| scholarly article | Q13442814 |
| P50 | author | Cristiana Stuani | Q63133919 |
| Emanuele Buratti | Q37374238 | ||
| P2093 | author name string | Francisco E Baralle | |
| Corrado Guarnaccia | |||
| Valentina Romano | |||
| Mauricio Budini | |||
| Laura De Conti | |||
| P2860 | cites work | Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping | Q24291081 |
| Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs | Q24317451 | ||
| TDP-43 regulates retinoblastoma protein phosphorylation through the repression of cyclin-dependent kinase 6 expression | Q24318430 | ||
| Stress granule assembly is mediated by prion-like aggregation of TIA-1 | Q24559953 | ||
| Structural insights into TDP-43 in nucleic-acid binding and domain interactions | Q24647225 | ||
| TDP-43 overexpression enhances exon 7 inclusion during the survival of motor neuron pre-mRNA splicing | Q24651520 | ||
| Depletion of TDP 43 overrides the need for exonic and intronic splicing enhancers in the human apoA-II gene. | Q24811044 | ||
| Delineation of the core aggregation sequences of TDP-43 C-terminal fragment | Q47990018 | ||
| Absence of heterogeneous nuclear ribonucleoproteins and survival motor neuron protein in TDP-43 positive inclusions in frontotemporal lobar degeneration | Q48213035 | ||
| TDP-43 physically interacts with amyotrophic lateral sclerosis-linked mutant CuZn superoxide dismutase | Q57652550 | ||
| hnRNP A1 selectively interacts through its Gly-rich domain with different RNA-binding proteins | Q71176264 | ||
| TDP-43 and FUS: a nuclear affair | Q84433614 | ||
| Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis | Q28131672 | ||
| Characterization and functional implications of the RNA binding properties of nuclear factor TDP-43, a novel splicing regulator of CFTR exon 9 | Q28208568 | ||
| TDP-43 binds heterogeneous nuclear ribonucleoprotein A/B through its C-terminal tail: an important region for the inhibition of cystic fibrosis transmembrane conductance regulator exon 9 splicing | Q28271899 | ||
| Regulating gene expression through RNA nuclear retention | Q28278213 | ||
| TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia | Q28294001 | ||
| Tar DNA Binding Protein-43 (TDP-43) Associates with Stress Granules: Analysis of Cultured Cells and Pathological Brain Tissue | Q28475724 | ||
| Messenger-RNA-binding proteins and the messages they carry | Q29616012 | ||
| hnRNP complexes: composition, structure, and function | Q29619428 | ||
| A novel CpG-free vertebrate insulator silences the testis-specific SP-10 gene in somatic tissues: role for TDP-43 in insulator function | Q30444718 | ||
| Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6 | Q30492839 | ||
| Antagonistic factors control the unproductive splicing of SC35 terminal intron. | Q30493457 | ||
| Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis | Q30494776 | ||
| Phosphorylation promotes neurotoxicity in a Caenorhabditis elegans model of TDP-43 proteinopathy | Q30499509 | ||
| Sporadic ALS has compartment-specific aberrant exon splicing and altered cell-matrix adhesion biology | Q33552181 | ||
| TDP-43 regulates its mRNA levels through a negative feedback loop | Q33763346 | ||
| The C-terminal TDP-43 fragments have a high aggregation propensity and harm neurons by a dominant-negative mechanism | Q33786698 | ||
| TAR DNA-binding protein 43 in neurodegenerative disease | Q33941040 | ||
| ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS. | Q34068067 | ||
| Interaction with polyglutamine aggregates reveals a Q/N-rich domain in TDP-43. | Q34074385 | ||
| Nuclear factor TDP-43 can affect selected microRNA levels | Q34112413 | ||
| Phosphorylation regulates proteasomal-mediated degradation and solubility of TAR DNA binding protein-43 C-terminal fragments | Q34137537 | ||
| Review: transactive response DNA-binding protein 43 (TDP-43): mechanisms of neurodegeneration | Q34642738 | ||
| Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43. | Q34982074 | ||
| A "two-hit" hypothesis for inclusion formation by carboxyl-terminal fragments of TDP-43 protein linked to RNA depletion and impaired microtubule-dependent transport | Q34998181 | ||
| TDP-43 is recruited to stress granules in conditions of oxidative insult. | Q35003958 | ||
| The roles of heterogeneous nuclear ribonucleoproteins in tumour development and progression | Q36353980 | ||
| A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity | Q36609145 | ||
| Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation | Q36741538 | ||
| Multiple roles of TDP-43 in gene expression, splicing regulation, and human disease. | Q36991962 | ||
| hnRNP proteins and splicing control. | Q37124820 | ||
| Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies | Q37136781 | ||
| Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity | Q37164410 | ||
| Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. | Q37171556 | ||
| TDP-43 is a culprit in human neurodegeneration, and not just an innocent bystander | Q37204062 | ||
| Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies | Q37220481 | ||
| Functional mapping of the interaction between TDP-43 and hnRNP A2 in vivo | Q37259106 | ||
| Ribonucleoprotein complexes in neurologic diseases | Q37302017 | ||
| TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity | Q37339064 | ||
| Nuclear functions of heterogeneous nuclear ribonucleoproteins A/B. | Q37355839 | ||
| Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis | Q37379471 | ||
| Amyotrophic lateral sclerosis, frontotemporal dementia and beyond: the TDP-43 diseases | Q37409270 | ||
| The molecular links between TDP-43 dysfunction and neurodegeneration | Q37593727 | ||
| The evidence for altered RNA metabolism in amyotrophic lateral sclerosis (ALS). | Q37617743 | ||
| Phosphorylated and cleaved TDP-43 in ALS, FTLD and other neurodegenerative disorders and in cellular models of TDP-43 proteinopathy | Q37681653 | ||
| Aberrant RNA processing events in neurological disorders | Q37708346 | ||
| RNA processing pathways in amyotrophic lateral sclerosis | Q37720436 | ||
| TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration | Q37733168 | ||
| Protein aggregation and defective RNA metabolism as mechanisms for motor neuron damage | Q37734506 | ||
| TDP-43: a DNA and RNA binding protein with roles in neurodegenerative diseases. | Q37769924 | ||
| The role of RNA processing in the pathogenesis of motor neuron degeneration. | Q37774045 | ||
| Pathogenic TARDBP mutations in amyotrophic lateral sclerosis and frontotemporal dementia: disease-associated pathways. | Q37810561 | ||
| Implications of the prion-related Q/N domains in TDP-43 and FUS. | Q37816817 | ||
| Regulation of gene expression by TDP-43 and FUS/TLS in frontotemporal lobar degeneration | Q37827518 | ||
| RNA-binding proteins and RNA metabolism: a new scenario in the pathogenesis of Amyotrophic lateral sclerosis | Q37853914 | ||
| TDP-43: the relationship between protein aggregation and neurodegeneration in amyotrophic lateral sclerosis and frontotemporal lobar degeneration | Q37903412 | ||
| TDP-43 and FUS/TLS: cellular functions and implications for neurodegeneration. | Q37903416 | ||
| TDP-43 functions and pathogenic mechanisms implicated in TDP-43 proteinopathies | Q37904288 | ||
| RNA-binding proteins with prion-like domains in ALS and FTLD-U. | Q37918720 | ||
| Characterizing the RNA targets and position-dependent splicing regulation by TDP-43. | Q39584699 | ||
| Tumor metabolism: hnRNP proteins get in on the act | Q39699927 | ||
| Zinc induces depletion and aggregation of endogenous TDP-43. | Q39742732 | ||
| Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery. | Q39761567 | ||
| Methylene blue and dimebon inhibit aggregation of TDP-43 in cellular models. | Q39832220 | ||
| Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin | Q39838808 | ||
| Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43. | Q39839659 | ||
| Prion-like disorders: blurring the divide between transmissibility and infectivity | Q39863503 | ||
| Structural determinants of the cellular localization and shuttling of TDP-43. | Q39924105 | ||
| Induction of amyloid fibrils by the C-terminal fragments of TDP-43 in amyotrophic lateral sclerosis | Q43200632 | ||
| Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS). | Q46226347 | ||
| Human, Drosophila, and C.elegans TDP43: nucleic acid binding properties and splicing regulatory function | Q46434717 | ||
| Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behavior | Q47071494 | ||
| P433 | issue | 10 | |
| P407 | language of work or name | English | Q1860 |
| P1104 | number of pages | 14 | |
| P304 | page(s) | 7512-7525 | |
| P577 | publication date | 2012-01-10 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Cellular model of TAR DNA-binding protein 43 (TDP-43) aggregation based on its C-terminal Gln/Asn-rich region | |
| P478 | volume | 287 |
| Q37036144 | A novel Drosophila model of TDP-43 proteinopathies: N-terminal sequences combined with the Q/N domain induce protein functional loss and locomotion defects |
| Q35886826 | ALS-Causing Mutations Significantly Perturb the Self-Assembly and Interaction with Nucleic Acid of the Intrinsically Disordered Prion-Like Domain of TDP-43. |
| Q36873601 | Aberrant assembly of RNA recognition motif 1 links to pathogenic conversion of TAR DNA-binding protein of 43 kDa (TDP-43) |
| Q42367501 | An Amyloid-Like Pathological Conformation of TDP-43 Is Stabilized by Hypercooperative Hydrogen Bonds |
| Q50857769 | Analysis of hnRNPA1, A2/B1, and A3 genes in patients with amyotrophic lateral sclerosis. |
| Q57909514 | Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation |
| Q64897272 | Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2 |
| Q39370811 | Autophagy and Its Impact on Neurodegenerative Diseases: New Roles for TDP-43 and C9orf72. |
| Q90054708 | Chaperone Mediated Autophagy Degrades TDP-43 Protein and Is Affected by TDP-43 Aggregation |
| Q38883189 | Characterization and real-time imaging of the FTLD-related protein aggregation induced by amyloidogenic peptides |
| Q36065980 | Comparison of parallel high-throughput RNA sequencing between knockout of TDP-43 and its overexpression reveals primarily nonreciprocal and nonoverlapping gene expression changes in the central nervous system of Drosophila |
| Q39029166 | Disease-associated mutations of TDP-43 promote turnover of the protein through the proteasomal pathway |
| Q93263787 | Dysregulation of TDP-43 intracellular localization and early onset ALS are associated with a TARDBP S375G variant |
| Q37622661 | Evolutionarily conserved heterogeneous nuclear ribonucleoprotein (hnRNP) A/B proteins functionally interact with human and Drosophila TAR DNA-binding protein 43 (TDP-43). |
| Q38743399 | Exosome secretion is a key pathway for clearance of pathological TDP-43. |
| Q36414413 | Exposure to ALS-FTD-CSF generates TDP-43 aggregates in glioblastoma cells through exosomes and TNTs-like structure. |
| Q34803107 | Functional genomic screen of human stem cell differentiation reveals pathways involved in neurodevelopment and neurodegeneration. |
| Q27301865 | Interaction of RNA with a C-terminal fragment of the amyotrophic lateral sclerosis-associated TDP43 reduces cytotoxicity |
| Q38962082 | Neurodegeneration and RNA-binding proteins |
| Q39344391 | New routes in frontotemporal dementia drug discovery |
| Q34094693 | Nuclear TAR DNA-binding protein 43: A new target for amyotrophic lateral sclerosis treatment |
| Q60895956 | Nucleo-cytoplasmic transport of TDP-43 studied in real time: impaired microglia function leads to axonal spreading of TDP-43 in degenerating motor neurons |
| Q38910098 | Peptidylprolyl isomerase A governs TARDBP function and assembly in heterogeneous nuclear ribonucleoprotein complexes |
| Q44359436 | Platelet phosphorylated TDP-43: an exploratory study for a peripheral surrogate biomarker development for Alzheimer's disease |
| Q38752717 | Point mutations in the N-terminal domain of transactive response DNA-binding protein 43 kDa (TDP-43) compromise its stability, dimerization, and functions. |
| Q37380181 | Prion-like nuclear aggregation of TDP-43 during heat shock is regulated by HSP40/70 chaperones |
| Q39237605 | Prions on the run: How extracellular vesicles serve as delivery vehicles for self-templating protein aggregates |
| Q49571548 | Robustness and Vulnerability of the Autoregulatory System That Maintains Nuclear TDP-43 Levels: A Trade-off Hypothesis for ALS Pathology Based on in Silico Data. |
| Q30541190 | Selective forelimb impairment in rats expressing a pathological TDP-43 25 kDa C-terminal fragment to mimic amyotrophic lateral sclerosis |
| Q38974988 | Structural Evidence of Amyloid Fibril Formation in the Putative Aggregation Domain of TDP-43. |
| Q92535116 | Structural Insights Into TDP-43 and Effects of Post-translational Modifications |
| Q37000560 | Structural transformation of the amyloidogenic core region of TDP-43 protein initiates its aggregation and cytoplasmic inclusion |
| Q38161293 | Synaptic control of local translation: the plot thickens with new characters |
| Q52365240 | TAR DNA-binding protein 43 (TDP-43) liquid-liquid phase separation is mediated by just a few aromatic residues. |
| Q34831850 | TDP-43 N terminus encodes a novel ubiquitin-like fold and its unfolded form in equilibrium that can be shifted by binding to ssDNA |
| Q38743891 | TDP-43 aggregation mirrors TDP-43 knockdown, affecting the expression levels of a common set of proteins |
| Q36310560 | TDP-43 is intercellularly transmitted across axon terminals |
| Q41762388 | TDP-43 loss of cellular function through aggregation requires additional structural determinants beyond its C-terminal Q/N prion-like domain |
| Q34954162 | Targeting RNA binding proteins involved in neurodegeneration |
| Q38197689 | Targeting TDP-43 in neurodegenerative diseases |
| Q33692255 | The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases |
| Q58740132 | The N Termini of TAR DNA-Binding Protein 43 (TDP43) C-Terminal Fragments Influence Degradation, Aggregation Propensity, and Morphology |
| Q41094549 | The N-terminal dimerization is required for TDP-43 splicing activity |
| Q27703592 | The TDP-43 N-terminal domain structure at high resolution |
| Q30541099 | The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation |
| Q41817397 | The structural integrity of TDP-43 N-terminus is required for efficient aggregate entrapment and consequent loss of protein function |
| Q36748388 | Two mutations G335D and Q343R within the amyloidogenic core region of TDP-43 influence its aggregation and inclusion formation |
| Q35739624 | Valproate Attenuates 25-kDa C-Terminal Fragment of TDP-43-Induced Neuronal Toxicity via Suppressing Endoplasmic Reticulum Stress and Activating Autophagy |
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