Anti-inflammatory effects of four potential anti-endotoxaemic drugs assessed in vitro using equine whole blood assays

scientific article published on 19 November 2014

Anti-inflammatory effects of four potential anti-endotoxaemic drugs assessed in vitro using equine whole blood assays is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/JVP.12182
P8608Fatcat IDrelease_u5a64c6e5rfojetywjnxq4aidy
P698PubMed publication ID25407884

P50authorSebastien H BauquierQ83147823
Simon R. BaileyQ39717298
Elizabeth M. TudorQ47800066
P2093author name stringE Tudor
J R Bauquier
P2860cites workThe immunopathology of sepsis: pathogen recognition, systemic inflammation, the compensatory anti-inflammatory response, and regulatory T cellsQ27022093
Novel HMGB1-inhibiting therapeutic agents for experimental sepsisQ33814903
Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammationQ34156078
The effect of oral metformin on insulin sensitivity in insulin-resistant poniesQ34166697
Synergistic activation of NF-{kappa}B by bacterial chemoattractant and TNF{alpha} is mediated by p38 MAPK-dependent RelA acetylationQ34251052
Metformin inhibits HMGB1 release in LPS‐treated RAW 264.7 cells and increases survival rate of endotoxaemic miceQ34672050
Beneficial effects of ethyl pyruvate through inhibiting high-mobility group box 1 expression and TLR4/NF-κB pathway after traumatic brain injury in the rat.Q35104577
Azithromycin inhibits macrophage interleukin-1β production through inhibition of activator protein-1 in lipopolysaccharide-induced murine pulmonary neutrophilia.Q39613461
Anti-inflammatory activity of azithromycin as measured by its NF-kappaB, inhibitory activityQ39744364
Azithromycin reduces tumor necrosis factor-alpha production in lipopolysaccharide-stimulated THP-1 monocytic cells by modification of stress response and p38 MAPK pathwayQ39822510
Azithromycin selectively reduces tumor necrosis factor alpha levels in cystic fibrosis airway epithelial cellsQ40185293
Ethyl pyruvate diminishes the inflammatory response to lipopolysaccharide infusion in horsesQ40275623
Metformin inhibits cytokine-induced nuclear factor kappaB activation via AMP-activated protein kinase activation in vascular endothelial cellsQ40331177
Roflumilast inhibits lipopolysaccharide-induced inflammatory mediators via suppression of nuclear factor-kappaB, p38 mitogen-activated protein kinase, and c-Jun NH2-terminal kinase activationQ40380708
Proinflammatory and anti-inflammatory cytokines as mediators in the pathogenesis of septic shockQ41662628
Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocytic cellsQ42025731
Ethyl pyruvate decreases proinflammatory gene expression in lipopolysaccharide-stimulated equine monocytesQ42745547
Metformin, an antidiabetic agent, suppresses the production of tumor necrosis factor and tissue factor by inhibiting early growth response factor-1 expression in human monocytes in vitroQ43108065
Differential inhibition of equine neutrophil function by phosphodiesterase inhibitors.Q43736166
Immunopharmacological potential of selective phosphodiesterase inhibition. I. Differential regulation of lipopolysaccharide-mediated proinflammatory cytokine (interleukin-6 and tumor necrosis factor-alpha) biosynthesis in alveolar epithelial cellsQ43863064
Pharmacokinetics of azithromycin in foals after i.v. and oral dose and disposition into phagocytes.Q43986552
Resuscitation with Ringer's ethyl pyruvate solution prolongs survival and modulates plasma cytokine and nitrite/nitrate concentrations in a rat model of lipopolysaccharide-induced shockQ44236446
In vitro and ex vivo effects of the phosphodiesterase 4 inhibitor, rolipram, on thromboxane production in equine bloodQ44384324
Effects of oral clenbuterol on the clinical and inflammatory response to endotoxaemia in the horseQ45791487
ASP3258, an orally active potent phosphodiesterase 4 inhibitor with low emetic activityQ48287601
Effects of continuous or intermittent lipopolysaccharide administration for 48 hours on the systemic inflammatory response in horsesQ48621789
P433issue3
P921main subjectwhole bloodQ7997549
P304page(s)290-296
P577publication date2014-11-19
P1433published inJournal of Veterinary Pharmacology and TherapeuticsQ15753250
P1476titleAnti-inflammatory effects of four potential anti-endotoxaemic drugs assessed in vitro using equine whole blood assays
P478volume38

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cites work (P2860)
Q92381511A Review on The Protective Effects of Metformin in Sepsis-Induced Organ Failure
Q92254014Anti-inflammatory effects of a p38 MAP kinase inhibitor, doramapimod, against bacterial cell wall toxins in equine whole blood
Q38626464Effects of polymyxin-B on TNF-α production in equine whole blood stimulated with three different bacterial toxins
Q40506281Identification and characterization of antibacterial compound(s) of cockroaches (Periplaneta americana).
Q92856263Modulation of TNF-α, IL-1Ra and IFN-γ in equine whole blood culture by glucocorticoids

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