Lipoprotein cholesterol uptake mediates up-regulation of bile-acid synthesis by increasing cholesterol 7alpha-hydroxylase but not sterol 27-hydroxylase gene expression in cultured rat hepatocytes

scientific article published on July 1999

Lipoprotein cholesterol uptake mediates up-regulation of bile-acid synthesis by increasing cholesterol 7alpha-hydroxylase but not sterol 27-hydroxylase gene expression in cultured rat hepatocytes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1042/0264-6021:3410339
P932PMC publication ID1220365
P698PubMed publication ID10393091
P5875ResearchGate publication ID12906331

P2093author name stringH M Princen
W H Mager
J Twisk
M F Hoekman
L van der Fits
S M Post
E C de Wit
P2860cites workPotential bile acid precursors in plasma--possible indicators of biosynthetic pathways to cholic and chenodeoxycholic acids in manQ68562278
Substrate stimulation of 7 alpha-hydroxylase, an enzyme located in the cholesterol-poor endoplasmic reticulumQ68768242
Hepatic metabolism and secretion of a cholesterol-enriched lipoprotein fractionQ68995280
Regulation of bile acid synthesis in cultured rat hepatocytes: stimulation by apoE-rich high density lipoproteinsQ69226806
Differences in 27-hydroxycholesterol concentrations in plasma and liver of baboons with high and low responses to dietary cholesterol and fatQ70480992
Regulation of bile acid synthesis. Measurement of cholesterol 7 alpha-hydroxylase activity in rat liver microsomal preparations in the absence of endogenous cholesterolQ70799692
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Biochemical site of regulation of bile acid biosynthesis in the ratQ71648895
Bile acid secretion by cultured rat hepatocytes. Regulation by cholesterol availabilityQ71687841
Effects of lovastatin and dietary cholesterol on bile acid kinetics and bile lipid composition in healthy male subjectsQ72022466
Insulin suppresses bile acid synthesis in cultured rat hepatocytes by down-regulation of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase gene transcriptionQ72511343
Increased bile acid pool inhibits cholesterol 7 alpha-hydroxylase in cholesterol-fed rabbitsQ73933606
Two 7 alpha-hydroxylase enzymes in bile acid biosynthesisQ28268767
Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alphaQ28273937
Apolipoprotein E: cholesterol transport protein with expanding role in cell biologyQ28294791
Bile Acid Synthesis in Man: Metabolism of 7α-Hydroxycholesterol-14C and 26-Hydroxycholesterol-3HQ28364385
Suppression of sterol 27-hydroxylase mRNA and transcriptional activity by bile acids in cultured rat hepatocytesQ28368343
Regulation of cholesterol 7 alpha-hydroxylase in the liver. Cloning, sequencing, and regulation of cholesterol 7 alpha-hydroxylase mRNAQ28564959
Cloning and regulation of cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesisQ28568754
Cafestol, the cholesterol-raising factor in boiled coffee, suppresses bile acid synthesis by downregulation of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase in rat hepatocytesQ28578676
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Effect of Biliary Drainage on Individual Reactions in the Conversion of Cholesterol to Taurocholic Acid. Bile Acids and Steroids 180Q34054626
Cholesterol and bile acids regulate cholesterol 7 alpha-hydroxylase expression at the transcriptional level in culture and in transgenic mice.Q36651232
Identification and characterization of a putative bile acid-responsive element in cholesterol 7 alpha-hydroxylase gene promoterQ38306616
Ketoconazole blocks bile acid synthesis in hepatocyte monolayer cultures and in vivo in rat by inhibiting cholesterol 7 alpha-hydroxylaseQ40919334
Cyclosporin A blocks bile acid synthesis in cultured hepatocytes by specific inhibition of chenodeoxycholic acid synthesisQ42023326
Differential feedback regulation of cholesterol 7 alpha-hydroxylase mRNA and transcriptional activity by rat bile acids in primary monolayer cultures of rat hepatocytesQ42161320
Cellular free cholesterol in Hep G2 cells is only partially available for down-regulation of low-density-lipoprotein receptor activityQ42164591
An in vivo evaluation of the quantitative significance of several potential pathways to cholic and chenodeoxycholic acids from cholesterol in man.Q42272100
Transcriptional regulation of the gene encoding cholesterol 7 alpha-hydroxylase in the rat.Q42288372
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Bile acid synthesis by cultured rabbit hepatocytes: stimulation by three lipoprotein fractionsQ44081776
Regulation of cholesterol 7 alpha-hydroxylase mRNA and transcriptional activity by taurocholate and cholesterol in the chronic biliary diverted rat.Q44952306
Cholesterol 7 alpha-hydroxylase: evidence for transcriptional regulation by cholesterol or metabolic products of cholesterol in the rat.Q45092257
Role of newly synthesized cholesterol or its metabolites on the regulation of bile acid biosynthesis after short-term biliary diversion in the rat.Q45092339
Regulation of sterol 27-hydroxylase and an alternative pathway of bile acid biosynthesis in primary cultures of rat hepatocytesQ45096819
Transcriptional regulation of hepatic sterol 27-hydroxylase by bile acidsQ45101437
Quantitative estimations of the contribution of different bile acid pathways to total bile acid synthesis in the rat.Q45108263
On the mechanism of stimulation of cholesterol 7 alpha-hydroxylase by dietary cholesterol.Q45128967
Characterisation of rat hepatocyte monolayers for investigation of the metabolism of bile saltsQ49249399
On the saturation of the cholesterol 7 alpha-hydroxylase in human liver microsomesQ50165847
Structural Aspects of Bile Acids Involved in the Regulation of Cholesterol 7alpha-Hydroxylase and Sterol 27-HydroxylaseQ63916805
Cholesterol 7 alpha-hydroxylaseQ67010992
Effect of lymphatic drainage on 7alpha-hydroxylation of cholesterol in rat liverQ67435250
46 Reversed-phase high-performance liquid chromatography assay of cholesterol 7α-hydroxylaseQ67842858
Regulation of hepatic sterol metabolism in the rat. Parallel regulation of activity and mRNA for 7 alpha-hydroxylase but not 3-hydroxy-3-methylglutaryl-coenzyme A reductase or low density lipoprotein receptorQ68070797
The effect of inhibition of cholesterol esterification on the fate of cholesterol derived from HDL in rat hepatocyte monolayersQ68257193
P407language of work or nameEnglishQ1860
P921main subjectlipoproteinQ28350
P1104number of pages8
P304page(s)339-346
P577publication date1999-07-01
P1433published inBiochemical JournalQ864221
P1476titleLipoprotein cholesterol uptake mediates up-regulation of bile-acid synthesis by increasing cholesterol 7alpha-hydroxylase but not sterol 27-hydroxylase gene expression in cultured rat hepatocytes
P478volume341 ( Pt 2)