17AAG-induced internalisation of HER2-specific Affibody molecules

scientific article published on 10 August 2016

17AAG-induced internalisation of HER2-specific Affibody molecules is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3892/OL.2016.4990
P932PMC publication ID5038849
P698PubMed publication ID27698830

P2093author name stringSture Lindegren
Lars Gedda
Lovisa Göstring
P2860cites workSensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90Q28143497
The deaf and the dumb: the biology of ErbB-2 and ErbB-3Q28185247
ErbB2 degradation mediated by the co-chaperone protein CHIPQ28208008
Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancerQ29547699
Endocytosis and sorting of ErbB2 and the site of action of cancer therapeutics trastuzumab and geldanamycinQ30839490
Alternative binding proteins: affibody binding proteins developed from a small three-helix bundle scaffoldQ33330736
125I-labeled human epidermal growth factor. Binding, internalization, and degradation in human fibroblastsQ36198091
Down regulation of epidermal growth factor receptors: direct demonstration of receptor degradation in human fibroblastsQ36210313
Targeting of multiple signalling pathways by heat shock protein 90 molecular chaperone inhibitorsQ36720680
Phase II trial of gemcitabine and tanespimycin (17AAG) in metastatic pancreatic cancer: a Mayo Clinic Phase II Consortium study.Q36999363
Hsp90 is expressed and represents a therapeutic target in human oesophageal cancer using the inhibitor 17-allylamino-17-demethoxygeldanamycinQ37081037
A phase II study of 17-allylamino-17-demethoxygeldanamycin in metastatic or locally advanced, unresectable breast cancerQ37338986
Engineered affinity proteins for tumour-targeting applicationsQ37430356
Geldanamycin and its anti-cancer activitiesQ37619906
Chemical and radiochemical considerations in radiolabeling with α-emitting radionuclides.Q37971505
Association with membrane protrusions makes ErbB2 an internalization-resistant receptorQ38345553
Slow internalization of anti-HER2 synthetic affibody monomer 111In-DOTA-ZHER2:342-pep2: implications for development of labeled tracers.Q39943343
A combination of Trastuzumab and 17-AAG induces enhanced ubiquitinylation and lysosomal pathway-dependent ErbB2 degradation and cytotoxicity in ErbB2-overexpressing breast cancer cellsQ39943622
An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer modelsQ40025393
Potentiation of paclitaxel activity by the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin in human ovarian carcinoma cell lines with high levels of activated AKT.Q40274520
Geldanamycin stimulates internalization of ErbB2 in a proteasome-dependent way.Q40340333
Inhibition of phosphatidylinositol 3'-kinase increases efficacy of paclitaxel in in vitro and in vivo ovarian cancer models.Q40748731
ErbB-2 amplification inhibits down-regulation and induces constitutive activation of both ErbB-2 and epidermal growth factor receptors.Q40966152
The processing and fate of antibodies and their radiolabels bound to the surface of tumor cells in vitro: a comparison of nine radiolabels.Q41469562
Geldanamycin induces ErbB-2 degradation by proteolytic fragmentationQ42800575
Direct procedure for the production of 211At-labeled antibodies with an epsilon-lysyl-3-(trimethylstannyl)benzamide immunoconjugateQ46429197
Targeting of HER2-expressing tumors using 111In-ABY-025, a second-generation affibody molecule with a fundamentally reengineered scaffold.Q54667220
Molecular imaging of HER2-expressing malignant tumors in breast cancer patients using synthetic 111In- or 68Ga-labeled affibody molecules.Q54673289
Coregulation of epidermal growth factor receptor/human epidermal growth factor receptor 2 (HER2) levels and locations: quantitative analysis of HER2 overexpression effectsQ73075684
Radiation doses to the cell nucleus in single cells and cells in micrometastases in targeted therapy with (131)I labeled ligands or antibodiesQ73516010
Clinical experience with the heat shock protein-90 inhibitor, tanespimycin, in patients with relapsed lymphomaQ85074832
P433issue4
P304page(s)2574-2580
P577publication date2016-08-10
P1433published inOncology LettersQ20640514
P1476title17AAG-induced internalisation of HER2-specific Affibody molecules
P478volume12

Reverse relations

Q93086999Mathematical modeling of drug-induced receptor internalization in the HER2-positive SKBR3 breast cancer cell-linecites workP2860