| review article | Q7318358 |
| scholarly article | Q13442814 |
| P356 | DOI | 10.1016/S0026-0495(97)90259-6 |
| P698 | PubMed publication ID | 9054475 |
| P2093 | author name string | Stacpoole PW | |
| P2860 | cites work | Sequence and organization of the human mitochondrial genome | Q27860659 |
| Diabetes mellitus associated with a pathogenic point mutation in mitochondrial DNA | Q28184211 | ||
| A controlled clinical trial of dichloroacetate for treatment of lactic acidosis in adults. The Dichloroacetate-Lactic Acidosis Study Group | Q28202643 | ||
| Myocardial reperfusion: a double-edged sword? | Q28236054 | ||
| The biologic clock: the mitochondria? | Q28249363 | ||
| Vitamin C elevates red blood cell glutathione in healthy adults | Q28259925 | ||
| Zidovudine myopathy: a distinctive disorder associated with mitochondrial dysfunction | Q28333104 | ||
| Role of free radicals and catalytic metal ions in human disease: an overview | Q29618022 | ||
| Effect of dichloroacetate on recovery of brain lactate, phosphorus energy metabolites, and glutamate during reperfusion after complete cerebral ischemia in rats | Q30840690 | ||
| Ferritin: structure, gene regulation, and cellular function in animals, plants, and microorganisms | Q34049507 | ||
| Acidosis during ischemia promotes adenosine triphosphate resynthesis in postischemic rat heart. In vivo regulation of 5'-nucleotidase | Q34118360 | ||
| Intracellular glucose oxidation and glycogen synthase activity are reduced in non-insulin-dependent (type II) diabetes independent of impaired glucose uptake | Q34243161 | ||
| Oxygen radicals generated at reflow induce peroxidation of membrane lipids in reperfused hearts | Q34264913 | ||
| A different genetic code in human mitochondria | Q34280642 | ||
| Cytochrome oxidase: an endogenous metabolic marker for neuronal activity | Q34413256 | ||
| Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART). | Q34464251 | ||
| Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons | Q34560112 | ||
| Importance of maternal history of non-insulin dependent diabetic patients | Q35179396 | ||
| Alternative excitotoxic hypotheses | Q35227246 | ||
| Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses? | Q35254212 | ||
| Reactive oxygen species and the central nervous system | Q35389986 | ||
| Recombinant superoxide dismutase reduces oxygen free radical concentrations in reperfused myocardium | Q35583614 | ||
| Does the mitochondrial DNA play a role in the pathogenesis of diabetes? | Q35654346 | ||
| Relationship between antioxidants, prooxidants, and the aging process | Q35656688 | ||
| Diseases of the mitochondrial DNA. | Q35671010 | ||
| Detection of a specific mitochondrial DNA deletion in tissues of older humans | Q35891834 | ||
| Targeting proteins to mitochondria: a current overview | Q36285645 | ||
| Ten unorthodox perspectives on evolution prompted by comparative population genetic findings on mitochondrial DNA | Q36468295 | ||
| Neurological disease and mitochondrial genes | Q36654770 | ||
| Cholinergic mechanisms in learning, memory and dementia: a review of recent evidence | Q36679262 | ||
| Biological Effects of ω-3 Fatty Acids in Diabetes Mellitus | Q36923363 | ||
| Effects of changes of pH on the contractile function of cardiac muscle | Q37936255 | ||
| Mitochondrial mutations may increase oxidative stress: implications for carcinogenesis and aging? | Q37936915 | ||
| Biogenesis of mitochondria | Q38195055 | ||
| The pharmacology of dichloroacetate | Q38300732 | ||
| Dichloroacetate increases glucose use and decreases lactate in developing rat brain | Q38472490 | ||
| ATP and brain function | Q38597443 | ||
| Free radicals in ischemic and reperfusion myocardial injury: is this the time for clinical trials? | Q38721151 | ||
| Mechanisms of glycolytic inhibition in ischemic rat hearts | Q39063412 | ||
| Free radicals and myocardial ischemia: overview and outlook | Q39182196 | ||
| A Role of Mitochondrial Glutathione Peroxidase in Modulating Mitochondrial Oxidations in Liver | Q39188226 | ||
| On the role of mitochondria in transmitter release from motor nerve terminals | Q39338197 | ||
| The mitochondrial electron transport and oxidative phosphorylation system | Q39382891 | ||
| Oxygen-derived free radicals in postischemic tissue injury | Q39492590 | ||
| Influence of acidosis on lipid peroxidation in brain tissues in vitro. | Q48483303 | ||
| An immunochemical study of the pyruvate dehydrogenase deficit in Alzheimer's disease brain | Q48490885 | ||
| What causes infarction in ischemic brain?: The Robert Wartenberg Lecture | Q48541821 | ||
| The activity of pyruvate dehydrogenase in rat brain during postnatal development | Q48580986 | ||
| Effects of dichloroacetate on pyruvate metabolism in rat brain in vivo | Q48616285 | ||
| Influence of in vitro lactic acidosis and hypercapnia on respiratory activity of isolated rat brain mitochondria | Q48627993 | ||
| Effects of dichloroacetate on brain tissue pyruvate dehydrogenase | Q48731883 | ||
| Thiamine-dependent enzyme changes in temporal cortex of patients with Alzheimer's disease | Q48852396 | ||
| Enzyme activities in relation to pH and lactate in postmortem brain in Alzheimer-type and other dementias | Q48868584 | ||
| The regulation of pyruvate dehydrogenase activity in rat hippocampal slices: Effect of dichloroacetate | Q48921493 | ||
| Age-related modifications of cytochrome C oxidase activity in discrete brain regions | Q48926024 | ||
| Neurological protection by dichloroacetate depending on the severity of injury in the paraplegic rat. | Q48940642 | ||
| Brain lactic acidosis and synaptic function | Q49121608 | ||
| Acidosis reduces NMDA receptor activation, glutamate neurotoxicity, and oxygen-glucose deprivation neuronal injury in cortical cultures | Q49136129 | ||
| A subtype of diabetes mellitus associated with a mutation of mitochondrial DNA. | Q50525235 | ||
| Adult-onset diabetes mellitus and neurosensory hearing loss in maternal relatives of MELAS patients in a family with the tRNA(Leu(UUR)) mutation. | Q50530038 | ||
| Mutation in mitochondrial tRNALeu(UUR) gene in a large pedigree with maternally transmitted type II diabetes mellitus and deafness | Q50537181 | ||
| Insulin and proinsulin secretion in subjects with abnormal glucose tolerance and a mitochondrial tRNA(Leu(UUR)) mutation. | Q51584715 | ||
| Total-body and myocardial substrate oxidation in congestive heart failure. | Q51596891 | ||
| Metabolic Effects of Dichloroacetate in Patients with Diabetes Mellitus and Hyperlipoproteinemia | Q51665212 | ||
| Brain dysfunction in mild to moderate hypoxia. | Q52101584 | ||
| Brain pyruvate dehydrogenase: phosphorylation and enzyme activity altered by a training experience. | Q52292047 | ||
| Natural history and course of acquired lactic acidosis in adults. DCA-Lactic Acidosis Study Group. | Q52374590 | ||
| Coenzyme a-acetylating enzymes in Alzheimer's disease: Possible cholinergic ‘compartment’ of pyruvate dehydrogenase | Q53196480 | ||
| Insulin resistance in mitochondrial gene mutation. | Q54200944 | ||
| Oxygen-mediated myocardial damage during ischameia and reperfusion: Role of the cellular defences against oxygen toxicity | Q57312585 | ||
| Redox regulation of fos and jun DNA-binding activity in vitro | Q57963256 | ||
| Pharmacologic doses of vitamin E improve insulin action in healthy subjects and non-insulin-dependent diabetic patients | Q58829456 | ||
| Carnitine stimulation of pyruvate dehydrogenase complex (PDHC) in isolated human skeletal muscle mitochondria | Q60746877 | ||
| Maternally inherited myopathy and cardiomyopathy: association with mutation in mitochondrial DNA tRNALeu(UUR) | Q61606262 | ||
| DECLINE IN SKELETAL MUSCLE MITOCHONDRIAL RESPIRATORY CHAIN FUNCTION: POSSIBLE FACTOR IN AGEING | Q61874684 | ||
| Short-term TPN containing n-3 fatty acids ameliorate lactic acidosis induced by endotoxin in guinea pigs. | Q64985226 | ||
| Activation of the pyruvate dehydrogenase complex in isolated fat cell mitochondria by hydrogen peroxide and t-butyl hydroperoxide | Q67289050 | ||
| Influence of mitochondrial radical formation on energy-linked respiration | Q67403592 | ||
| Point mutations in mitochondrial DNA in patients with hypertrophic cardiomyopathy | Q67586161 | ||
| Age-related Decrease in Respiratory Muscle Mitochondrial Function in Rats | Q67720292 | ||
| Analyses of mitochondrial respiratory chain function and mitochondrial DNA deletion in human skeletal muscle: effect of ageing | Q67970677 | ||
| Hypoxemia is associated with mitochondrial DNA damage and gene induction. Implications for cardiac disease | Q67971248 | ||
| The relative contribution of glucose and fatty acids to ATP production in hearts reperfused following ischemia | Q67983961 | ||
| Mitochondrial oxidative phosphorylation defects in Parkinson's disease | Q68060626 | ||
| Intracellular Ca2+ concentration and pHi during metabolic inhibition | Q68077083 | ||
| Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: an age-related alteration | Q68078839 | ||
| Role of synaptosomal enzymatic alterations and drug treatment in brain aging | Q68079353 | ||
| Diets enriched with N-3 fatty acids ameliorate lactic acidosis by improving endotoxin-induced tissue hypoperfusion in guinea pigs | Q68192843 | ||
| Myocardial metabolic and hemodynamic effects of dichloroacetate in coronary artery disease | Q68253213 | ||
| Multiple mitochondrial DNA deletions exist in cardiomyocytes of patients with hypertrophic or dilated cardiomyopathy | Q68424891 | ||
| Age-related changes in the activity of the pyruvate carrier and in the lipid composition in rat-heart mitochondria | Q68736519 | ||
| Brain lactate during partial global ischemia and reperfusion: effect of pretreatment with dichloroacetate in a rat model | Q69051690 | ||
| Familial diabetes aggregation in type I diabetics: gestational diabetes an apparent risk factor for increased diabetes susceptibility in the offspring | Q69057004 | ||
| Focal ischemia of the rat brain, with special reference to the influence of plasma glucose concentration | Q69102344 | ||
| Enhancement of iron-catalyzed free radical formation by acidosis in brain homogenates: differences in effect by lactic acid and CO2 | Q69173527 | ||
| Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease | Q69356679 | ||
| Abnormalities of the electron transport chain in idiopathic Parkinson's disease | Q69361952 | ||
| Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases | Q69368213 | ||
| Liver mitochondrial respiratory functions decline with age | Q69423702 | ||
| Treatment of lactic acidosis: effects of dichloroacetate on lactate and pyruvate levels in the cerebrospinal fluid | Q69568399 | ||
| Age-dependent increase in deleted mitochondrial DNA in the human heart: possible contributory factor to presbycardia | Q70160150 | ||
| Age-dependent changes in rat brain mitochondria of synaptic and non-synaptic origins | Q70183748 | ||
| Mechanisms of ischemic brain damage | Q70214064 | ||
| Relative effects of dietary saturated, monounsaturated, and polyunsaturated fatty acids on cardiac arrhythmias in rats | Q70539192 | ||
| Nonenzymatic decarboxylation of pyruvate | Q70608179 | ||
| Diabetes mellitus is one of the heterogeneous phenotypic features of a mitochondrial DNA point mutation within the tRNALeu(UUR) gene | Q70669999 | ||
| Phosphorylation‐Mediated Changes in Pyruvate Dehydrogenase Activity Influence Pyruvate‐Supported Calcium Accumulation by Brain Mitochondria | Q70800125 | ||
| Evidence that the 40,000 Mr phosphoprotein influenced by high frequency synaptic stimulation is the alpha subunit of pyruvate dehydrogenase | Q70901828 | ||
| Decreased flux through pyruvate dehydrogenase by thiol oxidation during t-butyl hydroperoxide metabolism in perfused rat liver | Q71068656 | ||
| Effects of dichloroacetate on brain pyruvate dehydrogenase | Q71249395 | ||
| Extra-pancreatic manifestations in diabetes secondary to mitochondrial DNA point mutation within the tRNALeu(UUR) gene | Q71733516 | ||
| Mitochondrial gene defects in patients with NIDDM | Q72134564 | ||
| Japanese case of diabetes mellitus and deafness with mutation in mitochondrial tRNA(Leu(UUR)) gene | Q72218707 | ||
| Mitochondrial gene mutation in islet-cell-antibody-positive patients who were initially non-insulin-dependent diabetics | Q72229102 | ||
| Effect of pyruvate on rat heart thiol status during ischemia and hypoxia followed by reperfusion | Q72584949 | ||
| Antioxidants in adipose tissue and risk of myocardial infarction: the EURAMIC Study | Q72657326 | ||
| New accomplices in cell death | Q72657737 | ||
| Lactic acidosis | Q72815481 | ||
| Brain cell death following ischemia and reperfusion | Q104176973 | ||
| Prooxidant states and tumor promotion | Q39492603 | ||
| Role of toxic effects of oxygen in reperfusion damage | Q39519112 | ||
| Neurotoxicity at the N-methyl-D-aspartate receptor in energy-compromised neurons. An hypothesis for cell death in aging and disease. | Q39528853 | ||
| Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced | Q39531608 | ||
| Mechanisms decreasing glucose oxidation in diabetes and starvation: role of lipid fuels and hormones. | Q39567008 | ||
| Oxygen-derived free radicals and postischemic myocardial dysfunction ("stunned myocardium"). | Q39645520 | ||
| Oxygen radicals and human disease | Q39668375 | ||
| Gestational diabetes mellitus: a syndrome with phenotypic and genotypic heterogeneity | Q39741246 | ||
| Synaptic Phosphoproteins: Specific Changes After Repetitive Stimulation of the Hippocampal Slice | Q40192686 | ||
| Effects of age on brain oxidative metabolism in vivo | Q40209000 | ||
| Mitochondrial role in cell aging | Q40300244 | ||
| Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle | Q40334538 | ||
| Vitamin C (ascorbic acid): new roles, new requirements? | Q40714416 | ||
| Evolving concepts about the role of acidosis in ischemic neuropathology | Q40840232 | ||
| Mitochondrial DNA alterations as a source of human disorders | Q40878686 | ||
| Mitochondrial genetics: a paradigm for aging and degenerative diseases? | Q41112226 | ||
| Inhibition of lactate-induced swelling by dichloroacetate in human astrocytoma cells | Q41150928 | ||
| Effect of acidosis on lipid peroxidation in brain slices | Q41181892 | ||
| Comparison of sodium bicarbonate with dichloroacetate treatment of hyperlactatemia and lactic acidosis in the ischemic rat. | Q41300997 | ||
| Regulation of glucose transport and GLUT1 glucose transporter expression by O2 in muscle cells in culture | Q41638607 | ||
| Mitochondrial complex I deficiency in Parkinson's disease | Q41821730 | ||
| The regulation of pyruvate oxidation during membrane depolarization of rat brain synaptosomes | Q41833053 | ||
| Age-associated accumulation of 8-hydroxydeoxyguanosine in mitochondrial DNA of human diaphragm | Q41879903 | ||
| The release of iron from horse spleen ferritin by reduced flavins | Q42051438 | ||
| Pyruvate carboxylation as an anaplerotic mechanism in the isolated perfused rat heart | Q42874438 | ||
| Intracellular calcium concentrations during "chemical hypoxia" and excitotoxic neuronal injury | Q43414054 | ||
| Relationship between metabolic recovery and the EEG prolonged ischemia of cat brain | Q43450837 | ||
| Free radical activity in type 2 diabetes | Q43592247 | ||
| The protective action of pyruvate on recovery of ischemic rat heart: comparison with other oxidizable substrates | Q43627187 | ||
| Antagonism of non-NMDA receptors augments the neuroprotective effect of NMDA receptor blockade in cortical cultures subjected to prolonged deprivation of oxygen and glucose | Q43840051 | ||
| Regulation of reductive processes by glutathione | Q43844826 | ||
| Effect of dichloroacetate on regional energy metabolites and pyruvate dehydrogenase activity during ischemia and reperfusion in gerbil brain | Q44209885 | ||
| Treatment of chronic congenital lactic acidosis by oral administration of dichloroacetate | Q44292555 | ||
| Facilitating postischemic reduction of cerebral lactate in rats | Q44444894 | ||
| Lactic acidosis complicating the acquired immunodeficiency syndrome | Q44462540 | ||
| Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease and senescence | Q44498466 | ||
| Dietary polyunsaturated fatty acids and mortality in the Multiple Risk Factor Intervention Trial (MRFIT). | Q44606760 | ||
| Changes in cell membranes during aging | Q45118265 | ||
| Reduction in spinal cord postischemic lactic acidosis and functional improvement with dichloroacetate | Q45288285 | ||
| Evidence for a defect in NADH: ubiquinone oxidoreductase (complex I) in Huntington's disease | Q45294442 | ||
| Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain | Q45304576 | ||
| Effect of pyruvate on regional ventricular function in normal and stunned myocardium. | Q45909656 | ||
| Improved hemodynamic function and mechanical efficiency in congestive heart failure with sodium dichloroacetate | Q46147997 | ||
| Perinatal development of heart, kidney, and liver mitochondrial antioxidant defense | Q46330056 | ||
| The mitochondrial receptor complex: a central role of MOM22 in mediating preprotein transfer from receptors to the general insertion pore | Q48106541 | ||
| Effects of dichloroacetate in spinal stroke in the rabbit | Q48218730 | ||
| A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds | Q48233568 | ||
| Age-dependent impairment of mitochondrial function in primate brain | Q48291742 | ||
| Mitochondrial and nuclear gene expression for cytochrome oxidase subunits are disproportionately regulated by functional activity in neurons. | Q48293942 | ||
| Do defecs in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases? | Q48317832 | ||
| Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age | Q48403808 | ||
| Pyruvate dehydrogenase dephosphorylation in rat brain synaptosomes and mitochondria: evidence for a calcium-mediated effect in response to depolarization, and variations due to ageing | Q48444604 | ||
| P433 | issue | 3 | |
| P921 | main subject | lactic acidosis | Q1500373 |
| P1104 | number of pages | 16 | |
| P304 | page(s) | 306-321 | |
| P577 | publication date | 1997-03-01 | |
| P1433 | published in | Metabolism | Q15764354 |
| P1476 | title | Lactic acidosis and other mitochondrial disorders | |
| P478 | volume | 46 |
| Q39885131 | A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis |
| Q44446413 | Assessment of acid-base status and plasma lactate concentrations in arterial, mixed venous, and portal blood from dogs during experimental hepatic blood inflow occlusion |
| Q33704062 | Cancer cell metabolism: its relevance to cancer treatment |
| Q48163834 | Complete Mitochondrial Complex I Deficiency Induces an Up-Regulation of Respiratory Fluxes That Is Abolished by Traces of Functional Complex I. |
| Q73940041 | Dichloroacetate as metabolic therapy for myocardial ischemia and failure |
| Q43620377 | Early recognition of acute cardiovascular beriberi by interpretation of hemodynamics |
| Q36250291 | Lactic acidosis: from sour milk to septic shock |
| Q40604268 | Lactic and hydrochloric acids induce different patterns of inflammatory response in LPS-stimulated RAW 264.7 cells |
| Q34675383 | Metabolic acidosis in the intensive care unit |
| Q77291654 | Mitochondrial Toxicity Associated with Nucleoside Reverse Transcriptase Inhibitor Therapy |
| Q35532937 | Mitochondrial respiratory complex I dysfunction promotes tumorigenesis through ROS alteration and AKT activation |
| Q34279271 | Mitochondrial toxicity and HIV therapy |
| Q35019241 | Mouse and bovine models for human IVF. |
| Q34533270 | Population kinetics, efficacy, and safety of dichloroacetate for lactic acidosis due to severe malaria in children |
| Q44693675 | Serum L-lactate and pyruvate in HIV-infected patients with and without presumed NRTI-related adverse events compared to healthy volunteers |
| Q51224385 | Severe metabolic acidosis after a single tonic-clonic seizure. |
| Q26825142 | Sleep disorders associated with primary mitochondrial diseases |
| Q90540850 | Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution |
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| Q37982890 | The pyruvate dehydrogenase complex as a therapeutic target for age-related diseases |
| Q45862867 | The signal and the trap: targeted delivery and retention of proteins in the mitochondrion |
| Q38988403 | Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1. |
| Q35257790 | Treatment of congenital lactic acidosis with dichloroacetate |
| Q36971240 | Unusual presentation of anaplastic large cell lymphoma with clinical course mimicking fever of unknown origin and sepsis: autopsy study of five cases |
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