Therapeutic benefits of intravenous cardiosphere-derived cell therapy in rats with pulmonary hypertension

scientific article published on 24 August 2017

Therapeutic benefits of intravenous cardiosphere-derived cell therapy in rats with pulmonary hypertension is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PONE.0183557
P932PMC publication ID5570343
P698PubMed publication ID28837618

P50authorRyan C MiddletonQ96195387
P2093author name stringEduardo Marbán
Xuan Xu
Mario Fournier
Michael I Lewis
P2860cites workProinflammatory Signature of the Dysfunctional Endothelium in Pulmonary Hypertension. Role of the Macrophage Migration Inhibitory Factor/CD74 ComplexQ48155147
Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens.Q48414650
Survival in incident and prevalent cohorts of patients with pulmonary arterial hypertension.Q51688048
Intratracheal mesenchymal stem cell administration attenuates monocrotaline-induced pulmonary hypertension and endothelial dysfunctionQ57374670
Dexamethasone reverses monocrotaline-induced pulmonary arterial hypertension in ratsQ61712109
Dendritic cell recruitment in lesions of human and experimental pulmonary hypertensionQ61895176
Development of morphologic, hemodynamic, and biochemical changes in lungs of rats given monocrotaline pyrroleQ68628023
Development of Crotalaria pulmonary hypertension: hemodynamic and structural studyQ70534991
Molecular pathogenesis of pulmonary arterial hypertensionQ24634317
Intrapericardial Delivery of Cardiosphere-Derived Cells: An Immunological Study in a Clinically Relevant Large Animal ModelQ28550109
Therapeutic Benefits of Induced Pluripotent Stem Cells in Monocrotaline-Induced Pulmonary Arterial HypertensionQ28553086
Fractalkine-induced smooth muscle cell proliferation in pulmonary hypertensionQ28575888
Validation of contrast-enhanced magnetic resonance imaging to monitor regenerative efficacy after cell therapy in a porcine model of convalescent myocardial infarctionQ30570123
Blocking macrophage leukotriene b4 prevents endothelial injury and reverses pulmonary hypertensionQ33593640
Inflammation and immunity in the pathogenesis of pulmonary arterial hypertensionQ33898213
Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice.Q35050037
Therapeutic efficacy of cardiosphere-derived cells in a transgenic mouse model of non-ischaemic dilated cardiomyopathyQ35203566
Safety and efficacy of allogeneic cell therapy in infarcted rats transplanted with mismatched cardiosphere-derived cellsQ35666637
Direct comparison of different stem cell types and subpopulations reveals superior paracrine potency and myocardial repair efficacy with cardiosphere-derived cellsQ35799278
Macrophages mediate cardioprotective cellular postconditioning in acute myocardial infarctionQ36040528
Fibroblasts Rendered Antifibrotic, Antiapoptotic, and Angiogenic by Priming With Cardiosphere-Derived Extracellular Membrane VesiclesQ36121826
Modern age pathology of pulmonary arterial hypertensionQ37457479
Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure.Q37596193
Targeted delivery of genes to endothelial cells and cell- and gene-based therapy in pulmonary vascular diseasesQ38165146
Endothelial-like progenitor cells engineered to produce prostacyclin rescue monocrotaline-induced pulmonary arterial hypertension and provide right ventricle benefitsQ38488215
Challenges and opportunities in treating inflammation associated with pulmonary hypertensionQ38812727
Five-Year outcomes of patients enrolled in the REVEAL RegistryQ38996624
Cardiosphere-derived cells reverse heart failure with preserved ejection fraction (HFpEF) in rats by decreasing fibrosis and inflammationQ40286144
Exosomes as critical agents of cardiac regeneration triggered by cell therapy.Q40477633
Isolation and expansion of functionally-competent cardiac progenitor cells directly from heart biopsiesQ41061514
Progressive endothelial cell damage in an inflammatory model of pulmonary hypertensionQ43175522
Mesenchymal stem cell-based prostacyclin synthase gene therapy for pulmonary hypertension ratsQ43259343
Chronic sildenafil treatment inhibits monocrotaline-induced pulmonary hypertension in ratsQ44575160
Progressive right ventricular dysfunction in patients with pulmonary arterial hypertension responding to therapyQ44682915
Rescue of monocrotaline-induced pulmonary arterial hypertension using bone marrow-derived endothelial-like progenitor cells: efficacy of combined cell and eNOS gene therapy in established diseaseQ45251410
Altered bone morphogenetic protein and transforming growth factor-beta signaling in rat models of pulmonary hypertension: potential for activin receptor-like kinase-5 inhibition in prevention and progression of diseaseQ46157334
Functional class improvement and 3-year survival outcomes in patients with pulmonary arterial hypertension in the REVEAL RegistryQ46954401
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)e0183557
P577publication date2017-08-24
P1433published inPLOS OneQ564954
P1476titleTherapeutic benefits of intravenous cardiosphere-derived cell therapy in rats with pulmonary hypertension
P478volume12

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cites work (P2860)
Q94603780Allogeneic cardiosphere-derived cells (CAP-1002) in critically ill COVID-19 patients: compassionate-use case series
Q61810177Clinical trial design and new therapies for pulmonary arterial hypertension
Q64076884Disease-modifying bioactivity of intravenous cardiosphere-derived cells and exosomes in mdx mice
Q90473072Infant cardiosphere-derived cells exhibit non-durable heart protection in dilated cardiomyopathy rats
Q64040079Regenerative cell therapy for pulmonary arterial hypertension in animal models: a systematic review

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