Methylation of CpG in a small region of the hMLH1 promoter invariably correlates with the absence of gene expression.

scientific article published on May 1999

Methylation of CpG in a small region of the hMLH1 promoter invariably correlates with the absence of gene expression. is …
instance of (P31):
scholarly articleQ13442814

External links are
P698PubMed publication ID10232580

P2093author name stringG Deng
Y S Kim
A Chen
J Hong
H S Chae
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)2029-2033
P577publication date1999-05-01
P1433published inCancer ResearchQ326097
P1476titleMethylation of CpG in a small region of the hMLH1 promoter invariably correlates with the absence of gene expression
P478volume59

Reverse relations

cites work (P2860)
Q24792846A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines
Q33317627A novel method to quantify local CpG methylation density by regional methylation elongation assay on microarray
Q35013990A review on the molecular diagnostics of Lynch syndrome: a central role for the pathology laboratory
Q35566861A study of molecular signals deregulating mismatch repair genes in prostate cancer compared to benign prostatic hyperplasia
Q33518543Activin signaling in microsatellite stable colon cancers is disrupted by a combination of genetic and epigenetic mechanisms.
Q28298882Alterations of copy number of methylation pattern in mismatch repair genes by methylation specific-multiplex ligation-dependent probe amplification in cases of colon cancer
Q45805261Analysis of mismatch repair gene mutations in Turkish HNPCC patients.
Q51449182Association between methylation in mismatch repair genes, V600E BRAF mutation and microsatellite instability in colorectal cancer patients
Q43688934BRAF mutation in sporadic colorectal cancer and Lynch syndrome.
Q41056167BRAF mutation-specific promoter methylation of FOX genes in colorectal cancer
Q43226742Cancer epigenetics: new therapies and new challenges.
Q55314343Clinical impact of endometrial cancer stratified by genetic mutational profiles, POLE mutation, and microsatellite instability.
Q36463826Clinicopathologic Risk Factor Distributions for MLH1 Promoter Region Methylation in CIMP-Positive Tumors.
Q54551065Clinicopathologic and molecular features of sporadic microsatellite- and chromosomal-stable colorectal cancers.
Q89723158Clinicopathological significance of deficient DNA mismatch repair and MLH1 promoter methylation in endometrioid endometrial carcinoma
Q36081155ColoSeq provides comprehensive lynch and polyposis syndrome mutational analysis using massively parallel sequencing
Q37447203Colorectal Choriocarcinoma in a Patient with Probable Lynch Syndrome
Q33291970Colorectal carcinogenesis: road maps to cancer
Q33729779Colorectal carcinomas with microsatellite instability display a different pattern of target gene mutations according to large bowel site of origin
Q34101774Comparative features of colorectal and gastric cancers with microsatellite instability in Chinese patients
Q46100093Constitutional MLH1 methylation presenting with colonic polyposis syndrome and not Lynch syndrome
Q24645280CpG methylation plays a vital role in determining tissue- and cell-specific expression of the human cell-death-inducing DFF45-like effector A gene through the regulation of Sp1/Sp3 binding
Q35878544DNA hypermethylation appears early and shows increased frequency with dysplasia in Lynch syndrome-associated colorectal adenomas and carcinomas
Q42261678DNA methylation in promoter region as biomarkers in prostate cancer
Q33621598DNA methylation pattern changes upon long-term culture and aging of human mesenchymal stromal cells
Q30985494Demethylation by 5-aza-2'-deoxycytidine in colorectal cancer cells targets genomic DNA whilst promoter CpG island methylation persists
Q36813981Deregulation of Wnt/β-catenin signaling through genetic or epigenetic alterations in human neuroendocrine tumors
Q64109038Development of an MSI-positive colon tumor with aberrant DNA methylation in a PPAP patient
Q33892398Early onset MSI-H colon cancer with MLH1 promoter methylation, is there a genetic predisposition?
Q28303873Endometrial cancer and Lynch syndrome: clinical and pathologic considerations
Q38123671Endometrial tumour BRAF mutations and MLH1 promoter methylation as predictors of germline mismatch repair gene mutation status: a literature review
Q90197000Enhanced CRISPR-based DNA demethylation by Casilio-ME-mediated RNA-guided coupling of methylcytosine oxidation and DNA repair pathways
Q37200574Epigenetic Loss of MLH1 Expression in Normal Human Hematopoietic Stem Cell Clones is Defined by the Promoter CpG Methylation Pattern Observed by High-Throughput Methylation Specific Sequencing
Q90221699Epigenetic Modifications Compromise Mitochondrial DNA Quality Control in the Development of Diabetic Retinopathy
Q33855895Epigenetic changes (aberrant DNA methylation) in colorectal neoplasia
Q36549885Epigenetic phenotypes distinguish microsatellite-stable and -unstable colorectal cancers
Q37357503Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer
Q24812104Epigenetics of cervical cancer. An overview and therapeutic perspectives
Q36643558Expression of hMLH1 is inactivated in the gastric adenomas with enhanced microsatellite instability.
Q54542839Externalization of Saw-Tooth Architecture in Small Serrated Polyps Implies the Presence of Methylation of IGFBP7
Q34627551Fatty acid binding protein 3 (fabp3) is associated with insulin, lipids and cardiovascular phenotypes of the metabolic syndrome through epigenetic modifications in a Northern European family population
Q37103121Feasibility of screening for Lynch syndrome among patients with colorectal cancer
Q36623407Frequent loss of expression without sequence mutations of the DCC gene in primary gastric cancer
Q35810106Genetic and epigenetic modification of MLH1 accounts for a major share of microsatellite-unstable colorectal cancers
Q37122495Genetic diagnosis strategy of hereditary non-polyposis colorectal cancer
Q21563514Genomic variability within an organism exposes its cell lineage tree
Q35653610Germline promoter hypermethylation of tumor suppressor genes in gastric cancer
Q33723714Global methylation and promoter-specific methylation of the P16, SOCS-1, E-cadherin, P73 and SHP-1 genes and their expression in patients with multiple myeloma during active disease and remission
Q24292710HOXA5 regulates hMLH1 expression in breast cancer cells
Q44335624How Helpful Is Age at Colorectal Cancer Onset in Finding HNPCC?
Q36539162Hypermethylated MAL gene - a silent marker of early colon tumorigenesis
Q60928870Hypermethylation of multiple Wnt antagonist genes in gastric neoplasia: Is H pylori infection blasting fuse?
Q38282399Hypermethylation of the hMLH1 gene promoter in solitary and multiple gastric cancers with microsatellite instability
Q96133145Identification of High-Frequency Methylation Sites in RNF180 Promoter Region Affecting Expression and Their Relationship with Prognosis of Gastric Cancer
Q36906164Impact of BRAF, MLH1 on the incidence of microsatellite instability high colorectal cancer in populations based study.
Q36697095Impairment of MLH1 and CDKN2A in oncogenesis of laryngeal cancer.
Q28183803Inactivation of hMLH1 and hMSH2 by promoter methylation in primary non-small cell lung tumors and matched sputum samples
Q37298574Intra-tumor heterogeneity of MLH1 promoter methylation revealed by deep single molecule bisulfite sequencing
Q36947800Isolated Loss of PMS2 Immunohistochemical Expression is Frequently Caused by Heterogenous MLH1 Promoter Hypermethylation in Lynch Syndrome Screening for Endometrial Cancer Patients
Q34620502Loss of imprinting of the insulin-like growth factor II gene occurs by biallelic methylation in a core region of H19-associated CTCF-binding sites in colorectal cancer
Q36380153Lynch syndrome associated with two MLH1 promoter variants and allelic imbalance of MLH1 expression
Q34650716MLH1 Promoter Methylation Frequency in Colorectal Cancer Patients and Related Clinicopathological and Molecular Features
Q34512457MLH1 Region Polymorphisms Show a Significant Association with CpG Island Shore Methylation in a Large Cohort of Healthy Individuals
Q36213262MLH1 constitutional and somatic methylation in patients with MLH1 negative tumors fulfilling the revised Bethesda criteria
Q36035692MLH1 promoter hypermethylation in the analytical algorithm of Lynch syndrome: a cost-effectiveness study
Q47229202MLH1-93 G/a polymorphism is associated with MLH1 promoter methylation and protein loss in dysplastic sessile serrated adenomas with BRAFV600E mutation.
Q36695748MSH6 missense mutations are often associated with no or low cancer susceptibility
Q34225341Metastatic suppressor genes inactivated by aberrant methylation in gastric cancer
Q33947093Methylation analysis of MLH1 improves the selection of patients for genetic testing in Lynch syndrome.
Q28364163Methylation matters
Q36208014Methylation of Breast Cancer Predisposition Genes in Early-Onset Breast Cancer: Australian Breast Cancer Family Registry
Q36644067Methylation of hMLH1 promoter correlates with the gene silencing with a region-specific manner in colorectal cancer
Q40137519Methylation of the BIN1 gene promoter CpG island associated with breast and prostate cancer
Q33775531Methylation pattern of the O6-methylguanine-DNA methyltransferase gene in colon during progressive colorectal tumorigenesis.
Q34227653Microsatellite instability and ploidy status define three categories with distinctive prognostic impact in endometrioid endometrial cancer
Q33791731Microsatellite instability, MLH1 promoter methylation, and BRAF mutation analysis in sporadic colorectal cancers of different ethnic groups in Israel
Q38392332Molecular classification of gastric adenocarcinoma: translating new insights from the cancer genome atlas research network
Q34338885Multiplexed profiling of candidate genes for CpG island methylation status using a flexible PCR/LDR/Universal Array assay
Q36359174Parallel assessment of CpG methylation by two-color hybridization with oligonucleotide arrays
Q37288374Prevalence of Lynch syndrome among patients with newly diagnosed endometrial cancers
Q28534843Reassembly of nucleosomes at the MLH1 promoter initiates resilencing following decitabine exposure
Q85739124Regulation of MLH1 mRNA and protein expression by promoter methylation in primary colorectal cancer: a descriptive and prognostic cancer marker study
Q37166903Role of caspases in 5-FU and selenium-induced growth inhibition of colorectal cancer cells
Q36230771Sessile serrated adenoma shares similar genetic and epigenetic features with microsatellite unstable colon cancer in a location-dependent manner
Q30361259Silencing-specific methylation and single nucleotide polymorphism of hMLH1 promoter in gastric carcinomas.
Q30453828Simultaneous detection of CpG methylation and single nucleotide polymorphism by denaturing high performance liquid chromatography
Q34055785Spreading of Alu Methylation to the Promoter of the MLH1 Gene in Gastrointestinal Cancer
Q36530688Strategies for discovery and validation of methylated and hydroxymethylated DNA biomarkers
Q28247866The BRAF oncoprotein functions through the transcriptional repressor MAFG to mediate the CpG Island Methylator phenotype
Q36947020The MLH1 -93 G>A promoter polymorphism and genetic and epigenetic alterations in colon cancer
Q37692625The dynamic DNA methylation landscape of the mutL homolog 1 shore is altered by MLH1-93G>A polymorphism in normal tissues and colorectal cancer
Q90149797The polymorphic variant rs1800734 influences methylation acquisition and allele-specific TFAP4 binding in the MLH1 promoter leading to differential mRNA expression
Q92416866The prevalence and persistence of aberrant promoter DNA methylation in benzene-exposed Chinese workers
Q35749254The relationship between hypomethylation and CpG island methylation in colorectal neoplasia
Q37902054Therapeutic strategies to enhance the anticancer efficacy of histone deacetylase inhibitors.
Q49163294Topographic, histological and molecular study of aberrant crypt foci identified in human colon in different clinical groups
Q39354975hMLH1 promoter hypermethylation and MSI status in human endometrial carcinomas with and without metastases
Q35739695hMLH1 promoter methylation and silencing in primary endometrial cancers are associated with specific alterations in MBDs occupancy and histone modifications

Search more.