A protective Hsp70-TLR4 pathway in lethal oxidant lung injury

scientific article published on July 2013

A protective Hsp70-TLR4 pathway in lethal oxidant lung injury is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4049/JIMMUNOL.1300052
P932PMC publication ID3730854
P698PubMed publication ID23817427
P5875ResearchGate publication ID244481184

P2093author name stringYi Zhang
Tej K Pandita
Patty J Lee
Xuchen Zhang
Peiying Shan
Clayton R Hunt
P2860cites workIsoform-specific regulation and localization of the coxsackie and adenovirus receptor in human airway epitheliaQ24305441
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Cutting edge: TLR4 activation mediates liver ischemia/reperfusion inflammatory response via IFN regulatory factor 3-dependent MyD88-independent pathwayQ45178588
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Cutting edge: TLR4 deficiency confers susceptibility to lethal oxidant lung injuryQ47714677
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Enhanced immunogenicity of heat shock protein 70 peptide complexes from dendritic cell-tumor fusion cells.Q51978316
A TRIFfic perspective on acute lung injury.Q53482657
Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF)-mediated signaling contributes to innate immune responses in the lung during Escherichia coli pneumonia.Q54446398
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Oxygen therapy. Side effects and toxicityQ71463962
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Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene productQ28141458
Genomic instability and enhanced radiosensitivity in Hsp70.1- and Hsp70.3-deficient miceQ28506379
Insights into regulation and function of the major stress-induced hsp70 molecular chaperone in vivo: analysis of mice with targeted gene disruption of the hsp70.1 or hsp70.3 geneQ30764395
Toll-like receptor 4 mediates ozone-induced murine lung hyperpermeability via inducible nitric oxide synthaseQ31834143
The toll-Like receptor adaptor TRIF contributes to otitis media pathogenesis and recoveryQ33490848
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Expression of inducible stress protein 70 in rat heart myogenic cells confers protection against simulated ischemia-induced injuryQ34126736
Systemic lipopolysaccharide protects the brain from ischemic injury by reprogramming the response of the brain to stroke: a critical role for IRF3Q34160637
Overexpression of the rat inducible 70-kD heat stress protein in a transgenic mouse increases the resistance of the heart to ischemic injuryQ34206249
Toll-like receptor 4 signaling in liver injury and hepatic fibrogenesisQ34321742
Heat shock proteins and cardiovascular pathophysiology.Q34388079
Regulation of lung injury and repair by Toll-like receptors and hyaluronanQ34462186
Toll-like receptor 4 activation in cancer progression and therapyQ35550677
Alternative mechanism by which IFN-gamma enhances tumor recognition: active release of heat shock protein 72.Q35568966
All in the family: atypical Hsp70 chaperones are conserved modulators of Hsp70 activity.Q35753003
Hsp70 may protect cardiomyocytes from stress-induced injury by inhibiting Fas-mediated apoptosisQ35753015
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TLR4 activation mediates kidney ischemia/reperfusion injuryQ35987574
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Mechanisms of HSP72 release.Q36834704
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TRIF and IRF-3 binding to the TNF promoter results in macrophage TNF dysregulation and steatosis induced by chronic ethanolQ36949218
Gene expression profile of human airway epithelium induced by hyperoxia in vivoQ37098584
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Extracellular Hsp72, an endogenous DAMP, is released by virally infected airway epithelial cells and activates neutrophils via Toll-like receptor (TLR)-4.Q37184215
Myocardial TLR4 is a determinant of neutrophil infiltration after global myocardial ischemia: mediating KC and MCP-1 expression induced by extracellular HSC70.Q37264415
Hsp72 induces inflammation and regulates cytokine production in airway epithelium through a TLR4- and NF-kappaB-dependent mechanismQ37370504
Endogenous ligands of TLR2 and TLR4: agonists or assistants?Q37697340
Toll-like receptor 4 deficiency causes pulmonary emphysema.Q38743977
Adenoviral transfer of HSP-70 into pulmonary epithelium ameliorates experimental acute respiratory distress syndromeQ39738431
Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signalingQ40020382
Inducible activation of TLR4 confers resistance to hyperoxia-induced pulmonary apoptosisQ40296174
Small interfering RNA targeting heme oxygenase-1 enhances ischemia-reperfusion-induced lung apoptosis.Q40541858
Reactive oxygen species and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase mediate hyperoxia-induced cell death in lung epitheliumQ40669711
Endotoxin contamination in recombinant human heat shock protein 70 (Hsp70) preparation is responsible for the induction of tumor necrosis factor alpha release by murine macrophagesQ40693930
P433issue3
P407language of work or nameEnglishQ1860
P921main subjecttoll-like receptorQ408004
P304page(s)1393-1403
P577publication date2013-07-01
P1433published inJournal of ImmunologyQ3521441
P1476titleA protective Hsp70-TLR4 pathway in lethal oxidant lung injury
P478volume191

Reverse relations

cites work (P2860)
Q37040326An Endothelial Hsp70-TLR4 Axis Limits Nox3 Expression and Protects Against Oxidant Injury in Lungs
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Q28655716Bronchoalveolar Lavage Fluid Utilized Ex Vivo to Validate In Vivo Findings: Inhibition of Gap Junction Activity in Lung Tumor Promotion is Toll-Like Receptor 4-Dependent
Q34302887Cathepsin E promotes pulmonary emphysema via mitochondrial fission
Q35555139Endothelial CD74 mediates macrophage migration inhibitory factor protection in hyperoxic lung injury
Q40380226Endothelial PINK1 mediates the protective effects of NLRP3 deficiency during lethal oxidant injury
Q57784619Endothelial Stanniocalcin 1 Maintains Mitochondrial Bioenergetics and Prevents Oxidant-Induced Lung Injury via Toll-Like Receptor 4
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Q41096073Treatment with Geranylgeranylacetone Induces Heat Shock Protein 70 and Attenuates Neonatal Hyperoxic Lung Injury in a Model of Bronchopulmonary Dysplasia.

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