The novel Rac effector RIN-1 regulates neuronal cell migration and axon pathfinding in C. elegans

scientific article published on August 2013

The novel Rac effector RIN-1 regulates neuronal cell migration and axon pathfinding in C. elegans is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1242/DEV.089722
P932PMC publication ID4074257
P698PubMed publication ID23900541
P5875ResearchGate publication ID253648294

P50authorYukihiko KubotaQ57334360
P2093author name stringMotomichi Doi
Masaaki Miyamoto
Kiyoji Nishiwaki
Hideki Minematsu
P2860cites workThe Rab5 guanylate exchange factor Rin1 regulates endocytosis of the EphA4 receptor in mature excitatory neuronsQ36858652
Receptor-mediated endocytosis in the Caenorhabditis elegans oocyte.Q36956321
CED-10/Rac1 mediates axon guidance by regulating the asymmetric distribution of MIG-10/lamellipodin.Q37242270
Netrin, Slit and Wnt receptors allow axons to choose the axis of migration.Q37272801
The Caenorhabditis elegans P21-activated kinases are differentially required for UNC-6/netrin-mediated commissural motor axon guidanceQ38308396
The SRC homology 2 domain of Rin1 mediates its binding to the epidermal growth factor receptor and regulates receptor endocytosisQ38353980
CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegansQ39749591
Endocytic trafficking of Rac is required for the spatial restriction of signaling in cell migrationQ39963386
UNC-6/Netrin induces neuronal asymmetry and defines the site of axon formationQ40345230
ced-10 Rac and mig-2 function redundantly and act with unc-73 trio to control the orientation of vulval cell divisions and migrations in Caenorhabditis elegansQ43849683
Role of a new Rho family member in cell migration and axon guidance in C. elegansQ46184903
The netrin receptor UNC-40/DCC stimulates axon attraction and outgrowth through enabled and, in parallel, Rac and UNC-115/AbLIM.Q46349589
Regulators of endocytosis maintain localized receptor tyrosine kinase signaling in guided migrationQ46626360
Three C. elegans Rac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis.Q47069113
Distinct rac activation pathways control Caenorhabditis elegans cell migration and axon outgrowthQ47069232
Establishment of left/right asymmetry in neuroblast migration by UNC-40/DCC, UNC-73/Trio and DPY-19 proteins in C. elegans.Q47069270
Rin1 is a negative regulator of the IL3 receptor signal transduction pathways.Q53599362
A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5Q24291960
The RAS effector RIN1 modulates the formation of aversive memoriesQ24294343
RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migrationQ24301773
Identification of the switch in early-to-late endosome transitionQ24309112
Protein binding and signaling properties of RIN1 suggest a unique effector functionQ24319548
Multiple signaling mechanisms of the UNC-6/netrin receptors UNC-5 and UNC-40/DCC in vivoQ24548195
The small GTP-binding protein rac regulates growth factor-induced membrane rufflingQ27861063
A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and functionQ29620529
RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathwayQ30164512
A pathway for phagosome maturation during engulfment of apoptotic cellsQ30436503
Cloning and expression of sprint, a Drosophila homologue of RIN1.Q30982656
Rabx-5 regulates RAB-5 early endosomal compartments and synaptic vesicles in C. elegansQ31063785
Enhanced neuronal RNAi in C. elegans using SID-1.Q33952532
Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1.Q34101310
Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegansQ34399697
Caenorhabditis elegans RME-6 is a novel regulator of RAB-5 at the clathrin-coated pitQ34442081
Rin1 regulates insulin receptor signal transduction pathwaysQ34491332
Moving around in a worm: netrin UNC-6 and circumferential axon guidance in C. elegansQ34750271
Regulation of F-actin-dependent processes by the Abl family of tyrosine kinasesQ35140568
Rac proteins and the control of axon developmentQ35172832
How do Abl family kinases regulate cell shape and movement?Q35631928
The engulfment process of programmed cell death in caenorhabditis elegansQ35912786
Vps9 domain-containing proteins: activators of Rab5 GTPases from yeast to neuronsQ36332014
A protocol describing pharynx counts and a review of other assays of apoptotic cell death in the nematode worm Caenorhabditis elegansQ36779433
P433issue16
P407language of work or nameEnglishQ1860
P921main subjectCaenorhabditis elegansQ91703
Ras-related protein ced-10 CELE_C09G12.8Q29796438
P1104number of pages10
P304page(s)3435-3444
P577publication date2013-08-01
P1433published inDevelopmentQ3025404
P1476titleThe novel Rac effector RIN-1 regulates neuronal cell migration and axon pathfinding in C. elegans
P478volume140

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cites work (P2860)
Q58796473Distinct CED-10/Rac1 domains confer context-specific functions in development
Q60955118Perspectives of RAS and RHEB GTPase Signaling Pathways in Regenerating Brain Neurons
Q35956569Rac-GTPases Regulate Microtubule Stability and Axon Growth of Cortical GABAergic Interneurons.
Q52617275Regulation of early endosomes across eukaryotes: Evolution and functional homology of Vps9 proteins.

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