Sensitization of pain pathways in the spinal cord: cellular mechanisms

scientific article published on February 1998

Sensitization of pain pathways in the spinal cord: cellular mechanisms is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/S0301-0082(97)00067-1
P698PubMed publication ID9481803

P2093author name stringBaranauskas G
Nistri A
P2860cites workPain mechanisms: a new theoryQ28251567
TachykininsQ28294810
Activation of c-fos in the brainQ28299818
Magnesium gates glutamate-activated channels in mouse central neuronesQ29616237
Brain peptides: what, where, and why?Q34054789
N-methyl-D-aspartate antagonist MK801 improves outcome following traumatic spinal cord injury in rats: behavioral, anatomic, and neurochemical studiesQ34164446
Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neuronesQ34255679
Evidence for a central component of post-injury pain hypersensitivityQ34265604
NF-kappa B: a crucial transcription factor for glial and neuronal cell functionQ34428983
Nonpeptide antagonists herald new era in tachykinin researchQ35333599
GABA, glutamate and substance P-like immunoreactivity release: effects of novel GABAB antagonistsQ35873679
Common patterns of plasticity contributing to nociceptive sensitization in mammals and AplysiaQ36645313
Release of substance P-like immunoreactivity from isolated spinal cord of newborn ratQ39128597
Slow excitatory transmission in rat dorsal horn: possible mediation by peptidesQ39341067
Modulation of spinal excitability: co-operation between neurokinin and excitatory amino acid neurotransmittersQ39370851
No evidence for contribution of nitric oxide to spinal reflex activity in the rat spinal cord in vitroQ39382588
Contribution of NK1 and NK2 receptor activation to high threshold afferent fibre evoked ventral root responses in the rat spinal cord in vitroQ39388380
Repetitive stimulation induced potentiation of excitatory transmission in the rat dorsal horn: an in vitro studyQ39388523
Nerve section alters the interaction between C-fibre activity and intrathecal neuropeptides on the flexor reflex in ratQ69082177
Differential release of coexisting neurotransmitters: frequency dependence of the efflux of substance P, thyrotropin releasing hormone and [3H]serotonin from tissue slices of rat ventral spinal cordQ69107027
Physiology and morphology of multireceptive neurons with C-afferent fiber inputs in the deep dorsal horn of the rat lumbar spinal cordQ69402219
Thyrotropin-releasing hormone mimics descending slow synaptic potentials in rat spinal motoneuronsQ69872462
Ia afferent excitation of motoneurones in the in vitro new-born rat spinal cord is selectively antagonized by kynurenateQ69879104
Plasticity in the spinal cord sensory map following peripheral nerve injury in ratsQ71121160
An NK1 receptor-dependent component of the slow excitation recorded intracellularly from rat motoneurons following dorsal root stimulationQ71625336
Excitability changes of somatic and viscero-somatic nociceptive reflexes in the decerebrate-spinal rabbit: role of NMDA receptorsQ71629477
Inhibition of primate spinothalamic tract neurons by spinal glycine and GABA is reduced during central sensitizationQ71686930
Afferent volley patterns and the spinal release of immunoreactive substance P in the dorsal horn of the anaesthetized spinal catQ71701215
Unmyelinated nociceptive units in two skin areas of the ratQ71760728
The rising sun shines on substance P and related peptidesQ72079699
Differential Release of Endogenous 5‐Hydroxytryptamine, Substance P., and Neurokinin A from Rat Ventral Spinal Cord in Response to Electrical StimulationQ72088376
Noxious thermal and chemical stimulation induce increases in 3H-phorbol 12,13-dibutyrate binding in spinal cord dorsal horn as well as persistent pain and hyperalgesia, which is reduced by inhibition of protein kinase CQ72240763
Brain peptides as neurotransmittersQ72614435
Long-term potentiation and long-term depression of primary afferent neurotransmission in the rat spinal cordQ72640836
Substance P reduces tail-flick latency: implications for chronic pain syndromesQ72685061
Short-term plasticity in turtle dorsal horn neurons mediated by L-type Ca2+ channelsQ72829398
The effect of 5-HT1A receptor stimulation on nociceptive dorsal horn neurones in ratsQ73031628
Role of transforming growth factor-beta in long-term synaptic facilitation in AplysiaQ73081821
Nerve growth factor contributes to the up-regulation of growth-associated protein 43 and preprotachykinin a messenger RNAs in primary sensory neurons following peripheral inflammationQ52206815
The contribution of GABAA and glycine receptors to central sensitization: disinhibition and touch-evoked allodynia in the spinal cord.Q52215885
Small-caliber afferent inputs produce a heterosynaptic facilitation of the synaptic responses evoked by primary afferent A-fibers in the neonatal rat spinal cord in vitro.Q52224626
Rate of rise of the cumulative depolarization evoked by repetitive stimulation of small-caliber afferents is a predictor of action potential windup in rat spinal neurons in vitro.Q52225324
Spinal substance p and N-methyl-d-aspartate receptors are coactivated in the induction of central sensitization of the nociceptive flexor reflexQ52229203
Peripheral nerve injury triggers central sprouting of myelinated afferentsQ52233221
The induction and maintenance of central sensitization is dependent on N -methyl-d-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity statesQ52237708
Activity-Dependent Changes in Rat Ventral Horn Neurons in vitro; Summation of Prolonged Afferent Evoked Postsynaptic Depolarizations Produce a d-2-Amino-5-Phosphonovaleric Acid Sensitive Windup.Q52242625
Subthreshold components of the cutaneous mechanoreceptive fields of dorsal horn neurons in the rat lumbar spinal cord.Q52244638
Relative effectiveness of C primary afferent fibers of different origins in evoking a prolonged facilitation of the flexor reflex in the rat.Q52261619
Substance P and TRH share a common effector pathway in rat spinal motoneurones: an in vitro electrophysiological investigationQ54242564
Substance P modulates glutamate-induced currents in acutely isolated rat spinal dorsal horn neuronesQ57828967
A thalamic nucleus specific for pain and temperature sensationQ58315038
Different types of calcium channels mediate central synaptic transmissionQ59054415
Responses of Single Dorsal Cord Cells to Peripheral Cutaneous Unmyelinated FibresQ59076387
Excitatory action of hypothalamic substance P on spinal motoneurones of newborn ratsQ59077949
Electrophysiologic Analysis of Preemptive Effects of Spinal Opioids on N-methyl-D-aspartate Receptor--mediated EventsQ60679694
Excitatory amino acid receptor-mediated neurotransmission from cutaneous afferents in rat dorsal horn in vitroQ60713127
Rapid amplification and facilitation of mechanosensory discharge in Aplysia by noxious stimulationQ60713484
Exposure of rat spinal neurones to NMDA, AMPA and kainate produces only short-term enhancements of responses to noxious and non-noxious stimuliQ60772666
Alterations in neuronal excitability and the potency of spinal mu, delta and kappa opioids after carrageenan-induced inflammationQ67465026
Tachykinns mediate changes in spinal reflexes after activation of unmyelinated muscle afferents in the ratQ67692040
Enhanced responses of spinothalamic tract neurons to excitatory amino acids accompany capsaicin-induced sensitization in the monkeyQ68071189
Differential effects of excitatory amino acid antagonists on dorsal horn nociceptive neurones in the ratQ68083253
N-methyl-D,L-aspartate-induced locomotor activity in a spinal cord-hindlimb muscles preparation of the newborn rat studied in vitroQ68953078
Release of substance P from the cat spinal cordQ69022182
Injury-induced plasticity of spinal reflex activity: NK1 neurokinin receptor activation and enhanced A- and C-fiber mediated responses in the rat spinal cord in vitroQ39402486
Nerve growth factor induces mechanical allodynia associated with novel A fibre-evoked spinal reflex activity and enhanced neurokinin-1 receptor activation in the rat.Q39417487
Metabotropic glutamate receptor activation contributes to nociceptive reflex activity in the rat spinal cord in vitroQ39431863
Aplysia CREB2 represses long-term facilitation: relief of repression converts transient facilitation into long-term functional and structural changeQ39469791
Substance P: Localization in the Central Nervous System and in Some Primary Sensory NeuronsQ40349945
Intervention with spinal NMDA, adenosine, and NO systems for pain modulation.Q40458739
Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidenceQ40485751
Neurotransmitter functions of mammalian tachykininsQ40486282
The pathophysiology of chronic pain--increased sensitivity to low threshold A beta-fibre inputs.Q40563563
The role of excitatory amino acid receptors and intracellular messengers in persistent nociception after tissue injury in ratsQ40622661
Central hyperexcitability triggered by noxious inputsQ40771187
The tail-flick and formalin tests in rodents: changes in skin temperature as a confounding factorQ40834630
Tachykinin receptors: a radioligand binding perspective.Q40853954
Nitric oxide (NO) and nociceptive processing in the spinal cordQ40887811
Mechanisms of hyperalgesia and morphine tolerance: a current view of their possible interactions.Q41002806
A novel long-latency response of locus coeruleus neurons to noxious stimuli: mediation by peripheral C-fibersQ41034590
Plasticity of cutaneous primary afferent projections to the spinal dorsal hornQ41061467
Basal and touch-evoked fos-like immunoreactivity during experimental inflammation in the rat.Q42527815
Sodium and calcium channels in bovine chromaffin cellsQ42665483
The roles of spinal adenosine receptors in the control of acute and more persistent nociceptive responses of dorsal horn neurones in the anaesthetized rat.Q42708290
The effects of cholinoceptor agonists and antagonists on C-fibre evoked responses in the substantia gelatinosa of neonatal rat spinal cord slicesQ42920713
Substance P opens cation channels and closes potassium channels in rat locus coeruleus neuronsQ43590011
Properties of a facilitating calcium current in pace-maker neurones of the snail, Helix pomatiaQ43766546
Nociceptive responses of neurons in medial thalamus and their relationship to spinothalamic pathwaysQ44111927
Experimental immunohistochemical studies on the localization and distribution of substance P in cat primary sensory neuronsQ44350659
Trigeminothalamic neurons in nucleus caudalis responsive to tactile, thermal, and nociceptive stimulation of monkey's faceQ45006593
Plasticity of the peptidergic mediation of spinal reflex facilitation after peripheral nerve section in the ratQ45083313
Long-term potentiation in an isolated peripheral nerve-spinal cord preparationQ46216675
Increased receptive field size of dorsal horn neurons following chronic spinal cord hemisections in catsQ47280380
Evidence for involvement of N-methylaspartate receptors in 'wind-up' of class 2 neurones in the dorsal horn of the rat.Q48193147
Lack of potent antinociceptive activity by substance P antagonist CP-96,345 in the rat spinal cordQ48392555
Substance P and NMDA receptor-mediated slow potentials in neonatal rat spinal cord: age-related changesQ48407646
Sensitization of high threshold receptors with unmyelinated (C) afferent fibersQ48419833
Protein kinase C reduces Mg2+ block of NMDA-receptor channels as a mechanism of modulationQ48493712
Nitric oxide acts directly in the presynaptic neuron to produce long-term potentiation in cultured hippocampal neurons.Q48830266
Excitatory and inhibitory transmission from dorsal root afferents to neonate rat motoneurons in vitroQ48839187
NMDA receptor-independent mechanisms responsible for the rate of rise of cumulative depolarization evoked by trains of dorsal root stimuli on rat spinal motoneuronesQ48864357
Amplification of spinal nociceptive transmission depends on the generation of nitric oxide in normal and carrageenan ratsQ48888407
The specific antagonistic effect of intrathecal spantide II on substance P- and C-fiber conditioning stimulation-induced facilitation of the nociceptive flexor reflex in rat.Q48899439
Neuronal responses to noxious stimulation in rat somatosensory cortexQ48965822
Responses of dorsal horn cells of M. mulatta to cutaneous and sural nerve A and C fiber stimuliQ48968795
Plasticity in spinal nociception after peripheral nerve section: reduced effectiveness of the NMDA receptor antagonist MK-801 in blocking wind-up and central sensitization of the flexor reflexQ49321904
Neuropathic pain in rats is associated with altered nitric oxide synthase activity in neural tissue.Q50615620
Modulation of plateau properties in dorsal horn neurones in a slice preparation of the turtle spinal cord.Q51547442
Modulation of regenerative membrane properties by stimulation of metabotropic glutamate receptors in rat deep dorsal horn neurons.Q51561107
Thyrotropin-releasing hormone facilitates spinal nociceptive responses by potentiating NMDA receptor-mediated transmission.Q51573369
Effects of RP 67580 on substance P-elicited responses and postsynaptic potentials of motoneurones of the rat isolated spinal cord.Q51616861
Multiple types of tachykinin receptor mediate a slow excitation of rat spinal motoneurones in vitro.Q51642820
A study of the barium-sensitive and -insensitive components of the action of thyrotropin-releasing hormone on lumbar motoneurons of the rat isolated spinal cord.Q51653711
Excitatory amino acid receptor mediation of sensory inputs to functionally identified dorsal horn neurons in cat spinal cordQ51662487
A simplified preparation for relating cellular events to behavior: mechanisms contributing to habituation, dishabituation, and sensitization of the Aplysia gill-withdrawal reflex.Q52195155
Inflammatory pain hypersensitivity mediated by phenotypic switch in myelinated primary sensory neurons.Q52198922
Reorganization of central terminals of myelinated primary afferents in the rat dorsal horn following peripheral axotomy.Q52206001
P433issue3
P304page(s)349-365
P577publication date1998-02-01
P1433published inProgress in NeurobiologyQ15716615
P1476titleSensitization of pain pathways in the spinal cord: cellular mechanisms
P478volume54

Reverse relations

cites work (P2860)
Q42906382A Role for Protein Kinase C-Dependent Upregulation of Adrenomedullin in the Development of Morphine Tolerance in Male Rats
Q28511263Altered inhibitory synaptic transmission in superficial dorsal horn neurones in spastic and oscillator mice
Q44413821Altered temporal pattern of evoked afferent activity in a rat model of vincristine-induced painful peripheral neuropathy
Q44633576Altered temporal pattern of mechanically evoked C-fiber activity in a model of diabetic neuropathy in the rat
Q45961968Application of nucleus pulposus to L5 dorsal root ganglion in rats enhances nociceptive dorsal horn neuronal windup.
Q46932657Associations between autonomic dysfunction and pain in chemotherapy-induced polyneuropathy
Q33819051Back pain: delimiting the problem in the next millennium
Q44847897Bidirectional modulation of windup by NMDA receptors in the rat spinal trigeminal nucleus
Q24684137Biology and therapy of fibromyalgia. New therapies in fibromyalgia
Q39141992Calcium signalling through L-type calcium channels: role in pathophysiology of spinal nociceptive transmission
Q46355500Cav1.2 and Cav1.3 L-type calcium channels independently control short- and long-term sensitization to pain.
Q34582951Central sensitization: a biopsychosocial explanation for chronic widespread pain in patients with fibromyalgia and chronic fatigue syndrome
Q34719473Cervical myofascial pain and headache
Q35893191Changes in the disposition of substance P in the rostral ventromedial medulla after inflammatory injury in the rat.
Q43892555Characterization of the single-channel properties of NMDA receptors in laminae I and II of the dorsal horn of neonatal rat spinal cord
Q41740218Chronic hypersensitivity for inflammatory nociceptor sensitization mediated by the epsilon isozyme of protein kinase C.
Q38126171Conserved systems and functional genomic assessment of nociception.
Q33654435Contrasting alterations to synaptic and intrinsic properties in upper-cervical superficial dorsal horn neurons following acute neck muscle inflammation.
Q36392817Decreased nociceptive sensitization in mice lacking the fragile X mental retardation protein: role of mGluR1/5 and mTOR
Q37486673Demonstration of cutaneous allodynia in association with chronic pelvic pain
Q43565356Depression of windup of spinal neurons in the neonatal rat spinal cord in vitro by an NK3 tachykinin receptor antagonist
Q34659433Descending control of pain
Q44264983Differential efficacy of intrathecal NMDA receptor antagonists on inflammatory mechanical and thermal hyperalgesia in rats
Q33400940Differential endogenous pain modulation in complex-regional pain syndrome
Q61411820Dynamic balance of metabotropic inputs causes dorsal horn neurons to switch functional states
Q33799565Dynamics of intrinsic electrophysiological properties in spinal cord neurones
Q39235930Effect of high-frequency alternating current on spinal afferent nociceptive transmission
Q35191517Effects and consequences of nerve injury on the electrical properties of sensory neurons
Q24654992Effects of neurokinin-1 receptor agonism and antagonism in the rostral ventromedial medulla of rats with acute or persistent inflammatory nociception
Q24670430Efficacy of antiepileptic isomers of valproic acid and valpromide in a rat model of neuropathic pain
Q48306894Electroacupuncture analgesia, stress responses, and variations in sensitivity in rats anesthetized with different sub-MAC anesthetics.
Q44658659Electrophysiologic characterization of the antinociceptive actions of S18616, a novel and potent alpha2-adrenoceptor agonist, after acute and persistent pain states
Q73437046Evaluation of the activity of a novel metabotropic glutamate receptor antagonist (+/-)-2-amino-2-(3-cis and trans-carboxycyclobutyl-3-(9-thioxanthyl)propionic acid) in the in vitro neonatal spinal cord and in an in vivo pain model
Q35140250Exercise and its troubles.
Q35729778Fibromyalgia: revisiting the literature.
Q44380439Glutamate and nitric oxide pathway in chronic daily headache: evidence from cerebrospinal fluid
Q44881021Glutamate and tachykinin receptors in central sensitization of withdrawal reflexes in the decerebrated rabbit.
Q33693745Group I metabotropic glutamate receptors: implications for brain diseases
Q47202347Histamine H1 Receptor Antagonists Facilitate Electroacupuncture Analgesia.
Q51080006Impaired escape performance and enhanced conditioned fear in rats following exposure to an uncontrollable stressor are mediated by glutamate and nitric oxide in the dorsal raphe nucleus.
Q44448197In vitro characterization of [3H]MethoxyPyEP, an mGluR5 selective radioligand
Q33934993Increased neuronal expression of neurokinin-1 receptor and stimulus-evoked internalization of the receptor in the rostral ventromedial medulla of the rat after peripheral inflammatory injury
Q35152165Induction of pain facilitation by sustained opioid exposure: relationship to opioid antinociceptive tolerance
Q46694990Interaction between neurotransmitter antagonists and effects of sacral neuromodulation in rats with chronically hyperactive bladder
Q45283842Intrinsic membrane properties of spinal dorsal horn neurones modulate nociceptive information processing in vivo
Q44011881L-Arginine/nitric oxide pathway in chronic tension-type headache: relation with serotonin content and secretion and glutamate content
Q34081579Loss of central inhibition: implications for behavioral hypersensitivity after contusive spinal cord injury in rats.
Q43814125Low doses of N-methyl-D-aspartate antagonists in superficial laminae of medulla oblongata facilitate wind-up of convergent neurones
Q35674815Mechanically-evoked C-fiber activity in painful alcohol and AIDS therapy neuropathy in the rat
Q43940190Metabotropic glutamate receptor 5 upregulation in A-fibers after spinal nerve injury: 2-methyl-6-(phenylethynyl)-pyridine (MPEP) reverses the induced thermal hyperalgesia.
Q39551983Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function. I. Selective blockade of mGlu5 receptors in models of acute, persistent and chronic pain.
Q39349057Modern pain neuroscience in clinical practice: applied to post-cancer, paediatric and sports-related pain
Q31841405Mu opiates inhibit long-term potentiation induction in the spinal cord slice
Q42953307Multiple Firing Patterns in Deep Dorsal Horn Neurons of the Spinal Cord: Computational Analysis of Mechanisms and Functional Implications
Q33930017NMDA Receptors and Colitis: Basic Science and Clinical Implications.
Q43016940NMDA channels together with L-type calcium currents and calcium-activated nonspecific cationic currents are sufficient to generate windup in WDR neurons
Q36877182Neurochemical and behavioral features in genetic absence epilepsy and in acutely induced absence seizures
Q28199083Neuromodulation of Na+ channels: an unexpected form of cellular plasticity
Q34430616Neuropathic pain: a possible role for the melanocortin system?
Q48453047Neurotrophin-induced preprotachykinin-A gene promoter modulation in organotypic rat spinal cord culture
Q38303334Nociception and role of immune system in pain
Q44007939Nociceptors and mediators in acute inflammatory pain
Q28343437Non-NMDA glutamate receptors modulate capsaicin induced c-fos expression within trigeminal nucleus caudalis
Q30540975Nonassociative learning as gated neural integrator and differentiator in stimulus-response pathways
Q37211782PDZ domains at excitatory synapses: potential molecular targets for persistent pain treatment
Q35015961Pain Management Doesn't have to be a Pain: Working and Communicating Effectively with Patients who have Chronic Pain
Q48935879Pain: Molecular mechanisms
Q28390235Pathophysiological tissue changes associated with repetitive movement: a review of the evidence
Q44963287Peripheral noxious stimulation induces phosphorylation of the NMDA receptor NR1 subunit at the PKC-dependent site, serine-896, in spinal cord dorsal horn neurons
Q33783641Plasticity in the enteric nervous system.
Q51379172Plateau potential-dependent windup of the response to primary afferent stimuli in rat dorsal horn neurons.
Q35539662Polymorphism of the Glutamate Transporter Protein EAAT2 and Migraine Transformation into Chronic Daily Headache
Q34418349Pregabalin for the management of fibromyalgia syndrome
Q46932848Regulation of Na(v)1.2 channels by brain-derived neurotrophic factor, TrkB, and associated Fyn kinase
Q37374503Rehabilitation of chronic whiplash: treatment of cervical dysfunctions or chronic pain syndrome?
Q47983752Role of group II and III metabotropic glutamate receptors in rhythmic patterns of the neonatal rat spinal cord in vitro
Q44625449Roles of histamine receptors in pain perception: a study using receptors gene knockout mice
Q25255569Selective up-regulation of NMDA-NR1 receptor expression in myenteric plexus after TNBS induced colitis in rats
Q36016687Self-reported comorbid pains in severe headaches or migraines in a US national sample
Q38108479Sensitization and pain
Q39420233Sleep disturbances and severe stress as glial activators: key targets for treating central sensitization in chronic pain patients?
Q42554084Spinal NMDA NR1 subunit expression following transient TNBS colitis
Q34094017Spinal dorsal horn synaptic plasticity: involvement of group I metabotropic glutamate receptors
Q45084899Spinal neurons that express NK-1 receptors modulate descending controls that project through the dorsolateral funiculus
Q38302767Structural and functional assessment of skin nerve fibres in small-fibre pathology.
Q31882054Sustained L-type calcium currents in dissociated deep dorsal horn neurons of the rat: characteristics and modulation
Q27015036TRPV1 and SP: key elements for sepsis outcome?
Q38818781The Anti-Allodynic Gabapentinoids: Myths, Paradoxes, and Acute Effects.
Q39188043The Effect of a Novel form of Extended-Release Gabapentin on Pain and Sleep in Fibromyalgia Subjects: An Open-Label Pilot Study
Q52552492The coding of noxious mechanical and thermal stimuli of deep dorsal horn neurones is attenuated in NK1 knockout mice
Q41977639The impact of morphine after a spinal cord injury
Q48284194The induction of pain: an integrative review
Q35578610The pathogenesis of muscle pain
Q38120080The role of mitochondrial dysfunctions due to oxidative and nitrosative stress in the chronic pain or chronic fatigue syndromes and fibromyalgia patients: peripheral and central mechanisms as therapeutic targets?
Q42714549Timing in the absence of supraspinal input III: regularly spaced cutaneous stimulation prevents and reverses the spinal learning deficit produced by peripheral inflammation
Q43959884Two N-methyl-D-aspartate receptors in rat dorsal root ganglia with different subunit composition and localization
Q47795998Voltage-dependent switching of sensorimotor integration by a lobster central pattern generator.
Q34965551Vulnerability of the developing brain. Neuronal mechanisms
Q91813066Windup of Nociceptive Flexion Reflex Depends on Synaptic and Intrinsic Properties of Dorsal Horn Neurons in Adult Rats
Q44274656Windup of flexion reflexes in chronic human spinal cord injury: a marker for neuronal plateau potentials?
Q44954803[Functional neuroanatomy for pain stimuli. Reception, transmission, and processing].

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