| scholarly article | Q13442814 |
| P50 | author | James Posada | Q98474312 |
| P2093 | author name string | J. A. Cooper | |
| M. H. Cobb | |||
| E. G. Krebs | |||
| R. Seger | |||
| N. G. Ahn | |||
| A. M. Jensen | |||
| E. S. Munar | |||
| P2860 | cites work | Demonstration that the leukocyte common antigen CD45 is a protein tyrosine phosphatase | Q24293361 |
| ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF | Q24304344 | ||
| A mammalian protein kinase with potential for serine/threonine and tyrosine phosphorylation is related to cell cycle regulators | Q24310682 | ||
| A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding | Q25938984 | ||
| “Western Blotting”: Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A | Q28131712 | ||
| Recent progress in characterization of protein kinase cascades for phosphorylation of ribosomal protein S6. | Q30439463 | ||
| Raf-1 is a potential substrate for mitogen-activated protein kinase in vivo | Q30439640 | ||
| Autophosphorylation in vitro of recombinant 42-kilodalton mitogen-activated protein kinase on tyrosine | Q30445802 | ||
| Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase) | Q30446229 | ||
| Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro | Q30450903 | ||
| Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase | Q30453375 | ||
| Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II. | Q30460881 | ||
| Xenopus MAP kinase activator: identification and function as a key intermediate in the phosphorylation cascade | Q33937504 | ||
| Phosphorylation of c-jun mediated by MAP kinases. | Q34947174 | ||
| MAP kinase by any other name smells just as sweet | Q35224916 | ||
| Extracellular signal-regulated kinases: ERKs in progress | Q36746413 | ||
| Extracellular signal-regulated kinases 2 autophosphorylates on a subset of peptides phosphorylated in intact cells in response to insulin and nerve growth factor: analysis by peptide mapping | Q37370822 | ||
| Epidermal growth factor (EGF) receptor T669 peptide kinase from 3T3-L1 cells is an EGF-stimulated "MAP" kinase | Q37448443 | ||
| Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation | Q37547362 | ||
| Mouse Erk-1 gene product is a serine/threonine protein kinase that has the potential to phosphorylate tyrosine | Q37603131 | ||
| Okadaic acid: a new probe for the study of cellular regulation | Q37876246 | ||
| Purification and properties of extracellular signal-regulated kinase 1, an insulin-stimulated microtubule-associated protein 2 kinase | Q41699936 | ||
| An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control | Q41728250 | ||
| Requirements for Phosphorylation of Map Kinase During Meiosis in Xenopus Oocytes | Q50794909 | ||
| Acid and base hydrolysis of phosphoproteins bound to immobilon facilitates analysis of phosphoamino acids in gel-fractionated proteins. | Q53518465 | ||
| Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases | Q59097215 | ||
| [42] Detection and quantification of phosphotyrosine in proteins | Q115796934 | ||
| P433 | issue | 20 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | biochemistry | Q7094 |
| cell biology | Q7141 | ||
| P304 | page(s) | 14373-14381 | |
| P577 | publication date | 1992-07-01 | |
| 1992-07-15 | |||
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells | |
| P478 | volume | 267 |
| Q35722274 | A 50-kDa ERK-like protein is up-regulated by a dual altered peptide ligand that suppresses myasthenia gravis-associated responses |
| Q28345384 | A conserved docking site in MEKs mediates high-affinity binding to MAP kinases and cooperates with a scaffold protein to enhance signal transmission |
| Q24563631 | A protein factor for ras p21-dependent activation of mitogen-activated protein (MAP) kinase through MAP kinase kinase |
| Q90347933 | A quantitative model of developmental RTK signaling |
| Q35200753 | A requirement for extracellular signal-regulated kinase (ERK) function in the activation of AP-1 by Ha-Ras, phorbol 12-myristate 13-acetate, and serum |
| Q73663722 | ATMPK4, an Arabidopsis homolog of mitogen-activated protein kinase, is activated in vitro by AtMEK1 through threonine phosphorylation |
| Q34001456 | Activation of phosphotyrosine phosphatase activity attenuates mitogen-activated protein kinase signaling and inhibits c-FOS and nitric oxide synthase expression in macrophages infected with Leishmania donovani |
| Q30451011 | Activation of the mitogen-activated protein kinase pathway in Triton X-100 disrupted NIH-3T3 cells by p21 ras and in vitro by plasma membranes from NIH 3T3 cells |
| Q92132707 | An ultrasensitive fiveplex activity assay for cellular kinases |
| Q43554233 | Arsenite inhibits Ras-dependent activation of ERK but activates ERK in the presence of oncogenic Ras in baboon vascular smooth muscle cells |
| Q28583306 | Association of MEK1 with p21ras.GMPPNP is dependent on B-Raf |
| Q34988660 | Baicalein inhibits the invasion and metastatic capabilities of hepatocellular carcinoma cells via down-regulation of the ERK pathway |
| Q30306546 | Biochemical and biological functions of the N-terminal, noncatalytic domain of extracellular signal-regulated kinase 2. |
| Q28573164 | Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain |
| Q45748449 | Complete nucleotide sequence of bean pod mottle virus RNA1: sequence comparisons and evolutionary relationships to other comoviruses |
| Q37633990 | Constitutive mutant and putative regulatory serine phosphorylation site of mammalian MAP kinase kinase (MEK1). |
| Q31813560 | Developmental expression of retinal cone cGMP-gated channels: evidence for rapid turnover and trophic regulation. |
| Q52166598 | Developmental regulation of neuronal KCa channels by TGFbeta 1: transcriptional and posttranscriptional effects mediated by Erk MAP kinase. |
| Q34743737 | Differential activation of mitogen-activated protein kinase in response to basic fibroblast growth factor in skeletal muscle cells |
| Q34450770 | Differential effects on cAMP on the MAP kinase cascade: evidence for a cAMP-insensitive step that can bypass Raf-1 |
| Q41412772 | Divergent effects of intrinsically active MEK variants on developmental Ras signaling |
| Q30463790 | Dual phosphorylation and autophosphorylation in mitogen-activated protein (MAP) kinase activation |
| Q44005835 | Eicosapentaenoic acid and docosahexaenoic acid modulate MAP kinase enzyme activity in human T-cells |
| Q24562377 | Expression cloning of a human dual-specificity phosphatase |
| Q36800532 | Functional coupling of adenosine A2a receptor to inhibition of the mitogen-activated protein kinase cascade in Chinese hamster ovary cells |
| Q34605401 | Genetic analysis of the Caenorhabditis elegans MAP kinase gene mpk-1 |
| Q47669262 | How activating mutations affect MEK1 regulation and function |
| Q24602577 | Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2. |
| Q34934364 | Immunosuppression in Hamsters with Progressive Visceral Leishmaniasis Is Associated with an Impairment of Protein Kinase C Activity in Their Lymphocytes That Can Be Partially Reversed by Okadaic Acid or Anti-Transforming Growth Factor β Antibody |
| Q41822444 | Improved intra-array and interarray normalization of peptide microarray phosphorylation for phosphorylome and kinome profiling by rational selection of relevant spots |
| Q45117950 | In vitro and in vivo metabolism of the anti-cancer agent CI-1040, a MEK inhibitor, in rat, monkey, and human |
| Q40637213 | In vitro substrate specificity of protein tyrosine kinases |
| Q37599060 | In vivo severity ranking of Ras pathway mutations associated with developmental disorders |
| Q34455351 | Interconnected network motifs control podocyte morphology and kidney function |
| Q58428561 | Intrinsically active MEK variants are differentially regulated by proteinases and phosphatases |
| Q40023699 | Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for lipopolysaccharide stimulation of tumor necrosis factor alpha (TNF-alpha) translation: glucocorticoids inhibit TNF-alpha translation by blocking JNK/SAPK. |
| Q33897202 | Kinase inhibitors in cancer therapy: a look ahead |
| Q34145511 | Ligation of the T cell receptor complex results in activation of the Ras/Raf-1/MEK/MAPK cascade in human T lymphocytes |
| Q41429925 | Lipopolysaccharide signals activation of tumor necrosis factor biosynthesis through the ras/raf-1/MEK/MAPK pathway. |
| Q34467087 | MAP kinase modules: the excursion model and the steps that count |
| Q34440555 | MEK-1 phosphorylation by MEK kinase, Raf, and mitogen-activated protein kinase: analysis of phosphopeptides and regulation of activity |
| Q28581201 | MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase |
| Q30454068 | Metabolic labeling of mitogen-activated protein kinase kinase in A431 cells demonstrates phosphorylation on serine and threonine residues |
| Q34473609 | Mitogen-activated protein kinase (MAPK)-docking sites in MAPK kinases function as tethers that are crucial for MAPK regulation in vivo |
| Q24614153 | Mitogen-activated protein kinase kinase 1 (MKK1) is negatively regulated by threonine phosphorylation |
| Q24310254 | Molecular Cloning, Expression, and Characterization of the Human Mitogen-Activated Protein Kinase p44erk1 |
| Q30454074 | Molecular structure of a protein-tyrosine/threonine kinase activating p42 mitogen-activated protein (MAP) kinase: MAP kinase kinase |
| Q24563960 | N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome |
| Q41949103 | Nerve growth factor stimulates a novel protein kinase in PC-12 cells that phosphorylates and activates mitogen-activated protein kinase kinase (MEK). |
| Q40637218 | Networking with mitogen-activated protein kinases. |
| Q33895259 | New algorithm to determine true colocalization in combination with image restoration and time-lapse confocal microscopy to MAP kinases in mitochondria |
| Q39791081 | Noncatalytic function of ERK1/2 can promote Raf/MEK/ERK-mediated growth arrest signaling |
| Q30453600 | Novel membrane-targeted ERK1 and ERK2 chimeras which act as dominant negative, isotype-specific mitogen-activated protein kinase inhibitors of Ras-Raf-mediated transcriptional activation of c-fos in NIH 3T3 cells |
| Q36105057 | Nuclear translocation of mitogen-activated protein kinase kinase (MEK1) in response to mitogenic stimulation |
| Q41493279 | Phosphorylation of JAK2 at serine 523: a negative regulator of JAK2 that is stimulated by growth hormone and epidermal growth factor. |
| Q42148556 | Platelet-derived growth factor and angiotensin II stimulate the mitogen-activated protein kinase cascade in renal mesangial cells: comparison of hypertrophic and hyperplastic agonists |
| Q24564451 | Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells |
| Q36663797 | Protein-tyrosine phosphatase activity of CD45 is activated by sequential phosphorylation by two kinases |
| Q35346084 | Protein-tyrosine-phosphatase 2C is phosphorylated and inhibited by 44-kDa mitogen-activated protein kinase |
| Q24564113 | Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product |
| Q24607777 | RAS and RAF-1 form a signalling complex with MEK-1 but not MEK-2. |
| Q36375189 | Raf-1 and p21v-ras cooperate in the activation of mitogen-activated protein kinase |
| Q40791763 | Requirement for the MAP kinase kinase/MAP kinase cascade in Xenopus oocyte maturation. |
| Q40656340 | Schizosaccharomyces pombe Spk1 is a tyrosine-phosphorylated protein functionally related to Xenopus mitogen-activated protein kinase |
| Q35670500 | Shortage of mitogen-activated protein kinase is responsible for resistance to AP-1 transactivation and transformation in mouse JB6 cells. |
| Q37965017 | Signal control through Raf: in sickness and in health |
| Q40733258 | Signal transduction pathways involving the Raf proto-oncogene |
| Q36381460 | Signal transduction via the MAP kinases: proceed at your own RSK. |
| Q42370944 | Stimulation by extracellular ATP and UTP of the mitogen-activated protein kinase cascade and proliferation of rat renal mesangial cells |
| Q36288543 | Stimulation by phospholipids of a protein-tyrosine-phosphatase containing two src homology 2 domains |
| Q36260506 | The ERK cascade: a prototype of MAPK signaling |
| Q40637233 | The MAP kinase cascade. Discovery of a new signal transduction pathway |
| Q30450997 | The MPM-2 antibody inhibits mitogen-activated protein kinase activity by binding to an epitope containing phosphothreonine-183 |
| Q40953401 | The interaction of mitogen-activated protein kinases to Epstein-Barr virus activation in Akata cells |
| Q28609138 | The mitogen-activated protein kinase cascade is activated by B-Raf in response to nerve growth factor through interaction with p21ras |
| Q37371237 | The mitogen-activated protein kinase pathway can mediate growth inhibition and proliferation in smooth muscle cells. Dependence on the availability of downstream targets |
| Q48257428 | The mitogen-activated protein kinase pathway mediates estrogen neuroprotection after glutamate toxicity in primary cortical neurons. |
| Q35140947 | The novel anti-MEK small molecule AZD6244 induces BIM-dependent and AKT-independent apoptosis in diffuse large B-cell lymphoma |
| Q42124615 | Transmembrane signalling mechanisms regulating expression of cationic amino acid transporters and inducible nitric oxide synthase in rat vascular smooth muscle cells. |
| Q40975709 | Tyrosine phosphatase SHP-2 dephosphorylates the platelet-derived growth factor receptor but enhances its downstream signalling |
| Q40796442 | Tyrosine-phosphorylated extracellular signal--regulated kinase associates with the Golgi complex during G2/M phase of the cell cycle: evidence for regulation of Golgi structure |
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