Olaparib in combination with irinotecan, cisplatin, and mitomycin C in patients with advanced pancreatic cancer.

scientific article published on 19 April 2017

Olaparib in combination with irinotecan, cisplatin, and mitomycin C in patients with advanced pancreatic cancer. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.18632/ONCOTARGET.17237
P932PMC publication ID5546463
P698PubMed publication ID28454122

P50authorPaul ObersteinQ57885707
Lei ZhengQ59833013
Michael GogginsQ63021511
Mark YarchoanQ85494951
Elizabeth JaffeeQ29452184
P2093author name stringDung T Le
Ross C Donehower
Robert L Fine
Nilofer S Azad
Daniel A Laheru
Ana De Jesus-Acosta
Burles A Johnson
Melinda C Myzak
P2860cites workFanconi anemia gene mutations in young-onset pancreatic cancerQ73400804
High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugsQ24644255
Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility geneQ24658271
Management of borderline resectable pancreatic cancerQ26781445
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriersQ27851474
DNA-Repair Defects and Olaparib in Metastatic Prostate CancerQ27853235
New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)Q28131668
Cancer statistics, 2016Q29547383
FOLFIRINOX versus gemcitabine for metastatic pancreatic cancerQ29547638
Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabineQ29616728
Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trialQ29619615
Pancreatic cancerQ29622871
Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trialQ30080035
A phase I combination study of olaparib with cisplatin and gemcitabine in adults with solid tumors.Q33161027
Niraparib Maintenance Therapy in Platinum-Sensitive, Recurrent Ovarian CancerQ33435836
Irinotecan, cisplatin and mitomycin in inoperable gastro-oesophageal and pancreatic cancers - a new active regimenQ36646204
PARP inhibition selectively increases sensitivity to cisplatin in ERCC1-low non-small cell lung cancer cells.Q36740692
BRCA germline mutations in Jewish patients with pancreatic adenocarcinomaQ36854437
A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repairQ37203855
Overall survival in patients with platinum-sensitive recurrent serous ovarian cancer receiving olaparib maintenance monotherapy: an updated analysis from a randomised, placebo-controlled, double-blind, phase 2 trial.Q38387666
FDA Approval Summary: Olaparib Monotherapy in Patients with Deleterious Germline BRCA-Mutated Advanced Ovarian Cancer Treated with Three or More Lines of ChemotherapyQ38549680
Genomic analyses identify molecular subtypes of pancreatic cancerQ38791499
Cancer treatment and survivorship statistics, 2016.Q38859236
Cisplatin resistance associated with PARP hyperactivationQ43703967
Evaluation of candidate genes MAP2K4, MADH4, ACVR1B, and BRCA2 in familial pancreatic cancer: deleterious BRCA2 mutations in 17%.Q44049901
Olaparib in combination with paclitaxel in patients with advanced gastric cancer who have progressed following first-line therapy (GOLD): a double-blind, randomised, placebo-controlled, phase 3 trialQ47440559
Germline BRCA Mutations in a Large Clinic-Based Cohort of Patients With Pancreatic AdenocarcinomaQ50852180
Phase I study of olaparib plus gemcitabine in patients with advanced solid tumours and comparison with gemcitabine alone in patients with locally advanced/metastatic pancreatic cancer.Q53649002
Olaparib monotherapy in patients with advanced cancer and a germline BRCA1/2 mutationQ56240758
P433issue27
P407language of work or nameEnglishQ1860
P921main subjectolaparibQ7083106
irinotecanQ412197
P304page(s)44073-44081
P577publication date2017-07-01
P1433published inOncotargetQ1573155
P1476titleOlaparib in combination with irinotecan, cisplatin, and mitomycin C in patients with advanced pancreatic cancer
P478volume8