The Food-Associated Ribotoxin Deoxynivalenol Modulates Inducible NO Synthase in Human Intestinal Cell Model.

scientific article published on 12 March 2015

The Food-Associated Ribotoxin Deoxynivalenol Modulates Inducible NO Synthase in Human Intestinal Cell Model. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/TOXSCI/KFV058
P698PubMed publication ID25766886
P5875ResearchGate publication ID273464204

P50authorIsabelle P OswaldQ57143285
Marc MarescaQ57317194
Josette PerrierQ88060396
Eric Di PasqualeQ97904162
Cendrine NicolettiQ97904165
Fabien GrazianiQ114318812
Ange PujolQ114318813
P2093author name stringPhilippe Pinton
Loriane Armand
P2860cites workImpacts of the feed contaminant deoxynivalenol on the intestine of monogastric animals: poultry and swine.Q38263480
Role of nitric oxide in host defense in murine salmonellosis as a function of its antibacterial and antiapoptotic activitiesQ39655032
Protein expression profiling of mouse thymoma cells upon exposure to the trichothecene deoxynivalenol (DON): Implications for its mechanism of actionQ39673600
Deoxynivalenol and nivalenol inhibit lipopolysaccharide-induced nitric oxide production by mouse macrophage cellsQ39783299
Rapamycin down-regulates inducible nitric oxide synthase by inducing proteasomal degradationQ39844856
Zinc protoporphyrin inhibition of lipopolysaccharide-, lipoteichoic acid-, and peptidoglycan-induced nitric oxide production through stimulating iNOS protein ubiquitinationQ39859434
Modulation of nitric oxide, hydrogen peroxide and cytokine production in a clonal macrophage model by the trichothecene vomitoxin (deoxynivalenol).Q41046704
Bacterial induction of inducible nitric oxide synthase in cultured human intestinal epithelial cellsQ41071682
Deoxynivalenol alone or in combination with nivalenol and zearalenone induce systemic histological changes in pigs.Q41734918
The food-associated fungal neurotoxin ochratoxin A inhibits the absorption of glutamate by astrocytes through a decrease in cell surface expression of the excitatory amino-acid transporters GLAST and GLT-1.Q43014431
Chronic ingestion of deoxynivalenol and fumonisin, alone or in interaction, induces morphological and immunological changes in the intestine of piglets.Q43414760
Both direct and indirect effects account for the pro-inflammatory activity of enteropathogenic mycotoxins on the human intestinal epithelium: stimulation of interleukin-8 secretion, potentiation of interleukin-1beta effect and increase in the transeQ46727480
The ribotoxin deoxynivalenol affects the viability and functions of glial cells.Q49059266
Enteropathogenic Escherichia coli (EPEC) effector-mediated suppression of antimicrobial nitric oxide production in a small intestinal epithelial model system.Q54474693
Innate immunity in the small intestineQ57253397
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
The impact of Fusarium mycotoxins on human and animal host susceptibility to infectious diseasesQ27004696
Deoxynivalenol as a new factor in the persistence of intestinal inflammatory diseases: an emerging hypothesis through possible modulation of Th17-mediated responseQ27321054
Effect of deoxynivalenol and other Type B trichothecenes on the intestine: a reviewQ33736548
The intestinal epithelium is an integral component of a communications networkQ33808278
Proteomic analysis of the effects of the immunomodulatory mycotoxin deoxynivalenolQ33861765
Modulation of inducible nitric oxide synthase expression by the attaching and effacing bacterial pathogen citrobacter rodentium in infected miceQ34184792
Paradigms of protein degradation by the proteasomeQ34410240
Evaluation of an oral subchronic exposure of deoxynivalenol on the composition of human gut microbiota in a model of human microbiota-associated ratsQ35049126
Comparison of anorectic and emetic potencies of deoxynivalenol (vomitoxin) to the plant metabolite deoxynivalenol-3-glucoside and synthetic deoxynivalenol derivatives EN139528 and EN139544.Q35102616
Effects of oral exposure to naturally-occurring and synthetic deoxynivalenol congeners on proinflammatory cytokine and chemokine mRNA expression in the mouse.Q35534227
Inhibition of nitric oxide and inflammatory cytokines in LPS-stimulated murine macrophages by resveratrol, a potent proteasome inhibitorQ36086859
The effects of mycotoxins, fungal food contaminants, on the intestinal epithelial cell-derived innate immune response.Q36250149
Mixtures in the real world: the importance of plant self-defense toxicants, mycotoxins, and the human dietQ36732776
The toxicological impacts of the Fusarium mycotoxin, deoxynivalenol, in poultry flocks with special reference to immunotoxicityQ37005507
The expression of type-1 and type-2 nitric oxide synthase in selected tissues of the gastrointestinal tract during mixed mycotoxicosisQ37357904
Some food-associated mycotoxins as potential risk factors in humans predisposed to chronic intestinal inflammatory diseases.Q37751087
Deoxynivalenol: mechanisms of action, human exposure, and toxicological relevanceQ37783539
Epithelial barrier biology: good fences make good neighboursQ37951617
Trichothecene toxicity in eukaryotes: cellular and molecular mechanisms in plants and animalsQ38070336
From the gut to the brain: journey and pathophysiological effects of the food-associated trichothecene mycotoxin deoxynivalenolQ38101247
Public health impacts of foodborne mycotoxinsQ38178306
P433issue2
P921main subjectdeoxynivalenolQ420518
P304page(s)372-382
P577publication date2015-03-12
P1433published inToxicological SciencesQ2446966
P1476titleThe Food-Associated Ribotoxin Deoxynivalenol Modulates Inducible NO Synthase in Human Intestinal Cell Model
P478volume145

Reverse relations

cites work (P2860)
Q36560606Barrier protection via Toll-like receptor 2 signaling in porcine intestinal epithelial cells damaged by deoxynivalnol
Q35894734Biochemical Characterization of a Recombinant UDP-glucosyltransferase from Rice and Enzymatic Production of Deoxynivalenol-3-O-β-D-glucoside
Q90581245Deoxynivalenol induces structural alterations in epidermoid carcinoma cells A431 and impairs the response to biomechanical stimulation
Q47219798Detoxification of Fusarium-contaminated maize with sodium sulphite - in vivo efficacy with special emphasis on mycotoxin residues and piglet health
Q94496424Dynamic Malignant Wave of Ribosome-Insulted Gut Niche via the Wnt-CTGF/CCN2 Circuit
Q64102203Effect of Strains on Intestinal Barrier Function and Inflammatory Response
Q93089695Effects of Saccharomyces cerevisiae on alleviating cytotoxicity of porcine jejunal epithelia cells induced by deoxynivalenol
Q37641144Forthcoming Challenges in Mycotoxins Toxicology Research for Safer Food-A Need for Multi-Omics Approach
Q37209011Hydrolytic Fate of 3/15-Acetyldeoxynivalenol in Humans: Specific Deacetylation by the Small Intestine and Liver Revealed Using in Vitro and ex Vivo Approaches
Q36401480Molecular Mechanisms of Lipoic Acid Protection against Aflatoxin B₁-Induced Liver Oxidative Damage and Inflammatory Responses in Broilers
Q47161667Nitric oxide mediates apoptosis and mitochondrial dysfunction and plays a role in growth hormone deficiency by nivalenol in GH3 cells
Q37378866Phosphoproteome Analysis Reveals the Molecular Mechanisms Underlying Deoxynivalenol-Induced Intestinal Toxicity in IPEC-J2 Cells
Q47160469Risks to human and animal health related to the presence of deoxynivalenol and its acetylated and modified forms in food and feed
Q37700056The Food Contaminant Deoxynivalenol Exacerbates the Genotoxicity of Gut Microbiota

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