G-quadruplexes in promoters throughout the human genome

scientific article published on 14 December 2006

G-quadruplexes in promoters throughout the human genome is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/NAR/GKL1057
P932PMC publication ID1802602
P698PubMed publication ID17169996
P5875ResearchGate publication ID6630054

P50authorJulian HuppertQ691216
P2093author name stringShankar Balasubramanian
P2860cites workQuadruplex DNA: sequence, topology and structureQ22065978
Highly prevalent putative quadruplex sequence motifs in human DNAQ24529050
Prevalence of quadruplexes in the human genomeQ24529051
Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcriptionQ24535577
Genome-wide mapping of DNase hypersensitive sites using massively parallel signature sequencing (MPSS)Q24540045
Facilitation of a structural transition in the polypurine/polypyrimidine tract within the proximal promoter region of the human VEGF gene by the presence of potassium and G-quadruplex-interactive agentsQ24816211
G-quadruplex DNA structures--variations on a themeQ28201734
In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronucleiQ28204801
DNA tetraplex formation in the control region of c-mycQ28262361
Telomere end-binding proteins control the formation of G-quadruplex DNA structures in vivoQ28270626
Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its implications for meiosisQ28297567
Structure and function of telomeresQ29615759
Following G-quartet formation by UV-spectroscopyQ32012738
Extreme conformational diversity in human telomeric DNAQ33229923
Nuclease hypersensitive sites in chromatinQ34164152
Studies on the structure and dynamics of the human telomeric G quadruplex by single-molecule fluorescence resonance energy transferQ34382392
Promotion of parallel DNA quadruplexes by a yeast telomere binding protein: a circular dichroism study.Q35655409
Helix formation by guanylic acidQ36397431
An intramolecular G-quadruplex structure with mixed parallel/antiparallel G-strands formed in the human BCL-2 promoter region in solutionQ36914814
Evidence for the presence of a guanine quadruplex forming region within a polypurine tract of the hypoxia inducible factor 1alpha promoterQ38318016
The cationic porphyrin TMPyP4 down-regulates c-MYC and human telomerase reverse transcriptase expression and inhibits tumor growth in vivoQ38359848
CpG islands and genesQ40406688
Hairpin and parallel quartet structures for telomeric sequences.Q40533496
Influence of loop size on the stability of intramolecular DNA quadruplexesQ40899964
Putative DNA quadruplex formation within the human c-kit oncogeneQ41774419
A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogeneQ42108961
Gene function correlates with potential for G4 DNA formation in the human genomeQ43056206
Loop-length-dependent folding of G-quadruplexesQ45188262
Telomeric DNA oligonucleotides form novel intramolecular structures containing guanine-guanine base pairsQ46058606
Clusters of CpG dinucleotides implicated by nuclease hypersensitivity as control elements of housekeeping genesQ59057684
The chicken beta-globin gene promoter forms a novel "cinched" tetrahelical structureQ71049030
Structure and stability of human telomeric sequenceQ72136114
A novel K(+)-dependent DNA synthesis arrest site in a commonly occurring sequence motif in eukaryotesQ72724840
The dynamic character of the G-quadruplex element in the c-MYC promoter and modification by TMPyP4Q80334969
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)406-413
P577publication date2006-12-14
P1433published inNucleic Acids ResearchQ135122
P1476titleG-quadruplexes in promoters throughout the human genome
P478volume35

Reverse relations

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Q41432433Genome-wide study predicts promoter-G4 DNA motifs regulate selective functions in bacteria: radioresistance of D. radiodurans involves G4 DNA-mediated regulation
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Q35458052Guanine quadruplexes are formed by specific regions of human transposable elements
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Q35313952HIV-1 nucleocapsid protein increases strand transfer recombination by promoting dimeric G-quartet formation
Q37502062HIV-1 nucleocapsid proteins as molecular chaperones for tetramolecular antiparallel G-quadruplex formation
Q36676471Hairpins participating in folding of human telomeric sequence quadruplexes studied by standard and T-REMD simulations
Q47101370Hi-fidelity discrimination of isomiRs using G-quadruplex gatekeepers
Q35600057Hidden among the crowd: differential DNA methylation-expression correlations in cancer occur at important oncogenic pathways
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Q38288597High-resolution three-dimensional NMR structure of the KRAS proto-oncogene promoter reveals key features of a G-quadruplex involved in transcriptional regulation
Q41614461Highly Improved Electrospray Ionization-Mass Spectrometry Detection of G-Quadruplex-Folded Oligonucleotides and Their Complexes with Small Molecules
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Q47139277Hydrodynamic Models of G-Quadruplex Structures
Q37358166Identification and characterization of nucleolin as a c-myc G-quadruplex-binding protein
Q41630512Identification of G-Quadruplex Inducers Usinga Simple, Inexpensiveand Rapid High Throughput Assay, and TheirInhibition of Human Telomerase
Q54239430Identification of G-quadruplex forming sequences in three manatee papillomaviruses.
Q33846114Identification of G-quadruplex structures that possess transcriptional regulating functions in the Dele and Cdc6 CpG islands
Q92532838Identification of LARK as a novel and conserved G-quadruplex binding protein in invertebrates and vertebrates
Q41694000Identification of multiple genomic DNA sequences which form i-motif structures at neutral pH
Q47152552Impact of Repetitive Elements on the Y Chromosome Formation in Plants.
Q38302099In silico identification of novel ligands for G-quadruplex in the c-MYC promoter
Q24655904In vivo veritas: using yeast to probe the biological functions of G-quadruplexes
Q90079787In vivo visualization of the i-motif DNA secondary structure in the Bombyx mori testis
Q84947879In-cell NMR spectroscopy
Q35084925Induction of Ras by SAF-1/MAZ through a feed-forward loop promotes angiogenesis in breast cancer
Q38346238Insight into G-DNA structural polymorphism and folding from sequence and loop connectivity through free energy analysis
Q41986001Interaction of human telomeric DNA with N-methyl mesoporphyrin IX.
Q37760871Interaction of metal complexes with G-quadruplex DNA.
Q34495859Interactions of actinomycin D with human telomeric G-quadruplex DNA.
Q29300196Intramolecular DNA quadruplexes with different arrangements of short and long loops
Q37477870Intramolecular telomeric G-quadruplexes dramatically inhibit DNA synthesis by replicative and translesion polymerases, revealing their potential to lead to genetic change
Q39301317Investigation of the interactions between Pt(II) and Pd(II) derivatives of 5,10,15,20-tetrakis (N-methyl-4-pyridyl) porphyrin and G-quadruplex DNA.
Q53240545Investigation of the nanoviscosity effect of a G-quadruplex and single-strand DNA using fluorescence correlation spectroscopy.
Q36124108Isothermal folding of G-quadruplexes.
Q36532666KRAS promoter oligonucleotide with decoy activity dimerizes into a unique topology consisting of two G-quadruplex units
Q35184856Kinetic discrimination in recognition of DNA quadruplex targets by guanine-rich heteroquadruplex-forming PNA probes.
Q36777809Kinetics and mechanism of K+- and Na+-induced folding of models of human telomeric DNA into G-quadruplex structures
Q33645110Loop and backbone modifications of peptide nucleic acid improve g-quadruplex binding selectivity
Q41195188Loop flexibility in human telomeric quadruplex small-molecule complexes
Q36769518MAZ-binding G4-decoy with locked nucleic acid and twisted intercalating nucleic acid modifications suppresses KRAS in pancreatic cancer cells and delays tumor growth in mice
Q36376134Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands
Q34271763Making sense of G‐quadruplex and i‐motif functions in oncogene promoters
Q35088054Mapping the sequences of potential guanine quadruplex motifs
Q39017132Mechanisms and regulation of DNA replication initiation in eukaryotes
Q90224942Mechanisms of DNA Replication and Repair: Insights from the Study of G-Quadruplexes
Q33635614Mechanistic insight into ligand binding to G-quadruplex DNA
Q28073017Metal Cations in G-Quadruplex Folding and Stability
Q24652408Metastases suppressor NM23-H2 interaction with G-quadruplex DNA within c-MYC promoter nuclease hypersensitive element induces c-MYC expression
Q34583957Microsatellite tandem repeats are abundant in human promoters and are associated with regulatory elements
Q90459412Mitochondrial genetic variation is enriched in G-quadruplex regions that stall DNA synthesis in vitro
Q64226592Modulation of the ATM/autophagy pathway by a G-quadruplex ligand tips the balance between senescence and apoptosis in cancer cells
Q34377302Molecular and cellular functions of the FANCJ DNA helicase defective in cancer and in Fanconi anemia
Q33566519Molecular crowding creates an essential environment for the formation of stable G-quadruplexes in long double-stranded DNA
Q26997917Molecular dynamics simulations of G-DNA and perspectives on the simulation of nucleic acid structures
Q40404059Molecular dynamics simulations reveal the balance of forces governing the formation of a guanine tetrad-a common structural unit of G-quadruplex DNA.
Q52655666Molecular mechanism of G-quadruplex unwinding helicase: sequential and repetitive unfolding of G-quadruplex by Pif1 helicase.
Q33509185Molecular models for intrastrand DNA G-quadruplexes
Q38297161Multivalent LKγ-PNA oligomers bind to a human telomere DNA G-rich sequence to form quadruplexes
Q34139085Mycobacterium tuberculosis DinG is a structure-specific helicase that unwinds G4 DNA: implications for targeting G4 DNA as a novel therapeutic approach.
Q39718977Myricetin arrests human telomeric G-quadruplex structure: a new mechanistic approach as an anticancer agent.
Q34178666N-methylmesoporphyrin IX fluorescence as a reporter of strand orientation in guanine quadruplexes
Q64268919Naphthalene Diimides as Multimodal G-Quadruplex-Selective Ligands
Q42559394New insights into replication origin characteristics in metazoans
Q34473652Non-B DNA structure-induced genetic instability and evolution
Q45897870Non-B DNA structures show diverse conformations and complex transition kinetics comparable to RNA or proteins--a perspective from mechanical unfolding and refolding experiments
Q90348520Non-duplex G-Quadruplex Structures Emerge as Mediators of Epigenetic Modifications
Q38223036Noncanonical DNA secondary structures as drug targets: the prospect of the i-motif
Q41509732Not all G-quadruplexes are created equally: an investigation of the structural polymorphism of the c-Myc G-quadruplex-forming sequence and its interaction with the porphyrin TMPyP4
Q36160697Nucleolin stabilizes G-quadruplex structures folded by the LTR promoter and silences HIV-1 viral transcription.
Q43077386Odorant Sensory Input Modulates DNA Secondary Structure Formation and Heterogeneous Ribonucleoprotein Recruitment on the Tyrosine Hydroxylase and Glutamic Acid Decarboxylase 1 Promoters in the Olfactory Bulb
Q89721926On the wrong DNA track: Molecular mechanisms of repeat-mediated genome instability
Q28730507Origins and functional impact of copy number variation in the human genome
Q41840434PPG peptide nucleic acids that promote DNA guanine quadruplexes
Q91990363Parallel G-triplexes and G-hairpins as potential transitory ensembles in the folding of parallel-stranded DNA G-Quadruplexes
Q64073280Parasitic Protozoa: Unusual Roles for G-Quadruplexes in Early-Diverging Eukaryotes
Q38941956Permanganate/S1 Nuclease Footprinting Reveals Non-B DNA Structures with Regulatory Potential across a Mammalian Genome
Q45224673Photo-cross-linking probes for trapping G-quadruplex DNA.
Q57773610Phthalocyanines: a new class of G-quadruplex-ligands with many potential applications
Q42559976Position and stability are determining factors for translation repression by an RNA G-quadruplex-forming sequence within the 5' UTR of the NRAS proto-oncogene
Q34551196Possible regulatory roles of promoter g-quadruplexes in cardiac function-related genes - human TnIc as a model.
Q48052846Potential G-quadruplexes in the human long non-coding transcriptome
Q87918916Potential Roles for G-Quadruplexes in Mitochondria
Q34489700Potential non-B DNA regions in the human genome are associated with higher rates of nucleotide mutation and expression variation
Q37421083Predictable suppression of gene expression by 5'-UTR-based RNA quadruplexes
Q37206342Predicting and understanding the stability of G-quadruplexes
Q58563211Probing of G-Quadruplex Structures via Ligand-Sensitized Photochemical Reactions in U-Substituted DNA
Q47651724Probing the Binding Pathway of BRACO19 to a Parallel-Stranded Human Telomeric G-Quadruplex Using Molecular Dynamics Binding Simulation with AMBER DNA OL15 and Ligand GAFF2 Force Fields.
Q64268640Promise of G-Quadruplex Structure Binding Ligands as Epigenetic Modifiers with Anti-Cancer Effects
Q36040836Promoter G-quadruplex sequences are targets for base oxidation and strand cleavage during hypoxia-induced transcription
Q54610594Promoting the formation and stabilization of human telomeric G-quadruplex DNA, inhibition of telomerase and cytotoxicity by phenanthroline derivatives.
Q37199532Protein hnRNP A1 and its derivative Up1 unfold quadruplex DNA in the human KRAS promoter: implications for transcription
Q33491273Putative DNA G-quadruplex formation within the promoters of Plasmodium falciparum var genes
Q36978680Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells
Q42233040QGRS-H Predictor: a web server for predicting homologous quadruplex forming G-rich sequence motifs in nucleotide sequences
Q43033108QuadBase: genome-wide database of G4 DNA--occurrence and conservation in human, chimpanzee, mouse and rat promoters and 146 microbes
Q39755305Quadruplex structures of muscle gene promoter sequences enhance in vivo MyoD-dependent gene expression
Q61809661Quadruplex-forming oligonucleotide targeted to the VEGF promoter inhibits growth of non-small cell lung cancer cells
Q41892831Quadruplex-forming sequences occupy discrete regions inside plant LTR retrotransposons
Q35956042Quadruplex-single nucleotide polymorphisms (Quad-SNP) influence gene expression difference among individuals.
Q36959081Quantitative analysis and prediction of G-quadruplex forming sequences in double-stranded DNA
Q97418183R-loop induced G-quadruplex in non-template promotes transcription by successive R-loop formation
Q46389161RNA G-Quadruplexes as Key Motifs of the Transcriptome.
Q34401522RNA G-Quadruplexes in the model plant species Arabidopsis thaliana: prevalence and possible functional roles
Q64915572Raman Spectroscopy and Aptamers for a Label-Free Approach: Diagnostic and Application Tools.
Q58727613Rapid Screen of Potential i-Motif Forming Sequences in DNA Repair Gene Promoters
Q38533976Rational design of substituted diarylureas: a scaffold for binding to G-quadruplex motifs
Q28272354Re-evaluation of G-quadruplex propensity with G4Hunter
Q34313082RecQ-core of BLM unfolds telomeric G-quadruplex in the absence of ATP
Q64267793Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy
Q40056190Recognition and binding of human telomeric G-quadruplex DNA by unfolding protein 1.
Q42130554Recognition and discrimination of DNA quadruplexes by acridine-peptide conjugates
Q38956978Recognition of Local DNA Structures by p53 Protein.
Q33919766Regulation of gene expression by the BLM helicase correlates with the presence of G-quadruplex DNA motifs.
Q92349215Relationship Between G-Quadruplex Sequence Composition in Viruses and Their Hosts
Q42065104Relevance of G-quadruplex structures to pharmacogenetics.
Q36969038Replicating Large Genomes: Divide and Conquer
Q34231778Replication protein A unfolds G-quadruplex structures with varying degrees of efficiency
Q38426871Resolution of quadruplex polymorphism by size-exclusion chromatography
Q61054815Role of Alkali Metal Ions in G-Quadruplex Nucleic Acid Structure and Stability
Q47715732Rotation of Guanine Amino Groups in G-Quadruplexes: A Probe for Local Structure and Ligand Binding
Q28066419SVA retrotransposons as potential modulators of neuropeptide gene expression
Q33884294Selection for the G4 DNA motif at the 5' end of human genes
Q64269602Selectivity of Terpyridine Platinum Anticancer Drugs for G-quadruplex DNA
Q36033796Separation of Quadruplex Polymorphism in DNA Sequences by Reversed-Phase Chromatography
Q91971897Sequence Dynamics of Pre-mRNA G-Quadruplexes in Plants
Q41809692Sequence occurrence and structural uniqueness of a G-quadruplex in the human c-kit promoter
Q35217229Sequencing and G-quadruplex folding of the canine proto-oncogene KIT promoter region: might dog be used as a model for human disease?
Q48130711Serendipitous Discovery of a Guanine-rich DNA Molecule with a Highly Stable Structure in Urea.
Q38472428Seven essential questions on G-quadruplexes
Q37092887Single molecule conformational analysis of DNA G-quadruplexes
Q36717884Single molecule conformational analysis of the biologically relevant DNA G-quadruplex in the promoter of the proto-oncogene c-MYC.
Q33986998Single molecule force spectroscopy on G-quadruplex DNA
Q36376130Single-molecule conformational analysis of G-quadruplex formation in the promoter DNA duplex of the proto-oncogene c-kit.
Q52630066Single-molecule study of G-quadruplex disruption using dynamic force spectroscopy.
Q58728327Site-specific amino acid substitution in dodecameric peptides determines the stability and unfolding of c-MYC quadruplex promoting apoptosis in cancer cells
Q35805318Small Molecule Microarrays Enable the Identification of a Selective, Quadruplex-Binding Inhibitor of MYC Expression
Q89644393Small-molecule G-quadruplex stabilizers reveal a novel pathway of autophagy regulation in neurons
Q42951468Sole and Stable RNA Duplexes of G-Rich Sequences Located in the 5′-Untranslated Region of Protooncogenes
Q58095945Soluble Siglec-14 glycan-recognition protein is generated by alternative splicing and suppresses myeloid inflammatory responses
Q58858891Solution NMR Structure of a Ligand/Hybrid-2-G-Quadruplex Complex Reveals Rearrangements that Affect Ligand Binding
Q48121568Solution NMR Structure of a Ligand/Hybrid-2-G-Quadruplex Complex Reveals Rearrangements that Affect Ligand Binding.
Q27662546Solution structures of all parallel-stranded monomeric and dimeric G-quadruplex scaffolds of the human c-kit2 promoter
Q27678724Solution-state structure of an intramolecular G-quadruplex with propeller, diagonal and edgewise loops
Q46384438Spectroscopic and biological studies of phenanthroline compounds: selective recognition of gene-promoter G-quadruplex DNAs preferred over duplex DNA.
Q36909305Stability and kinetics of G-quadruplex structures
Q37477590Stabilization of G-quadruplex in the BCL2 promoter region in double-stranded DNA by invading short PNAs.
Q53509701Stabilization of human telomeric G-quadruplex and inhibition of telomerase activity by propeller-shaped trinuclear Pt(II) complexes.
Q37377116Strand invasion of DNA quadruplexes by PNA: comparison of homologous and complementary hybridization.
Q27680131Structural Studies on Dinuclear Ruthenium(II) Complexes That Bind Diastereoselectively to an Antiparallel Folded Human Telomere Sequence
Q33915919Structural insights into G-quadruplexes: towards new anticancer drugs
Q38290815Structural polymorphism within a regulatory element of the human KRAS promoter: formation of G4-DNA recognized by nuclear proteins
Q92874361Structure and Function of Multimeric G-Quadruplexes
Q27710266Structure and possible function of a G-quadruplex in the long terminal repeat of the proviral HIV-1 genome
Q38928964Structure, Properties, and Biological Relevance of the DNA and RNA G-Quadruplexes: Overview 50 Years after Their Discovery.
Q37776535Structure, location and interactions of G‐quadruplexes
Q35127680Structure-based drug design: from nucleic acid to membrane protein targets
Q55068987Structure-based virtual screening of novel natural alkaloid derivatives as potential binders of h-telo and c-myc DNA G-quadruplex conformations.
Q36978525Structures, folding patterns, and functions of intramolecular DNA G-quadruplexes found in eukaryotic promoter regions
Q51193183Study of G-quadruplexes in the STAT3 gene using electrospray ionization mass spectrometry.
Q92484019Subtle structural alterations in G-quadruplex DNA regulate site specificity of fluorescence light-up probes
Q33963896Successful computational prediction of novel imprinted genes from epigenomic features.
Q89967382Surface Dependent Dual Recognition of a G-quadruplex DNA With Neomycin-Intercalator Conjugates
Q38988080Synthesis and Evaluation of Quinazolone Derivatives as a New Class of c-KIT G-Quadruplex Binding Ligands.
Q61796666Synthesis and Telomeric G-Quadruplex-Stabilizing Ability of Macrocyclic Hexaoxazoles Bearing Three Side Chains
Q63761318Synthesis of New DNA G-Quadruplex Constructs with Anthraquinone Insertions and Their Anticoagulant Activity
Q34097355Synthesis of bis-indole carboxamides as G-quadruplex stabilizing and inducing ligands.
Q36403831Synthesis, Binding and Antiviral Properties of Potent Core-Extended Naphthalene Diimides Targeting the HIV-1 Long Terminal Repeat Promoter G-Quadruplexes
Q36933901TMPyP4 promotes cancer cell migration at low doses, but induces cell death at high doses
Q28548406TMPyP4, a Stabilizer of Nucleic Acid Secondary Structure, Is a Novel Acetylcholinesterase Inhibitor
Q42026181Targeted Detection of G-Quadruplexes in Cellular RNAs.
Q35047100Targeting C-myc G-quadruplex: dual recognition by aminosugar-bisbenzimidazoles with varying linker lengths.
Q34824479Targeting DNA G-quadruplexes with helical small molecules
Q38365328Targeting G-quadruplex structures with extrinsic fluorogenic dyes: promising fluorescence sensors
Q34174883Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?
Q34352558Targeting MYC Expression through G-Quadruplexes
Q35084061Targeting a c-MYC G-quadruplex DNA with a fragment library
Q37394332Targeting loop adenines in G-quadruplex by a selective oxirane.
Q48195145Targeting multiple effector pathways in pancreatic ductal adenocarcinoma with a G-quadruplex-binding small molecule.
Q51038636Targeting promoter G-quadruplex DNAs by indenopyrimidine-based ligands.
Q39483766Targeting the c-Kit Promoter G-quadruplexes with 6-Substituted Indenoisoquinolines
Q37982375Telomerase-independent paths to immortality in predictable cancer subtypes
Q39460276Telomere targeting with a new G4 ligand enhances radiation-induced killing of human glioblastoma cells
Q53310015Telomeres and telomerase as targeted therapies in cancer treatment
Q38802341Telomeric G-quadruplex-forming DNA fragments induce TLR9-mediated and LL-37-regulated invasion in breast cancer cells in vitro.
Q37494834Telomestatin impairs glioma stem cell survival and growth through the disruption of telomeric G-quadruplex and inhibition of the proto-oncogene, c-Myb.
Q38344798Template-assembled synthetic G-quadruplex (TASQ): a useful system for investigating the interactions of ligands with constrained quadruplex topologies.
Q51826552Tetraphenylethene Derivatives with Different Numbers of Positively Charged Side Arms have Different Multimeric G-Quadruplex Recognition Specificity.
Q44386987The 3D structures of G-quadruplexes of HIV-1 integrase inhibitors: molecular dynamics simulations in aqueous solution and in the gas phase
Q58691724The Amino Acid Composition of Quadruplex Binding Proteins Reveals a Shared Motif and Predicts New Potential Quadruplex Interactors
Q34293129The C-terminus of nucleolin promotes the formation of the c-MYC G-quadruplex and inhibits c-MYC promoter activity
Q38704867The Consequences of Overlapping G-Quadruplexes and i-Motifs in the Platelet-Derived Growth Factor Receptor β Core Promoter Nuclease Hypersensitive Element Can Explain the Unexpected Effects of Mutations and Provide Opportunities for Selective Target
Q35620887The DEAH-box RNA helicase RHAU binds an intramolecular RNA G-quadruplex in TERC and associates with telomerase holoenzyme
Q91642373The DNA secondary structures at telomeres and genome instability
Q57471221The Emerging Role of DNA Damage in the Pathogenesis of the C9orf72 Repeat Expansion in Amyotrophic Lateral Sclerosis
Q88542296The Fifth Domain in the G-Quadruplex-Forming Sequence of the Human NEIL3 Promoter Locks DNA Folding in Response to Oxidative Damage
Q48362923The G-quadruplex (G4) resolvase DHX36 efficiently and specifically disrupts DNA G4s via a translocation-based helicase mechanism.
Q42173513The G-quadruplex DNA stabilizing drug pyridostatin promotes DNA damage and downregulates transcription of Brca1 in neurons.
Q28289973The G4 genome
Q92258047The Influence of Quadruplex Structure in Proximity to P53 Target Sequences on the Transactivation Potential of P53 Alpha Isoforms
Q33991095The KRAS promoter responds to Myc-associated zinc finger and poly(ADP-ribose) polymerase 1 proteins, which recognize a critical quadruplex-forming GA-element
Q35562087The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures
Q90428760The Relation Between Position and Chemical Composition of Bis-Indole Substituents Determines their Interactions with G-Quadruplex DNA
Q99408946The Structure and Function of DNA G-Quadruplexes
Q37905612The application of DNA and RNA G-quadruplexes to therapeutic medicines.
Q40330362The chromatin environment shapes DNA replication origin organization and defines origin classes
Q39037703The clustering of CpG islands may constitute an important determinant of the 3D organization of interphase chromosomes.
Q42582885The disruptive positions in human G-quadruplex motifs are less polymorphic and more conserved than their neutral counterparts
Q35486616The essential Schizosaccharomyces pombe Pfh1 DNA helicase promotes fork movement past G-quadruplex motifs to prevent DNA damage
Q37872840The evolving world of protein-G-quadruplex recognition: a medicinal chemist's perspective.
Q39067948The functions of the multi-tasking Pfh1Pif1 helicase
Q34688459The genome-wide distribution of non-B DNA motifs is shaped by operon structure and suggests the transcriptional importance of non-B DNA structures in Escherichia coli
Q34374607The guanine-quadruplex structure in the human c-myc gene's promoter is converted into B-DNA form by the human poly(ADP-ribose)polymerase-1.
Q89828444The hTERT core promoter forms three parallel G-quadruplexes
Q37455886The i-motif in the bcl-2 P1 promoter forms an unexpectedly stable structure with a unique 8:5:7 loop folding pattern
Q35967182The importance of being supercoiled: how DNA mechanics regulate dynamic processes
Q37375112The importance of negative superhelicity in inducing the formation of G-quadruplex and i-motif structures in the c-Myc promoter: implications for drug targeting and control of gene expression
Q52735441The interplay between G-quadruplex and Transcription.
Q100958405The long noncoding RNA LUCAT1 promotes colorectal cancer cell proliferation by antagonizing Nucleolin to regulate MYC expression
Q34011118The proximal promoter region of the human vascular endothelial growth factor gene has a G-quadruplex structure that can be targeted by G-quadruplex-interactive agents.
Q92095194The regulation and functions of DNA and RNA G-quadruplexes
Q38315073The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements
Q35126113The role of G-quadruplex/i-motif secondary structures as cis-acting regulatory elements
Q37631442The role of supercoiling in transcriptional control of MYC and its importance in molecular therapeutics
Q37793791The structural diversity of deoxyribozymes
Q37168915The yeast Pif1 helicase prevents genomic instability caused by G-quadruplex-forming CEB1 sequences in vivo
Q38065578The yin and yang of repair mechanisms in DNA structure-induced genetic instability
Q92203169Thermodynamically stable and genetically unstable G-quadruplexes are depleted in genomes across species
Q35488141Topoisomerase I plays a critical role in suppressing genome instability at a highly transcribed G-quadruplex-forming sequence
Q38293500Transcription-dependent nucleolar cap localization and possible nuclear function of DExH RNA helicase RHAU.
Q42326319Transcriptional control by G-quadruplexes: In vivo roles and perspectives for specific intervention
Q41653404Transcriptome guided identification of novel functions of RECQ1 helicase
Q41295157Transfecting RNA quadruplexes results in few transcriptome perturbations
Q40041919Translational repression of the disintegrin and metalloprotease ADAM10 by a stable G-quadruplex secondary structure in its 5'-untranslated region
Q38592333Transposable elements and G-quadruplexes.
Q41842359Triarylpyridines: a versatile small molecule scaffold for G-quadruplex recognition
Q42947453Trisubstituted isoalloxazines as a new class of G-quadruplex binding ligands: small molecule regulation of c-kit oncogene expression
Q64884889Two-quartet kit* G-quadruplex is formed via double-stranded pre-folded structure.
Q37880722Unraveling DNA dynamics using atomic force microscopy
Q41853653Use of competition dialysis in the discovery of G-quadruplex selective ligands.
Q48263612Using Genome Sequence to Enable the Design of Medicines and Chemical Probes.
Q41674412Using hidden Markov models to investigate G-quadruplex motifs in genomic sequences
Q36948968V-shaped dinuclear Pt(II) complexes: selective interaction with human telomeric G-quadruplex and significant inhibition towards telomerase
Q33633720Verification of specific G-quadruplex structure by using a novel cyanine dye supramolecular assembly: II. The binding characterization with specific intramolecular G-quadruplex and the recognizing mechanism
Q38735386Visualization of DNA G-quadruplexes in herpes simplex virus 1-infected cells
Q90190612Why do G-quadruplexes dimerize through the 5'-ends? Driving forces for G4 DNA dimerization examined in atomic detail
Q41462876Wild-type p53 binds to MYC promoter G-quadruplex
Q36337728Xanthine and 8-oxoguanine in G-quadruplexes: formation of a G·G·X·O tetrad
Q35735600Yeast transcription co-activator Sub1 and its human homolog PC4 preferentially bind to G-quadruplex DNA.
Q35740579Yin Yang 1 contains G-quadruplex structures in its promoter and 5'-UTR and its expression is modulated by G4 resolvase 1
Q38612729Zinc-finger transcription factors are associated with guanine quadruplex motifs in human, chimpanzee, mouse and rat promoters genome-wide.
Q44468706[Ru(bpy)2dppz-idzo]2+: a colorimetric molecular "light switch" and powerful stabilizer for G-quadruplex DNA.

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