Anti-inflammatory synergy of MEN16132, a kinin B(2) receptor antagonist, and dexamethasone in carrageenan-induced knee joint arthritis in rats

scientific article published on December 2010

Anti-inflammatory synergy of MEN16132, a kinin B(2) receptor antagonist, and dexamethasone in carrageenan-induced knee joint arthritis in rats is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1476-5381.2010.00995.X
P932PMC publication ID3010571
P698PubMed publication ID20726984
P5875ResearchGate publication ID45797460

P2093author name stringC A Maggi
S Giuliani
C Valenti
M Tramontana
C Cialdai
P2860cites workTumour necrosis factor-alpha mediates carrageenin-induced knee-joint incapacitation and also triggers overt nociception in previously inflamed rat knee-jointsQ78048345
International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequencesQ28237006
Human tissue kallikreinQ28293675
Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitorsQ29547463
OARSI recommendations for the management of hip and knee osteoarthritis, part I: critical appraisal of existing treatment guidelines and systematic review of current research evidenceQ33295110
Identification and functional importance of plasma kallikrein in the synovial fluids of patients with rheumatoid, psoriatic, and osteoarthritisQ33567265
Arthritis and pain. Future targets to control osteoarthritis painQ34636446
Bradykinin initiates cytokine-mediated inflammatory hyperalgesiaQ34729234
Glucocorticoids in rheumatoid arthritis: effects on erosions and boneQ34735524
Studies on kallikrein: failure of some anti-inflammatory drugs to affect release of kininQ34795018
The pivotal role of tumour necrosis factor alpha in the development of inflammatory hyperalgesiaQ35871035
An overview of the effects of annexin 1 on cells involved in the inflammatory processQ36165863
Regulation of angiogenesis by the kallikrein-kinin systemQ36536347
Intracellular signaling in primary sensory neurons and persistent painQ37144214
Knee osteoarthritis: a role for bradykinin?Q37267272
Bradykinin potentiates cytokine-induced prostaglandin biosynthesis in osteoblasts by enhanced expression of cyclooxygenase 2, resulting in increased RANKL expressionQ40165573
Pathogenic responses of bradykinin system in chronic inflammatory rheumatoid diseaseQ40498652
Characterization of bradykinin receptors in a human osteoblastic cell lineQ40764725
The assay of glandular kallikrein and prekallikrein in human mixed salivaQ41294194
Bradykinin-induced neurogenic migration of neutrophils into the rat knee jointQ41724745
Selective inhibitors of cyclo-oxygenase-2 (COX-2) induce hypoalgesia in a rat paw model of inflammationQ41866780
Effects of an orally active non-peptide bradykinin B2 receptor antagonist, FR173657, on plasma exudation in rat carrageenin-induced pleurisyQ41966399
Bradykinin B1 and B2 receptors, tumour necrosis factor alpha and inflammatory hyperalgesiaQ41975774
Kallikreins, kininogens and kinin receptors on circulating and synovial fluid neutrophils: role in kinin generation in rheumatoid arthritisQ42450258
Mechanism of bradykinin‐induced plasma extravasation in the rat knee jointQ42479233
Mechanisms of prostanoid synthesis in human synovial cells: cytokine-peptide synergismQ42526278
Tumor necrosis factor causes amplification of arachidonic acid metabolism in response to interleukin 1, bradykinin, and other agonistsQ42835304
Modeling corticosteroid effects in a rat model of rheumatoid arthritis II: mechanistic pharmacodynamic model for dexamethasone effects in Lewis rats with collagen-induced arthritisQ43249855
Effect of Intra-articular 4-(S)-amino-5-(4-{4-[2,4-dichloro-3-(2,4-dimethyl-8-quinolyloxymethyl)phenylsulfonamido]-tetrahydro-2H-4-pyranylcarbonyl} piperazino)-5-oxopentyl](trimethyl)ammonium chloride hydrochloride (MEN16132), a kinin B2 receptor anQ43278309
Relationships between pain-related mediators and both synovitis and joint pain in patients with internal derangements and osteoarthritis of the temporomandibular jointQ44153399
MEN16132, a novel potent and selective nonpeptide antagonist for the human bradykinin B2 receptor. In vitro pharmacology and molecular characterization.Q46409814
Glucocorticoids suppress transcriptional up-regulation of bradykinin receptors in a murine in vitro model of chronic airway inflammationQ46442628
MEN16132, a novel potent and selective nonpeptide kinin B2 receptor antagonist: in vivo activity on bradykinin-induced bronchoconstriction and nasal mucosa microvascular leakage in anesthetized guinea pigsQ46606928
The activity of fine afferent nerve fibres of the rat knee joint and their modulation by inflammatory mediators.Q46662003
Contrast-enhanced ultrasound in monitoring the efficacy of a bradykinin receptor 2 antagonist in painful knee osteoarthritis compared with MRI.Q46674813
Guide to Receptors and Channels (GRAC), 4th EditionQ56639335
Influence of a long-acting bradykinin antagonist, Hoe 140, on some acute inflammatory reactions in the ratQ68183701
Inhibition of rats adjuvant arthritis by a bradykinin antagonist Hoe 140 and its influence on kallikreinsQ71351369
Quantitation of eosinophil and neutrophil infiltration into rat lung by specific assays for eosinophil peroxidase and myeloperoxidase. Application in a Brown Norway rat model of allergic pulmonary inflammationQ71771048
Inhibitory effect of annexin I on synovial inflammation in rat adjuvant arthritisQ77993370
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectdexamethasoneQ422252
P304page(s)1616-1627
P577publication date2010-12-01
P1433published inBritish Journal of PharmacologyQ919631
P1476titleAnti-inflammatory synergy of MEN16132, a kinin B(2) receptor antagonist, and dexamethasone in carrageenan-induced knee joint arthritis in rats
P478volume161

Reverse relations

cites work (P2860)
Q34395915Antagonism of bradykinin B2 receptor prevents inflammatory responses in human endothelial cells by quenching the NF-kB pathway activation
Q39448953Bradykinin enhances Sindbis virus infection in human brain microvascular endothelial cells.
Q41848003Fasitibant chloride, a kinin B₂ receptor antagonist, and dexamethasone interact to inhibit carrageenan-induced inflammatory arthritis in rats
Q61450662Fasitibant prevents the bradykinin and interleukin 1β synergism on prostaglandin E2 release and cyclooxygenase 2 expression in human fibroblast-like synoviocytes
Q47987127P2X3 and P2X2/3 Receptors Play a Crucial Role in Articular Hyperalgesia Development Through Inflammatory Mechanisms in the Knee Joint Experimental Synovitis
Q36160155Photobiomodulation therapy in the modulation of inflammatory mediators and bradykinin receptors in an experimental model of acute osteoarthritis
Q91461179Sequestration of artemin reduces inflammation-induced activation and sensitization of bone marrow nociceptors in a rodent model of carrageenan-induced inflammatory bone pain

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