The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts.

scientific article published on May 1999

The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1083/JCB.145.3.527
P932PMC publication ID2185088
P698PubMed publication ID10225954

P50authorColin DunstanQ43109492
P2093author name stringH Hsu
M Kelley
S Kaufman
W J Boyle
S Hu
Y Qian
T L Burgess
C Capparelli
D L Lacey
G Van
B D Ring
P2860cites workOsteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activationQ24311588
Osteoprotegerin: a novel secreted protein involved in the regulation of bone densityQ24313918
TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cellsQ24315251
Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesisQ24324701
A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell functionQ24336057
osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcificationQ24603266
Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligandQ24653311
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKLQ24682139
Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinaseQ28278061
The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptorQ28285539
RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesisQ28293009
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesisQ28589430
Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in miceQ29547898
Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitroQ34459310
Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in miceQ35607627
Organization of osteoclast microfilaments during the attachment to bone surface in vitro.Q35938974
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Osteopetrosis in Src-deficient mice is due to an autonomous defect of osteoclasts.Q36301037
TRANCE is necessary and sufficient for osteoblast-mediated activation of bone resorption in osteoclasts.Q36404187
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Clear zone in osteoclast function: role of podosomes in regulation of bone-resorbing activityQ37202816
Osteopontin stimulates gelsolin-associated phosphoinositide levels and phosphatidylinositol triphosphate-hydroxyl kinaseQ37380833
Differentiation-inducing factor purified from conditioned medium of mitogen-treated spleen cell cultures stimulates bone resorptionQ37394770
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Macrophage colony-stimulating factor stimulates survival and chemotactic behavior in isolated osteoclastsQ41773356
Osteoclasts express high levels of pp60c-src in association with intracellular membranesQ41774224
Control of cytosolic free calcium in rat and chicken osteoclasts. The role of extracellular calcium and calcitoninQ42493447
Stimulation of bone resorption and osteoclast clear zone formation by low pH: a time-course studyQ42510053
Osteoclasts express high levels of p60c-src, preferentially on ruffled border membranesQ44362843
'Calcium-activated' intracellular calcium elevation: a novel mechanism of osteoclast regulation.Q46038419
Wortmannin, a specific inhibitor of phosphatidylinositol-3 kinase, blocks osteoclastic bone resorption.Q52511692
Osteoclast recruiting activity in bone matrix.Q54203071
Kinetics of the osteoclast cytoskeleton during the resorption cycle in vitro.Q54258542
Effect of substrate composition on bone resorption by rabbit osteoclasts.Q54697571
Adhesion patterns and cytoskeleton of rabbit osteoclasts on bone slices and glassQ68027596
Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow culturesQ68274092
Effect of pH on bone resorption by rat osteoclasts in vitroQ69545244
Bone Resorbing Activity in Supernatant Fluid from Cultured Human Peripheral Blood LeukocytesQ70436209
Engagement of the osteoclast integrin alpha v beta 3 by osteopontin stimulates phosphatidylinositol 3-hydroxyl kinase activityQ71697953
Chemical and physical properties of the extracellular matrix are required for the actin ring formation in osteoclastsQ71908639
Wortmannin, a potent inhibitor of phosphatidylinositol 3-kinase, inhibits osteoclastic bone resorption in vitroQ72280664
A novel cytokine with osteoclastopoietic activityQ72663875
Phosphatidylinositol-3 kinase is involved in ruffled border formation in osteoclastsQ73589789
Phosphatidylinositol 3-kinase association with the osteoclast cytoskeleton, and its involvement in osteoclast attachment and spreadingQ74062887
P433issue3
P407language of work or nameEnglishQ1860
P1104number of pages12
P304page(s)527-538
P577publication date1999-05-01
P1433published inJournal of Cell BiologyQ1524550
P1476titleThe ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts
P478volume145