Steroid metabolism in the mammalian brain: 5alpha-reduction and aromatization

scientific article published on January 1997

Steroid metabolism in the mammalian brain: 5alpha-reduction and aromatization is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/S0361-9230(97)00216-5
P8608Fatcat IDrelease_mmdaob3cgffh7b64dnvd2ej4wm
P698PubMed publication ID9370201
P5875ResearchGate publication ID13860107

P50authorPaola Negri-CesiQ39185702
P2093author name stringCelotti F
Poletti A
P2860cites workIsolation of a full-length cDNA insert encoding human aromatase system cytochrome P-450 and its expression in nonsteroidogenic cellsQ24293133
Deletion of steroid 5 alpha-reductase 2 gene in male pseudohermaphroditismQ24311401
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Structure of 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase complexed with NADP+Q27733250
Estrogen resistance caused by a mutation in the estrogen-receptor gene in a manQ28248505
Progesterone 5-alpha-reduction in neuronal and in different types of glial cell cultures: type 1 and 2 astrocytes and oligodendrocytesQ28254828
Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning of multiple cDNAs encoding structurally related proteins in humansQ28294603
Molecular cloning and expression of rat liver 3 alpha-hydroxysteroid dehydrogenaseQ28333537
Identification of type 1 5alpha-reductase in myelin membranes of male and female rat brainQ28569291
Structure of human type II 5 alpha-reductase geneQ29038931
The isolation of transcription factors from lambda gt11 cDNA expression libraries: human steroid 5 alpha-reductase 1 has sequence-specific DNA binding activityQ31039155
Molecular cloning of rat liver 3α-hydroxysteroid dehydrogenase and identification of structurally related proteins from rat lung and kidneyQ34118473
Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogensQ34368450
Steroid hormone metabolites are barbiturate-like modulators of the GABA receptorQ34384840
Differential distribution of the 5-alpha-reductase in the central nervous system of the rat and the mouse: are the white matter structures of the brain target tissue for testosterone action?Q36483581
Cloning, expression and functional characterization of type 1 and type 2 steroid 5 alpha-reductases from Cynomolgus monkey: comparisons with human and rat isoenzymesQ36702228
Brain 5alpha-reductase: cellular, enzymatic, and molecular perspectives and implications for biological functionQ84900530
Novel exon 1 of the aromatase gene specific for aromatase transcripts in human brainQ36743222
Expression and distribution of cortical type aromatase mRNA variant in the adult rat brainQ36870626
Adrenal steroid influences on the survival of hippocampal neuronsQ38017525
Pre- and postnatal ontogeny of aromatase cytochrome P450 messenger ribonucleic acid expression in the male rat brain studied by in situ hybridizationQ38303791
Sexual differentiation of the central nervous systemQ40099802
Steroid 5 alpha-reductase: two genes/two enzymesQ40643006
Mammalian 3 alpha-hydroxysteroid dehydrogenasesQ40928657
Metabolism of steroids in the brain: a new insight into the role of 5alpha-reductase and aromatase in brain differentiation and functionsQ41212680
Metabolism and binding of androgens in the spinal cord of the rat.Q41448461
Timing and duration of dihydrotestosterone treatment affect the development of motoneuron number and morphology in a sexually dimorphic rat spinal nucleusQ41839154
Immunocytochemical distribution of aromatase cytochrome P450 in the rat brain using peptide-generated polyclonal antibodiesQ42474194
Characterization of rat 5alpha-reductases type 1 and type 2 expressed in Saccharomyces cerevisiaeQ42981338
Role of monoamines in the male differentiation of the brain induced by androgen aromatizationQ43310649
Kinetic properties of the 5 alpha-reductase of testosterone in the purified myelin, in the subcortical white matter and in the cerebral cortex of the male rat brainQ44887566
Neuronal and non-neuronal aromatase in primary cultures of developing zebra finch telencephalon.Q46027461
Androgen regulates synaptic input to motoneurons of the adult rat spinal cord.Q46234542
Pituitary and brain 5alpha-reductase messenger RNA levels in control, castrated, and dihydrotestosterone-treated ratsQ47818246
Analysis of the expression and the first exon of aromatase mRNA in monkey brainQ48070277
Distribution and ontogeny of 3 alpha-hydroxysteroid dehydrogenase in the rat brainQ48092499
Cell type- and region-specific expression of aromatase mRNA in cultured brain cellsQ48097129
Brain aromatization and its associated structuresQ48151139
Effects of neonatal intracerebral implantation of sex steroids on sexual behaviour, social play behaviour and gonadotrophin secretionQ48174977
Aromatase activity in cultured brain cells: difference between neurons and gliaQ48432682
Postnatal administration of dihydrotestosterone to the male rat abolishes sexual dimorphism in the accessory olfactory bulb: a volumetric studyQ48454126
Differentiation of the sexually dimorphic nucleus in the preoptic area of the rat brain is inhibited by postnatal treatment with an estrogen antagonistQ48687111
Expression of androgen-activating enzymes in cultured cells of developing rat brain.Q48793377
5 alpha-reductase activity in isolated and cultured neuronal and glial cells of the rat.Q48969032
Immunocytochemical localization of aromatase in the brainQ49016806
5 alpha-reduced androgens play a key role in murine parturition.Q51021236
Aromatase activity in the rat brain: hormonal regulation and sex differences.Q51057441
Women with steroid 5 alpha-reductase 2 deficiency have normal concentrations of plasma 5 alpha-dihydroprogesterone during the luteal phaseQ57632913
Oestradiol synergizes with 5 alpha-dihydrotestosterone or 3 alpha- but not 3 beta-androstanediol in inducing sexual behaviour in castrated ratsQ68023576
Ontogenetic development of the 5 alpha-reductase in the rat brain: cerebral cortex, hypothalamus, purified myelin and isolated oligodendrocytesQ68029338
Testosterone metabolism in brain cells and membranesQ68068876
Testosterone 5 alpha-reductase activity in the rat brain is highly concentrated in white matter structures and in purified myelin sheaths of axonsQ68472642
Testosterone metabolism in peripheral nerves: presence of the 5 alpha-reductase-3 alpha-hydroxysteroid-dehydrogenase enzymatic system in the sciatic nerve of adult and aged ratsQ68718386
Androgen action in fetal mouse spinal cord cultures: metabolic and morphologic aspectsQ68984748
Administration of testosterone attenuates neuronal loss following axotomy in the brain-stem motor nuclei of female ratsQ69386582
5 alpha-reductase, aromatase, and androgen receptor levels in the monkey brain during fetal developmentQ69939126
Testosterone 5 alpha-reductase in spinal cord of Xenopus laevisQ70274365
3 alpha-Hydroxysteroid oxidoreductase in rat brainQ70927270
Functional ovarian and placental isoforms of porcine aromataseQ71172496
Immunohistochemical presence of 5 alpha-reductase rat type 1-containing cells in the rat brainQ71546031
Immunocytochemical localization of human 5 alpha-reductase 2 with polyclonal antibodies in androgen target and non-target human tissuesQ72363502
Immunocytochemical localization of 5 alpha-reductase in rat brainQ72406228
Immunocytochemical localization of aromatase-containing neurons in the rat brain during pre- and postnatal developmentQ72790551
P433issue4
P304page(s)365-375
P577publication date1997-01-01
P1433published inBrain Research BulletinQ4955784
P1476titleSteroid metabolism in the mammalian brain: 5alpha-reduction and aromatization
P478volume44

Reverse relations

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