Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity

scientific article published on 8 February 2017

Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1083734572
P356DOI10.1038/NATURE21356
P932PMC publication ID5334176
P698PubMed publication ID28178237

P50authorVineet BafnaQ37380360
Tomoyuki KogaQ55590556
Frank B FurnariQ56528881
Doruk BeyterQ57414828
Robert J Wechsler-ReyaQ89497608
P2093author name stringBing Ren
Webster K Cavenee
Bin Li
Michael D Taylor
Geoffrey M Wahl
Paul S Mischel
Scott R Vandenberg
David A Nathanson
Harley I Kornblum
Catherine Lee
Sharmeela Kaushal
P Nagesh Rao
Viraj Deshpande
Kristen M Turner
Karen Arden
Jessica Rusert
P2860cites workInitial sequencing and analysis of the human genomeQ21045365
Cancer genome landscapesQ22242276
Fast and accurate short read alignment with Burrows-Wheeler transformQ24653853
The human genome browser at UCSCQ24672361
Different Facets of Copy Number Changes: Permanent, Transient, and AdaptiveQ26769649
Evolution of the cancer genomeQ27020991
The clonal evolution of tumor cell populationsQ28271546
Clonal evolution in cancerQ29547696
Intra-tumour heterogeneity: a looking glass for cancer?Q29620149
Amplified human MYC oncogenes localized to replicating submicroscopic circular DNA moleculesQ33585674
Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA.Q33725972
ReadDepth: a parallel R package for detecting copy number alterations from short sequencing readsQ33815928
Evolutionary dynamics of carcinogenesis and why targeted therapy does not work.Q34005286
Accumulation of driver and passenger mutations during tumor progressionQ34276850
The architecture and evolution of cancer neochromosomesQ34454339
Biological and therapeutic impact of intratumor heterogeneity in cancer evolutionQ34457994
The Emerging Hallmarks of Cancer MetabolismQ36468964
Double minute chromosomes can be produced from precursors derived from a chromosomal deletionQ36786407
Temporal and spatial evolution of somatic chromosomal alterations: a case-cohort study of Barrett's esophagusQ37524048
Inference of tumor evolution during chemotherapy by computational modeling and in situ analysis of genetic and phenotypic cellular diversityQ37592617
Pan-cancer patterns of somatic copy number alterationQ37666205
Recent progress in understanding mechanisms of mammalian DNA amplificationQ38648620
Gene amplification as double minutes or homogeneously staining regions in solid tumors: origin and structureQ39680216
Pan-cancer analysis of the extent and consequences of intratumor heterogeneity.Q40139573
Gene amplification in cultured animal cellsQ40182130
A central role for chromosome breakage in gene amplification, deletion formation, and amplicon integrationQ41696612
Extrachromosomal driver mutations in glioblastoma and low-grade gliomaQ42105308
Double minute chromosomes in glioblastoma multiforme are revealed by precise reconstruction of oncogenic ampliconsQ42691642
Mitotic segregation of viral and cellular acentric extrachromosomal molecules by chromosome tethering.Q45988398
Gene amplification and drug resistance in cultured murine cells.Q52430373
Frequency of double minute chromosomes and combined cytogenetic abnormalities and their characteristics.Q53287308
SELECTION OF CHROMOSOMAL VARIANT IN AMETHOPTERIN-RESISTANT SUBLINES OF LEUKEMIA L1210 WITH INCREASED LEVELS OF DIHYDROFOLATE REDUCTASEQ76545767
P433issue7643
P407language of work or nameEnglishQ1860
P304page(s)122-125
P577publication date2017-02-08
P1433published inNatureQ180445
P1476titleExtrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity
P478volume543

Reverse relations

cites work (P2860)
Q58714444Q58714444
Q64069332A Systematic Pan-Cancer Analysis of Genetic Heterogeneity Reveals Associations with Epigenetic Modifiers
Q57799991A call to arms: Unifying the fight against resistance
Q95643250ATAC-seq identifies thousands of extrachromosomal circular DNA in cancer and cell lines
Q91736543Altered cellular metabolism in gliomas - an emerging landscape of actionable co-dependency targets
Q98891345AmpliconReconstructor integrates NGS and optical mapping to resolve the complex structures of focal amplifications
Q42170478Amplification of the EGFR gene can be maintained and modulated by variation of EGF concentrations in in vitro models of glioblastoma multiforme.
Q47304287Biological and therapeutic implications of multisector sequencing in newly diagnosed glioblastomas
Q57108220Breast cancer treatment and its effects on aging
Q90508529CRISPR-C: circularization of genes and chromosome by CRISPR in human cells
Q89367910Cancer genomics: ECdetect hunts extrachromosomal DNA
Q64068632Celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells
Q89359080Cell-Free eccDNAs: A New Type of Nucleic Acid Component for Liquid Biopsy?
Q57482261Centromeres License the Mitotic Condensation of Yeast Chromosome Arms
Q92129424Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements
Q55217333Circular DNA elements of chromosomal origin are common in healthy human somatic tissue.
Q76137878Circular ecDNA promotes accessible chromatin and high oncogene expression
Q91892015Clinical Implications of Sub-grouping HER2 Positive Tumors by Amplicon Structure and Co-amplified Genes
Q57461758Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine
Q46143032Cooperation and cheating as innovation: insights from cellular societies.
Q49843069Cooperative p16 and p21 action protects female astrocytes from transformation
Q90596850Cross-talk between Lysine-Modifying Enzymes Controls Site-Specific DNA Amplifications
Q92270276Defining EGFR amplification status for clinical trial inclusion
Q88595570Detection and analysis of ancient segmental duplications in mammalian genomes
Q61794394Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma
Q47734896Discoveries of Extrachromosomal Circles of DNA in Normal and Tumor Cells
Q92468687Double minute chromosomes harboring MDM2 amplification in a pediatric atypical lipomatous tumor
Q90380663Double-strand breakage in the extrachromosomal double minutes triggers their aggregation in the nucleus, micronucleation, and morphological transformation
Q89848700EGFRvIII: An Oncogene with Ambiguous Role
Q102075251Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma
Q50100856Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies
Q52580362Evolution of Genome Architecture in Archaea: Spontaneous Generation of a New Chromosome in Haloferax volcanii.
Q90099858Experimental models and tools to tackle glioblastoma
Q61124706Exploring the landscape of focal amplifications in cancer using AmpliconArchitect
Q98513888Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers
Q92026183Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma
Q52727063Extrachromosomal circular DNA-based amplification and transmission of herbicide resistance in crop weed Amaranthus palmeri.
Q91725743Extrachromosomal circular DNAs: an extra piece of evidence to depict tumor heterogeneity
Q92372589Extrachromosomal oncogene amplification in tumour pathogenesis and evolution
Q60918185Finding the Right Way to Target EGFR in Glioblastomas; Lessons from Lung Adenocarcinomas
Q92970072GSVD- and tensor GSVD-uncovered patterns of DNA copy-number alterations predict adenocarcinomas survival in general and in response to platinum
Q98288898Gaps and Doubts in Search to Recognize Glioblastoma Cellular Origin and Tumor Initiating Cells
Q57048305Genetic Abnormalities, Clonal Evolution, and Cancer Stem Cells of Brain Tumors
Q57192156Genomic Copy-Number Loss Is Rescued by Self-Limiting Production of DNA Circles
Q38623761Genomic Evolution of Breast Cancer Metastasis and Relapse
Q52333995Genomic profiling of dedifferentiated liposarcoma compared to matched well-differentiated liposarcoma reveals higher genomic complexity and a common origin.
Q50061542Glioma Through the Looking GLASS: Molecular Evolution of Diffuse Gliomas and the Glioma Longitudinal AnalySiS Consortium.
Q64242792Identification of Extrachromosomal Linear microDNAs Interacted with microRNAs in the Cell Nuclei
Q64272457Identification of portal vein tumor thrombus with an independent clonal origin in hepatocellular carcinoma via multi-omics data analysis
Q47108082Impediment of Replication Forks by Long Non-coding RNA Provokes Chromosomal Rearrangements by Error-Prone Restart.
Q90740935Induction of Apoptotic Death and Cell Cycle Arrest in HeLa Cells by Extracellular Factors of Breast Cancer Cells
Q64389130Inhibiting homologous recombination decreases extrachromosomal amplification but has no effect on intrachromosomal amplification in methotrexate-resistant colon cancer cells
Q90286090Liquid Biopsy: The Unique Test for Chasing the Genetics of Solid Tumors
Q91709770Locus-patterned sequence oriented enrichment for multi-dimensional gene analysis
Q93012197Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells
Q90391294Loop-closure kinetics reveal a stable, right-handed DNA intermediate in Cre recombination
Q33836755MYC Deregulation in Primary Human Cancers.
Q49043341MYC-containing amplicons in acute myeloid leukemia: Genomic structures, evolution, and transcriptional consequences
Q52691499MYC-containing amplicons in acute myeloid leukemia: genomic structures, evolution, and transcriptional consequences.
Q88371746Mapping of genomic EGFRvIII deletions in glioblastoma: insight into rearrangement mechanisms and biomarker development
Q94559563Mechanisms Underlying Recurrent Genomic Amplification in Human Cancers
Q47315881Modulating secreted components of tumor microenvironment: A masterstroke in tumor therapeutics.
Q92257868Molecular Characteristics of Uveal Melanoma: Insights from the Cancer Genome Atlas (TCGA) Project
Q90284271NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling
Q92290181Near-Random Distribution of Chromosome-Derived Circular DNA in the Condensed Genome of Pigeons and the Larger, More Repeat-Rich Human Genome
Q54940588Non-invasive detection of human cardiomyocyte death using methylation patterns of circulating DNA.
Q94654016Novel insights into breast cancer copy number genetic heterogeneity revealed by single-cell genome sequencing
Q64387452Overlooked: Extrachromosomal DNA and Their Possible Impact on Whole Genome Sequencing
Q48194423Patient monitoring through liquid biopsies using circulating tumor DNA.
Q58797497Patterns and mechanisms of structural variations in human cancer
Q98906952Pervasive chromosomal instability and karyotype order in tumour evolution
Q46217495Rebuilding Chromosomes After Catastrophe: Emerging Mechanisms of Chromothripsis.
Q52608306Reconstructing the molecular life history of gliomas.
Q92015484Recovering rearranged cancer chromosomes from karyotype graphs
Q91924464Sensitive detection of circular DNAs at single-nucleotide resolution using guided realignment of partially aligned reads
Q60301258Single-cell copy number variant detection reveals the dynamics and diversity of adaptation
Q64069101Small extrachromosomal circular DNAs, microDNA, produce short regulatory RNAs that suppress gene expression independent of canonical promoters
Q91518791Stem cell fate in cancer growth, progression and therapy resistance
Q61799297Structural rearrangements generate cell-specific, gene-independent CRISPR-Cas9 loss of fitness effects
Q57147068Structure and evolution of double minutes in diagnosis and relapse brain tumors
Q64243646Tailored NEOadjuvant epirubicin, cyclophosphamide and Nanoparticle Albumin-Bound paclitaxel for breast cancer: The phase II NEONAB trial-Clinical outcomes and molecular determinants of response
Q88727480Targeting cancer's metabolic co-dependencies: A landscape shaped by genotype and tissue context
Q46436702Targeting epidermal growth factor receptor co-dependent signaling pathways in glioblastoma
Q88866802The impact of mitotic errors on cell proliferation and tumorigenesis
Q91341661The landscape of selection in 551 esophageal adenocarcinomas defines genomic biomarkers for the clinic
Q47750195The significance of intertumor and intratumor heterogeneity in liver cancer
Q91638771Transcription-induced formation of extrachromosomal DNA during yeast ageing
Q46650799Unravelling biology and shifting paradigms in cancer with single-cell sequencing
Q47236022Using single-cell multiple omics approaches to resolve tumor heterogeneity
Q52630979ViFi: accurate detection of viral integration and mRNA fusion reveals indiscriminate and unregulated transcription in proximal genomic regions in cervical cancer.
Q64089731When less is more: Gaining power through gene rearrangement of amplified
Q102379185ecDNA within tumors: a new mechanism that drives tumor heterogeneity and drug resistance

Search more.