQ38625535
Studying noncovalent protein complexes by electrospray ionization mass spectrometryQ41671168
Monitoring copopulated conformational states during protein folding events using electrospray ionization-ion mobility spectrometry-mass spectrometryQ41932531
P304page(s)63-70
P577publication date2013-07-01
P1433published inInternational Journal of Mass SpectrometryQ534231
P859sponsorStructure and dynamics of oligomeric intermediates in amyloid assemblyQ63345007
P1476titleA tale of a tail: Structural insights into the conformational properties of the polyglutamine protein ataxin-3.
P478volume345-347

Reverse relations

cites work (P2860)
Q36115804Enhanced molecular mobility of ordinarily structured regions drives polyglutamine disease
Q40433494Examination of Ataxin-3 (atx-3) Aggregation by Structural Mass Spectrometry Techniques: A Rationale for Expedited Aggregation upon Polyglutamine (polyQ) Expansion
Q47559358Identification of a novel site of interaction between ataxin-3 and the amyloid aggregation inhibitor polyglutamine binding peptide 1.
Q47136857Ion Mobility Collision Cross Section Compendium
Q52803097Mass spectrometry-enabled structural biology of membrane proteins.
Q30432441Trinucleotide repeats: a structural perspective

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