BMP-2 induced Dspp transcription is mediated by Dlx3/Osx signaling pathway in odontoblasts

scientific article published on 7 September 2017

BMP-2 induced Dspp transcription is mediated by Dlx3/Osx signaling pathway in odontoblasts is …
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P6179Dimensions Publication ID1091465487
P356DOI10.1038/S41598-017-10908-8
P932PMC publication ID5589848
P698PubMed publication ID28883412

P50authorZhi ChenQ47415305
P2093author name stringGuohua Yuan
Mary MacDougall
Chen Zhi
Guobin Yang
P2860cites workThe novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formationQ24292169
The Canonical BMP Signaling Pathway Plays a Crucial Part in Stimulation of Dentin Sialophosphoprotein Expression by BMP-2Q24299791
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Dentin phosphoprotein and dentin sialoprotein are cleavage products expressed from a single transcript coded by a gene on human chromosome 4. Dentin phosphoprotein DNA sequence determinationQ24312880
Bone morphogenetic protein-2 (BMP-2) transactivates Dlx3 through Smad1 and Smad4: alternative mode for Dlx3 induction in mouse keratinocytesQ24548327
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingQ25938984
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nucleiQ27860728
DSPP mutation in dentinogenesis imperfecta Shields type IIQ28200045
Dentinogenesis imperfecta 1 with or without progressive hearing loss is associated with distinct mutations in DSPPQ28200065
The expression of dentin sialophosphoprotein gene in boneQ28208862
Dentin matrix proteinsQ28267456
The CCAAT enhancer-binding protein (C/EBP)beta and Nrf1 interact to regulate dentin sialophosphoprotein (DSPP) gene expression during odontoblast differentiationQ28276958
BMP-2-induced Runx2 expression is mediated by Dlx5, and TGF-beta 1 opposes the BMP-2-induced osteoblast differentiation by suppression of Dlx5 expressionQ28570736
Neural crest deletion of Dlx3 leads to major dentin defects through down-regulation of DsppQ28587606
Bmp2 in osteoblasts of periosteum and trabecular bone links bone formation to vascularization and mesenchymal stem cells.Q30544691
Genomic organization, chromosomal mapping, and promoter analysis of the mouse dentin sialophosphoprotein (Dspp) gene, which codes for both dentin sialoprotein and dentin phosphoprotein.Q32067766
Expression and activity of osteoblast-targeted Cre recombinase transgenes in murine skeletal tissues.Q50790300
Dentin sialophosphoprotein is processed by MMP-2 and MMP-20 in vitro and in vivo.Q52004411
Regulatory role of transforming growth factor-beta, bone morphogenetic protein-2, and protein-4 on gene expression of extracellular matrix proteins and differentiation of dental pulp cells.Q52217972
A protein kinase A (PKA)/β-catenin pathway sustains the BMP2/DLX3-induced osteogenic differentiation in dental follicle cells (DFCs).Q53662456
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Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for bone morphogenetic protein-2A (BMP-2A)Q68581207
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Side population cells isolated from porcine dental pulp tissue with self-renewal and multipotency for dentinogenesis, chondrogenesis, adipogenesis, and neurogenesisQ33252093
Stromal derived factor-1 regulates bone morphogenetic protein 2-induced osteogenic differentiation of primary mesenchymal stem cellsQ34355502
Transcriptional activation by the homeodomain protein distal-less 3.Q34693689
The application of bone morphogenetic proteins to dental tissue engineeringQ35209485
Bmp2 is required for odontoblast differentiation and pulp vasculogenesisQ35596542
Critical molecular switches involved in BMP-2-induced osteogenic differentiation of mesenchymal cellsQ36325243
Regulation of osteoblast differentiation by transcription factorsQ36516535
Immunohistochemical localization of the NH(2)-terminal and COOH-terminal fragments of dentin sialoprotein in mouse teethQ36601655
DSPP Is Essential for Normal Development of the Dental-Craniofacial ComplexQ36617299
miR-145 and miR-143 regulate odontoblast differentiation through targeting Klf4 and Osx genes in a feedback loopQ36725043
Molecular consequences of a frameshifted DLX3 mutant leading to Tricho-Dento-Osseous syndromeQ36761820
Dlx3 transcriptional regulation of osteoblast differentiation: temporal recruitment of Msx2, Dlx3, and Dlx5 homeodomain proteins to chromatin of the osteocalcin gene.Q37527101
Bone morphogenetic protein 2 mediates dentin sialophosphoprotein expression and odontoblast differentiation via NF-Y signalingQ38291613
Bone morphogenetic protein-2 (BMP-2) signaling to the Col2alpha1 gene in chondroblasts requires the homeobox gene Dlx-2.Q38299154
Transient upregulation of CBFA1 in response to bone morphogenetic protein-2 and transforming growth factor beta1 in C2C12 myogenic cells coincides with suppression of the myogenic phenotype but is not sufficient for osteoblast differentiationQ38326843
TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiationQ39645151
Runx2, osx, and dspp in tooth developmentQ39794651
BMP2 regulates Osterix through Msx2 and Runx2 during osteoblast differentiationQ39950593
BMP2 commitment to the osteogenic lineage involves activation of Runx2 by DLX3 and a homeodomain transcriptional network.Q40216541
Use of green fluorescent fusion protein to track activation of the transcription factor osterix during early osteoblast differentiationQ40404782
Regulation of the Cell Type-specific dentin sialophosphoprotein gene expression in mouse odontoblasts by a novel transcription repressor and an activator CCAAT-binding factorQ40528966
BMP-2-induced Osterix expression is mediated by Dlx5 but is independent of Runx2.Q40636491
Spatial expression of Cbfa1/Runx2 isoforms in teeth and characterization of binding sites in the DSPP geneQ40682686
Temperature sensitive simian virus 40 large T antigen immortalization of murine odontoblast cell cultures: establishment of clonal odontoblast cell lineQ41402672
The effects of osterix on the proliferation and odontoblastic differentiation of human dental papilla cellsQ41725433
Mutation of the signal peptide region of the bicistronic gene DSPP affects translocation to the endoplasmic reticulum and results in defective dentine biomineralizationQ44159131
Effects of homeobox gene distal-less 3 on proliferation and odontoblastic differentiation of human dental pulp cellsQ44166002
Bone morphogenetic protein-2 enhances osterix gene expression in chondrocytesQ44368993
Differential regulation of dentin sialophosphoprotein expression by Runx2 during odontoblast cytodifferentiationQ46283520
Dentin sialophosphoprotein knockout mouse teeth display widened predentin zone and develop defective dentin mineralization similar to human dentinogenesis imperfecta type III.Q46287190
Gene expression patterns of murine dentin matrix protein 1 (Dmp1) and dentin sialophosphoprotein (DSPP) suggest distinct developmental functions in vivoQ46292203
A novel splice acceptor mutation in the DSPP gene causing dentinogenesis imperfecta type II.Q47228958
Expression of Dlx genes during the development of the murine dentitionQ47642271
Immunolocalization of Bone Morphogenetic Protein-2 and -3 and Osteogenic Protein-1 during murine tooth root morphogenesis and in other craniofacial structuresQ48095109
Craniofacial variations in the tricho-dento-osseous syndromeQ48569368
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)10775
P577publication date2017-09-07
P1433published inScientific ReportsQ2261792
P1476titleBMP-2 induced Dspp transcription is mediated by Dlx3/Osx signaling pathway in odontoblasts
P478volume7