Emerging views about the molecular structure of the spliceosomal catalytic center

scientific article published on 12 October 2012

Emerging views about the molecular structure of the spliceosomal catalytic center is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4161/RNA.22359
P932PMC publication ID3597571
P698PubMed publication ID23064115
P5875ResearchGate publication ID232246802

P2093author name stringVladimir Pena
Jana Schmitzová
P2860cites workCwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centreQ24301865
Splicing-related catalysis by protein-free snRNAsQ43770734
Is the spliceosome a ribonucleoprotein enzyme?Q46668714
U2–U6 RNA folding reveals a group II intron-like domain and a four-helix junctionQ57080150
The spliceosome shows its metalQ58324052
"Five easy pieces"Q68053624
Prp8 protein: at the heart of the spliceosomeQ24537373
The C-terminal region of hPrp8 interacts with the conserved GU dinucleotide at the 5' splice siteQ24539330
A general two-metal-ion mechanism for catalytic RNAQ24562157
Solution structure of domain 5 of a group II intron ribozyme reveals a new RNA motifQ27643034
Structure of a multipartite protein-protein interaction domain in splicing factor prp8 and its link to retinitis pigmentosaQ27643886
Crystal Structure of a Self-Spliced Group II IntronQ27650229
Crystal structure of the  -finger domain of Prp8 reveals analogy to ribosomal proteinsQ27652048
Structural elucidation of a PRP8 core domain from the heart of the spliceosomeQ27652426
Structure and function of an RNase H domain at the heart of the spliceosomeQ27652459
Structure of the mRNA splicing complex component Cwc2: insights into RNA recognitionQ27674589
Structure of the yeast U2/U6 snRNA complexQ27677233
Crystal structure of Cwc2 reveals a novel architecture of a multipartite RNA-binding proteinQ27677980
Crystal structure of a group II intron in the pre-catalytic stateQ27678382
Crystal structure at 1.92 A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpinQ27730785
Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal componentsQ27937542
A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosomeQ28201291
Strategies for RNA folding and assemblyQ28291162
Mechanism of maturase-promoted group II intron splicingQ28366346
Spliceosome Structure and FunctionQ29392298
The generality of self-splicing RNA: relationship to nuclear mRNA splicingQ30457101
A group II intron-encoded maturase functions preferentially in cis and requires both the reverse transcriptase and X domains to promote RNA splicingQ33203803
Multiple roles for U6 snRNA in the splicing pathwayQ33872375
Protein-free small nuclear RNAs catalyze a two-step splicing reactionQ34018172
Prp8, the pivotal protein of the spliceosomal catalytic center, evolved from a retroelement-encoded reverse transcriptaseQ34026315
A catalytically active group II intron domain 5 can function in the U12-dependent spliceosomeQ34131822
Evidence for two active sites in the spliceosome provided by stereochemistry of pre-mRNA splicingQ34357049
Spliceosomal snRNAs: Mg(2+)-dependent chemistry at the catalytic core?Q34635318
The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosomeQ35014709
Group II introns: mobile ribozymes that invade DNA.Q35119248
Functional interactions of Prp8 with both splice sites at the spliceosomal catalytic centerQ35203137
Three essential and conserved regions of the group II intron are proximal to the 5'-splice siteQ36294532
Extensive interactions of PRP8 protein with the 5' and 3' splice sites during splicing suggest a role in stabilization of exon alignment by U5 snRNA.Q38294598
Metal ion catalysis during the exon-ligation step of nuclear pre-mRNA splicing: extending the parallels between the spliceosome and group II intronsQ38315124
Multiple functions for the invariant AGC triad of U6 snRNA.Q41815683
Metal-ion coordination by U6 small nuclear RNA contributes to catalysis in the spliceosome.Q42679830
A structural analysis of the group II intron active site and implications for the spliceosomeQ42852645
P433issue11
P921main subjectmolecular geometryQ911331
spliceosomeQ915868
P304page(s)1311-1318
P577publication date2012-10-12
P1433published inRNA BiologyQ7277167
P1476titleEmerging views about the molecular structure of the spliceosomal catalytic center
P478volume9

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