Structure of dimeric axonemal dynein in cilia suggests an alternative mechanism of force generation

scientific article published on 2 July 2014

Structure of dimeric axonemal dynein in cilia suggests an alternative mechanism of force generation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/CM.21180
P698PubMed publication ID24953776
P5875ResearchGate publication ID263323194

P50authorYohsuke ImaiQ41020285
Khanh Huy BuiQ41598162
P2093author name stringTakashi Ishikawa
Hironori Ueno
Takami Yamaguchi
Takuji Ishikawa
P2860cites workThe alpha subunit of sea urchin sperm outer arm dynein mediates structural and rigor binding to microtubulesQ36531787
Dynein achieves processive motion using both stochastic and coordinated steppingQ40846018
Dual-axis tomography: an approach with alignment methods that preserve resolutionQ41069925
Mouse respiratory cilia with the asymmetric axonemal structure on sparsely distributed ciliary cells can generate overall directional flowQ41614137
Functional reconstitution of Chlamydomonas outer dynein arms from alpha-beta and gamma subunits: requirement of a third factorQ42770898
Dynein structure and power stroke.Q44334352
Four ATP-binding sites in the midregion of the β heavy chain of dyneinQ46096782
Systematic comparison of in vitro motile properties between Chlamydomonas wild-type and mutant outer arm dyneins each lacking one of the three heavy chains.Q46174532
ATP hydrolysis cycle-dependent tail motions in cytoplasmic dyneinQ46478238
Multiple nucleotide-binding sites in the sequence of dynein β heavy chainQ48215129
An extended microtubule-binding structure within the dynein motor domainQ59096941
Microtubule translocation caused by three subspecies of inner-arm dynein from Chlamydomonas flagellaQ68420373
Transport and arrangement of the outer-dynein-arm docking complex in the flagella of Chlamydomonas mutants that lack outer dynein armsQ73688068
Kinetic characterization of tail swing steps in the ATPase cycle of Dictyostelium cytoplasmic dyneinQ80427397
Heterogeneity of dynein structure implies coordinated suppression of dynein motor activity in the axonemeQ84089908
X-ray structure of a functional full-length dynein motor domainQ84166100
A 20-year experience of electron microscopy in the diagnosis of primary ciliary dyskinesiaQ84748826
Mutations in DNAH5 cause primary ciliary dyskinesia and randomization of left-right asymmetryQ24292162
ATP-driven remodeling of the linker domain in the dynein motorQ24294935
Mislocalization of DNAH5 and DNAH9 in respiratory cells from patients with primary ciliary dyskinesiaQ24297464
DNAH5 mutations are a common cause of primary ciliary dyskinesia with outer dynein arm defectsQ24318839
Crystal structure of the dynein motor domainQ24600725
Single-molecule analysis of dynein processivity and stepping behaviorQ24601278
The 2.8 Å crystal structure of the dynein motor domainQ27677933
Insights into dynein motor domain function from a 3.3-Å crystal structureQ27678078
SPIDER and WEB: processing and visualization of images in 3D electron microscopy and related fieldsQ27860560
UCSF Chimera--a visualization system for exploratory research and analysisQ27860666
Adenosine Triphosphate-Induced Sliding of Tubules in Trypsin-Treated Flagella of Sea-Urchin SpermQ28251355
Myosin V walks hand-over-hand: single fluorophore imaging with 1.5-nm localizationQ29615477
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Three-dimensional structures of the flagellar dynein-microtubule complex by cryoelectron microscopyQ30480426
Dynein pulls microtubules without rotating its stalkQ30485077
Cytoplasmic dynein moves through uncoordinated stepping of the AAA+ ring domainsQ30578826
Molecular architecture of inner dynein arms in situ in Chlamydomonas reinhardtii flagella.Q33386682
Asymmetry of inner dynein arms and inter-doublet links in Chlamydomonas flagellaQ33492150
Nucleotide-induced global conformational changes of flagellar dynein arms revealed by in situ analysis.Q33572779
Force-induced bidirectional stepping of cytoplasmic dyneinQ33777174
Kinesin walks hand-over-handQ34284942
Interspecies conservation of outer arm dynein intermediate chain sequences defines two intermediate chain subclassesQ34449186
Overlapping hand-over-hand mechanism of single molecular motility of cytoplasmic dyneinQ34507133
3D structural analysis of flagella/cilia by cryo-electron tomography.Q34623994
Lateralization defects and ciliary dyskinesia: lessons from algaeQ35076952
Design and regulation of the AAA+ microtubule motor dyneinQ35705280
Polarity and asymmetry in the arrangement of dynein and related structures in the Chlamydomonas axonemeQ36205308
The motile beta/IC1 subunit of sea urchin sperm outer arm dynein does not form a rigor bondQ36531783
P433issue7
P304page(s)412-422
P577publication date2014-07-02
P1433published inCytoskeletonQ2196987
P1476titleStructure of dimeric axonemal dynein in cilia suggests an alternative mechanism of force generation
P478volume71

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cites work (P2860)
Q30376431A computational model of dynein activation patterns that can explain nodal cilia rotation
Q52355491A microtubule-dynein tethering complex regulates the axonemal inner dynein f (I1).
Q38948108Axoneme Structure from Motile Cilia
Q30619433Cryo-electron tomography of motile cilia and flagella
Q35837649Knockdown of Inner Arm Protein IC138 in Trypanosoma brucei Causes Defective Motility and Flagellar Detachment
Q41358973Lis1 restricts the conformational changes in cytoplasmic dynein on microtubules.
Q60389153Seeing cilia: imaging modalities for ciliary motion and clinical connections
Q27304940Structure and function of outer dynein arm intermediate and light chain complex.
Q35229307The more we know, the more we have to discover: an exciting future for understanding cilia and ciliopathies

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