Functional conservation of HIV-1 Gag: implications for rational drug design

scientific article published on 31 October 2013

Functional conservation of HIV-1 Gag: implications for rational drug design is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1006218607
P356DOI10.1186/1742-4690-10-126
P932PMC publication ID4228425
P698PubMed publication ID24176092
P5875ResearchGate publication ID258213123

P50authorAnne-Mieke VandammeQ28743834
Arnout VoetQ56850113
P2093author name stringKristof Theys
Soo-Yon Rhee
Jens Verheyen
Guangdi Li
P2860cites workThe prototype HIV-1 maturation inhibitor, bevirimat, binds to the CA-SP1 cleavage site in immature Gag particlesQ21245046
The Protein Data BankQ24515306
A single polymorphism in HIV-1 subtype C SP1 is sufficient to confer natural resistance to the maturation inhibitor bevirimatQ24606079
HIV type 1 Gag as a target for antiviral therapyQ24614498
Phase I and II study of the safety, virologic effect, and pharmacokinetics/pharmacodynamics of single-dose 3-o-(3',3'-dimethylsuccinyl)betulinic acid (bevirimat) against human immunodeficiency virus infectionQ24672964
A global approach to HIV-1 vaccine developmentQ27024614
Residues in the HIV-1 capsid assembly inhibitor binding site are essential for maintaining the assembly-competent quaternary structure of the capsid proteinQ27651983
HIV Capsid is a Tractable Target for Small Molecule Therapeutic InterventionQ27666355
Distinct Effects of Two HIV-1 Capsid Assembly Inhibitor Families That Bind the Same Site within the N-Terminal Domain of the Viral CA ProteinQ27678471
Monitoring binding of HIV-1 capsid assembly inhibitors using (19)F ligand-and (15)N protein-based NMR and X-ray crystallography: early hit validation of a benzodiazepine seriesQ27683977
Maturation inhibitors: a new therapeutic class targets the virus structureQ28256231
SeaView version 4: A multiplatform graphical user interface for sequence alignment and phylogenetic tree buildingQ29547665
Global trends in molecular epidemiology of HIV-1 during 2000-2007.Q30399382
Polymorphisms in Gag spacer peptide 1 confer varying levels of resistance to the HIV- 1 maturation inhibitor bevirimatQ33864444
Diversity considerations in HIV-1 vaccine selectionQ34136023
Identification of a small-molecule inhibitor of HIV-1 assembly that targets the phosphatidylinositol (4,5)-bisphosphate binding site of the HIV-1 matrix protein.Q34567234
Antiviral activity of α-helical stapled peptides designed from the HIV-1 capsid dimerization domainQ34989840
Mapping of positive selection sites in the HIV-1 genome in the context of RNA and protein structural constraints.Q35589028
Analysis of small molecule ligands targeting the HIV-1 matrix protein-RNA binding siteQ36508756
Discovery of a small-molecule antiviral targeting the HIV-1 matrix protein.Q36569418
The structural biology of HIV-1: mechanistic and therapeutic insightsQ36656440
Development of prophylactic vaccines against HIV-1.Q37042563
Nucleocapsid protein function in early infection processesQ37086413
Novel targets for antiretroviral therapy: clinical progress to dateQ37385347
Molecular recognition in the human immunodeficiency virus capsid and antiviral designQ38021264
Human Immunodeficiency Virus Gag and protease: partners in resistanceQ38032330
The NTD-CTD intersubunit interface plays a critical role in assembly and stabilization of the HIV-1 capsidQ39180622
Conservation among HSP60 sequences in relation to structure, function, and evolutionQ41728761
Automated subtyping of HIV-1 genetic sequences for clinical and surveillance purposes: performance evaluation of the new REGA version 3 and seven other toolsQ42263635
Novel inhibitor binding site discovery on HIV-1 capsid N-terminal domain by NMR and X-ray crystallographyQ42712492
Natural variation of HIV-1 group M integrase: implications for a new class of antiretroviral inhibitorsQ42746719
Identification of cavities on protein surface using multiple computational approaches for drug binding site prediction.Q45936749
Increased sequence diversity coverage improves detection of HIV-specific T cell responsesQ48076652
Detecting hypermutations in viral sequences with an emphasis on G --> A hypermutationQ73929271
P304page(s)126
P577publication date2013-10-31
P1433published inRetrovirologyQ15793508
P1476titleFunctional conservation of HIV-1 Gag: implications for rational drug design
P478volume10

Reverse relations

cites work (P2860)
Q35094794A new ensemble coevolution system for detecting HIV-1 protein coevolution.
Q30373040An integrated map of HIV genome-wide variation from a population perspective.
Q37253013Analysis of Major Histocompatibility Complex-Bound HIV Peptides Identified from Various Cell Types Reveals Common Nested Peptides and Novel T Cell Responses
Q27755387Approved Antiviral Drugs over the Past 50 Years
Q59351035Broad-Spectrum Antiviral Activity of an Ankyrin Repeat Protein on Viral Assembly against Chimeric NL4-3 Viruses Carrying Gag/PR Derived from Circulating Strains among Northern Thai Patients
Q91983821CA Mutation N57A Has Distinct Strain-Specific HIV-1 Capsid Uncoating and Infectivity Phenotypes
Q35795095CRF19_cpx is an Evolutionary fit HIV-1 Variant Strongly Associated With Rapid Progression to AIDS in Cuba
Q34992565Compensatory substitutions in the HIV-1 capsid reduce the fitness cost associated with resistance to a capsid-targeting small-molecule inhibitor
Q59355929Computational Design of Epitope-Enriched HIV-1 Gag Antigens with Preserved Structure and Function for Induction of Broad CD8 T Cell Responses
Q35201628Crystal structure of an antiviral ankyrin targeting the HIV-1 capsid and molecular modeling of the ankyrin-capsid complex
Q28546549Deep sequencing of protease inhibitor resistant HIV patient isolates reveals patterns of correlated mutations in Gag and protease
Q27324193Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication.
Q91938838GS-CA Compounds: First-In-Class HIV-1 Capsid Inhibitors Covering Multiple Grounds
Q36096436Genetic Diversity and Selective Pressure in Hepatitis C Virus Genotypes 1-6: Significance for Direct-Acting Antiviral Treatment and Drug Resistance
Q26746070HIV Genome-Wide Protein Associations: a Review of 30 Years of Research
Q52578356HIV Resistance Prediction to Reverse Transcriptase Inhibitors: Focus on Open Data.
Q36672006HIV-1 Capsid Inhibitors as Antiretroviral Agents
Q34304136HIV-1 Gag C-terminal amino acid substitutions emerging under selective pressure of protease inhibitors in patient populations infected with different HIV-1 subtypes
Q35761626HIV-1 Gag as an Antiviral Target: Development of Assembly and Maturation Inhibitors
Q38860284HIV-1 Resistance to the Capsid-Targeting Inhibitor PF74 Results in Altered Dependence on Host Factors Required for Virus Nuclear Entry.
Q38716274Inhibition of HIV-1 Maturation via Small-Molecule Targeting of the Amino-Terminal Domain in the Viral Capsid Protein
Q54204420Inhibitors of the HIV-1 capsid, a target of opportunity.
Q35664524Microplate-based assay for identifying small molecules that bind a specific intersubunit interface within the assembled HIV-1 capsid
Q49354408No evidence of ongoing evolution in replication competent latent HIV-1 in a patient followed up for two years
Q38370190Nucleocapsid Protein: A Desirable Target for Future Therapies Against HIV-1.
Q93058713Off-Pathway Assembly: A Broad-Spectrum Mechanism of Action for Drugs That Undermine Controlled HIV-1 Viral Capsid Formation
Q38897238Preferential Targeting of Conserved Gag Regions after Vaccination with a Heterologous DNA Prime-Modified Vaccinia Virus Ankara Boost HIV-1 Vaccine Regimen
Q93140697Reviewing HIV-1 Gag Mutations in Protease Inhibitors Resistance: Insights for Possible Novel Gag Inhibitor Designs
Q38230956Roles of HIV-1 capsid in viral replication and immune evasion
Q90438789Selection analyses of paired HIV-1 gag and gp41 sequences obtained before and after antiretroviral therapy
Q92773004Specific inter-domain interactions stabilize a compact HIV-1 Gag conformation
Q40471717Structure of FIV capsid C-terminal domain demonstrates lentiviral evasion of genetic fragility by coevolved substitutions.
Q36259014The PTAP sequence duplication in HIV-1 subtype C Gag p6 in drug-naive subjects of India and South Africa