Increased interleukin-1β levels following low dose MDMA induces tolerance against the 5-HT neurotoxicity produced by challenge MDMA.

scientific article published on 24 November 2011

Increased interleukin-1β levels following low dose MDMA induces tolerance against the 5-HT neurotoxicity produced by challenge MDMA. is …
instance of (P31):
scholarly articleQ13442814
MDMAQ69488

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P6179Dimensions Publication ID1049506342
P356DOI10.1186/1742-2094-8-165
P932PMC publication ID3283542
P698PubMed publication ID22114930
P5875ResearchGate publication ID51828311

P2093author name stringEsther O'Shea
Andrea Mayado
Elisa Torres
Maria D Gutierrez-Lopez
Maria I Colado
P2860cites workThe relationship between the degree of neurodegeneration of rat brain 5-HT nerve terminals and the dose and frequency of administration of MDMA ('ecstasy').Q48374881
Region-specific induction of hypoxic tolerance by expression of stress proteins and antioxidant enzymesQ48545405
Cortical protection by localized striatal injection of IL-1ra following cerebral ischemia in the rat.Q48687973
Alterations in hippocampal function following repeated exposure to the amphetamine derivative methylenedioxymethamphetamine ("Ecstasy").Q48824498
Interleukin-1 mediates induction of tolerance to global ischemia in gerbil hippocampal CA1 neuronsQ48882811
ALTERATIONS IN LYSOSOMES (INTRACELLULAR ENZYMES) DURING SHOCK; EFFECTS OF PRECONDITIONING (TOLERANCE) AND PROTECTIVE DRUGSQ50268727
Chlormethiazole, dizocilpine and haloperidol prevent the degeneration of serotonergic nerve terminals induced by administration of MDMA ('Ecstasy') to ratsQ71694668
The interleukin-1 receptor antagonist (rhIL-1ra) protects against cerebral infarction in a rat model of hypoxia-ischemiaQ72572629
Modulation of the acute phase response by altered expression of the IL-1 type 1 receptor or IL-1raQ73630790
Interleukin-1Q74629939
Protein measurement with the Folin phenol reagentQ20900776
Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complexQ24321703
Potentiation of the T-lymphocyte response to mitogens. I. The responding cellQ24679275
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingQ25938984
Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the ratQ28189196
Cytokines and acute neurodegenerationQ28190084
Evidence that MDMA ('ecstasy') increases cannabinoid CB2 receptor expression in microglial cells: role in the neuroinflammatory response in rat brainQ28564583
3,4-Methylenedioxymethamphetamine increases pro-interleukin-1beta production and caspase-1 protease activity in frontal cortex, but not in hypothalamus, of Dark Agouti rats: role of interleukin-1beta in neurotoxicityQ28568813
Ischemic preconditioning and brain tolerance: temporal histological and functional outcomes, protein synthesis requirement, and interleukin-1 receptor antagonist and early gene expressionQ32024563
The pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy").Q34215236
Endogenous interleukin-1 receptor antagonist is neuroprotectiveQ34427502
Ischemic tolerance and endogenous neuroprotectionQ35126696
A review of the mechanisms involved in the acute MDMA (ecstasy)-induced hyperthermic responseQ35908473
Molecular physiology of preconditioning-induced brain tolerance to ischemiaQ37056974
Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitroQ37126896
Repeated exposure to MDMA provides neuroprotection against subsequent MDMA-induced serotonin depletion in brainQ37368451
MDMA-induced neurotoxicity: long-term effects on 5-HT biosynthesis and the influence of ambient temperatureQ38758177
Repeated intermittent methylenedioxymethamphetamine exposure protects against the behavioral and neurotoxic, but not hyperthermic, effects of an MDMA binge in adult ratsQ40365875
A study on the mechanisms by which minocycline protects against MDMA ('ecstasy')-induced neurotoxicity of 5-HT cortical neuronsQ40379051
3,4-Methylenedioxymethamphetamine increases interleukin-1beta levels and activates microglia in rat brain: studies on the relationship with acute hyperthermia and 5-HT depletionQ40532235
The two interleukin-1 receptors play different roles in IL-1 actions.Q40666059
Central action sites of interleukin-1 beta for inducing fever in rabbitsQ40758941
Changes in interleukin-1 signal modulators induced by 3,4-methylenedioxymethamphetamine (MDMA): regulation by CB2 receptors and implications for neurotoxicityQ41885785
Ischemic preconditioning-induced neuroprotection is associated with differential expression of IL-1beta and IL-1 receptor antagonist in the ischemic cortex.Q41954356
Studies on the role of dopamine in the degeneration of 5-HT nerve endings in the brain of Dark Agouti rats following 3,4-methylenedioxymethamphetamine (MDMA or 'ecstasy') administrationQ42008895
Attenuation by chlormethiazole administration of the rise in extracellular amino acids following focal ischaemia in the cerebral cortex of the rat.Q42015751
In vivo evidence for free radical involvement in the degeneration of rat brain 5-HT following administration of MDMA ('ecstasy') and p-chloroamphetamine but not the degeneration following fenfluramineQ42261569
Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity.Q42489289
Activation of the nuclear factor-kappaB is a key event in brain tolerance.Q43653405
Endogenous interleukin-1 receptor antagonist mediates anti-inflammatory and neuroprotective actions of cannabinoids in neurons and glia.Q44524201
‘Ischemic tolerance’ phenomenon detected in various brain regionsQ44805794
Effect of repeated ('binge') dosing of MDMA to rats housed at normal and high temperature on neurotoxic damage to cerebral 5-HT and dopamine neuronesQ45053012
(+/-)-3,4-Methylenedioxymethamphetamine administration to rats does not decrease levels of the serotonin transporter protein or alter its distribution between endosomes and the plasma membraneQ46529137
Kainic acid-induced oxidative injury is attenuated by hypoxic preconditioningQ46555128
Biochemical and histological evidence that methylenedioxymethylamphetamine (MDMA) is toxic to neurons in the rat brainQ46580669
Repeated adolescent 3,4-methylenedioxymethamphetamine (MDMA) exposure in rats attenuates the effects of a subsequent challenge with MDMA or a 5-hydroxytryptamine(1A) receptor agonist.Q46910077
Endotoxin preconditioning protects neurones from in vitro ischemia: role of endogenous IL-1beta and TNF-alphaQ46913266
Evidence for a role of Hsp70 in the neuroprotection induced by heat shock pre-treatment against 3,4-methylenedioxymethamphetamine toxicity in rat brainQ48258439
P921main subjectneurotoxicityQ3338704
P304page(s)165
P577publication date2011-11-24
P1433published inJournal of NeuroinflammationQ15716679
P1476titleIncreased interleukin-1β levels following low dose MDMA induces tolerance against the 5-HT neurotoxicity produced by challenge MDMA.
P478volume8

Reverse relations

cites work (P2860)
Q58112081Cognitive deficits and neurotoxicity induced by synthetic cathinones: is there a role for neuroinflammation?
Q36612395IL-1RAcPb signaling regulates adaptive mechanisms in neurons that promote their long-term survival following excitotoxic insults
Q64103344Increased iNOS and Nitrosative Stress in Dopaminergic Neurons of MDMA-Exposed Rats
Q28389929Interleukin 1 receptor contributes to methamphetamine- and sleep deprivation-induced hypersomnolence
Q37052573Sigma receptor antagonists attenuate acute methamphetamine-induced hyperthermia by a mechanism independent of IL-1β mRNA expression in the hypothalamus.

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