Viral envelope is a major determinant of enhanced fitness of a multidrug-resistant HIV-1 variant

scientific article published on April 2015

Viral envelope is a major determinant of enhanced fitness of a multidrug-resistant HIV-1 variant is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1097/QAI.0000000000000524
P932PMC publication ID4357569
P698PubMed publication ID25622054

P2093author name stringMartin Markowitz
Nicole Prada
Hiroshi Mohri
P2860cites workThe HIV-1 Envelope Glycoproteins: Fusogens, Antigens, and ImmunogensQ22242262
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Impaired fitness of human immunodeficiency virus type 1 variants with high-level resistance to protease inhibitorsQ28379411
N348I in the connection domain of HIV-1 reverse transcriptase confers zidovudine and nevirapine resistanceQ28471689
Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular cloneQ29547734
Viral load and heterosexual transmission of human immunodeficiency virus type 1. Rakai Project Study GroupQ29614934
Effects of CCR5 and CD4 cell surface concentrations on infections by macrophagetropic isolates of human immunodeficiency virus type 1.Q29622903
Human immunodeficiency virus type 1 pathogenesis in SCID-hu mice correlates with syncytium-inducing phenotype and viral replicationQ30305454
A dual infection/competition assay shows a correlation between ex vivo human immunodeficiency virus type 1 fitness and disease progressionQ33604871
Differences in the fitness of two diverse wild-type human immunodeficiency virus type 1 isolates are related to the efficiency of cell binding and entryQ33788743
Transcriptional and posttranscriptional regulation of HIV-1 gene expressionQ34030804
A computer program designed to screen rapidly for HIV type 1 intersubtype recombinant sequencesQ34372546
Infection with multidrug resistant, dual-tropic HIV-1 and rapid progression to AIDS: a case reportQ34405065
Modeling and estimation of replication fitness of human immunodeficiency virus type 1 in vitro experiments by using a growth competition assayQ34434646
Origin and evolution of HIV-1 in breast milk determined by single-genome amplification and sequencingQ34742873
Infectivity and replication capacity of drug-resistant human immunodeficiency virus type 1 variants isolated during primary infectionQ35104695
The fitness cost of mutations associated with human immunodeficiency virus type 1 drug resistance is modulated by mutational interactionsQ35784897
Reduced replication of 3TC-resistant HIV-1 variants in primary cells due to a processivity defect of the reverse transcriptase enzyme.Q35905947
The envelope glycoprotein ectodomains determine the efficiency of CD4+ T lymphocyte depletion in simian-human immunodeficiency virus-infected macaquesQ36401769
Phenotype-associated sequence variation in the third variable domain of the human immunodeficiency virus type 1 gp120 moleculeQ36697652
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Clinical significance of human immunodeficiency virus type 1 replication fitnessQ36969857
In vitro characterization of multidrug-resistant HIV-1 isolates from a recently infected patient associated with dual tropism and rapid disease progressionQ37051661
The heptad repeat 2 domain is a major determinant for enhanced human immunodeficiency virus type 1 (HIV-1) fusion and pathogenicity of a highly pathogenic HIV-1 Env.Q37410623
HIV-1 assembly, budding, and maturationQ38023864
Replicative fitness of protease inhibitor-resistant mutants of human immunodeficiency virus type 1.Q39550343
Relative replicative fitness of zidovudine-resistant human immunodeficiency virus type 1 isolates in vitroQ39578289
Human immunodeficiency virus type 1 protease cleavage site mutations associated with protease inhibitor cross-resistance selected by indinavir, ritonavir, and/or saquinavirQ39601382
Three residues in HIV-1 matrix contribute to protease inhibitor susceptibility and replication capacityQ39621109
Transmission fitness of drug-resistant human immunodeficiency virus and the prevalence of resistance in the antiretroviral-treated populationQ39642550
Improved envelope function selected by long-term cultivation of a translation-impaired HIV-1 mutantQ41040160
Primary HIV-1 R5 isolates from end-stage disease display enhanced viral fitness in parallel with increased gp120 net chargeQ48073666
Compensatory mutations at the HIV cleavage sites p7/p1 and p1/p6-gag in therapy-naive and therapy-experienced patients.Q53570987
Increased fitness of drug resistant HIV-1 protease as a result of acquisition of compensatory mutations during suboptimal therapyQ73271748
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectmultiple drug resistanceQ643839
P304page(s)487-494
P577publication date2015-04-01
P1433published inJournal of Acquired Immune Deficiency SyndromesQ6294722
P1476titleViral envelope is a major determinant of enhanced fitness of a multidrug-resistant HIV-1 variant
P478volume68

Reverse relations

Q40548483High-Sequence Diversity and Rapid Virus Turnover Contribute to Higher Rates of Coreceptor Switching in Treatment-Experienced Subjects with HIV-1 Viremiacites workP2860

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