Biosynthetic processing of neu differentiation factor. Glycosylation trafficking, and regulated cleavage from the cell surface

scientific article published on August 1995

Biosynthetic processing of neu differentiation factor. Glycosylation trafficking, and regulated cleavage from the cell surface is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.270.32.19188
P698PubMed publication ID7642587
P5875ResearchGate publication ID15555743

P2093author name stringHu S
Burgess TL
Qian YX
Ross SL
Brankow D
P2860cites workNeu differentiation factor: a transmembrane glycoprotein containing an EGF domain and an immunoglobulin homology unitQ44744920
Transmembrane TGF-alpha precursors activate EGF/TGF-alpha receptors.Q45931354
The cytoplasmic carboxy-terminal amino acid specifies cleavage of membrane TGF alpha into soluble growth factorQ67975102
The TGF-alpha precursor expressed on the cell surface binds to the EGF receptor on adjacent cells, leading to signal transductionQ69052663
Substrate specificity of protein kinase C. Use of synthetic peptides corresponding to physiological sites as probes for substrate recognition requirementsQ70153719
NDF/heregulin stimulates the phosphorylation of Her3/erbB3Q72093770
Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous systemQ24321601
Isolation of the neu/HER-2 stimulatory ligand: a 44 kd glycoprotein that induces differentiation of mammary tumor cellsQ24337943
Identification of heregulin, a specific activator of p185erbB2Q24338146
Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumorsQ24339400
Steel-Dickie mutation encodes a c-kit ligand lacking transmembrane and cytoplasmic domainsQ24561693
Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activityQ24612623
Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2Q24642142
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogeneQ27860693
Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the Sld mutantQ28270083
Heregulin induces tyrosine phosphorylation of HER4/p180erbB4Q28589513
Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancerQ29547699
Neu differentiation factor upregulates epidermal migration and integrin expression in excisional wounds.Q34203118
Amplification and expression of sequences cotransfected with a modular dihydrofolate reductase complementary DNA geneQ34253873
ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the neu ligand familyQ34361950
The exocrine protein trypsinogen is targeted into the secretory granules of an endocrine cell line: studies by gene transferQ36212613
Activated release of membrane-anchored TGF-alpha in the absence of cytosolQ36232614
Association of the transmembrane TGF-alpha precursor with a protein kinase complexQ36234321
Structural and functional aspects of the multiplicity of Neu differentiation factorsQ36648114
Support of human hematopoiesis in long-term bone marrow cultures by murine stromal cells selectively expressing the membrane-bound and secreted forms of the human homolog of the steel gene product, stem cell factorQ37146514
Cleavage of the membrane precursor for transforming growth factor alpha is a regulated processQ37414612
Acetylcholine receptor-inducing activity stimulates expression of the epsilon-subunit gene of the muscle acetylcholine receptorQ37586203
Juxtacrine cell signaling moleculesQ40492300
Neu and its ligands: from an oncogene to neural factorsQ40621935
Neu differentiation factors: a family of alternatively spliced neuronal and mesenchymal factorsQ40623822
Genetic dissection of signal transduction mediated by the sevenless receptor tyrosine kinase in Drosophila.Q40659647
Signaling mechanisms in induction of the R7 photoreceptor in the developing Drosophila retinaQ40671590
A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signalingQ40673334
Membrane-anchored growth factors.Q40856819
A nonsecretable cell surface mutant of tumor necrosis factor (TNF) kills by cell-to-cell contactQ41717895
Different transforming growth factor-alpha species are derived from a glycosylated and palmitoylated transmembrane precursorQ44458941
P433issue32
P407language of work or nameEnglishQ1860
P921main subjectglycosylationQ898365
P304page(s)19188-19196
P577publication date1995-08-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleBiosynthetic processing of neu differentiation factor. Glycosylation trafficking, and regulated cleavage from the cell surface
P478volume270

Reverse relations

cites work (P2860)
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Q28590093Domain-specific gene disruption reveals critical regulation of neuregulin signaling by its cytoplasmic tail
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Q40160293Meltrin beta (ADAM19) mediates ectodomain shedding of Neuregulin beta1 in the Golgi apparatus: fluorescence correlation spectroscopic observation of the dynamics of ectodomain shedding in living cells
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