Ondansetron. A review of its pharmacology and preliminary clinical findings in novel applications

scientific article published on November 1996

Ondansetron. A review of its pharmacology and preliminary clinical findings in novel applications is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1042459490
P356DOI10.2165/00003495-199652050-00010
P698PubMed publication ID9118822

P50authorAlexander MarkhamQ4719549
P2093author name stringM I Wilde
A Markham
P2860cites workThe effect of GR38032F, novel 5-HT3-receptor antagonist on gastric emptying in the guinea-pigQ24681951
Selective 5-hydroxytryptamine antagonism: a role in irritable bowel syndrome and functional dyspepsia?Q33486166
Ondansetron: a pharmacoeconomic and quality-of-life evaluation of its antiemetic activity in patients receiving cancer chemotherapyQ33560391
The pharmacokinetics of ondansetron after intravenous injection in healthy volunteers phenotyped as poor or extensive metabolisers of debrisoquineQ34346070
Serotonergic mediation of postprandial colonic tonic and phasic responses in humansQ34378949
The pharmacokinetics of intravenous ondansetron in patients with hepatic impairmentQ34403658
Pharmacology and preclinical antiemetic properties of ondansetronQ35349111
Ondansetron metabolism and pharmacokineticsQ35349275
Pharmacology of ondansetronQ35487423
Ondansetron quells drug-resistant emesis in theophylline poisoningQ72608194
Modulation of norepinephrine release by serotonergic receptors in the rat hippocampus as measured by in vivo microdialysisQ72632948
5-hydroxytryptamine 3-receptor antagonist modulates gallbladder emptying and motilin release induced by erythromycinQ72658552
Jaundice with ondansetronQ72683613
Modulatory role of 5-HT3 receptors in gastric function and ethanol-induced mucosal damage in rat stomachsQ72835928
Nausea, abdominal pain and diarrhoea of uncertain cause responding to ondansetronQ72844408
Anaphylactoid-anaphylactic reactions associated with ondansetronQ72939046
The effect of a 5-HT3 receptor antagonist, ondansetron, on brain stimulation reward, and its interaction with direct and indirect stimulants of central dopaminergic transmissionQ72957854
Effects of acute GR38032F (odansetron), a 5-HT3 receptor antagonist, on dopamine and serotonin metabolism in mesolimbic and nigrostriatal dopaminergic neuronsQ93523877
Ondansetron for intractable vertigo complicating acute brainstem disordersQ95820977
Ondansetron: pharmacology of a specific 5HT3-receptor antagonistQ35561324
Ondansetron and related 5-HT3 antagonists: recent advancesQ35644115
Serotonin and psychiatric disorders. A key to new therapeutic approachesQ36111671
Serotonin receptor subtypes and neuropsychiatric diseases: focus on 5-HT1D and 5-HT3 receptor agentsQ36459024
Use of ondansetron for control of projectile vomiting in patients with neurosurgical trauma: two case reportsQ38566839
A pilot study of intravenous ondansetron for hyperemesis gravidarumQ39465331
The use of ondansetron in the treatment of nausea and vomiting associated with acetaminophen poisoningQ39469615
Relief of cholestatic pruritus by a novel class of drugs: 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists: effectiveness of ondansetronQ39476222
Treatment of acute gouty arthritis with the 5-hydroxytryptamine antagonist ondansetronQ39481272
Treatment of pruritus: a new indication for serotonin type 3 receptor antagonistsQ39492197
Ondansetron in the treatment of intractable nausea associated with theophylline toxicityQ39494120
Ondansetron Clinical PharmacokineticsQ40431009
The role of 5-HT3 receptors in drug dependenceQ40480633
Ondansetron. An update of its therapeutic use in chemotherapy-induced and postoperative nausea and vomitingQ40490584
Interactions between 5-HT3 receptors and cerebral dopamine function: implications for the treatment of schizophrenia and psychoactive substance abuseQ40576772
5HT drugs in animal models of anxietyQ40601511
Ondansetron, clinical development for postoperative nausea and vomiting: current studies and future directionsQ40621526
The breadth of action of the 5-HT3 receptor antagonists.Q40761408
5-HT3 receptors: pharmacologic and therapeutic aspectsQ41095351
Effect of 5-hydroxytryptamine on external carotid nerve activity and its blockade by GR38032F in anesthetized ratsQ41822756
An examination of the 5-HT3 receptor mediating contraction and evoked [3H]-acetylcholine release in the guinea-pig ileumQ42025632
5HT3 receptor antagonists do not block nicotine induced hyperactivity in ratsQ42277669
Inhibitory effect of ethanol on the 5-hydroxytryptamine-induced Bezold-Jarisch reflex — involvement of peripheral 5-HT3 receptorsQ42277889
Managing an extrapyramidal reaction caused by ondansetronQ42277940
Extrapyramidal reaction caused by ondansetronQ42500504
The effects of granisetron, ICS 205-930 and ondansetron on the visceral pain reflex induced by duodenal distensionQ42562426
Dysphoria after treatment with ondansetronQ42564682
Conflicting evidence regarding the efficacy of ondansetron in benzodiazepine withdrawal.Q42601432
The comparison of benzodiazepine derivatives and serotonergic agonists and antagonists in two animal models of anxietyQ42606450
Ondansetron usage in HIV positive patients: a pilot study on the control of nausea and vomiting in patients on high dose co-trimoxazole for Pneumocystis carinii pneumoniaQ42608013
Pharmacokinetics of ondansetron in patients with hepatic insufficiencyQ42633540
Serotonergic innervation of the hippocampus and nucleus accumbens septi and the anxiolytic-like action of the 5-HT3 receptor antagonists.Q42692565
Selective 5-hydroxytryptamine type 3 receptor antagonism with ondansetron as treatment for diarrhea-predominant irritable bowel syndrome: a pilot studyQ43310092
Effect of a 5HT3-antagonist (ondansetron) on rectal sensitivity and compliance in health and the irritable bowel syndrome.Q43328501
Effects of chronic administration of ondansetron (GR38032F), a selective 5-HT3 receptor antagonist, on monoamine metabolism in mesolimbic and nigrostriatal dopaminergic neurons and on striatal D2-receptor bindingQ43559808
Ondansetron in carcinoid syndromeQ44197996
Failure of ondansetron to block the discriminative or reinforcing stimulus effects of cocaine in the rat.Q44410438
The effects of ondansetron, a 5-HT3 receptor antagonist, on cognition in rodents and primatesQ44750193
Sites of action of ondansetron to inhibit withdrawal from drugs of abuse.Q46026737
Modulation by 5-HT3 and 5-HT4 receptors of the release of 5-hydroxytryptamine from the guinea-pig small intestineQ46598073
Activation of 5-HT3 receptors enhances the electrically evoked release of [3H]noradrenaline in rat brain limbic structuresQ48124510
Investigation of the role of 5-HT3 receptors in the secretion of prolactin, ACTH and reninQ48260316
Involvement of the serotonergic system in ethanol intake in the rat.Q48288168
5-HT3 receptor antagonists inhibit morphine-induced stimulation of mesolimbic dopamine release and function in the rat.Q48347747
Ondansetron, a 5-HT3 receptor antagonist, partially attenuates the effects of amphetamine: a pilot study in healthy volunteersQ48588432
Concentration of ondansetron in cerebrospinal fluid following oral dosing in volunteersQ48591312
Evaluation of the effects of diazepam and an experimental anti-anxiety drug on regional cerebral blood flowQ48650660
Ondansetron inhibits a behavioural consequence of withdrawing from drugs of abuseQ48895181
Prophylactic antiemetic therapy with ondansetron, tropisetron, granisetron and metoclopramide in patients undergoing laparoscopic cholecystectomy: a randomized, double-blind comparison with placeboQ50166769
Effect of the 5-HT3 antagonist ondansetron on voluntary ethanol intake in rats and mice maintained on a limited access procedure.Q52271427
Ondansetron and opiate craving. A novel pharmacological approach to addiction.Q52271903
Serotoninergic control of gonadotrophin and prolactin secretion in women.Q52363721
Ondansetron in the treatment of theophylline overdoseQ53690011
A randomized double-blinded comparison of the antiemetic efficacy of ondansetron and droperidol in patients receiving high-dose interleukin-2.Q53905620
Ondansetron and alcohol pharmacokineticsQ60644613
Effect of Serotonin on the Immunoreactive Thyrotropin-Releasing Hormone Concentrations of the Rat StomachQ64971849
Ondansetron in carcinoid syndromeQ67518483
Ondansetron and hyperemesis gravidarumQ67523377
Ondansetron to prevent emesis following N-acetylcysteine for acetaminophen intoxicationQ67524440
Ondansetron: indications and applications in the paediatric intensive care unitQ67601842
5-Hydroxytryptamine3-receptor blockade protects against gastric mucosal damage in ratsQ67878676
Determination of Ondansetron in Plasma and Its Pharmacokinetics in the Young and ElderlyQ67907197
Age and gender effects on ondansetron pharmacokinetics: evaluation of healthy aged volunteersQ68052423
Effects of the 5-HT3 antagonist GR38032F (ondansetron) on benzodiazepine withdrawal in ratsQ68163258
Ondansetron in treatment of schizophreniaQ68299138
Gastric emptying and subjective symptoms of nausea: lack of effects of a 5-hydroxytryptamine-3 antagonist ondansetron on gastric emptying in patients with gastric stasis syndromeQ68434433
The effect of ondansetron on gastric emptying in the conscious ratQ68442040
Colonic transit in man is slowed by ondansetron (GR38032F), a selective 5-hydroxytryptamine receptor (type 3) antagonistQ68444360
Effects of various serotonergic agents on alcohol intake and alcohol preference in Wistar rats selected at two different levels of alcohol preferenceQ70778012
Multiple forms of cytochrome P450 are involved in the metabolism of ondansetron in humansQ70978018
Rapid intravenous administration of ondansetron or metoclopramide is not associated with cardiovascular compromise in childrenQ71563767
Extrapyramidal reaction caused by ondansetronQ71601634
Pathogenetic aspects of responsiveness to ondansetron (5-hydroxytryptamine type 3 receptor antagonist) in patients with primary fibromyalgia syndrome--a preliminary studyQ71654293
Evidence that the amygdala is involved in the inhibitory effects of 5-HT3 receptor antagonists on alcohol drinking in ratsQ71711586
Comparative study of the affinities of the 5-HT3 receptor antagonists, YM060, YM114 (KAE-393), granisetron and ondansetron in rat vagus nerve and cerebral cortexQ71760170
Studies on the effects of certain 5-HT-3 receptor antagonists on ethanol preference and withdrawal seizures in the ratQ71986323
The influence of peripheral or central administration of ondansetron on stress-induced gastric ulceration in ratsQ71994568
The polymorphic cytochrome P-4502D6 is involved in the metabolism of both 5-hydroxytryptamine antagonists, tropisetron and ondansetronQ72019512
Upregulated expression of peripheral serotonergic receptors in migraine and cluster headache by sumatriptanQ72054251
Comparison of potencies of 5-HT3 receptor antagonists at inhibiting aversive behavior to illumination and the von Bezold-Jarisch reflex in the mouseQ72071722
Ondasentron in the treatment of diabetic diarrheaQ72133591
Treatment of diarrhea in carcinoid syndrome with ondansetron, tropisetron, and clonidineQ72157181
Influence of 5-HT3 receptor antagonists in visceromotor and nociceptive responses to rectal distension before and during experimental colitis in ratsQ72166274
Ondansetron for symptomatic relief in terminal uraemiaQ72174050
Ondansetron and hyperemesis gravidarumQ72208941
Improvement of cholestatic pruritus by ondansetronQ72218628
Treatment of chronic cryptosporidiosis-induced diarrhea with a serotonin receptor antagonistQ72279872
Comparison of the pharmacokinetics of an ondansetron solution (8 mg) when administered intravenously, orally, to the colon, and to the rectumQ72320780
Anaphylactoid reactions associated with ondansetronQ72365914
Ondansetron for pruritus due to cholestasisQ72379137
Psychiatric complications associated with ondansetronQ72392951
Ondansetron for treating nausea and vomiting in the poisoned patientQ72455171
Ondansetron in theophylline overdoseQ72543507
Seizure associated with ondansetronQ72561569
[Therapy of generalized tendomyopathy (fibromyalgia) caused by blocking 5-HT3 receptors]Q72581701
Profile of action of 5-HT3 receptor antagonists, ondansetron and WAY 100289, in the elevated plus-maze test of anxiety of mice.Q51126863
Antagonism of amphetamine-induced disruption of latent inhibition in rats by haloperidol and ondansetron: implications for a possible antipsychotic action of ondansetron.Q51134758
Antagonists at the serotonin-3 receptor can reduce the fear-potentiated startle response in the rat: evidence for different types of anxiolytic activity?Q51138018
Attenuation of some alcohol-induced mood changes and the desire to drink by 5-HT3 receptor blockade: a preliminary study in healthy male volunteers.Q51146628
Ondansetron for the treatment of pruritus after spinal opioids.Q51578521
Ascending colon response to feeding: evidence for a 5-hydroxytryptamine-3 mechanism.Q51588383
Ondansetron absorption in adults: effect of dosage form, food, and antacids.Q51594802
A 5HT3 antagonist corrects the postprandial colonic hypertonic response in carcinoid diarrhea.Q51595408
Pharmacokinetics of intravenous ondansetron in healthy children undergoing ear, nose, and throat surgery.Q51596251
Prevention of nausea and vomiting after day case gynaecological laparoscopy. A comparison of ondansetron, droperidol, metoclopramide and placebo.Q51603877
Anxiolytics' effects on the actual driving performance of patients and healthy volunteers in a standardized test. An integration of three studies.Q51615291
GR 38032F (ondansetron), a selective 5HT3 receptor antagonist, slows colonic transit in healthy man.Q51616453
Effect of selective 5HT3 antagonist (GR 38032F) on small intestinal transit and release of gastrointestinal peptides.Q51619066
5-HT3 receptor modulation of behavior during withdrawal from continuous or intermittent cocaine.Q51638521
Potentiation of physical dependence on diazepam by ondansetron in rats.Q51645148
Effects of serotonergic anxiolytics on physical dependence on diazepam in mice.Q51655524
Parameters of self-administration of cocaine in rats under a progressive-ratio schedule.Q51661784
Cardiovascular stability with rapid intravenous infusion of ondansetron.Q51664745
Ultrashort noninvasive opiate detoxification.Q51665206
Effect of serotonin 5-HT1, 5-HT2, and 5-HT3 receptor antagonists on the prolactin response to restraint and ether stressQ51683999
Effects of cocaine alone and in combination with prazosin or ondansetron on multiple fixed-interval fixed-ratio performance in pigeonsQ51686652
GR38032F, a serotonin 5-HT3 antagonist, fails to alter cocaine self-administration in rats.Q51713094
The effects of ondansetron (GR38032F) in rats and mice treated subchronically with diazepam.Q51745563
Clinical efficacy of the 5-HT3 antagonist ondansetron in alcohol abuse and dependence.Q52024450
Comparison of the effects of the 5-HT3 receptor antagonists WAY-100579 and ondansetron on spatial learning in the water maze in rats with excitotoxic lesions of the forebrain cholinergic projection system.Q52048174
Ondansetron improves cognitive performance in the Morris water maze spatial navigation task.Q52052069
Serotonergic modulation of anticholinergic effects on cognition and behavior in elderly humans.Q52052081
Effects of ondansetron pretreatment on acute responses to ethanol in social drinkers.Q52057066
A study to evaluate the effect of ondansetron on psychomotor performance after repeated oral dosing in healthy subjectsQ52103647
Serotonin 5-HT3 antagonists fail to affect ethanol self-administration of rats.Q52214866
Influence of 5-HT3 receptor antagonists and the indirect 5-HT agonist, dexfenfluramine, on heroin self-administration in rats.Q52217110
Effect of 5-HT3 receptor antagonists on the discriminative stimulus properties of morphine in rats.Q52228710
Ondansetron and arecoline prevent scopolamine-induced cognitive deficits in the marmosetQ52231738
5-HT3 receptor antagonists reverse helpless behaviour in ratsQ52232621
Effects of the 5-HT3 antagonist ondansetron on benzodiazepine-induced operant behavioural dependence in rats.Q52234544
The effect of ondansetron on cognitive performance in the marmosetQ52238849
Effect of drugs influencing 5-HT function on ethanol drinking and feeding behaviour in rats: studies using a drinkometer system.Q52265125
P433issue5
P921main subjectpharmacologyQ128406
P304page(s)773-794
P577publication date1996-11-01
P1433published inDrugsQ3040094
P1476titleOndansetron. A review of its pharmacology and preliminary clinical findings in novel applications
P478volume52

Reverse relations

cites work (P2860)
Q338565685-HT(3) receptor antagonists and anxiety; a preclinical and clinical review
Q392940025-HT3 receptors: A potential therapeutic target for epilepsy
Q45061444A preliminary study of the efficacy of ondansetron in the treatment of ataxia, poor balance and incoordination from brain injury
Q35071475A review of 25 years of the social interaction test
Q42690847A systematic investigation of the maximum tolerated dose of cytotoxic chemotherapy with and without supportive care in mice
Q36904890Acute infectious pediatric gastroenteritis: beyond oral rehydration therapy
Q34312351Advances in treating acute myeloid leukemia
Q42590441Assessment of ondansetron-associated hypokalemia in pediatric oncology patients
Q39820388Autoregulatory effects of serotonin on proliferation and signaling pathways in lung and small intestine neuroendocrine tumor cell lines
Q35074324Benefits and risks of newer treatments for chemotherapy-induced and postoperative nausea and vomiting
Q36718053Candidate genes for antidepressant response to selective serotonin reuptake inhibitors
Q44333120Chronic pain and ultrarapid opioid detoxification
Q39042372Comparative Pharmacology and Guide to the Use of the Serotonin 5-HT3 Receptor Antagonists for Postoperative Nausea and Vomiting
Q35605831Comparison of alcoholism subtypes as moderators of the response to sertraline treatment
Q45713757Does intravenous ondansetron affect gastric emptying of a solid meal, gastric electrical activity or blood hormone levels in healthy volunteers?
Q41563060Dolasetron. A review of its pharmacology and therapeutic potential in the management of nausea and vomiting induced by chemotherapy, radiotherapy or surgery
Q51474335Effects of ondansetron on gastric tone and motility changes induced by a prolonged intraduodenal infusion of nutrients. Results of a placebo-controlled study.
Q42162464Enhanced 5-HT(2A) receptor status in the hypothalamus and corpus striatum of ethanol-treated rats
Q50966263Evaluation of anticonvulsant and nootropic effect of ondansetron in mice.
Q34191975Extrapyramidal Reactions to Ondansetron: Cross-Reactivity Between Ondansetron and Prochlorperazine?
Q42068178Extrapyramidal side effects after metoclopramide administration in a post-anesthesia care unit -A case report-.
Q43790339Failure of ondansetron in treating cerebellar tremor in MS patients--an open-label pilot study
Q34481528Irritable bowel syndrome: an update on therapeutic modalities
Q38614128Laparoscopic surgery: a narrative review of pharmacotherapy in pain management
Q44340894Mirtazapine for pruritus
Q37946545Nasal route: an alternative approach for antiemetic drug delivery
Q37021326New approaches to understanding hallucinations in Parkinson's disease: phenomenology and possible origins
Q36600684Occupancy of α7 Nicotinic Acetylcholine Receptors in the Brain by Tropisetron: A Positron Emission Tomography Study Using [(11)C]CHIBA-1001 in Healthy Human Subjects
Q42628440Ondansetron to treat pruritus due to cholestatic jaundice
Q42717373Ondansetron-loaded biodegradable microspheres as a nasal sustained delivery system: in vitro/in vivo studies
Q43171584Ondansetron-loaded chitosan microspheres for nasal antiemetic drug delivery: an alternative approach to oral and parenteral routes
Q34298900Ondansetron: a review of its use as an antiemetic in children
Q34320153Ondansetron: a selective 5-HT(3) receptor antagonist and its applications in CNS-related disorders.
Q30490604Pharmacodynamics of memantine: an update
Q24202000Pharmacological interventions for pruritus in adult palliative care patients
Q24241586Pharmacological interventions for pruritus in adult palliative care patients
Q36193800Pharmacological interventions for pruritus in adult palliative care patients.
Q34146983Pharmacotherapy of behavioral and psychological symptoms of dementia: time for a different paradigm?
Q52021675Placental transfer of ondansetron during early human pregnancy.
Q44006893Prophylactic ondansetron is effective in the treatment of nausea and vomiting but not on pruritus after cesarean delivery with intrathecal sufentanil-morphine
Q37099029Pruritus and fatigue associated with liver disease: is there a role for ondansetron?
Q44852166Relative bioavailability of an extemporaneous ondansetron 4-mg capsule formulation versus solution
Q30435306Role of the serotonergic system in the neurobiology of alcoholism: implications for treatment
Q38570496Safety and efficacy of commonly used antiemetics
Q38794290Safety of treatment for gastroparesis
Q33951128The N-methyl-D-aspartate receptor channel blockers memantine, MRZ 2/579 and other amino-alkyl-cyclohexanes antagonise 5-HT(3) receptor currents in cultured HEK-293 and N1E-115 cell systems in a non-competitive manner
Q92535622The Pharmacology of Visual Hallucinations in Synucleinopathies
Q37685759The auspicious role of the 5-HT3 receptor in depression: a probable neuronal target?
Q37924850The in vivo neurochemistry of the brain during general anesthesia
Q24635649Treating nausea and vomiting in palliative care: a review
Q73535880Treatment of chronic bulimic symptoms: new answers, more questions
Q44149049Treatment of intractable hyperemesis gravidarum by ondansetron.
Q58700987Tricyclic antidepressant amitriptyline inhibits 5-hydroxytryptamine 3 receptor currents in NCB-20 cells
Q39745347Unique susceptibility of a human lung carcinoid tumor cell line to infection with BK virus

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