HIV-1 Tat C-terminus is cleaved by calpain 1: implication for Tat-mediated neurotoxicity

scientific article published on 31 October 2008

HIV-1 Tat C-terminus is cleaved by calpain 1: implication for Tat-mediated neurotoxicity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BBAMCR.2008.10.010
P932PMC publication ID2704945
P698PubMed publication ID19022302
P5875ResearchGate publication ID23486335

P2093author name stringFrancesca Peruzzi
Davide Eletto
Slava Rom
Giovanni Passiatore
P2860cites workThe C Terminus of HIV-1 Tat Modulates the Extent of CD178-mediated Apoptosis of T CellsQ22248066
MCP-1 (CCL2) protects human neurons and astrocytes from NMDA or HIV-tat-induced apoptosisQ24301992
A novel integrin specificity exemplified by binding of the alpha v beta 5 integrin to the basic domain of the HIV Tat protein and vitronectinQ24651246
Probability-based protein identification by searching sequence databases using mass spectrometry dataQ27860736
HIV-1 Tat through phosphorylation of NMDA receptors potentiates glutamate excitotoxicityQ28210557
HIV tat and neurotoxicityQ28239973
The multiple functions of HIV-1 Tat: proliferation versus apoptosisQ28271014
Synergistic neurotoxicity by human immunodeficiency virus proteins Tat and gp120: protection by memantineQ28369859
Cellular uptake of the tat protein from human immunodeficiency virusQ29620627
p73 Interacts with human immunodeficiency virus type 1 Tat in astrocytic cells and prevents its acetylation on lysine 28.Q33292132
Survival and differentiation of adult neuronal progenitor cells transplanted to the adult brain.Q33730685
Multifaceted activities of the HIV-1 transactivator of transcription, Tat.Q33743566
Calpain and caspase: can you tell the difference?Q33815206
HIV-1 Tat causes apoptotic death and calcium homeostasis alterations in rat neurons.Q34095509
A protein-based therapeutic for human cytomegalovirus infectionQ35083082
Recombinant human immunodeficiency virus type 1 genomes with tat unconstrained by overlapping reading frames reveal residues in Tat important for replication in tissue culture.Q35866513
Molecular determinants for cellular uptake of Tat protein of human immunodeficiency virus type 1 in brain cells.Q35879801
Brain fodrin: substrate for calpain I, an endogenous calcium-activated proteaseQ36270723
Molecular and cellular mechanisms of neuronal cell death in HIV dementiaQ36302067
Human immunodeficiency virus type 1 protease regulation of tat activity is essential for efficient reverse transcription and replicationQ36464170
OGG1 is degraded by calpain following oxidative stress and cisplatin exposureQ37234084
Requirement for the Second Coding Exon of Tat in the Optimal Replication of Macrophage-Tropic HIV-1Q39300134
p73 modulates HIV-1 Tat transcriptional and apoptotic activities in human astrocytes.Q40360359
The adult rat hippocampus contains primordial neural stem cellsQ41139813
Neuroanatomical and functional studies of peptide precursor-processing enzymesQ41704398
Brain-derived HIV-1 tat sequences from AIDS patients with dementia show increased molecular heterogeneity.Q44325797
The human immunodeficiency virus type-1 transcription factor Tat produces elevations in intracellular Ca2+ that require function of an N-methyl-D-aspartate receptor polyamine-sensitive siteQ44673435
On the sequential determinants of calpain cleavageQ44779399
Tubulin-mediated binding of human immunodeficiency virus-1 Tat to the cytoskeleton causes proteasomal-dependent degradation of microtubule-associated protein 2 and neuronal damage.Q45417744
Involvement of calpain in melanogenesis of mouse B16 melanoma cellsQ46841039
Calpain-regulated p35/cdk5 plays a central role in dopaminergic neuron death through modulation of the transcription factor myocyte enhancer factor 2.Q46890595
Proteomic profiling of accessory structures from the mouse sperm flagellumQ46923123
Furin cleavage of the HIV-1 Tat proteinQ47627653
An in vivo replication-important function in the second coding exon of Tat is constrained against mutation despite cytotoxic T lymphocyte selection.Q47657121
HIV-1 protein Tat induces apoptosis of hippocampal neurons by a mechanism involving caspase activation, calcium overload, and oxidative stressQ48313745
Gene expression of prohormone and proprotein convertases in the rat CNS: a comparative in situ hybridization analysisQ48323925
New human and simian HIV-related retroviruses possess functional transactivator (tat) geneQ48340140
Inhibition of furin-mediated processing results in suppression of astrocytoma cell growth and invasiveness.Q48582890
p14ARF is capable of promoting HIV-1 tat degradation.Q53483321
Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-leucine and tri-leucineQ71586820
Interaction of HIV Tat and matrix metalloproteinase in HIV neuropathogenesis: a new host defense mechanismQ79810628
P433issue2
P921main subjectneurotoxicityQ3338704
P304page(s)378-387
P577publication date2008-10-31
P1433published inBiochimica et Biophysica ActaQ864239
P1476titleHIV-1 Tat C-terminus is cleaved by calpain 1: implication for Tat-mediated neurotoxicity
P478volume1793

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cites work (P2860)
Q37857282Calpain inhibitors: a survey of compounds reported in the patent and scientific literature
Q41323155Cross-inhibition of pathogenic agents and the host proteins they exploit
Q38790617Fate of microglia during HIV-1 infection: From activation to senescence?
Q33889434HIV-1 Tat inhibits EAAT-2 through AEG-1 upregulation in models of HIV-associated neurocognitive disorder
Q42229248HIV-1 protein Tat produces biphasic changes in NMDA-evoked increases in intracellular Ca2+ concentration via activation of Src kinase and nitric oxide signaling pathways
Q36407266HIV-1-Tat Protein Inhibits SC35-mediated Tau Exon 10 Inclusion through Up-regulation of DYRK1A Kinase.
Q36430096Human immunodeficiency virus type 1 (HIV-1) transactivator of transcription through its intact core and cysteine-rich domains inhibits Wnt/β-catenin signaling in astrocytes: relevance to HIV neuropathogenesis
Q34363381Modulation of the stability and activities of HIV-1 Tat by its ubiquitination and carboxyl-terminal region
Q40743714Stability of HIV-1 subtype B and C Tat is associated with variation in the carboxyl-terminal region

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