A Novel Class of Dopamine D4 Receptor Ligands Bearing an Imidazoline Nucleus

scientific article published on 15 March 2016

A Novel Class of Dopamine D4 Receptor Ligands Bearing an Imidazoline Nucleus is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/CMDC.201600022
P932PMC publication ID4993638
P698PubMed publication ID26990230

P50authorSergi FerréQ39025293
Diego Dal BenQ43259191
Gianfabio GiorgioniQ57539490
Ajiroghene ThomasQ58905302
Alessandro BonifaziQ58915030
Thomas M KeckQ63622143
Fabio Del BelloQ91825413
P2093author name stringAmy H Newman
Alessandro Piergentili
Maria Pigini
Mario Giannella
Wilma Quaglia
Valerio Mammoli
Marta Sanchez-Soto
P2860cites workDopamine receptors: from structure to functionQ24336139
Multiple dopamine D4 receptor variants in the human populationQ24336675
Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective AntagonistQ27666030
Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reactionQ27860958
Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neurolepticsQ28258681
AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibilityQ29547658
A semiempirical free energy force field with charge-based desolvationQ29614316
Evidence of positive selection acting at the human dopamine receptor D4 gene locusQ33897512
RO-10-5824 is a selective dopamine D4 receptor agonist that increases novel object exploration in C57 miceQ34184781
A-412997 is a selective dopamine D4 receptor agonist in ratsQ34449795
1-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunctionQ34557924
Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunctionQ34588139
The combinatorial synthesis of bicyclic privileged structures or privileged substructures.Q35083549
Current perspectives on selective dopamine D(3) receptor antagonists as pharmacotherapeutics for addictions and related disordersQ35143623
Small-molecule library screening by docking with PyRxQ35548740
Blockade of dopamine d4 receptors attenuates reinstatement of extinguished nicotine-seeking behavior in ratsQ35679955
Identifying Medication Targets for Psychostimulant Addiction: Unraveling the Dopamine D3 Receptor HypothesisQ35892818
Ring substituents on substituted benzamide ligands indirectly mediate interactions with position 7.39 of transmembrane helix 7 of the D4 dopamine receptorQ36105365
Privileged structures as leads in medicinal chemistry.Q36386430
Sol-gel chemistry in medicinal science.Q36386439
The dopamine D3 receptor: a therapeutic target for the treatment of neuropsychiatric disordersQ36448714
Recent progress in development of dopamine receptor subtype-selective agents: potential therapeutics for neurological and psychiatric disordersQ36702967
Novel insights in dopamine receptor physiologyQ36782648
MOPAC: a semiempirical molecular orbital programQ37328051
Current perspectives on the selective regulation of dopamine D₂ and D₃ receptorsQ37807297
Recent advances in the search for D3- and D4-selective drugs: probes, models and candidatesQ37828272
Dopamine D3 receptor antagonists: a patent review (2007 - 2012).Q38071135
Biologically active compounds based on the privileged 2-imidazoline scaffold: The world beyond adrenergic/imidazoline receptor modulators.Q38281634
Low Doses of Allyphenyline and Cyclomethyline, Effective against Morphine Dependence, Elicit an Antidepressant-like Effect.Q39734497
Exploring multitarget interactions to reduce opiate withdrawal syndrome and psychiatric comorbidityQ39778292
Dopamine D4 ligands and models of receptor activation: 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and related heteroarylmethylarylpiperazines exhibit a substituent effect responsible for additional efficacy tuningQ40567031
Antagonism/Agonism modulation to build novel antihypertensives selectively triggering i1-imidazoline receptor activationQ40753365
Alpha2-adrenoreceptors profile modulation and high antinociceptive activity of (S)-(-)-2-[1-(biphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole.Q40761171
Distribution of dopamine D3 receptor expressing neurons in the human forebrain: comparison with D2 receptor expressing neuronsQ42466412
Fruitful adrenergic α(2C)-agonism/α(2A)-antagonism combination to prevent and contrast morphine tolerance and dependenceQ42868591
Novel imidazoline compounds as partial or full agonists of D2-like dopamine receptors inspired by I2-imidazoline binding sites ligand 2-BFI.Q42923558
Imaging dopamine D3 receptors in the human brain with positron emission tomography, [11C]PHNO, and a selective D3 receptor antagonist.Q42990725
Might adrenergic alpha2C-agonists/alpha2A-antagonists become novel therapeutic tools for pain treatment with morphine?Q43249450
Nefiracetam attenuates methamphetamine-induced discriminative stimulus effects in ratsQ45149998
Effects of L-745,870, a dopamine D4 receptor antagonist, on naloxone-induced morphine dependence in miceQ45150035
Modeling the similarity and divergence of dopamine D2-like receptors and identification of validated ligand-receptor complexesQ45249701
Dopamine agonist-induced penile erection and yawning: a comparative study in outbred Roman high- and low-avoidance ratsQ45851507
Novel ligands rationally designed for characterizing I2-imidazoline binding sites nature and functionsQ46459250
Involvement of dopamine D3 and D4 receptors in the discriminative stimulus properties of cocaine in the rat.Q46853733
Investigation of allyphenyline efficacy in the treatment of alcohol withdrawal symptoms.Q47712456
Discriminative-stimulus effects of methamphetamine and morphine in rats are attenuated by cAMP-related compounds.Q48466809
Labelling of I2B-imidazoline receptors by [3H]2-(2-benzofuranyl)-2-imidazoline (2-BFI) in rat brain and liver: characterization, regulation and relation to monoamine oxidase enzymes.Q48670124
Highly regioselective anti-markovnikov palladium-borate-catalyzed methoxycarbonylation reactions: unprecedented results for aryl olefins.Q50704903
PD168077, a D(4) receptor agonist, reverses object recognition deficits in rats: potential role for D(4) receptor mechanisms in improving cognitive dysfunction in schizophrenia.Q51030175
A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic MoleculesQ55918670
Substituted [(4-phenylpiperazinyl)-methyl]benzamides: selective dopamine D4 agonistsQ73435279
A C-glucosylflavone from leaves of Piper lhotzkyanumQ73468165
Favourable involvement of α2A-adrenoreceptor antagonism in the I₂-imidazoline binding sites-mediated morphine analgesia enhancementQ83523463
P433issue16
P921main subject2-imidazolineQ419555
P304page(s)1819-1828
P577publication date2016-03-15
P1433published inChemMedChemQ2962252
P1476titleA Novel Class of Dopamine D4 Receptor Ligands Bearing an Imidazoline Nucleus
P478volume11

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