Phosphatase and tensin homolog

tumor suppressor gene

Wikidata entity: Q416356

Wikimedia Commons category is PTEN phosphohydrolase



P682 biological process ... Q189092 (cell migration) cell migration
P682 biological process ... Q189101 (cell population proliferation) cell population proliferation
P682 biological process ... Q332154 (ageing) ageing
P682 biological process ... Q921513 (social behavior) social behavior
P682 biological process ... Q1101143 (dephosphorylation) dephosphorylation
P682 biological process ... Q492 (memory) memory
P682 biological process ... Q471817 (development of the heart) development of the heart
P682 biological process ... Q539568 (angiogenesis) angiogenesis
P682 biological process ... Q14890026 (response to inorganic substance) response to inorganic substance
P682 biological process ... Q14897693 (cellular response to nerve growth factor stimulus) cellular response to nerve growth factor stimulus
P682 biological process ... Q14901444 (cellular response to ethanol) cellular response to ethanol
P682 biological process ... Q14901669 (response to ATP) response to ATP
P682 biological process ... Q14901709 (negative regulation of potassium ion transmembrane transporter activity) negative regulation of potassium ion transmembrane transporter activity
P682 biological process ... Q14903032 (negative regulation of cardiac muscle cell proliferation) negative regulation of cardiac muscle cell proliferation
P682 biological process ... Q14903757 (negative regulation of epithelial to mesenchymal transition) negative regulation of epithelial to mesenchymal transition
P682 biological process ... Q14914159 (negative regulation of signaling receptor activity) negative regulation of signaling receptor activity
P682 biological process ... Q1128897 (prepulse inhibition) prepulse inhibition
P682 biological process ... Q1345738 (nervous system development) nervous system development
P682 biological process ... Q1517140 (long-term depression) long-term depression
P682 biological process ... Q1805481 (long-term potentiation) long-term potentiation
P682 biological process ... Q14818063 (positive regulation of apoptotic process) positive regulation of apoptotic process
P682 biological process ... Q14818081 (cellular response to hypoxia) cellular response to hypoxia
P682 biological process ... Q14818117 (positive regulation of cardiac muscle cell apoptotic process) positive regulation of cardiac muscle cell apoptotic process
P682 biological process ... Q14818129 (regulation of cell cycle) regulation of cell cycle
P682 biological process ... Q14819853 (learning or memory) learning or memory
P682 biological process ... Q21100355 (regulation of axon regeneration) regulation of axon regeneration
P682 biological process ... Q21100379 (regulation of cellular localization) regulation of cellular localization
P682 biological process ... Q21101197 (negative regulation of axon regeneration) negative regulation of axon regeneration
P682 biological process ... Q21102106 (cellular response to decreased oxygen levels) cellular response to decreased oxygen levels
P682 biological process ... Q21105499 (regulation of cyclin-dependent protein serine/threonine kinase activity) regulation of cyclin-dependent protein serine/threonine kinase activity
P682 biological process ... Q21106175 (cellular response to electrical stimulus) cellular response to electrical stimulus
P682 biological process ... Q21114170 (negative regulation of wound healing, spreading of epidermal cells) negative regulation of wound healing, spreading of epidermal cells
P682 biological process ... Q21116798 (positive regulation of TRAIL-activated apoptotic signaling pathway) positive regulation of TRAIL-activated apoptotic signaling pathway
P682 biological process ... Q21118137 (cellular response to insulin-like growth factor stimulus) cellular response to insulin-like growth factor stimulus
P682 biological process ... Q22245000 (positive regulation of ubiquitin protein ligase activity) positive regulation of ubiquitin protein ligase activity
P682 biological process ... Q22284789 (negative regulation of keratinocyte migration) negative regulation of keratinocyte migration
P682 biological process ... Q22304651 (negative regulation of vascular associated smooth muscle cell proliferation) negative regulation of vascular associated smooth muscle cell proliferation
P682 biological process ... Q14864234 (protein deubiquitination) protein deubiquitination
P682 biological process ... Q14864368 (neuron projection development) neuron projection development
P682 biological process ... Q14864396 (response to arsenic-containing substance) response to arsenic-containing substance
P682 biological process ... Q14864461 (positive regulation of DNA-binding transcription factor activity) positive regulation of DNA-binding transcription factor activity
P682 biological process ... Q14864694 (positive regulation of ubiquitin-dependent protein catabolic process) positive regulation of ubiquitin-dependent protein catabolic process
P682 biological process ... Q14864860 (negative regulation of neuron projection development) negative regulation of neuron projection development
P682 biological process ... Q14865335 (multicellular organismal response to stress) multicellular organismal response to stress
P682 biological process ... Q14865553 (negative regulation of cyclin-dependent protein serine/threonine kinase activity) negative regulation of cyclin-dependent protein serine/threonine kinase activity
P682 biological process ... Q14866196 (phosphatidylinositol biosynthetic process) phosphatidylinositol biosynthetic process
P682 biological process ... Q14872986 (positive regulation of apoptotic signaling pathway) positive regulation of apoptotic signaling pathway
P682 biological process ... Q14873008 (negative regulation of epithelial cell proliferation) negative regulation of epithelial cell proliferation
P682 biological process ... Q14873901 (cardiac muscle tissue development) cardiac muscle tissue development
P682 biological process ... Q14875863 (adult behavior) adult behavior
P682 biological process ... Q14876084 (negative regulation of cell size) negative regulation of cell size
P682 biological process ... Q14876136 (negative regulation of axonogenesis) negative regulation of axonogenesis
P682 biological process ... Q14878347 (regulation of B cell apoptotic process) regulation of B cell apoptotic process
P682 biological process ... Q1813773 (synapse assembly) synapse assembly
P682 biological process ... Q2792936 (lipid metabolism) lipid metabolism
P682 biological process ... Q11547226 (Maternal behavior) Maternal behavior
P682 biological process ... Q14330967 (central nervous system development) central nervous system development
P682 biological process ... Q14331120 (positive regulation of excitatory postsynaptic potential) positive regulation of excitatory postsynaptic potential
P682 biological process ... Q14819884 (response to ethanol) response to ethanol
P682 biological process ... Q14820875 (response to activity) response to activity
P682 biological process ... Q14820903 (male mating behavior) male mating behavior
P682 biological process ... Q14820916 (response to organic cyclic compound) response to organic cyclic compound
P682 biological process ... Q14821388 (positive regulation of ERK1 and ERK2 cascade) positive regulation of ERK1 and ERK2 cascade
P682 biological process ... Q14852017 (positive regulation of neuron differentiation) positive regulation of neuron differentiation
P682 biological process ... Q14859888 (response to zinc ion) response to zinc ion
P682 biological process ... Q14859937 (negative regulation of cell migration) negative regulation of cell migration
P682 biological process ... Q14860512 (endothelial cell migration) endothelial cell migration
P682 biological process ... Q14860785 (transcription initiation from RNA polymerase II promoter) transcription initiation from RNA polymerase II promoter
P682 biological process ... Q14860808 (response to nutrient) response to nutrient
P682 biological process ... Q14860812 (negative regulation of organ growth) negative regulation of organ growth
P682 biological process ... Q14860813 (brain morphogenesis) brain morphogenesis
P682 biological process ... Q14860865 (negative regulation of protein phosphorylation) negative regulation of protein phosphorylation
P682 biological process ... Q14861556 (response to organic substance) response to organic substance
P682 biological process ... Q14863045 (platelet-derived growth factor receptor signaling pathway) platelet-derived growth factor receptor signaling pathway
P682 biological process ... Q14863071 (cellular response to insulin stimulus) cellular response to insulin stimulus
P682 biological process ... Q14863072 (cellular response to leptin stimulus) cellular response to leptin stimulus
P682 biological process ... Q14863383 (protein dephosphorylation) protein dephosphorylation
P682 biological process ... Q14863403 (regulation of protein stability) regulation of protein stability
P682 biological process ... Q14863708 (prostate gland growth) prostate gland growth
P682 biological process ... Q14863711 (negative regulation of ERK1 and ERK2 cascade) negative regulation of ERK1 and ERK2 cascade
P682 biological process ... Q14864022 (response to glucose) response to glucose
P682 biological process ... Q14864042 (negative regulation of phagocytosis) negative regulation of phagocytosis
P682 biological process ... Q14599311 (apoptotic process) apoptotic process
P682 biological process ... Q14599399 (negative regulation of cell population proliferation) negative regulation of cell population proliferation
P682 biological process ... Q14878349 (neuron-neuron synaptic transmission) neuron-neuron synaptic transmission
P682 biological process ... Q14878350 (regulation of neuron projection development) regulation of neuron projection development
P682 biological process ... Q14878351 (negative regulation of phosphatidylinositol 3-kinase signaling) negative regulation of phosphatidylinositol 3-kinase signaling
P682 biological process ... Q14878352 (central nervous system neuron axonogenesis) central nervous system neuron axonogenesis
P682 biological process ... Q14878353 (negative regulation of myelination) negative regulation of myelination
P682 biological process ... Q14878354 (central nervous system myelin maintenance) central nervous system myelin maintenance
P682 biological process ... Q14878355 (regulation of cellular component size) regulation of cellular component size
P682 biological process ... Q14878356 (regulation of myeloid cell apoptotic process) regulation of myeloid cell apoptotic process
P682 biological process ... Q14878357 (peptidyl-tyrosine dephosphorylation) peptidyl-tyrosine dephosphorylation
P682 biological process ... Q14878358 (protein kinase B signaling) protein kinase B signaling
P682 biological process ... Q14878359 (inositol phosphate metabolic process) inositol phosphate metabolic process
P682 biological process ... Q14878360 (locomotor rhythm) locomotor rhythm
P682 biological process ... Q14878361 (inositol phosphate dephosphorylation) inositol phosphate dephosphorylation
P682 biological process ... Q14878362 (phosphatidylinositol dephosphorylation) phosphatidylinositol dephosphorylation
P682 biological process ... Q14878363 (forebrain morphogenesis) forebrain morphogenesis
P682 biological process ... Q14878364 (negative regulation of focal adhesion assembly) negative regulation of focal adhesion assembly
P682 biological process ... Q14878366 (negative regulation of protein kinase B signaling) negative regulation of protein kinase B signaling
P682 biological process ... Q14878367 (rhythmic synaptic transmission) rhythmic synaptic transmission
P682 biological process ... Q14878368 (synapse maturation) synapse maturation
P682 biological process ... Q14878369 (dendritic spine morphogenesis) dendritic spine morphogenesis
P682 biological process ... Q14878370 (negative regulation of dendritic spine morphogenesis) negative regulation of dendritic spine morphogenesis
P682 biological process ... Q14878371 (negative regulation of ribosome biogenesis) negative regulation of ribosome biogenesis
P682 biological process ... Q14878373 (negative regulation of excitatory postsynaptic potential) negative regulation of excitatory postsynaptic potential
P682 biological process ... Q14878374 (presynaptic membrane assembly) presynaptic membrane assembly
P682 biological process ... Q14878375 (negative regulation of G1/S transition of mitotic cell cycle) negative regulation of G1/S transition of mitotic cell cycle
P682 biological process ... Q14878376 (negative regulation of synaptic vesicle clustering) negative regulation of synaptic vesicle clustering
P682 biological process ... Q14884133 (regulation of synaptic transmission, GABAergic) regulation of synaptic transmission, GABAergic
P682 biological process ... Q14599533 (negative regulation of apoptotic process) negative regulation of apoptotic process
P682 biological process ... Q14633891 (positive regulation of cell population proliferation) positive regulation of cell population proliferation
P682 biological process ... Q14633893 (positive regulation of gene expression) positive regulation of gene expression
P682 biological process ... Q14633902 (response to estradiol) response to estradiol
P682 biological process ... Q14633923 (protein stabilization) protein stabilization
P682 biological process ... Q14645719 (locomotory behavior) locomotory behavior
P682 biological process ... Q14645727 (dentate gyrus development) dentate gyrus development
P682 biological process ... Q14645737 (postsynaptic density assembly) postsynaptic density assembly
P682 biological process ... Q14762275 (canonical Wnt signaling pathway) canonical Wnt signaling pathway
P681 cell component ... Q79899 (cytoplasm) cytoplasm
P681 cell component ... Q220599 (cytosol) cytosol
P681 cell component ... Q902079 (dendritic spine) dendritic spine
P681 cell component ... Q29548 (plasma membrane) plasma membrane
P681 cell component ... Q39572 (mitochondrion) mitochondrion
P681 cell component ... Q1640852 (Schmidt-Lanterman incisure) Schmidt-Lanterman incisure
P681 cell component ... Q14817956 (nucleoplasm) nucleoplasm
P681 cell component ... Q14817968 (PML body) PML body
P681 cell component ... Q14819446 (apical plasma membrane) apical plasma membrane
P681 cell component ... Q22327509 (postsynaptic cytosol) postsynaptic cytosol
P681 cell component ... Q14864257 (postsynaptic membrane) postsynaptic membrane
P681 cell component ... Q14877624 (cytoplasmic side of plasma membrane) cytoplasmic side of plasma membrane
P681 cell component ... Q14330629 (myelin sheath adaxonal region) myelin sheath adaxonal region
P681 cell component ... Q14353100 (cell projection) cell projection
P681 cell component ... Q40260 (nucleus) nucleus
P681 cell component ... Q14645596 (extracellular region) extracellular region
P681 cell component ... Q14645640 (neuron projection) neuron projection
P373 Commons category String PTEN phosphohydrolase ???
P702 encoded by ... Q14878377 (PTEN) PTEN
P2888 exact match Url UniProt ???
P703 found in taxon ... Q15978631 (Homo sapiens) Homo sapiens
P527 has part(s) ... Q24720256 (Tensin-type phosphatase domain) Tensin-type phosphatase domain
P527 has part(s) ... Q24741554 (Protein-tyrosine phosphatase, catalytic) Protein-tyrosine phosphatase, catalytic
P527 has part(s) ... Q24783188 (Protein-tyrosine phosphatase, active site) Protein-tyrosine phosphatase, active site
P527 has part(s) ... Q24786850 (Tensin phosphatase, C2 domain) Tensin phosphatase, C2 domain
P31 instance of ... Q8054 (protein) protein
P680 molecular function ... Q167149 (protein binding) protein binding
P680 molecular function ... Q14817984 (protein kinase binding) protein kinase binding
P680 molecular function ... Q21097301 (ubiquitin-specific protease binding) ubiquitin-specific protease binding
P680 molecular function ... Q21105131 (protein serine/threonine phosphatase activity) protein serine/threonine phosphatase activity
P680 molecular function ... Q21114172 (protein tyrosine kinase binding) protein tyrosine kinase binding
P680 molecular function ... Q14876754 (ionotropic glutamate receptor binding) ionotropic glutamate receptor binding
P680 molecular function ... Q14878339 (phosphatidylinositol-3-phosphatase activity) phosphatidylinositol-3-phosphatase activity
P680 molecular function ... Q14878340 (phosphoprotein phosphatase activity) phosphoprotein phosphatase activity
P680 molecular function ... Q14878341 (protein tyrosine phosphatase activity) protein tyrosine phosphatase activity
P680 molecular function ... Q14878342 (protein tyrosine/serine/threonine phosphatase activity) protein tyrosine/serine/threonine phosphatase activity
P680 molecular function ... Q14878343 (anaphase-promoting complex binding) anaphase-promoting complex binding
P680 molecular function ... Q14878344 (phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity) phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
P680 molecular function ... Q14878346 (phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity) phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
P680 molecular function ... Q14353168 (hydrolase activity) hydrolase activity
P680 molecular function ... Q14860298 (PDZ domain binding) PDZ domain binding
P680 molecular function ... Q14358833 (lipid binding) lipid binding
P680 molecular function ... Q14599289 (enzyme binding) enzyme binding
P680 molecular function ... Q14878345 (inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity) inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
P680 molecular function ... Q14878379 (platelet-derived growth factor receptor binding) platelet-derived growth factor receptor binding
P680 molecular function ... Q14762994 (identical protein binding) identical protein binding
P361 part of ... Q24741290 (Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN) Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN
P361 part of ... Q24743680 (Protein-tyrosine phosphatase-like) Protein-tyrosine phosphatase-like
P361 part of ... Q24768328 (Dual specificity phosphatase) Dual specificity phosphatase
P361 part of ... Q83130631 (Tensin-type phosphatase domain, protein family) Tensin-type phosphatase domain, protein family
P361 part of ... Q83137584 (Protein-tyrosine phosphatase, catalytic domain, protein family) Protein-tyrosine phosphatase, catalytic domain, protein family
P361 part of ... Q83165948 (Tensin phosphatase, C2 domain, protein family) Tensin phosphatase, C2 domain, protein family
P361 part of ... Q95353012 (Protein-tyrosine phosphatase, active site, protein family) Protein-tyrosine phosphatase, active site, protein family

External Ids
P705Ensembl protein IDENSP00000495622
P705Ensembl protein IDENSP00000483066
P705Ensembl protein IDENSP00000361021
P705Ensembl protein IDENSP00000494918
P646Freebase ID/m/096cc3
P6366Microsoft Academic ID (discontinued)2777609662
P10283OpenAlex IDC2777609662
P638PDB structure ID5BZX
P638PDB structure ID2KYL
P638PDB structure ID4O1V
P638PDB structure ID1D5R
P638PDB structure ID5BUG
P638PDB structure ID5BZZ
P637RefSeq protein IDNP_000305
P637RefSeq protein IDNP_001291646
P637RefSeq protein IDNP_001291647
P352UniProt protein IDP60484

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