Indoleamine 2,3-dioxygenase-expressing leukemic dendritic cells impair a leukemia-specific immune response by inducing potent T regulatory cells

scientific article published on 26 August 2010

Indoleamine 2,3-dioxygenase-expressing leukemic dendritic cells impair a leukemia-specific immune response by inducing potent T regulatory cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3324/HAEMATOL.2010.025924
P932PMC publication ID2995559
P698PubMed publication ID20801903
P5875ResearchGate publication ID46036208

P50authorMichele BaccaraniQ66370907
Emanuela OttavianiQ66382511
Raimondo De CristofaroQ42054575
Sergio RutellaQ42054583
P2093author name stringAntonio Curti
Roberto M Lemoli
Cecilia Evangelisti
Darina Ocadlikova
Valentina Salvestrini
Chiara Onofri
Michela Aluigi
Sara Trabanelli
P2860cites workTolerance, DCs and tryptophan: much ado about IDOQ28203295
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Thymosin 1 activates dendritic cell tryptophan catabolism and establishes a regulatory environment for balance of inflammation and toleranceQ58855391
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Stimulation of autologous proliferative and cytotoxic T-cell responses by "leukemic dendritic cells" derived from blast cells in acute myeloid leukemiaQ73785023
Circulating blood dendritic cells from myeloid leukemia patients display quantitative and cytogenetic abnormalities as well as functional impairmentQ77337172
Human acute myeloblastic leukemia cells differentiate in vitro into mature dendritic cells and induce the differentiation of cytotoxic T cells against autologous leukemiasQ78162686
CD34(+) acute myeloid and lymphoid leukemic blasts can be induced to differentiate into dendritic cellsQ78225346
Dendritic cells have the option to express IDO-mediated suppression or notQ81474897
Cancer immunoediting: from immunosurveillance to tumor escapeQ28212251
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survivalQ29547865
IDO expression by dendritic cells: tolerance and tryptophan catabolismQ29614752
Tryptophan catabolism and T-cell tolerance: immunosuppression by starvation?Q33740214
Malignant counterpart of myeloid dendritic cell (DC) belonging to acute myelogenous leukemia (AML) exhibits a dichotomous immunoregulatory potentialQ34170214
Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer.Q34515741
Increase of regulatory T cells in the peripheral blood of cancer patients.Q34531138
The indoleamine 2,3-dioxygenase pathway is essential for human plasmacytoid dendritic cell-induced adaptive T regulatory cell generationQ34657284
Standardization and quality control studies of 'real-time' quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia - a Europe Against Cancer program.Q35561038
Intratumoral CD4+CD25+ regulatory T-cell-mediated suppression of infiltrating CD4+ T cells in B-cell non-Hodgkin lymphomaQ35849633
Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenaseQ35925641
Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase.Q36376561
Regulatory T cells, tumour immunity and immunotherapyQ36430144
Feasibility of clinical dendritic cell vaccination in acute myeloid leukemiaQ36571706
Indoleamine 2,3-dioxygenase-expressing mature human monocyte-derived dendritic cells expand potent autologous regulatory T cells.Q37268984
The role of indoleamine 2,3-dioxygenase in the induction of immune tolerance: focus on hematologyQ37331219
Relationship between interferon-gamma, indoleamine 2,3-dioxygenase, and tryptophan catabolismQ37349845
Toward the identification of a tolerogenic signature in IDO-competent dendritic cells.Q38317862
Indoleamine 2,3-dioxygenase activity of acute myeloid leukemia cells can be measured from patients' sera by HPLC and is inducible by IFN-gamma.Q40068974
Modulation of tryptophan catabolism by human leukemic cells results in the conversion of CD25- into CD25+ T regulatory cellsQ40197317
More rapid method for simultaneous measurement of tryptophan and kynurenine by HPLC.Q43893230
CTLA-4-Ig regulates tryptophan catabolism in vivo.Q44170968
Functional plasticity of dendritic cell subsets as mediated by CD40 versus B7 activationQ44556007
Modulation of tryptophan catabolism by regulatory T cells.Q44632333
Regulation of human auto- and alloreactive T cells by indoleamine 2,3-dioxygenase (IDO)-producing dendritic cells: too much ado about IDO?Q45168864
Interferon-gamma-triggered indoleamine 2,3-dioxygenase competence in human monocyte-derived dendritic cells induces regulatory activity in allogeneic T cells.Q45922663
High INDO (indoleamine 2,3-dioxygenase) mRNA level in blasts of acute myeloid leukemic patients predicts poor clinical outcomeQ46218678
Reduced frequencies and suppressive function of CD4+CD25hi regulatory T cells in patients with chronic lymphocytic leukemia after therapy with fludarabineQ46508260
A clinical and immunologic phase 2 trial of Wilms tumor gene product 1 (WT1) peptide vaccination in patients with AML and MDS.Q47953114
Dendritic cells are functionally defective in multiple myeloma: the role of interleukin-6.Q51045048
In vivo peripheral expansion of naive CD4+CD25high FoxP3+ regulatory T cells in patients with multiple myeloma.Q51985543
CD4+CD25high Foxp3+ regulatory T cells in myelodysplastic syndrome (MDS).Q53239013
Acute myeloid leukemia cells constitutively express the immunoregulatory enzyme indoleamine 2,3-dioxygenase.Q54703524
The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cellsQ56902123
Increased population of CD4(+)CD25(high), regulatory T cells with their higher apoptotic and proliferating status in peripheral blood of acute myeloid leukemia patientsQ56902500
Immunosuppressive regulatory T cells are abundant in the reactive lymphocytes of Hodgkin lymphomaQ56903494
Interleukin-12 production by leukemia-derived dendritic cells counteracts the inhibitory effect of leukemic microenvironment on T cellsQ56999120
P433issue12
P921main subjectdendritic cellQ506253
leukemiaQ29496
P304page(s)2022-2030
P577publication date2010-08-26
P1433published inHaematologicaQ5638209
P1476titleIndoleamine 2,3-dioxygenase-expressing leukemic dendritic cells impair a leukemia-specific immune response by inducing potent T regulatory cells
P478volume95

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