Levosimendan affects oxidative and inflammatory pathways in the diaphragm of ventilated endotoxemic mice

scientific article published on 2 March 2015

Levosimendan affects oxidative and inflammatory pathways in the diaphragm of ventilated endotoxemic mice is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1012566954
P356DOI10.1186/S13054-015-0798-8
P932PMC publication ID4355991
P698PubMed publication ID25888356
P5875ResearchGate publication ID273510526

P50authorWillem-Jan M SchellekensQ85014645
Leo HeunksQ90429218
P N Richard DekhuijzenQ116773121
Hieronymus W H van HeesQ130305474
Marianne LinkelsQ130305552
P2093author name stringJohannes G van der Hoeven
Gert Jan Scheffer
P2860cites workLevosimendan effect on spinal cord ischemia-reperfusion injury following aortic clampingQ46740955
Levosimendan protects against experimental endotoxemic acute renal failureQ46897966
Caspase activation contributes to endotoxin-induced diaphragm weaknessQ46949571
Effects of levosimendan on myocardial ischaemia-reperfusion injuryQ46983946
Effect of short-term treatment with levosimendan on oxidative stress in renal tissues of rats.Q47590556
Mechanical ventilation induces alterations of the ubiquitin-proteasome pathway in the diaphragmQ47892462
Mechanical ventilation protects against diaphragm injury in sepsis: interaction of oxidative and mechanical stressesQ77487123
Peroxynitrite induces contractile dysfunction and lipid peroxidation in the diaphragmQ78117926
Endogenous peroxynitrite mediates mitochondrial dysfunction in rat diaphragm during endotoxemiaQ78176450
Cytokines are produced locally by myocytes in rat skeletal muscle during endotoxemiaQ83199998
No beneficial effects of levosimendan in acute porcine endotoxaemiaQ84109810
Toll-like receptor 4 signaling in ventilator-induced diaphragm atrophyQ84433305
Calpain and caspase-3 are required for sepsis-induced diaphragmatic weaknessQ84480749
Rapidly progressive diaphragmatic weakness and injury during mechanical ventilation in humansQ84976710
The calcium sensitizer levosimendan improves human diaphragm functionQ85019257
Nitric oxide and peroxynitrite in health and diseaseQ24645400
Antioxidant administration attenuates mechanical ventilation-induced rat diaphragm muscle atrophy independent of protein kinase B (PKB Akt) signallingQ28572937
Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and uglyQ29547442
Hypercapnia attenuates ventilator-induced diaphragm atrophy and modulates dysfunction.Q33752122
Regulation of skeletal muscle protein turnover during sepsisQ33775266
Muscle wasting and interleukin-6-induced atrogin-I expression in the cachectic Apc ( Min/+ ) mouseQ33839434
Increased proteolysis, myosin depletion, and atrophic AKT-FOXO signaling in human diaphragm disuseQ34665125
Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans.Q34764722
Animal models of acute lung injuryQ34795312
Blocking NO synthesis: how, where and why?Q35013972
Caspase-3 regulation of diaphragm myonuclear domain during mechanical ventilation-induced atrophyQ35855171
Plasma from septic shock patients induces loss of muscle protein.Q35908213
Evaluation of endotoxin models for the study of sepsisQ36351609
Activation of the ubiquitin-proteasome pathway in the diaphragm in chronic obstructive pulmonary diseaseQ37110291
Effect of proteasome inhibitors on endotoxin-induced diaphragm dysfunctionQ37218019
Sepsis-induced myopathyQ37666348
Levosimendan modulates programmed forms of cell death through K(ATP) channels and nitric oxide.Q39627718
Effects of levo- and dextrosimendan on NF-kappaB-mediated transcription, iNOS expression and NO production in response to inflammatory stimuli.Q39918710
Ventilator-induced diaphragmatic dysfunctionQ39926522
Low-tidal-volume mechanical ventilation induces a toll-like receptor 4-dependent inflammatory response in healthy miceQ40056501
Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expressionQ40321294
Increased duration of mechanical ventilation is associated with decreased diaphragmatic force: a prospective observational studyQ41771779
Levosimendan improves calcium sensitivity of diaphragm muscle fibres from a rat model of heart failureQ41874182
Endotoxin triggers nuclear factor-kappaB-dependent up-regulation of multiple proinflammatory genes in the diaphragmQ42496888
Diaphragm fiber strength is reduced in critically ill patients and restored by a troponin activator.Q42992319
Efficacy and safety of intravenous levosimendan compared with dobutamine in severe low-output heart failure (the LIDO study): a randomised double-blind trial.Q44074134
Expression of nitric oxide synthases and GTP cyclohydrolase I in the ventilatory and limb muscles during endotoxemiaQ44402634
The extrinsic caspase pathway modulates endotoxin-induced diaphragm contractile dysfunctionQ44554972
Trolox attenuates mechanical ventilation-induced diaphragmatic dysfunction and proteolysisQ45063932
Effects of intravenous and inhaled levosimendan in severe rodent sepsisQ46050849
Levosimendan enhances force generation of diaphragm muscle from patients with chronic obstructive pulmonary diseaseQ46259496
Formation of reactive nitrogen species during peroxidase-catalyzed oxidation of nitrite. A potential additional mechanism of nitric oxide-dependent toxicityQ46316617
Levosimendan is superior to enoximone in refractory cardiogenic shock complicating acute myocardial infarctionQ46457030
Inhaled levosimendan reduces mortality and release of proinflammatory mediators in a rat model of experimental ventilator-induced lung injuryQ46582094
Hypoxia-induced skeletal muscle fiber dysfunction: role for reactive nitrogen speciesQ46661224
P304page(s)69
P577publication date2015-03-02
P1433published inCritical CareQ5186602
P1476titleLevosimendan affects oxidative and inflammatory pathways in the diaphragm of ventilated endotoxemic mice
P478volume19

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cites work (P2860)
Q47808221Diaphragm Atrophy and Weakness in the Absence of Mitochondrial Dysfunction in the Critically Ill.
Q40438507Late Therapeutic Intervention with Antibiotics and Fluid Resuscitation Allows for a Prolonged Disease Course with High Survival in a Severe Murine Model of Sepsis
Q26738701Levosimendan beyond inotropy and acute heart failure: Evidence of pleiotropic effects on the heart and other organs: An expert panel position paper
Q47793271Levosimendan prevents bronchoconstriction and adverse respiratory tissue mechanical changes in rabbits
Q93216038Ventilator-induced diaphragm dysfunction in critical illness
Q92190679Ventilator-induced diaphragm dysfunction: translational mechanisms lead to therapeutical alternatives in the critically ill

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