Phosphatidylinositol 4-kinase III beta is the target of oxoglaucine and pachypodol (Ro 09-0179) for their anti-poliovirus activities, and is located at upstream of the target step of brefeldin A.

scientific article published on June 2015

Phosphatidylinositol 4-kinase III beta is the target of oxoglaucine and pachypodol (Ro 09-0179) for their anti-poliovirus activities, and is located at upstream of the target step of brefeldin A. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/1348-0421.12261
P698PubMed publication ID25891300

P50authorMinetaro AritaQ56428193
P2093author name stringAngel S Galabov
Stefan Philipov
P2860cites workPhosphatidylinositol 4-kinase III beta is essential for replication of human rhinovirus and its inhibition causes a lethal phenotype in vivoQ36970004
A novel, broad-spectrum inhibitor of enterovirus replication that targets host cell factor phosphatidylinositol 4-kinase IIIβ.Q37263877
The role of phosphatidylinositol 4-kinases and phosphatidylinositol 4-phosphate during viral replicationQ38033958
Phosphatidylinositol-4 kinase III beta and oxysterol-binding protein accumulate unesterified cholesterol on poliovirus-induced membrane structure.Q39023918
Fisetin and rutin as 3C protease inhibitors of enterovirus A71.Q39371556
Inhibition of enterovirus 71 replication by chrysosplenetin and penduletinQ39474460
A bifunctional anti-enterovirus compound that inhibits replication and the early stage of enterovirus 71 infection.Q39675700
Quantitative analysis of poliomyelitis-like paralysis in mice induced by a poliovirus replicon.Q40222004
A viral protein that blocks Arf1-mediated COP-I assembly by inhibiting the guanine nucleotide exchange factor GBF1.Q40247187
The poliovirus replication machinery can escape inhibition by an antiviral drug that targets a host cell proteinQ40579249
Mechanism of action at the molecular level of the antiviral drug 3(2H)-isoflavene against type 2 poliovirusQ40882626
Rhinovirus uses a phosphatidylinositol 4-phosphate/cholesterol counter-current for the formation of replication compartments at the ER-Golgi interface.Q41590405
Synthesis of syn and anti isomers of 6-[[(hydroxyimino)phenyl]methyl]-1-[(1-methylethyl)sulfonyl]-1H-benzimidazol-2-amine. Inhibitors of rhinovirus multiplicationQ42244612
Avoiding drug-resistance development by novel approach of combining anti-enteroviral substances against coxsackievirus B1 infection in miceQ43455484
Antiviral activity of natural occurring flavonoids in vitroQ44854260
Treatment with oxoglaucine can enhance host resistance to Candida albicans infection of mice with adjuvant arthritisQ45076999
Toll-like receptor-mediated anti-inflammatory action of glaucine and oxoglaucine.Q45990045
Cellular kinase inhibitors that suppress enterovirus replication have a conserved target in viral protein 3A similar to that of enviroxime.Q46013962
4'-Hydroxy-3-methoxyflavones with potent antipicornavirus activityQ50189844
An RNA virus hijacks an incognito function of a DNA repair enzymeQ24297078
ACBD3-mediated recruitment of PI4KB to picornavirus RNA replication sitesQ24298628
Valosin-containing protein (VCP/p97) is required for poliovirus replication and is involved in cellular protein secretion pathway in poliovirus infectionQ24306634
A nucleo-cytoplasmic SR protein functions in viral IRES-mediated translation initiationQ24337761
A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signalingQ24599676
Cellular COPII proteins are involved in production of the vesicles that form the poliovirus replication complex.Q27469873
Targeting Plasmodium PI(4)K to eliminate malariaQ27974482
Viral reorganization of the secretory pathway generates distinct organelles for RNA replicationQ28283814
Prevention of rhinovirus and poliovirus uncoating by WIN 51711, a new antiviral drugQ28360421
Generation of unique poliovirus RNA replication organellesQ28540297
Anti-enterovirus 71 effects of chrysin and its phosphate esterQ28540436
Inhibition of Enterovirus 71 replication by 7-hydroxyflavone and diisopropyl-flavon7-yl PhosphateQ28541413
Characterization of pharmacologically active compounds that inhibit poliovirus and enterovirus 71 infectivityQ33370037
Poliovirus replication requires the N-terminus but not the catalytic Sec7 domain of ArfGEF GBF1.Q34155593
Antiplasmodial activity of aporphine alkaloids and sesquiterpene lactones from Liriodendron tulipifera LQ34441633
Phosphatidylinositol 4-kinase III beta is a target of enviroxime-like compounds for antipoliovirus activity.Q34742005
Increased long chain acyl-Coa synthetase activity and fatty acid import is linked to membrane synthesis for development of picornavirus replication organellesQ34769274
Experimentally guided models reveal replication principles that shape the mutation distribution of RNA virusesQ35030377
Involvement of membrane traffic in the replication of poliovirus genomes: effects of brefeldin AQ35234487
Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding proteinQ35252021
Complex dynamic development of poliovirus membranous replication complexesQ35666111
Antipicornavirus flavone Ro 09-0179Q35718165
Spectrum and characteristics of the virus inhibitory action of 2-(alpha-hydroxybenzyl)-benzimidazoleQ36265401
Anti-hepatitis C virus activity and toxicity of type III phosphatidylinositol-4-kinase beta inhibitorsQ36276866
Picornavirus modification of a host mRNA decay proteinQ36367527
A cytoplasmic 57-kDa protein that is required for translation of picornavirus RNA by internal ribosomal entry is identical to the nuclear pyrimidine tract-binding proteinQ36481910
Oxysterol-binding protein family I is the target of minor enviroxime-like compounds.Q36760237
P433issue6
P921main subjectPoliovirusQ70923324
P304page(s)338-347
P577publication date2015-06-01
P1433published inMicrobiology and ImmunologyQ15767399
P1476titlePhosphatidylinositol 4-kinase III beta is the target of oxoglaucine and pachypodol (Ro 09-0179) for their anti-poliovirus activities, and is located at upstream of the target step of brefeldin A
P478volume59