| scholarly article | Q13442814 |
| review article | Q7318358 |
| P6179 | Dimensions Publication ID | 1091508986 |
| P356 | DOI | 10.1186/S12929-017-0377-1 |
| P932 | PMC publication ID | 5591517 |
| P698 | PubMed publication ID | 28886718 |
| P2093 | author name string | Michael E Hoffer | |
| Nigel H Greig | |||
| Robert E Becker | |||
| Barry J Hoffer | |||
| Chaim G Pick | |||
| Yung-Hsiao Chiang | |||
| P2860 | cites work | The experimental Alzheimer drug phenserine: preclinical pharmacokinetics and pharmacodynamics | Q48944505 |
| Depletion of choline acetyltransferase activity but preservation of M1 and M2 muscarinic receptor binding sites in temporal cortex following head injury: a preliminary human postmortem study | Q49020255 | ||
| The LEARn model: an epigenetic explanation for idiopathic neurobiological diseases | Q50306250 | ||
| Amelioration of acute sequelae of blast induced mild traumatic brain injury by N-acetyl cysteine: a double-blind, placebo controlled study | Q21133755 | ||
| Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model. | Q22242243 | ||
| Beneficial effects of n-acetylcysteine on ischaemic brain injury | Q24674975 | ||
| Traumatic Brain Injury Activation of the Adult Subventricular Zone Neurogenic Niche | Q26741133 | ||
| Functional circuits of new neurons in the dentate gyrus | Q26823208 | ||
| Epidemiology of mild traumatic brain injury and neurodegenerative disease | Q28082866 | ||
| Neurogenesis in the adult human hippocampus | Q28288339 | ||
| Traumatic brain injury and risk of dementia in older veterans | Q28391306 | ||
| Age-dependent neuroplasticity mechanisms in Alzheimer Tg2576 mice following modulation of brain amyloid-β levels | Q28488088 | ||
| Acetylcholine and experimental brain injury | Q51118075 | ||
| Acetylcholine and serotonin in the spinal fluid. | Q51328748 | ||
| The use of cholinergic blocking agents in the treatment of cranio-cerebral injuries. | Q51344819 | ||
| Atropine in the treatment of closed head injury. | Q51358944 | ||
| Upregulation of neuronal amyloid precursor protein (APP) and APP mRNA following magnesium sulphate (MgSO4) therapy in traumatic brain injury. | Q51371494 | ||
| Presence and action of acetylcholine in experimental brain trauma | Q51371748 | ||
| Loss of forebrain cholinergic neurons following fluid-percussion injury: implications for cognitive impairment in closed head injury | Q52051801 | ||
| Expression of endothelial and inducible NOS-isoforms is increased in Alzheimer's disease, in APP23 transgenic mice and after experimental brain lesion in rat: evidence for an induction by amyloid pathology. | Q53243973 | ||
| Selective acetyl- and butyrylcholinesterase inhibitors reduce amyloid-β ex vivo activation of peripheral chemo-cytokines from Alzheimer's disease subjects: exploring the cholinergic anti-inflammatory pathway. | Q53347422 | ||
| N-acetyl cysteine inhibits induction of no production by endotoxin or cytokine stimulated rat peritoneal macrophages, C6 glial cells and astrocytes | Q74069333 | ||
| Syntheses and anticholinesterase activities of (3aS)-N1, N8-bisnorphenserine, (3aS)-N1,N8-bisnorphysostigmine, their antipodal isomers, and other potential metabolites of phenserine | Q74668096 | ||
| [Anticholinergic therapy of craniocerebral trauma.] | Q79439740 | ||
| The 5'-untranslated region of Parkinson's disease alpha-synuclein messengerRNA contains a predicted iron responsive element | Q79838827 | ||
| Acetylcholine and neuronal activity; cholinesterase patterns and acetylcholine in the cerebrospinal fluids of patients with craniocerebral trauma | Q80323554 | ||
| Closed head injury--an inflammatory disease? | Q81683833 | ||
| Pathophysiology of traumatic brain injury | Q83519274 | ||
| Amyloid β accumulation in axons after traumatic brain injury in humans | Q48311745 | ||
| Long-term accumulation of amyloid-beta in axons following brain trauma without persistent upregulation of amyloid precursor protein genes | Q48425170 | ||
| Neuroprotective effects of N-acetylcysteine on experimental closed head trauma in rats | Q48507614 | ||
| Pharmacological modulation of Alzheimer's beta-amyloid precursor protein levels in the CSF of rats with forebrain cholinergic system lesions | Q48696243 | ||
| N-acetylcysteine normalizes neurochemical changes in the glutathione-deficient schizophrenia mouse model during development | Q48880981 | ||
| Cognitive Impairments Induced by Concussive Mild Traumatic Brain Injury in Mouse Are Ameliorated by Treatment with Phenserine via Multiple Non-Cholinergic and Cholinergic Mechanisms | Q28552599 | ||
| Synthesis of the Alzheimer drug Posiphen into its primary metabolic products (+)-N1-norPosiphen, (+)-N8-norPosiphen and (+)-N1, N8-bisnorPosiphen, their inhibition of amyloid precursor protein, α-Synuclein synthesis, interleukin-1β release, and [...] | Q28818062 | ||
| The epidemiology and impact of traumatic brain injury: a brief overview | Q29615639 | ||
| Tumor necrosis factor-α synthesis inhibitor, 3,6'-dithiothalidomide, reverses behavioral impairments induced by minimal traumatic brain injury in mice | Q30520539 | ||
| Exendin-4, a glucagon-like peptide-1 receptor agonist prevents mTBI-induced changes in hippocampus gene expression and memory deficits in mice | Q30531048 | ||
| Transcranial amelioration of inflammation and cell death after brain injury. | Q30572360 | ||
| Monosynaptic inputs to new neurons in the dentate gyrus. | Q30667853 | ||
| Closed-head minimal traumatic brain injury produces long-term cognitive deficits in mice | Q30791023 | ||
| Ischaemic brain damage is still common in fatal non-missile head injury | Q33629418 | ||
| The Molecular Pathophysiology of Concussive Brain Injury | Q33745886 | ||
| A modified controlled cortical impact technique to model mild traumatic brain injury mechanics in mice. | Q33771195 | ||
| Behavioral consequences of minimal traumatic brain injury in mice. | Q33875248 | ||
| Incretin mimetics as pharmacologic tools to elucidate and as a new drug strategy to treat traumatic brain injury | Q34362412 | ||
| A systematic review of brain injury epidemiology in Europe | Q34470717 | ||
| Neurotrophic and neuroprotective actions of (-)- and (+)-phenserine, candidate drugs for Alzheimer's disease | Q34575780 | ||
| Traumatic brain injury: assessment, resuscitation and early management | Q34633903 | ||
| Antioxidant therapy in acute central nervous system injury: current state | Q34661121 | ||
| The impact of traumatic brain injuries: a global perspective. | Q34731059 | ||
| Moderate and severe traumatic brain injury in adults. | Q34797375 | ||
| Neuroinflammatory responses to traumatic brain injury: etiology, clinical consequences, and therapeutic opportunities | Q34969902 | ||
| Dementia risk after traumatic brain injury vs nonbrain trauma: the role of age and severity | Q35053900 | ||
| Cognitive impairments accompanying rodent mild traumatic brain injury involve p53-dependent neuronal cell death and are ameliorated by the tetrahydrobenzothiazole PFT-α. | Q35060204 | ||
| Efficacy of N-acetyl cysteine in traumatic brain injury | Q35150842 | ||
| Transiently lowering tumor necrosis factor-α synthesis ameliorates neuronal cell loss and cognitive impairments induced by minimal traumatic brain injury in mice | Q35155498 | ||
| Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat | Q35298897 | ||
| General Articles Intracellular Thiol Concentration Modulating Inflammatory Response: Influence on the Regulation of Cell Functions Through Cysteine Prodrug Approach | Q35552103 | ||
| Modulation of human neural stem cell differentiation in Alzheimer (APP23) transgenic mice by phenserine. | Q35927997 | ||
| The anticholinesterase phenserine and its enantiomer posiphen as 5'untranslated-region-directed translation blockers of the Parkinson's alpha synuclein expression | Q36012226 | ||
| An overview of phenserine tartrate, a novel acetylcholinesterase inhibitor for the treatment of Alzheimer's disease | Q36172619 | ||
| Endogenous neurogenic cell response in the mature mammalian brain following traumatic injury | Q36233764 | ||
| Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development | Q36318080 | ||
| Targeting TNF-α to elucidate and ameliorate neuroinflammation in neurodegenerative diseases | Q36330960 | ||
| Microglia in the TBI brain: The good, the bad, and the dysregulated. | Q36399682 | ||
| Inhibitory effect on cerebral inflammatory response following traumatic brain injury in rats: a potential neuroprotective mechanism of N-acetylcysteine. | Q36645572 | ||
| Changes in mouse cognition and hippocampal gene expression observed in a mild physical- and blast-traumatic brain injury | Q36774039 | ||
| Donepezil is ineffective in promoting motor and cognitive benefits after controlled cortical impact injury in male rats | Q36795887 | ||
| CNS injury biomechanics and experimental models | Q36873689 | ||
| N-Acetylcysteine reverses cocaine-induced metaplasticity | Q37140681 | ||
| Physiological and pathological role of alpha-synuclein in Parkinson's disease through iron mediated oxidative stress; the role of a putative iron-responsive element | Q37166339 | ||
| Cholinomimetic agents and neurocognitive impairment following head injury: a systematic review. | Q37196372 | ||
| Delayed treatment with a p53 inhibitor enhances recovery in stroke brain | Q37212810 | ||
| Presenilin-1 mutation impairs cholinergic modulation of synaptic plasticity and suppresses NMDA currents in hippocampus slices | Q37280310 | ||
| Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases | Q37376532 | ||
| Sigma-1 receptors regulate hippocampal dendritic spine formation via a free radical-sensitive mechanism involving Rac1xGTP pathway | Q37471826 | ||
| Pharmacotherapy of traumatic brain injury: state of the science and the road forward: report of the Department of Defense Neurotrauma Pharmacology Workgroup | Q37508249 | ||
| Phenserine Efficacy in Alzheimer's Disease | Q37510264 | ||
| Repeat traumatic brain injury in the developing brain | Q37891210 | ||
| Neuroinflammation: beneficial and detrimental effects after traumatic brain injury | Q38072367 | ||
| Traumatic brain injury: oxidative stress and neuroprotection. | Q38095084 | ||
| Epigenetics of dementia: understanding the disease as a transformation rather than a state. | Q38865417 | ||
| The Impact of Traumatic Brain Injury on the Aging Brain | Q38901765 | ||
| Association of Traumatic Brain Injury With Late-Life Neurodegenerative Conditions and Neuropathologic Findings | Q39613940 | ||
| Head injury and brain ischaemia--implications for therapy | Q39813587 | ||
| Pathophysiologic Mechanisms of Cerebral Ischemia and Diffusion Hypoxia in Traumatic Brain Injury. | Q39885702 | ||
| The experimental Alzheimer's disease drug posiphen [(+)-phenserine] lowers amyloid-beta peptide levels in cell culture and mice. | Q40227332 | ||
| Phenserine and ring C hetero-analogues: drug candidates for the treatment of Alzheimer's disease | Q40616325 | ||
| Restoration of cerebrovascular responsiveness to hyperventilation by the oxygen radical scavenger n-acetylcysteine following experimental traumatic brain injury | Q41166632 | ||
| Dicyclomine, an M1 muscarinic antagonist, reduces biomarker levels, but not neuronal degeneration, in fluid percussion brain injury | Q42182877 | ||
| Early stage drug treatment that normalizes proinflammatory cytokine production attenuates synaptic dysfunction in a mouse model that exhibits age-dependent progression of Alzheimer's disease-related pathology | Q42276637 | ||
| Amyloid-β precursor protein synthesis inhibitors for Alzheimer's disease treatment. | Q42344346 | ||
| Effect of phenserine treatment on brain functional activity and amyloid in Alzheimer's disease | Q42646408 | ||
| Improvement of cerebral function by anti-amyloid precursor protein antibody infusion after traumatic brain injury in rats | Q43494630 | ||
| Time-dependent changes in rat brain cholinergic receptor expression after experimental brain injury | Q44287946 | ||
| The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice | Q44326540 | ||
| N-Acetyl-cysteine inhibits phospholipid metabolism, proinflammatory cytokine release, protease activity, and nuclear factor-kappaB deoxyribonucleic acid-binding activity in human fetal membranes in vitro. | Q44392903 | ||
| N-Acetyl cysteine protects against injury in a rat model of focal cerebral ischemia | Q44401022 | ||
| Administration of N-acetylcysteine after focal cerebral ischemia protects brain and reduces inflammation in a rat model of experimental stroke | Q44870573 | ||
| Combined scopolamine and morphine treatment of traumatic brain injury in the rat. | Q45092606 | ||
| Hypothermia blunts acetylcholine increase in CSF of traumatically brain injured rats | Q45094813 | ||
| Acetylcholinesterase inhibition and locomotor function after motor-sensory cortex impact injury | Q46448065 | ||
| Late N-acetylcysteine treatment prevents the deficits induced in the offspring of dams exposed to an immune stress during gestation | Q46728971 | ||
| Anticholinesterase and pharmacokinetic profile of phenserine in healthy elderly human subjects | Q46774121 | ||
| Mild traumatic brain injury induces persistent cognitive deficits and behavioral disturbances in mice. | Q47251536 | ||
| Novel pharmaceutical treatments for minimal traumatic brain injury and evaluation of animal models and methodologies supporting their development | Q47335504 | ||
| Cortical cholinergic dysfunction after human head injury | Q48031606 | ||
| Accumulation of amyloid beta and tau and the formation of neurofilament inclusions following diffuse brain injury in the pig. | Q48105099 | ||
| Temporal trends and volume-outcome associations after traumatic brain injury: a 12-year study in Taiwan | Q48194111 | ||
| Effective treatment of traumatic brain injury: learning from experience | Q48286031 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | carboxylic acid | Q134856 |
| amino acid | Q8066 | ||
| traumatic brain injury | Q1995526 | ||
| drug repositioning | Q5308921 | ||
| psychotropic drug | Q12830468 | ||
| biomedical investigative technique | Q66648976 | ||
| P5008 | on focus list of Wikimedia project | ScienceSource | Q55439927 |
| P304 | page(s) | 71 | |
| P577 | publication date | 2017-09-09 | |
| P1433 | published in | Journal of Biomedical Science | Q15759332 |
| P1476 | title | Repositioning drugs for traumatic brain injury - N-acetyl cysteine and Phenserine | |
| P478 | volume | 24 |
| Q92612287 | (-)-Phenserine Ameliorates Contusion Volume, Neuroinflammation, and Behavioral Impairments Induced by Traumatic Brain Injury in Mice |
| Q91799187 | (-)-Phenserine and the prevention of pre-programmed cell death and neuroinflammation in mild traumatic brain injury and Alzheimer's disease challenged mice |
| Q47677964 | Does traumatic brain injury hold the key to the Alzheimer's disease puzzle? |
| Q92513493 | Incretin Mimetics as Rational Candidates for the Treatment of Traumatic Brain Injury |
| Q91611173 | Medical and Dietary Uses of N-Acetylcysteine |
| Q98165160 | N-acetyl cysteine treatment preserves mitochondrial indices of functionality in the brain of hyperammonemic mice |
| Q88998630 | Sequential combined Treatment of Pifithrin-α and Posiphen Enhances Neurogenesis and Functional Recovery After Stroke |
Search more.