Characterization of ASKP1240, a fully human antibody targeting human CD40 with potent immunosuppressive effects

scientific article published on 14 April 2014

Characterization of ASKP1240, a fully human antibody targeting human CD40 with potent immunosuppressive effects is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/AJT.12678
P932PMC publication ID4225473
P698PubMed publication ID24731050
P5875ResearchGate publication ID261602772

P2093author name stringN Takahashi
T Ishikawa
H Tsumura
T Ishihara
N Kobayashi
M Goto
T Miura
S Sakuma
Y Miyao
K Maeta
K Okimura
A Ueno
N Kano
F Kinugasa
P2860cites workCD40-CD40 ligandQ28143324
IgG receptor polymorphisms: risk factors for diseaseQ33503157
CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primatesQ34433847
Tolerance and near-tolerance strategies in monkeys and their application to human renal transplantationQ34487760
Production of human monoclonal and polyclonal antibodies in TransChromo animalsQ34634571
What's in the pipeline? New immunosuppressive drugs in transplantationQ35025829
The platelet CD40L/GP IIb-IIIa axis in atherothrombotic diseaseQ35197406
Soluble CD40 ligand induces β 3 integrin tyrosine phosphorylation and triggers platelet activation by outside-in signalingQ36350146
A new look at blockade of T-cell costimulation: a therapeutic strategy for long-term maintenance immunosuppressionQ36447586
CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosisQ37696199
Long-term hepatic allograft acceptance based on CD40 blockade by ASKP1240 in nonhuman primatesQ39640425
Development of a chimeric anti-CD40 monoclonal antibody that synergizes with LEA29Y to prolong islet allograft survival.Q40459668
Efficacy and safety of ABI793, a novel human anti-human CD154 monoclonal antibody, in cynomolgus monkey renal allotransplantationQ40578442
CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation.Q40658295
Anti-CD40 therapy extends renal allograft survival in rhesus macaquesQ44190483
Monotherapy with the novel human anti-CD154 monoclonal antibody ABI793 in rhesus monkey renal transplantation model.Q44839204
Absence of CD40 signaling is associated with an increase in intimal thickening after arterial injuryQ46113707
IDEC-131 (anti-CD154), sirolimus and donor-specific transfusion facilitate operational tolerance in non-human primatesQ46427141
ASKP1240, a fully human anti-CD40 monoclonal antibody, prolongs pancreatic islet allograft survival in nonhuman primatesQ48032381
Protection of marmoset monkeys against EAE by treatment with a murine antibody blocking CD40 (mu5D12).Q48494762
Long-term inhibition of murine lupus by brief simultaneous blockade of the B7/CD28 and CD40/gp39 costimulation pathwaysQ56908183
Human platelet aggregation by murine monoclonal antiplatelet antibodies is subtype-dependentQ58481523
Activated platelets induce tissue factor expression on human umbilical vein endothelial cells by ligation of CD40Q62604578
CD40L stabilizes arterial thrombi by a β3 integrin–dependent mechanismQ63354517
Endocytosis and degradation of monoclonal antibodies targeting human B-cell malignanciesQ69522036
Prevention of collagen-induced arthritis with an antibody to gp39, the ligand for CD40Q72093299
Prevention of kidney allograft rejection using anti-CD40 and anti-CD86 in primatesQ73134598
Thromboembolic complications after treatment with monoclonal antibody against CD40 ligandQ73401367
Fc gamma Rs modulate cytotoxicity of anti-Fas antibodies: implications for agonistic antibody-based therapeuticsQ73627238
CD154 (CD40 ligand)-deficient mice exhibit prolonged bleeding time and decreased shear-induced platelet aggregatesQ73690749
Prevention of experimental colitis in SCID mice reconstituted with CD45RBhigh CD4+ T cells by blocking the CD40-CD154 interactionsQ73812280
CD40L-CD40 interactions regulate endothelial cell surface tissue factor and thrombomodulin expressionQ74310001
The immunobiology of inductive anti-CD40L therapy in transplantation: allograft acceptance is not dependent upon the deletion of graft-reactive T cellsQ74464420
Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primatesQ77890140
A novel fully human anti-CD40 monoclonal antibody, 4D11, for kidney transplantation in cynomolgus monkeysQ81567977
The role of CD40 in CD40L- and antibody-mediated platelet activationQ81873162
A human anti-CD40 monoclonal antibody, 4D11, for kidney transplantation in cynomolgus monkeys: induction and maintenance therapyQ84056960
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)1290-1299
P577publication date2014-04-14
P1433published inAmerican Journal of TransplantationQ4744273
P1476titleCharacterization of ASKP1240, a fully human antibody targeting human CD40 with potent immunosuppressive effects
P478volume14

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cites work (P2860)
Q92522477A randomized, phase 1b study of the pharmacokinetics, pharmacodynamics, safety, and tolerability of bleselumab, a fully human, anti-CD40 monoclonal antibody, in kidney transplantation
Q90154642CD11b is a novel alternate receptor for CD154 during alloimmunity
Q40256254CD40 Generation 2.5 Antisense Oligonucleotide Treatment Attenuates Doxorubicin-induced Nephropathy and Kidney Inflammation.
Q50614844Comparative Evaluation of αCD40 (2C10R4) and αCD154 (5C8H1 and IDEC-131) in a Nonhuman Primate Cardiac Allotransplant Model.
Q37375148Costimulation Blockade in Kidney Transplantation: An Update
Q36484383Current Treatment, Emerging Translational Therapies, and New Therapeutic Targets for Autoimmune Myasthenia Gravis
Q38786418Emerging drugs for prevention of T-cell mediated rejection in liver and kidney transplantation
Q90599620High Dimensional Renal Profiling: Towards a Better Understanding or Renal Transplant Immune Suppression
Q34484801Immunosuppressive Medications
Q53102364Mechanisms of Mixed Chimerism-Based Transplant Tolerance.
Q38445344Novel insights into anti-CD40/CD154 immunotherapy in transplant tolerance
Q37662989Old game, new players: Linking classical theories to new trends in transplant immunology
Q55552584Randomized, controlled study of bleselumab (ASKP1240) pharmacokinetics and safety in patients with moderate-to-severe plaque psoriasis.
Q38728589Sweeping antibody as a novel therapeutic antibody modality capable of eliminating soluble antigens from circulation.

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