Nascent secretory chain binding and translocation are distinct processes: differentiation by chemical alkylation

scientific article published on March 1989

Nascent secretory chain binding and translocation are distinct processes: differentiation by chemical alkylation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1083/JCB.108.3.789
P932PMC publication ID2115388
P698PubMed publication ID2537834
P5875ResearchGate publication ID20617985

P50authorGünter BlobelQ60108
P2093author name stringNicchitta CV
P2860cites workPreparation of microsomal membranes for cotranslational protein translocationQ49487241
Secretion requires a cytoplasmically disposed sulphydryl of the RER membraneQ49487565
How signal sequences maintain cleavage specificityQ57381692
Secretory protein translocation across membranes—the role of the ‘docking protein’Q59049591
The signal recognition particle receptor is a complex that contains two distinct polypeptide chainsQ24680311
Translocation of proteins across the endoplasmic reticulum. I. Signal recognition protein (SRP) binds to in-vitro-assembled polysomes synthesizing secretory proteinQ24681488
Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myelomaQ24681545
Trans-membrane Translocation of Proteins. The Direct Transfer ModelQ30409012
Nucleotide sequence of bovine prolactin messenger RNA. Evidence for sequence polymorphismQ30412284
On the translocation of proteins across membranesQ34596724
Membrane assembly in vitro : Synthesis, glycosylatio, and asymmetric insertion of a transmembrane proteinQ35042979
Translocation of proteins across the endoplasmic reticulum III. Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranesQ36205578
Translocation of proteins across the endoplasmic reticulum. II. Signal recognition protein (SRP) mediates the selective binding to microsomal membranes of in-vitro-assembled polysomes synthesizing secretory proteinQ36205601
Protein translocation across the endoplasmic reticulum. II. Isolation and characterization of the signal recognition particle receptorQ36209511
Characterization of secretory protein translocation: ribosome-membrane interaction in endoplasmic reticulumQ36213045
A former amino terminal signal sequence engineered to an internal location directs translocation of both flanking protein domainsQ36213858
Formation of a functional ribosome-membrane junction during translocation requires the participation of a GTP-binding proteinQ36216572
Integration of membrane proteins into the endoplasmic reticulum requires GTPQ36219022
Nascent polypeptide chains emerge from the exit domain of the large ribosomal subunit: immune mapping of the nascent chainQ36295457
Intracellular protein topogenesisQ36360251
The Assembly of Proteins into Biological Membranes: The Membrane Trigger HypothesisQ38000320
Translocation of secretory proteins across the microsomal membrane occurs through an environment accessible to aqueous perturbantsQ38352117
Formation of an intrachain disulfide bond on nascent immunoglobulin light chainsQ39683589
Controlled proteolysis of nascent polypeptides in rat liver cell fractions. I. Location of the polypeptides within ribosomesQ41121462
The spontaneous insertion of proteins into and across membranes: the helical hairpin hypothesisQ41649513
Guanosine triphosphate promotes the post-translational integration of opsin into the endoplasmic reticulum membraneQ41761039
A signal sequence receptor in the endoplasmic reticulum membraneQ46128766
Partial resistance of nascent polypeptide chains to proteolytic digestion due to ribosomal shieldingQ47708573
P433issue3
P407language of work or nameEnglishQ1860
P1104number of pages7
P304page(s)789-795
P577publication date1989-03-01
P1433published inJournal of Cell BiologyQ1524550
P1476titleNascent secretory chain binding and translocation are distinct processes: differentiation by chemical alkylation
P478volume108

Reverse relations

cites work (P2860)
Q52543076A stably folded presecretory protein associates with and upon unfolding translocates across the membrane of mammalian microsomes.
Q24550974ACAT1 and ACAT2 membrane topology segregates a serine residue essential for activity to opposite sides of the endoplasmic reticulum membrane
Q36716138Aberrant membrane insertion of a cytoplasmic tail deletion mutant of the hemagglutinin-neuraminidase glycoprotein of Newcastle disease virus
Q46072045Apparent Inhibition of Chloroplast Protein Import by Cold Temperatures Is Due to Energetic Considerations Not Membrane Fluidity
Q41099739Approaching the mechanism of protein transport across the ER membrane.
Q49486728Assembly of translocation-competent proteoliposomes from detergent-solubilized rough microsomes
Q49486554Biochemical fractionation and assembly of the membrane components that mediate nascent chain targeting and translocation
Q59689963Biogenesis of the Chloroplast-Encoded D1 Protein: Regulation of Translation Elongation, Insertion, and Assembly into Photosystem II
Q24322808Characterization of kinectin, a kinesin-binding protein: primary sequence and N-terminal topogenic signal analysis
Q46046637Connexin membrane protein biosynthesis is influenced by polypeptide positioning within the translocon and signal peptidase access
Q41212672Determinants of membrane-targeting and transmembrane translocation during bacterial protein export
Q36529989ER translocation intermediates are adjacent to a nonglycosylated 34-kD integral membrane protein
Q32012173Identification of a form of acyl-CoA:cholesterol acyltransferase specific to liver and intestine in nonhuman primates
Q36254630Identification of a novel stage of ribosome/nascent chain association with the endoplasmic reticulum membrane
Q36529347Identification of a novel, N-ethylmaleimide-sensitive cytosolic factor required for vesicular transport from endosomes to the trans-Golgi network in vitro
Q69665317Import of a mutant mitochondrial precursor fails to respond to stimulation by a cytosolic factor
Q49486465Lumenal proteins of the mammalian endoplasmic reticulum are required to complete protein translocation
Q35048873Mitochondria-associated endoplasmic reticulum membrane (MAM) regulates steroidogenic activity via steroidogenic acute regulatory protein (StAR)-voltage-dependent anion channel 2 (VDAC2) interaction
Q36235831NAC covers ribosome-associated nascent chains thereby forming a protective environment for regions of nascent chains just emerging from the peptidyl transferase center
Q37553485Passenger protein determines translocation versus retention in the endoplasmic reticulum for aromatase expression
Q35230254Polypeptide translocation across the endoplasmic reticulum membrane
Q24310098Primary structure of a human arginine-rich nuclear protein that colocalizes with spliceosome components
Q30442132Regulation of the ribosome-membrane junction at early stages of presecretory protein translocation in the mammalian endoplasmic reticulum
Q37797593Ribonucleoparticle-independent transport of proteins into mammalian microsomes
Q73357687Ribosome-independent regulation of translocon composition and Sec61alpha conformation
Q73453521Role of Sec61alpha in the regulated transfer of the ribosome-nascent chain complex from the signal recognition particle to the translocation channel
Q36342470Role of the cytoplasmic segments of Sec61alpha in the ribosome-binding and translocation-promoting activities of the Sec61 complex
Q41579580Secretion in yeast: preprotein binding to a membrane receptor and ATP-dependent translocation are sequential and separable events in vitro
Q38782872Signal peptidases in protein biosynthesis and intracellular transport
Q36239771Signal sequence region of mitochondrial precursor proteins binds to mitochondrial import receptor
Q36235677Stage- and ribosome-specific alterations in nascent chain-Sec61p interactions accompany translocation across the ER membrane
Q73263515Structural determinants for signal sequence function in the mammalian endoplasmic reticulum
Q27480316The NS2 protein of hepatitis C virus is a transmembrane polypeptide
Q41576875The first membrane spanning region of the lamin B receptor is sufficient for sorting to the inner nuclear membrane
Q52543237The membrane proteins TRAMp and sec61 alpha p may be involved in post-translational transport of presecretory proteins into mammalian microsomes.
Q41837962The signal sequence receptor, unlike the signal recognition particle receptor, is not essential for protein translocation
Q35186184Translocation of Proteins across and Integration of Membrane Proteins into the Rough Endoplasmic Reticulum
Q24311605cDNA cloning and sequencing of human fibrillarin, a conserved nucleolar protein recognized by autoimmune antisera

Search more.