Hepatic Immune Microenvironment in Alcoholic and Nonalcoholic Liver Disease

scientific article published on 9 August 2017

Hepatic Immune Microenvironment in Alcoholic and Nonalcoholic Liver Disease is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1155/2017/6862439
P932PMC publication ID5567444
P698PubMed publication ID28852648

P50authorHyon-Seung YiQ64515654
P2093author name stringJin-Seok Byun
P2860cites workEthanol affects the generation, cosignaling molecule expression, and function of plasmacytoid and myeloid dendritic cell subsets in vitro and in vivoQ46945116
B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodiesQ24598772
The Role of Innate Immunity in Alcoholic Liver DiseaseQ26773226
Liver natural killer cells: subsets and roles in liver immunityQ26774237
Kupffer cells in the liverQ26822031
Ethanol-induced inhibition of cytokine release and protein degranulation in human neutrophilsQ28218165
B cell-activating factor controls the production of adipokines and induces insulin resistanceQ28241621
Neutrophil to lymphocyte ratio: a new marker for predicting steatohepatitis and fibrosis in patients with nonalcoholic fatty liver diseaseQ82581144
Localization of oxidized phosphatidylcholine in nonalcoholic fatty liver disease: impact on disease progressionQ82639981
The role of innate cells is coupled to a Th1-polarized immune response in pediatric nonalcoholic steatohepatitisQ83195671
Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitisQ83679148
Increased immunoglobulin A in alcoholic liver cirrhosis: exploring the response of B cells to Toll-like receptor 9 activationQ84527447
Hepatic expression of CCL2 in alcoholic liver disease is associated with disease severity and neutrophil infiltratesQ84723541
Kupffer cell depletion prevents but has no therapeutic effect on metabolic and inflammatory changes induced by a high-fat dietQ84845677
NF-κB1 deficiency stimulates the progression of non-alcoholic steatohepatitis (NASH) in mice by promoting NKT-cell-mediated responsesQ84964668
Interleukin-17 exacerbates hepatic steatosis and inflammation in non-alcoholic fatty liver diseaseQ85068847
3, 3'-Diindolylmethane alleviates steatosis and the progression of NASH partly through shifting the imbalance of Treg/Th17 cells to Treg dominanceQ85676987
Major histocompatibility complex class I-related chains A and B (MIC A/B): a novel role in nonalcoholic steatohepatitis.Q50590704
Role of liver-infiltrating CD3+CD56+ natural killer T cells in the pathogenesis of nonalcoholic fatty liver disease.Q51752154
Neutrophil dysfunction in alcoholic hepatitis superimposed on cirrhosis is reversible and predicts the outcome.Q53536111
Severity of non-alcoholic fatty liver disease is associated with high systemic levels of tumor necrosis factor alpha and low serum interleukin 10 in morbidly obese patients.Q53536436
Butyrate protects liver against ischemia reperfusion injury by inhibiting nuclear factor kappa B activation in Kupffer cells.Q54337513
Role of immunodeficient animal models in the development of fructose induced NAFLD.Q54337526
Intrahepatic gene expression in human alcoholic hepatitis.Q54595370
TNF family member B cell-activating factor (BAFF) receptor-dependent and -independent roles for BAFF in B cell physiology.Q54707207
Clinical and biological relevance of hepatocyte apoptosis in alcoholic hepatitisQ61764200
Influence of ethanol consumption on natural killer cell activity in miceQ69547488
Portal tract macrophages are increased in alcoholic liver diseaseQ69737535
Acute alcohol intoxication suppresses natural killer cell activity and promotes tumor metastasisQ70992838
Inactivation of Kupffer cells prevents early alcohol-induced liver injuryQ72094198
Activation of nuclear factor kappa B and cytokine imbalance in experimental alcoholic liver disease in the ratQ73023401
Gadolinium chloride blocks alcohol-dependent liver toxicity in rats treated chronically with intragastric alcohol despite the induction of CYP2E1Q73424895
TH1 cytokine response of CD57+ T-cell subsets in healthy controls and patients with alcoholic liver diseaseQ74514030
Gene expression of tumor necrosis factor alpha and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patientsQ77318114
Autoantibodies against cytochromes P-4502E1 and P-4503A in alcoholicsQ77933506
Chronic alcohol consumption is associated with changes in the distribution, immunophenotype, and the inflammatory cytokine secretion profile of circulating dendritic cellsQ80040530
Serum leptin in patients with alcoholic liver diseaseQ80086869
Chronic ethanol consumption inhibits hepatic natural killer cell activity and accelerates murine cytomegalovirus-induced hepatitisQ80162138
A high-fat diet and regulatory T cells influence susceptibility to endotoxin-induced liver injuryQ80696372
Alcohol Consumption Decreases IL-2-Induced NF-kappaB Activity in Enriched NK Cells from C57BL/6 MiceQ44406858
Antigen peptide transporter 1 is involved in the development of fructose-induced hepatic steatosis in miceQ44665378
Chronic alcohol consumption accelerates liver injury in T cell-mediated hepatitis: alcohol disregulation of NF-kappaB and STAT3 signaling pathwaysQ44830103
Activated natural killer T cells induce liver injury by Fas and tumor necrosis factor-alpha during alcohol consumptionQ44887156
Energy restriction restores the impaired immune response in overweight (cafeteria) ratsQ44953669
Mechanisms of alcohol-induced suppression of B-cell responseQ44992595
T-cell activation after chronic ethanol ingestion in miceQ45185219
Kupffer cell function in chronic ethanol-fed rats.Q45287580
Cell-mediated hepatic injury in alcoholic liver disease. Veterans Affairs Cooperative Study Group 275.Q45336150
The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88.Q46367336
Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes.Q46614190
Adipocytokines: mediators linking adipose tissue, inflammation and immunityQ29619393
NKp46(+) natural killer cells attenuate metabolism-induced hepatic fibrosis by regulating macrophage activation in miceQ30277911
Natural killer cells in obesity: impaired function and increased susceptibility to the effects of cigarette smokeQ33526964
Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistanceQ33604466
Conventional DCs reduce liver ischemia/reperfusion injury in mice via IL-10 secretionQ33604905
Total fecal microbiota transplantation alleviates high-fat diet-induced steatohepatitis in mice via beneficial regulation of gut microbiotaQ33685907
C-C chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosisQ33750735
Alcohol facilitates CD1d loading, subsequent activation of NKT cells, and reduces the incidence of diabetes in NOD miceQ33869564
Dietary fatty acids modulate antigen presentation to hepatic NKT cells in nonalcoholic fatty liver disease.Q33902002
Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease.Q33905038
Pathophysiological roles of interleukin-18 in inflammatory liver diseasesQ33916627
Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat.Q34031152
Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease.Q34060210
Abrogation of the antifibrotic effects of natural killer cells/interferon-gamma contributes to alcohol acceleration of liver fibrosisQ34072530
Alcohol affects the late differentiation of progenitor B cellsQ34410146
Neutrophil-derived myeloperoxidase aggravates non-alcoholic steatohepatitis in low-density lipoprotein receptor-deficient miceQ34533851
Normocaloric low cholesterol diet modulates Th17/Treg balance in patients with chronic hepatitis C virus infectionQ34756669
Endocannabinoids in liver diseaseQ34776919
BAFF knockout improves systemic inflammation via regulating adipose tissue distribution in high-fat diet-induced obesityQ35040658
Pro-inflammatory activated Kupffer cells by lipids induce hepatic NKT cells deficiency through activation-induced cell deathQ35061420
Functions of liver natural killer cells are dependent on the severity of liver inflammation and fibrosis in chronic hepatitis C.Q35155996
Inhibition of type I natural killer T cells by retinoids or following sulfatide-mediated activation of type II natural killer T cells attenuates alcoholic liver disease in miceQ35224555
High fat diet causes depletion of intestinal eosinophils associated with intestinal permeabilityQ35594503
Effects of probiotics (cultured Lactobacillus subtilis/Streptococcus faecium) in the treatment of alcoholic hepatitis: randomized-controlled multicenter studyQ35753739
TLR2 and TLR9 contribute to alcohol-mediated liver injury through induction of CXCL1 and neutrophil infiltrationQ35817788
CD4+ROR γ t++ and Tregs in a Mouse Model of Diet-Induced Nonalcoholic SteatohepatitisQ35855499
Type II NKT cell-mediated anergy induction in type I NKT cells prevents inflammatory liver diseaseQ35879532
Stabilization of tumor necrosis factor-alpha mRNA in macrophages in response to chronic ethanol exposureQ35982209
Chronic alcohol consumption impairs distribution and compromises circulation of B cells in B16BL6 melanoma-bearing miceQ36132281
Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitisQ36168809
Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in miceQ36243894
Cutaneous immunization rapidly activates liver invariant Valpha14 NKT cells stimulating B-1 B cells to initiate T cell recruitment for elicitation of contact sensitivityQ36371566
Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastaseQ36377312
Chronic alcohol increases CD8+ T-cell immunosenescence in simian immunodeficiency virus-infected rhesus macaquesQ36404961
The relationship between alcohol consumption and cortisol secretion in an aging cohortQ36494426
NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesisQ36673866
Invariant natural killer T cells contribute to chronic-plus-binge ethanol-mediated liver injury by promoting hepatic neutrophil infiltrationQ36674421
Organ-specific features of natural killer cellsQ36750759
Alcohol dehydrogenase III exacerbates liver fibrosis by enhancing stellate cell activation and suppressing natural killer cells in miceQ36901235
Eosinophils secrete IL-4 to facilitate liver regenerationQ36932394
The current immune function of hepatic dendritic cells.Q36988431
Liver: An organ with predominant innate immunityQ37048206
Chronic plus binge ethanol feeding synergistically induces neutrophil infiltration and liver injury in mice: a critical role for E-selectinQ37053862
Hepatic immunophenotyping for streptozotocin-induced hyperglycemia in miceQ37134825
Kupffer cell and interleukin-12-dependent loss of natural killer T cells in hepatosteatosisQ37144593
Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseasesQ37326768
Increased hepatic myeloperoxidase activity in obese subjects with nonalcoholic steatohepatitisQ37362066
In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-alphaQ37403094
NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver diseaseQ37526716
Progression of alcoholic and non-alcoholic steatohepatitis: common metabolic aspects of innate immune system and oxidative stressQ37819737
Interaction of hepatic stellate cells with diverse types of immune cells: foe or friend?Q38121575
Immune surveillance by the liverQ38139201
Adoptive transfer of regulatory NKT lymphocytes ameliorates non-alcoholic steatohepatitis and glucose intolerance in ob/ob mice and is associated with intrahepatic CD8 trappingQ38315752
Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver diseaseQ38320784
Role of adaptive immunity in alcoholic liver diseaseQ38333417
Norepinephrine regulates hepatic innate immune system in leptin-deficient mice with nonalcoholic steatohepatitisQ38336681
Chronic alcohol consumption inhibits peripheral NK cell development and maturation by decreasing the availability of IL-15.Q39193836
Palmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytesQ40097681
Progression from Nonalcoholic Fatty Liver to Nonalcoholic Steatohepatitis Is Marked by a Higher Frequency of Th17 Cells in the Liver and an Increased Th17/Resting Regulatory T Cell Ratio in Peripheral Blood and in the Liver.Q40258465
The balance between IL-17 and IL-22 produced by liver-infiltrating T-helper cells critically controls NASH development in miceQ40333287
B cell-activating factor is associated with the histological severity of nonalcoholic fatty liver diseaseQ40707257
Plasma endotoxin concentrations in patients with alcoholic and non-alcoholic liver disease: reevaluation with an improved chromogenic assayQ41187748
Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excessQ41455865
Invariant NKT cells promote alcohol-induced steatohepatitis through interleukin-1β in miceQ41548774
Cytokine gene expression by Kupffer cells in experimental alcoholic liver diseaseQ41668234
Severity of liver injury in experimental alcoholic liver disease. Correlation with plasma endotoxin, prostaglandin E2, leukotriene B4, and thromboxane B2.Q42050277
Loss of Kupffer cells in diet-induced obesity is associated with increased hepatic steatosis, STAT3 signaling, and further decreases in insulin signalingQ42174682
Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytesQ42183683
Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in ratsQ43130477
Chronic alcohol consumption is associated with an increased cytotoxic profile of circulating lymphocytes that may be related with the development of liver injuryQ43143114
Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat.Q43568327
Hepatic B cells are readily activated by Toll-like receptor-4 ligation and secrete less interleukin-10 than lymphoid tissue B cellsQ43585852
ICAM-1 is involved in the mechanism of alcohol-induced liver injury: studies with knockout miceQ43607619
Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in miceQ43657691
Delivery of IkappaB superrepressor gene with adenovirus reduces early alcohol-induced liver injury in ratsQ43814817
Chronic ethanol consumption by mice results in activated splenic T cells.Q44253575
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjecthuman digestive systemQ9649
alcoholic liver diseaseQ558404
metabolic dysfunction–associated steatotic liver diseaseQ1546498
alcohol and healthQ11290178
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)6862439
P577publication date2017-08-09
P1433published inBioMed Research InternationalQ17509958
P1476titleHepatic Immune Microenvironment in Alcoholic and Nonalcoholic Liver Disease
P478volume2017

Reverse relations

cites work (P2860)
Q92278975Alpha-syntrophin deficiency protects against non-alcoholic steatohepatitis associated increase of macrophages, CD8+ T-cells and galectin-3 in the liver
Q88499459Intrahepatic T-Cell Receptor β Immune Repertoire Is Essential for Liver Regeneration
Q47205404Metabolomics technology and bioinformatics for precision medicine.
Q91281532Pharmacological Inhibition of CCR2/5 Signaling Prevents and Reverses Alcohol-Induced Liver Damage, Steatosis, and Inflammation in Mice
Q57050508Primary rat LSECs preserve their characteristic phenotype after cryopreservation
Q91590335Qianggan extract improved nonalcoholic steatohepatitis by modulating lncRNA/circRNA immune ceRNA networks
Q64897562Recent Insights Into the Role of Immune Cells in Alcoholic Liver Disease.
Q64097348T-cell senescence contributes to abnormal glucose homeostasis in humans and mice
Q94093775UEG Week 2018 Poster Presentations

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