Pharmacokinetics and pharmacodynamics of continuous infusion meropenem in overweight, obese, and morbidly obese patients with stable and unstable kidney function: a step toward dose optimization for the treatment of severe gram-negative bacterial in

scientific article published on 8 April 2015

Pharmacokinetics and pharmacodynamics of continuous infusion meropenem in overweight, obese, and morbidly obese patients with stable and unstable kidney function: a step toward dose optimization for the treatment of severe gram-negative bacterial in is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1032347647
P356DOI10.1007/S40262-015-0266-2
P698PubMed publication ID25850987

P50authorFederico PeaQ38544304
Piergiorgio CojuttiQ82046186
P2093author name stringManjunath P Pai
P2860cites workA novel approach to pharmacodynamic assessment of antimicrobial agents: new insights to dosing regimen designQ28476705
Prediction of creatinine clearance from serum creatinineQ29615603
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Evaluation by monte carlo simulation of the pharmacokinetics of two doses of meropenem administered intermittently or as a continuous infusion in healthy volunteers.Q33770046
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Continuous infusions of meropenem in ambulatory care: clinical efficacy, safety and stability.Q35206338
Clinical pharmacodynamics of meropenem in patients with lower respiratory tract infectionsQ35759054
Dosing nomograms for attaining optimum concentrations of meropenem by continuous infusion in critically ill patients with severe gram-negative infections: a pharmacokinetics/pharmacodynamics-based approachQ36396195
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Carbapenemase-producing Klebsiella pneumoniae: (when) might we still consider treating with carbapenems?Q37884104
Dosing regimen matters: the importance of early intervention and rapid attainment of the pharmacokinetic/pharmacodynamic targetQ37988861
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Influence of weight on aminoglycoside pharmacokinetics in normal weight and morbidly obese patientsQ40838757
Therapeutic drug monitoring of beta-lactams in critically ill patients: proof of conceptQ42946682
Stability of generic brands of meropenem reconstituted in isotonic saline.Q49046358
Quantification of lean bodyweight.Q50753849
Treatment of consecutive episodes of multidrug-resistant bacterial pleurisy with different aetiology in a heart transplant candidate: proof of concept of pharmacokinetic/pharmacodynamic optimisation of antimicrobial therapy at the infection site.Q54402133
Comparative pharmacokinetics and pharmacodynamics of doripenem and meropenem in obese patients.Q54561986
Steady-state pharmacokinetics and pharmacodynamics of meropenem in morbidly obese patients hospitalized in an intensive care unit.Q54766719
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Stability of generic meropenem solutions for administration by continuous infusion at normal and elevated temperaturesQ87459116
P433issue9
P921main subjectobesityQ12174
pharmacodynamicsQ725307
pharmacokineticsQ323936
meropenemQ421670
Gram-negative bacteriaQ632006
P304page(s)933-941
P577publication date2015-04-08
P1433published inClinical PharmacokineticsQ5133788
P1476titlePharmacokinetics and pharmacodynamics of continuous infusion meropenem in overweight, obese, and morbidly obese patients with stable and unstable kidney function: a step toward dose optimization for the treatment of severe gram-negative bacterial in
P478volume54

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cites work (P2860)
Q40367930Meropenem Dosing Based on a Population Pharmacokinetic-Pharmacodynamic Model in Elderly Patients with Infection of the Lower Respiratory Tract
Q87256160Optimal methodology is important for optimal pharmacokinetic studies, therapeutic drug monitoring and patient care
Q39344408Optimizing β-lactams treatment in critically-ill patients using pharmacokinetics/pharmacodynamics targets: are first conventional doses effective?
Q40494723Patient specific risk stratification for antimicrobial resistance and possible treatment strategies in gram-negative bacterial infections
Q39484436Population Pharmacokinetics and Pharmacodynamics of Meropenem in Nonobese, Obese, and Morbidly Obese Patients
Q40112541Population Pharmacokinetics of High Dose Continuous Infusion Meropenem and Considerations for the Use in the Treatment of Infections due to KPC-Producing Klebsiella pneumoniae
Q59263334Scaling beta-lactam antimicrobial pharmacokinetics from early life to old age
Q87242231Therapeutic drug monitoring and pharmacokinetics/pharmacodynamics of antibiotics as useful tools for translational research and personalized medicine
Q40172540What is the effect of obesity on piperacillin and meropenem trough concentrations in critically ill patients?

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