Volume expansion-sensing outward-rectifier Cl- channel: fresh start to the molecular identity and volume sensor

scientific article published on September 1997

Volume expansion-sensing outward-rectifier Cl- channel: fresh start to the molecular identity and volume sensor is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1152/AJPCELL.1997.273.3.C755
P698PubMed publication ID9316396

P2093author name stringOkada Y
P433issue3 Pt 1
P407language of work or nameEnglishQ1860
P304page(s)C755-89
P577publication date1997-09-01
P1433published inAmerican Journal of PhysiologyQ2160146
P1476titleVolume expansion-sensing outward-rectifier Cl- channel: fresh start to the molecular identity and volume sensor
P478volume273

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cites work (P2860)
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Q36436078Criteria for the molecular identification of the volume-sensitive outwardly rectifying Cl- channel
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Q41899236DCPIB, a specific inhibitor of volume regulated anion channels (VRACs), reduces infarct size in MCAo and the release of glutamate in the ischemic cortical penumbra
Q36497815DCPIB, the proposed selective blocker of volume-regulated anion channels, inhibits several glutamate transport pathways in glial cells
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Q62661280Differential expression of volume-regulated anion channels during cell cycle progression of human cervical cancer cells
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Q36377527Disruption of ionic and cell volume homeostasis in cerebral ischemia: The perfect storm
Q33584955Distinct contributions of LRRC8A and its paralogs to the VSOR anion channel from those of the ASOR anion channel
Q87037531Distinct pharmacological and molecular properties of the acid-sensitive outwardly rectifying (ASOR) anion channel from those of the volume-sensitive outwardly rectifying (VSOR) anion channel
Q24642246Diversity of Cl(-) channels
Q55058138Downregulation of Leucine-Rich Repeat-Containing 8A Limits Proliferation and Increases Sensitivity of Glioblastoma to Temozolomide and Carmustine.
Q73038604Dual modulation of swelling-activated chloride current by NO and NO donors in rabbit portal vein myocytes
Q40851191Dual role of ATP in supporting volume-regulated chloride channels in mouse fibroblasts
Q35753787Dual roles of plasmalemmal chloride channels in induction of cell death
Q48144654Effect of hyperglycemia on extracellular levels of amino acids and free fatty acids in the ischemic/reperfused rat cerebral cortex
Q26849648Effects of Hyponatremia on the Brain
Q35029227Effects of anion channel antagonists in canine colonic myocytes: comparative pharmacology of Cl-, Ca2+ and K+ currents
Q50514327Effects of chloride channel inhibitors on H(2)O(2)-induced renal epithelial cell injury.
Q44278227Effects of osmotic changes on the chemoreceptor cell of rat carotid body
Q41768757Effects of sulphonylureas on the volume-sensitive anion channel in rat pancreatic beta-cells
Q24302042Epithelial-mesenchymal transition and its implications for fibrosis
Q28269714Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance
Q35902374Evidence for P-Glycoprotein Involvement in Cell Volume Regulation Using Coulter Sizing in Flow Cytometry
Q74529102Evidence for several mechanisms of volume regulation in neuroblastoma x glioma hybrid NG108-15 cells
Q43921792Evidence for swelling-induced adenosine and adenine nucleotide release in rat cerebral cortex exposed to monocarboxylate-containing or hypotonic artificial cerebrospinal fluids
Q48022797Expression of pI(Cln) in Escherichia coli gives a strong tolerance to hypotonic stress
Q44945996Expression of the skate (Raja erinacea) AE1 osmolyte channel in Xenopus laevis oocytes: monovalent cation permeability
Q28344017Expression of volume-sensitive Cl(-) channels and ClC-3 in acinar cells isolated from the rat lacrimal gland and submandibular salivary gland
Q48269952Functional and molecular characterization of a volume-sensitive chloride current in rat brain endothelial cells
Q74331985Functional and molecular expression of volume-regulated chloride channels in canine vascular smooth muscle cells
Q43879145Functional reconstitution of an eicosanoid-modulated Cl- channel from bovine tracheal smooth muscle
Q37872651GABA(A) receptor and glycine receptor activation by paracrine/autocrine release of endogenous agonists: more than a simple communication pathway.
Q48645156Glycine blocks the regulatory volume response of mouse oocytes to hypoosmotic stress
Q40988448High intracellular chloride delays the activation of the volume-sensitive chloride conductance in mouse L-fibroblasts
Q28365664Human cervical cancer cells use Ca2+ signalling, protein tyrosine phosphorylation and MAP kinase in regulatory volume decrease
Q24537545Human salivary histatin 5 causes disordered volume regulation and cell cycle arrest in Candida albicans
Q38314817Human scavenger receptor B1 is involved in recognition of apoptotic thymocytes by thymic nurse cells
Q40726472Human trabecular meshwork cell volume regulation
Q33881454Hypo-osmotic swelling modifies glutamate-glutamine cycle in the cerebral cortex and in astrocyte cultures
Q40098520Hypomethylation-induced expression of S100A4 in endometrial carcinoma
Q40916812Hyposmotically activated chloride channels in cultured rabbit non-pigmented ciliary epithelial cells
Q40598776Hypotonic cell swelling stimulates permeability to cAMP in a rat colonic cell line
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Q35312210ICln: a new regulator of non-erythroid 4.1R localisation and function
Q40696317IK channels are involved in the regulatory volume decrease in human epithelial cells
Q22010798Identification of an acid-activated Cl(-) channel from human skeletal muscles
Q39062409Identification of key signaling molecules involved in the activation of the swelling-activated chloride current in human glioblastoma cells.
Q44113502Ileal brake activation: macronutrient-specific effects on eating behavior?
Q40688515Impaired activity of volume-sensitive anion channel during lactacidosis-induced swelling in neuronally differentiated NG108-15 cells
Q38763113Inactivation and Anion Selectivity of Volume-regulated Anion Channels (VRACs) Depend on C-terminal Residues of the First Extracellular Loop.
Q24794867Induction by transforming growth factor-beta1 of epithelial to mesenchymal transition is a rare event in vitro
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Q31804351Influence of protein kinases on the osmosensitive release of taurine from cerebellar granule neurons
Q41775757Inhibition of COX 1 and 2 prior to renal ischemia/reperfusion injury decreases the development of fibrosis
Q40121250Inhibition of ERK and JNK decreases both osmosensitive taurine release and cell proliferation in glioma cells
Q40799809Inhibition of VRAC by c-Src tyrosine kinase targeted to caveolae is mediated by the Src homology domains
Q35678845Inhibition of release of taurine and excitatory amino acids in ischemia and neuroprotection
Q40599107Inhibition of the endogenous volume-regulated anion channel (VRAC) in HEK293 cells by acidic di-aryl-ureas
Q77928588Inhibition of volume-regulated anion channels by expression of the cystic fibrosis transmembrane conductance regulator
Q28345843Inhibition of volume-regulated anion channels in cultured endothelial cells by the anti-oestrogens clomiphene and nafoxidine
Q64903406Injection of mRNA isolated from trophozoites of Giardia intestinalis induces expression of three types of chloride currents in Xenopus laevis oocytes.
Q48088022Intracellular ATP depletion inhibits swelling-induced D-[3H]aspartate release from primary astrocyte cultures
Q42804450Intracellular cyclic AMP inhibits native and recombinant volume-regulated chloride channels from mammalian heart
Q77381287Involvement of PKC-alpha in regulatory volume decrease responses and activation of volume-sensitive chloride channels in human cervical cancer HT-3 cells
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Q42840259Ion channels in volume regulation of clonal kidney cells
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Q22008725Isolation of a gene product expressed by a subpopulation of human lung fibroblasts by differential display
Q56974841LRRC8 N termini influence pore properties and gating of volume-regulated anion channels (VRACs)
Q28115770LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength
Q56965800LRRC8/VRAC anion channels are required for late stages of spermatid development in mice
Q54998617LRRC8/VRAC anion channels enhance β-cell glucose sensing and insulin secretion.
Q34436035LRRC8A protein is indispensable for swelling-activated and ATP-induced release of excitatory amino acids in rat astrocytes.
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Q57179323Molecular Biology and Physiology of Volume-Regulated Anion Channel (VRAC)
Q101133373Molecular and cellular mechanisms of liver fibrosis and its regression
Q47916694Molecular composition and heterogeneity of the LRRC8-containing swelling-activated osmolyte channels in primary rat astrocytes
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Q33910084Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis
Q34572311Ochratoxin A-induced renal cortex fibrosis and epithelial-to-mesenchymal transition: molecular mechanisms of ochratoxin A-injury and potential effects of red wine.
Q40429237Opening of plasma membrane voltage-dependent anion channels (VDAC) precedes caspase activation in neuronal apoptosis induced by toxic stimuli
Q35678800Osmolytes and mechanisms involved in regulatory volume decrease under conditions of sudden or gradual osmolarity decrease
Q34350861Osmoregulation and cell volume regulation in the preimplantation embryo
Q34583109Osmosensitive release of neurotransmitter amino acids: relevance and mechanisms
Q36944190Osmosignaling and volume regulation in intestinal epithelial cells
Q64063252Osmotic Demyelination: From an Oligodendrocyte to an Astrocyte Perspective
Q40922073Osmotic cell swelling-induced ATP release mediates the activation of extracellular signal-regulated protein kinase (Erk)-1/2 but not the activation of osmo-sensitive anion channels
Q33927917Osmotic regulation of neuronal activity: a new role for taurine and glial cells in a hypothalamic neuroendocrine structure
Q39754656P2X4 activation modulates volume-sensitive outwardly rectifying chloride channels in rat hepatoma cells.
Q43766340PGE(2), Ca(2+), and cAMP mediate ATP activation of Cl(-) channels in pigmented ciliary epithelial cells
Q37378261Pathophysiology and puzzles of the volume-sensitive outwardly rectifying anion channel.
Q44163357Peroxynitrite enhances astrocytic volume-sensitive excitatory amino acid release via a src tyrosine kinase-dependent mechanism
Q35042593Pharmacological characterization of volume-sensitive, taurine permeable anion channels in rat supraoptic glial cells
Q46983634Pharmacological comparison of swelling-activated excitatory amino acid release and Cl- currents in cultured rat astrocytes
Q28345472Phloretin differentially inhibits volume-sensitive and cyclic AMP-activated, but not Ca-activated, Cl(-) channels
Q43071221Potential link between cysteinyl-leukotriene receptors and release of bioactive amino acids in regulation of lung function. Focus on "Volume-sensitive release of organic osmolytes in the human lung epithelial cell line A549: role of the 5-lipoxygena
Q73011073Potentiation of a voltage-gated proton current in acidosis-induced swelling of rat microglia
Q44600253Potentiation of the osmosensitive taurine release and cell volume regulation by cytosolic Ca2+ rise in cultured cerebellar astrocytes.
Q44814354Prostaglandin E2 activates outwardly rectifying Cl(-) channels via a cAMP-dependent pathway and reduces cell motility in rat osteoclasts
Q78407112Proteolytic modification of swelling-activated Cl- current in LNCaP prostate cancer epithelial cells
Q34205309Receptor-mediated control of regulatory volume decrease (RVD) and apoptotic volume decrease (AVD).
Q36436205Recombinant pICln forms highly cation-selective channels when reconstituted into artificial and biological membranes
Q55473066Recovery from lactacidosis-induced glial cell swelling with the aid of exogenous anion channels.
Q36343377Reduced intracellular ionic strength as the initial trigger for activation of endothelial volume-regulated anion channels
Q28565813Reduction of phospholemman expression decreases osmosensitive taurine efflux in astrocytes
Q43636805Regulation of I(Cl,swell) in neuroblastoma cells by G protein signaling pathways
Q74525937Regulation of a volume-sensitive anion channel in rat pancreatic beta-cells by intracellular adenine nucleotides
Q84400915Regulation of bradykinin-induced activation of volume-sensitive outwardly rectifying anion channels by Ca2+ nanodomains in mouse astrocytes
Q35678796Regulation of the cellular content of the organic osmolyte taurine in mammalian cells
Q33903142Regulation of volume-activated chloride channels by P-glycoprotein: phosphorylation has the final say!
Q44185290Regulation of volume-sensitive outwardly rectifying anion channels in pulmonary arterial smooth muscle cells by PKC.
Q37616204Regulatory Roles of Anoctamin-6 in Human Trabecular Meshwork Cells
Q42825809Regulatory volume decrease after swelling induced by urea in fibroblasts: prominent role of organic osmolytes.
Q48561729Relation between food intake and visual analogue scale ratings of appetite and other sensations in healthy older and young subjects
Q51577479Relationship between TMEM16A/anoctamin 1 and LRRC8A.
Q33828111Research and progress on ClC‑2 (Review).
Q42813751Rho family GTP binding proteins are involved in the regulatory volume decrease process in NIH3T3 mouse fibroblasts
Q74583836Role of Rho and Rho kinase in the activation of volume-regulated anion channels in bovine endothelial cells
Q79448744Role of acid-sensitive outwardly rectifying anion channels in acidosis-induced cell death in human epithelial cells
Q38110755Role of ion transport in control of apoptotic cell death
Q38633779Role of volume-regulated and calcium-activated anion channels in cell volume homeostasis, cancer and drug resistance
Q27919694Roles of aquaporin-3 water channels in volume-regulatory water flow in a human epithelial cell line.
Q37683578Roles of taurine-mediated tonic GABAA receptor activation in the radial migration of neurons in the fetal mouse cerebral cortex
Q48456927Roles of two types of anion channels in glutamate release from mouse astrocytes under ischemic or osmotic stress
Q50469378Roles of volume-activated Cl- currents and regulatory volume decrease in the cell cycle and proliferation in nasopharyngeal carcinoma cells.
Q46857265Roles of volume-sensitive Cl- channel in cisplatin-induced apoptosis in human epidermoid cancer cells
Q48279637Roles of volume-sensitive chloride channel in excitotoxic neuronal injury.
Q37281646S100A4 mediates endometrial cancer invasion and is a target of TGF-beta1 signaling
Q49463301SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia
Q24294436SWELL1, a plasma membrane protein, is an essential component of volume-regulated anion channel
Q38309419Salt and osmosensing: role of cytoplasmic hydrogel
Q44265266Secretory activation of basolateral membrane Cl- channels in guinea pig distal colonic crypts
Q34074231Signaling events during swelling and regulatory volume decrease.
Q46364686Sodium-dependent activity of aquaporin-1 in rat glioma cells: a new mechanism of cell volume regulation
Q36459044Spatial distribution of maxi-anion channel on cardiomyocytes detected by smart-patch technique
Q34543136Specific and essential but not sufficient roles of LRRC8A in the activity of volume-sensitive outwardly rectifying anion channel (VSOR)
Q40615986Streptomycin and its analogues are potent inhibitors of the hypotonicity‐induced Ca2+ entry and Cl− channel activity
Q26851981Structure and function of TMEM16 proteins (anoctamins)
Q34500340Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs
Q40926762Sulphonic acid derivatives as probes of pore properties of volume-regulated anion channels in endothelial cells
Q42360679Swelling-activated and arachidonic acid-induced currents are TREK-1 in rat bladder smooth muscle cells
Q35669532Swelling-activated anion channels are essential for volume regulation of mouse thymocytes
Q42183727Swelling-activated pathways in human T-lymphocytes studied by cell volumetry and electrorotation
Q40900210Swelling-activated, cystic fibrosis transmembrane conductance regulator-augmented ATP release and Cl- conductances in murine C127 cells
Q36436272Swelling-induced, CFTR-independent ATP release from a human epithelial cell line: lack of correlation with volume-sensitive cl(-) channels
Q77928604Synergetic activation of outwardly rectifying Cl- currents by hypotonic stress and external Ca2+ in murine osteoclasts
Q45880357Systemic administration of naked plasmid encoding hepatocyte growth factor ameliorates chronic renal fibrosis in mice
Q48940507The GXGXG motif in the pI(Cln) protein is not important for the nucleotide sensitivity of the pI(Cln)-induced Cl- current in Xenopus oocytes
Q36197432The apoptotic volume decrease is an upstream event of MAP kinase activation during Staurosporine-induced apoptosis in HeLa cells
Q24652992The basics of epithelial-mesenchymal transition
Q34576674The cytoskeleton and cell volume regulation
Q35575915The fall and rise of active chloride transport: Implications for regulation of intraocular pressure
Q35041864The gastric H,K-ATPase blocker lansoprazole is an inhibitor of chloride channels
Q41753104The list of potential volume-sensitive chloride currents continues to swell (and shrink).
Q37429965The maxi-anion channel: a classical channel playing novel roles through an unidentified molecular entity
Q34216368The molecular and functional interaction between ICln and HSPC038 proteins modulates the regulation of cell volume
Q38687643The properties, functions, and pathophysiology of maxi-anion channels
Q42485963The role of ClC-3 in volume-activated chloride currents and volume regulation in bovine epithelial cells demonstrated by antisense inhibition
Q35581297The role of renal proximal tubular cells in diabetic nephropathy
Q47867124The signaling role for chloride in the bidirectional communication between neurons and astrocytes.
Q64265976Tweety Homologs (TTYH) Freshly Join the Journey of Molecular Identification of the VRAC/VSOR Channel Pore
Q64266008Tweety-homolog () Family Encodes the Pore-forming Subunits of the Swelling-dependent Volume-regulated Anion Channel (VRAC) in the Brain
Q37285042Two conventional protein kinase C isoforms, alpha and beta I, are involved in the ATP-induced activation of volume-regulated anion channel and glutamate release in cultured astrocytes
Q33380149Two distinct modes of hypoosmotic medium-induced release of excitatory amino acids and taurine in the rat brain in vivo
Q42484389Tyrosine phosphorylation modulates the osmosensitivity of volume-dependent taurine efflux from glial cells in the rat supraoptic nucleus
Q39101638Up-regulation of Kv7.1 channels in thromboxane A2-induced colonic cancer cell proliferation
Q46064724Upholding a role for EMT in breast cancer metastasis.
Q40654172Upregulation of Swelling‐Activated Cl− Channel Sensitivity to Cell Volume by Activation of EGF Receptors in Murine Mammary Cells
Q34520478VRACs and other ion channels and transporters in the regulation of cell volume and beyond
Q35987680Vesicular and conductive mechanisms of nucleotide release
Q33828450Volume regulated anion channel currents of rat hippocampal neurons and their contribution to oxygen-and-glucose deprivation induced neuronal death
Q36436392Volume-dependent ATP-conductive large-conductance anion channel as a pathway for swelling-induced ATP release
Q34503545Volume-regulated anion channel--a frenemy within the brain
Q36445294Volume-regulated anion channels serve as an auto/paracrine nucleotide release pathway in aortic endothelial cells
Q40852795Volume-regulated chloride conductance in the LNCaP human prostate cancer cell line
Q36439008Volume-sensitive K(+)/Cl(-) cotransport in rabbit erythrocytes. Analysis of the rate-limiting activation and inactivation events
Q34576857Volume-sensitive anion channels mediate osmosensitive glutathione release from rat thymocytes
Q36473835Volume-sensitive chloride channels involved in apoptotic volume decrease and cell death.
Q38924973Volume-sensitive outwardly rectifying Cl(-) channels contribute to butyrate-triggered apoptosis of murine colonic epithelial MCE301 cells.
Q43182560Volume-sensitive outwardly rectifying chloride channel in white adipocytes from normal and diabetic mice.
Q37108106Water and ion channels: crucial in the initiation and progression of apoptosis in central nervous system?
Q34187024Wide nanoscopic pore of maxi-anion channel suits its function as an ATP-conductive pathway
Q37681848miR-34c attenuates epithelial-mesenchymal transition and kidney fibrosis with ureteral obstruction.

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