Genome-wide screen for modifiers of Na (+) /K (+) ATPase alleles identifies critical genetic loci

scientific article published on 5 December 2014

Genome-wide screen for modifiers of Na (+) /K (+) ATPase alleles identifies critical genetic loci is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1035106491
P356DOI10.1186/S13041-014-0089-3
P932PMC publication ID4302446
P698PubMed publication ID25476251
P5875ResearchGate publication ID269187261

P2093author name stringMichael J Palladino
Aaron D Talsma
Alexandra LaMonaca
Emily D Wieczorek
John F Chaves
P2860cites workDrosophila neurotrophins reveal a common mechanism for nervous system formationQ21563556
Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCPQ21666110
dDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in DrosophilaQ24530188
Vilse, a conserved Rac/Cdc42 GAP mediating Robo repulsion in tracheal cells and axonsQ24562721
De novo mutations in ATP1A3 cause alternating hemiplegia of childhoodQ24600468
Drosophila model of human inherited triosephosphate isomerase deficiency glycolytic enzymopathyQ24676326
Cloning and characterization of a potassium-dependent sodium/calcium exchanger in DrosophilaQ24684797
Toll-6 and Toll-7 function as neurotrophin receptors in the Drosophila melanogaster CNSQ27313234
Modes of metabolic compensation during mitochondrial disease using the Drosophila model of ATP6 dysfunctionQ27317174
Rapid-onset dystonia-parkinsonism: linkage to chromosome 19q13Q28141878
Alternating hemiplegia of childhood: early characteristics and evolution of a neurodevelopmental syndromeQ28236896
Temperature-sensitive paralytic mutations demonstrate that synaptic exocytosis requires SNARE complex assembly and disassemblyQ28281473
Alpha3Na+/K+-ATPase is a neuronal receptor for agrinQ28577669
The mle(napts) RNA helicase mutation in drosophila results in a splicing catastrophe of the para Na+ channel transcript in a region of RNA editing.Q52170282
A gradient of cytoplasmic Cactus degradation establishes the nuclear localization gradient of the dorsal morphogen in Drosophila.Q52199100
A Drosophila NSF mutantQ52537194
Intermediate form between alternating hemiplegia of childhood and rapid-onset dystonia-parkinsonism.Q53847409
Using FlyAtlas to identify better Drosophila melanogaster models of human diseaseQ29615721
Analysis of temperature-sensitive mutants reveals new genes involved in the courtship song of DrosophilaQ30498638
Regulation of Drosophila TRPL channels by immunophilin FKBP59.Q30701605
Molecular cloning and functional expression of the first insect FMRFamide receptorQ30846705
Characterization of the Drosophila melanogaster ribosomal proteomeQ33252898
Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexesQ33382329
A Drosophila behavioral mutant, down and out (dao), is defective in an essential regulator of Erg potassium channels.Q33777996
Glutactin, a novel Drosophila basement membrane-related glycoprotein with sequence similarity to serine esterases.Q33919372
Subunit contributions to histone methyltransferase activities of fly and worm polycomb group complexesQ33924962
Ouabain, a steroid hormone that signals with slow calcium oscillations.Q33949448
Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila.Q33964215
Na+,K+-ATPase: structure, mechanism, and regulation.Q34017236
Drosophila as a model for epilepsy: bss is a gain-of-function mutation in the para sodium channel gene that leads to seizuresQ34152362
Evidence for a separate type of migraine with aura: sporadic hemiplegic migraineQ34179270
A Sod2 null mutation confers severely reduced adult life span in DrosophilaQ34287545
Presynaptic alpha2delta-3 is required for synaptic morphogenesis independent of its Ca2+-channel functionsQ34378519
Drosophila couch potato mutants exhibit complex neurological abnormalities including epilepsy phenotypesQ34572732
The mei-P26 gene encodes a RING finger B-box coiled-coil-NHL protein that regulates seizure susceptibility in DrosophiliaQ34573468
Neuropathology in Drosophila membrane excitability mutantsQ34587578
Genetic modifiers of the Drosophila NSF mutant, comatose, include a temperature-sensitive paralytic allele of the calcium channel alpha1-subunit gene, cacophonyQ34609325
A genetic screen for suppressors and enhancers of the Drosophila PAN GU cell cycle kinase identifies cyclin B as a targetQ34613014
Temperature-sensitive paralytic mutants are enriched for those causing neurodegeneration in Drosophila.Q34615437
Protons at the gate: DEG/ENaC ion channels help us feel and rememberQ34623311
Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a shared structure.Q34711250
A Cullin1-based SCF E3 ubiquitin ligase targets the InR/PI3K/TOR pathway to regulate neuronal pruning.Q34998125
Neurophysiological defects in temperature-sensitive paralytic mutants of Drosophila melanogasterQ35024840
Molecular characterization and functional expression of the DSC1 channelQ35057907
The Na,K-ATPaseQ35233980
Na,K-ATPase: isoform structure, function, and expressionQ35233983
MicroRNA transgene overexpression complements deficiency-based modifier screens in DrosophilaQ35748253
A novel Drosophila SOD2 mutant demonstrates a role for mitochondrial ROS in neurodevelopment and diseaseQ36206004
The regulatory complex of Drosophila melanogaster 26S proteasomes. Subunit composition and localization of a deubiquitylating enzymeQ36342543
Tombola, a tesmin/TSO1-family protein, regulates transcriptional activation in the Drosophila male germline and physically interacts with always earlyQ36437286
Conversion of neurons and glia to external-cell fates in the external sensory organs of Drosophila hamlet mutants by a cousin-cousin cell-type respecificationQ37413205
Novel mutations affecting the Na, K ATPase alpha model complex neurological diseases and implicate the sodium pump in increased longevityQ37470011
A Drosophila mutant with a temperature-sensitive block in nerve conductionQ37593423
Sporadic and familial hemiplegic migraine: pathophysiological mechanisms, clinical characteristics, diagnosis, and managementQ37860502
Drosophila painless is a Ca2+-requiring channel activated by noxious heatQ39933446
Synaptic transmission reversibly conditioned by single-gene mutation in Drosophila melanogasterQ39981184
Distinct roles for N-ethylmaleimide-sensitive fusion protein (NSF) suggested by the identification of a second Drosophila NSF homolog.Q40464131
A mutation of the Drosophila sodium pump alpha subunit gene results in bang-sensitive paralysisQ41045006
The Drosophila Na,K-ATPase alpha-subunit gene: gene structure, promoter function and analysis of a cold-sensitive recessive-lethal mutationQ41116922
Molecular characterization of daughterless, a Drosophila sex determination gene with multiple roles in developmentQ41261560
Cyclic nucleotide phosphodiesterases in Drosophila melanogaster.Q41889474
Connectin: a homophilic cell adhesion molecule expressed on a subset of muscles and the motoneurons that innervate them in DrosophilaQ42020417
Metabolic disruption in Drosophila bang-sensitive seizure mutantsQ42421200
Partially reversible cortical metabolic dysfunction in familial hemiplegic migraine with prolonged auraQ43126261
Sightless has homology to transmembrane acyltransferases and is required to generate active Hedgehog proteinQ43709883
In vivo modification of Na(+),K(+)-ATPase activity in DrosophilaQ43787373
Characterization of a novel Drosophila melanogaster galectin. Expression in developing immune, neural, and muscle tissuesQ43865563
Axon pruning during Drosophila metamorphosis: evidence for local degeneration and requirement of the ubiquitin-proteasome systemQ44485246
Contribution of Drosophila DEG/ENaC genes to salt tasteQ44505350
The Drosophila easily shocked gene: a mutation in a phospholipid synthetic pathway causes seizure, neuronal failure, and paralysis.Q46028601
Seizure suppression by top1 mutations in Drosophila.Q46535283
Mutations in the K+/Cl- cotransporter gene kazachoc (kcc) increase seizure susceptibility in Drosophila.Q46619464
Mutations in a Drosophila alpha2delta voltage-gated calcium channel subunit reveal a crucial synaptic functionQ46825820
Blood-brain barrier defects associated with Rbp9 mutationQ47070293
Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein SlimbQ47070747
Drosophila exocyst components Sec5, Sec6, and Sec15 regulate DE-Cadherin trafficking from recycling endosomes to the plasma membraneQ47070861
A typical N-terminal extensions confer novel regulatory properties on GTP cyclohydrolase isoforms in Drosophila melanogasterQ47071156
Neural dysfunction and neurodegeneration in Drosophila Na+/K+ ATPase alpha subunit mutants.Q47071329
Plexin A-Semaphorin-1a Reverse Signaling Regulates Photoreceptor Axon Guidance inDrosophilaQ47071412
Cloning and characterization of a Na+-driven anion exchanger (NDAE1). A new bicarbonate transporterQ47071843
DAMB, a novel dopamine receptor expressed specifically in Drosophila mushroom bodiesQ47072027
Genetic dissection of monoamine neurotransmitter synthesis in DrosophilaQ47072222
Cloning and functional characterization of a novel dopamine receptor from Drosophila melanogaster.Q47072444
Bi-directional signaling by Semaphorin 1a during central synapse formation in DrosophilaQ47072460
Transcriptional and post-transcriptional control mechanisms coordinate the onset of spermatid differentiation with meiosis I in Drosophila.Q47072624
Rasp, a putative transmembrane acyltransferase, is required for Hedgehog signalingQ47072725
Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst componentsQ47072877
Synaptic function modulated by changes in the ratio of synaptotagmin I and IV.Q47933649
The Drosophila erg K+ channel polypeptide is encoded by the seizure locusQ48054809
A Component of Calcium-activated Potassium Channels Encoded by the Drosophila slo LocusQ48215777
Molecular analysis of the para locus, a sodium channel gene in DrosophilaQ48287063
A population-based study of familial hemiplegic migraine suggests revised diagnostic criteriaQ48599309
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P304page(s)89
P577publication date2014-12-05
P1433published inMolecular BrainQ6895938
P1476titleGenome-wide screen for modifiers of Na (+) /K (+) ATPase alleles identifies critical genetic loci
P478volume7

Reverse relations

cites work (P2860)
Q37176868Evaluation of the Nicotinic Acetylcholine Receptor-Associated Proteome at Baseline and Following Nicotine Exposure in Human and Mouse Cortex.
Q41488584Kek-6: A truncated-Trk-like receptor for Drosophila neurotrophin 2 regulates structural synaptic plasticity.