Maxadilan, the Lutzomyia longipalpis vasodilator, drives plasma leakage via PAC1-CXCR1/2-pathway

scientific article published on 19 October 2011

Maxadilan, the Lutzomyia longipalpis vasodilator, drives plasma leakage via PAC1-CXCR1/2-pathway is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.MVR.2011.10.003
P932PMC publication ID3694432
P698PubMed publication ID22036674
P5875ResearchGate publication ID51756028

P50authorElvira M SaraivaQ41565845
Erik SvensjöQ41565849
Marcelo Torres BozzaQ43251499
P2093author name stringMauro M Teixeira
Christina Barja-Fidalgo
Julio Scharfstein
Ethan A Lerner
Erik Svensjö
Elvira M Saraiva
Rafael Silveira Amendola
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Opening the flood-gates: how neutrophil-endothelial interactions regulate permeabilityQ37604059
Salivary gland homogenates of Lutzomyia longipalpis and its vasodilatory peptide maxadilan cause plasma leakage via PAC1 receptor activation.Q39871527
Dextran sulfate inhibits PMN-dependent hydrostatic pulmonary edema induced by tumor necrosis factorQ41155609
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Bradykinin and prostaglandin E1, E2 and F2alpha-induced macromolecular leakage in the hamster cheek pouchQ43545192
Intravital fluorescence microscopy and phototocicity: effects on leukocytes.Q43959459
Maxadilan activates PAC1 receptors expressed in Xenopus laevis xelanophoresQ44230293
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Dextran sulfate prevents LTB4-induced permeability increase, but not neutrophil emigration, in the hamster cheek pouchQ46223552
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Maxadilan. Cloning and functional expression of the gene encoding this potent vasodilator peptideQ48189249
Proteolytic generation of kinins in tissues infected by Trypanosoma cruzi depends on CXC chemokine secretion by macrophages activated via Toll-like 2 receptors.Q51764386
Lidocaine inhibits granulocyte adherence and prevents granulocyte delivery to inflammatory sites.Q51875061
Isolation of maxadilan, a potent vasodilatory peptide from the salivary glands of the sand fly Lutzomyia longipalpis.Q52448381
Maxadilan, the vasodilator from sand flies, is a specific pituitary adenylate cyclase activating peptide type I receptor agonist.Q52552040
Saliva from Lutzomyia longipalpis induces CC chemokine ligand 2/monocyte chemoattractant protein-1 expression and macrophage recruitment.Q52663244
Dextran sulfate activates contact system and mediates arterial hypotension via B2 kinin receptorsQ58898559
Control of vascular permeability by polymorphonuclear leukocytes in inflammationQ59077548
Shear-dependent inhibition of granulocyte adhesion to cultured endothelium by dextran sulfateQ69059363
Characterization of dextran sulfate-induced guinea pig tracheal plasma extravasationQ71867516
Increase in vascular permeability induced by leukotriene B4 and the role of polymorphonuclear leukocytesQ72673593
Isolation of large numbers of fully viable human neutrophils: a preparative technique using percoll density gradient centrifugationQ72958240
Interaction of disintegrins with human neutrophils induces cytoskeleton reorganization, focal adhesion kinase activation, and extracellular-regulated kinase-2 nuclear translocation, interfering with the chemotactic functionQ74101692
Sandfly maxadilan exacerbates infection with Leishmania major and vaccinating against it protects against L. major infectionQ74844618
Phlebotomus papatasi sand fly salivary gland lysate down-regulates a Th1, but up-regulates a Th2, response in mice infected with Leishmania majorQ77573965
Mechanisms and modulation of pituitary adenylate cyclase-activating protein-induced calcium mobilization in human neutrophilsQ80058367
The neuropeptide pituitary adenylate cyclase activating polypeptide modulates Ca2+ and pro-inflammatory functions in human monocytes through the G protein-coupled receptors VPAC-1 and formyl peptide receptor-like 1Q80671180
P433issue2
P921main subjectLutzomyia longipalpisQ14688675
P304page(s)185-193
P577publication date2011-10-19
P1433published inMicrovascular ResearchQ15752704
P1476titleMaxadilan, the Lutzomyia longipalpis vasodilator, drives plasma leakage via PAC1-CXCR1/2-pathway
P478volume83

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cites work (P2860)
Q38794015Backup Mechanisms Maintain PACAP/VIP-Induced Arterial Relaxations in Pituitary Adenylate Cyclase-Activating Polypeptide-Deficient Mice
Q35061170Differential regulatory role of pituitary adenylate cyclase-activating polypeptide in the serum-transfer arthritis model.
Q40086382Mast Cell Coupling to the Kallikrein-Kinin System Fuels Intracardiac Parasitism and Worsens Heart Pathology in Experimental Chagas Disease.
Q28834687PAC1R agonist maxadilan enhances hADSC viability and neural differentiation potential
Q58797905PACAP38 and PAC receptor blockade: a new target for headache?

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