Altered cleavage and secretion of a recombinant beta-APP bearing the Swedish familial Alzheimer's disease mutation

scientific article published on March 1994

Altered cleavage and secretion of a recombinant beta-APP bearing the Swedish familial Alzheimer's disease mutation is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1037990547
P356DOI10.1038/NG0394-251
P698PubMed publication ID8012386

P2093author name stringRoberts SB
Felsenstein KM
Hunihan LW
P2860cites workA pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloidQ28207898
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's diseaseQ28241772
Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein geneQ28245149
Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid proteinQ29547803
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptorQ29618322
Expression of a human placental alkaline phosphatase gene in transfected cells: use as a reporter for studies of gene expressionQ33643601
Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein productionQ34280406
A mutation in the amyloid precursor protein associated with hereditary Alzheimer's diseaseQ34955569
5'-3' exonucleases in phosphorothioate-based oligonucleotide-directed mutagenesisQ35943171
Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cellsQ36152115
Beta-amyloid precursor protein cleavage by a membrane-bound proteaseQ37092735
Processing of the beta-amyloid precursor protein carrying the familial, Dutch-type, and a novel recombinant C-terminal mutationQ41560682
Production of the Alzheimer amyloid beta protein by normal proteolytic processingQ41599298
Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic DerivativesQ41640193
Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cellsQ41675251
Cleavage of amyloid beta peptide during constitutive processing of its precursorQ41852594
Mis-sense mutation Val→Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's diseaseQ44230499
Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processingQ45039717
Secretion of β-amyloid precursor protein cleaved at the amino terminus of the β-amyloid peptideQ46160439
Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch typeQ48265529
Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril proteinQ48634030
An alternative secretase cleavage produces soluble Alzheimer amyloid precursor protein containing a potentially amyloidogenic sequenceQ53179651
Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.Q53180704
Amyloid precursor protein gene mutation in early-onset Alzheimer's disease.Q53181178
The genetic defect causing familial Alzheimer's disease maps on chromosome 21.Q53189946
Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.Q53209417
Secreted placental alkaline phosphatase: a powerful new quantitative indicator of gene expression in eukaryotic cellsQ68504983
Analysis of synthesis, processing, and secretion of proteins expressed in mammalian cellsQ68877190
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectSwedenQ34
Alzheimer's diseaseQ11081
P304page(s)251-255
P577publication date1994-03-01
P1433published inNature GeneticsQ976454
P1476titleAltered cleavage and secretion of a recombinant beta-APP bearing the Swedish familial Alzheimer's disease mutation
P478volume6

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cites work (P2860)
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