Cholesterol lowering effects of mono-lactose-appended β-cyclodextrin in Niemann-Pick type C disease-like HepG2 cells

scientific article published on 3 November 2015

Cholesterol lowering effects of mono-lactose-appended β-cyclodextrin in Niemann-Pick type C disease-like HepG2 cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3762/BJOC.11.224
P932PMC publication ID4660966
P698PubMed publication ID26664628
P5875ResearchGate publication ID283662737

P50authorYuki KondoQ59705484
Yoichi IshitsukaQ73209250
P2093author name stringTetsumi Irie
Takumi Era
Hidetoshi Arima
Keiichi Motoyama
Taishi Higashi
Rena Nishiyama
Yuki Maeda
Yumi Hirai
P2860cites workHighly soluble cyclodextrin derivatives: chemistry, properties, and trends in developmentQ73850461
Design, synthesis and evaluation of monovalent ligands for the asialoglycoprotein receptor (ASGP-R)Q84569674
Chronic cyclodextrin treatment of murine Niemann-Pick C disease ameliorates neuronal cholesterol and glycosphingolipid storage and disease progressionQ21142752
Niemann-Pick disease type CQ21202883
Identification of HE1 as the second gene of Niemann-Pick C diseaseQ24290663
Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasisQ24315133
Autophagy in lysosomal storage disordersQ24601671
The role of autophagy in neurodegenerative diseaseQ29614834
Cholesterol depletion disrupts caveolae and insulin receptor signaling for metabolic control via insulin receptor substrate-1, but not for mitogen-activated protein kinase controlQ31716904
Endocytosis of beta-cyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cellsQ33777920
Niemann-Pick C disease and mobilization of lysosomal cholesterol by cyclodextrinQ33945068
Accumulation of cholera toxin and GM1 ganglioside in the early endosome of Niemann-Pick C1-deficient cellsQ33947729
Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1-/- mouseQ34930699
Cholesterol oxidation products are sensitive and specific blood-based biomarkers for Niemann-Pick C1 diseaseQ35205918
β-Cyclodextrin-threaded biocleavable polyrotaxanes ameliorate impaired autophagic flux in Niemann-Pick type C disease.Q35351552
Impaired proteolysis underlies autophagic dysfunction in Niemann-Pick type C diseaseQ36714243
2-Hydroxypropyl-β-cyclodextrin promotes transcription factor EB-mediated activation of autophagy: implications for therapyQ37683328
Niemann‐Pick type C disease: molecular mechanisms and potential therapeutic approachesQ37784257
Treatment options for lysosomal storage disorders: developing insightsQ38046227
Impaired autophagy in the lipid-storage disorder Niemann-Pick type C1 diseaseQ38315736
Asialoglycoprotein receptor mediated hepatocyte targeting - strategies and applicationsQ38363250
Design and evaluation of folate-appended α-, β-, and γ-cyclodextrins having a caproic acid as a tumor selective antitumor drug carrier in vitro and in vivoQ39068359
HPGCD outperforms HPBCD as a potential treatment for Niemann-Pick disease type C during disease modeling with iPS cells.Q39072413
Folate-appended β-cyclodextrin as a promising tumor targeting carrier for antitumor drugs in vitro and in vivoQ39185713
Cyclodextrins in drug carrier systemsQ39754307
Effects of cyclodextrin in two patients with Niemann-Pick Type C diseaseQ40265254
Disruption and therapeutic rescue of autophagy in a human neuronal model of Niemann Pick type C1Q41959895
Alteration of plasmalemmal caveolae mimics endothelial dysfunction observed in atheromatous rabbit aortaQ43619786
Association of autophagy with cholesterol-accumulated compartments in Niemann-Pick disease type C cellsQ46063599
P304page(s)2079-2086
P577publication date2015-11-03
P1433published inBeilstein Journal of Organic ChemistryQ2894008
P1476titleCholesterol lowering effects of mono-lactose-appended β-cyclodextrin in Niemann-Pick type C disease-like HepG2 cells
P478volume11

Reverse relations

cites work (P2860)
Q51737749In vitro evaluation of 2-hydroxyalkylated β-cyclodextrins as potential therapeutic agents for Niemann-Pick Type C disease.
Q92305542In vivo Efficacy and Safety Evaluation of Lactosyl-β-cyclodextrin as a Therapeutic Agent for Hepatomegaly in Niemann-Pick Type C Disease
Q42154145Superstructures with cyclodextrins: chemistry and applications III.
Q37587827Synthesis of multi-lactose-appended β-cyclodextrin and its cholesterol-lowering effects in Niemann-Pick type C disease-like HepG2 cells

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