Synthesis and calpain inhibitory activity of peptidomimetic compounds with constrained amino acids at the P2 position

scientific article published on 27 July 2008

Synthesis and calpain inhibitory activity of peptidomimetic compounds with constrained amino acids at the P2 position is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.BMCL.2008.07.094
P932PMC publication ID2575414
P698PubMed publication ID18694642
P5875ResearchGate publication ID23163297

P2093author name stringIsaac O Donkor
Rajani Korukonda
P2860cites workCrystal structures of calpain-E64 and -leupeptin inhibitor complexes reveal mobile loops gating the active siteQ45112642
Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicityQ45244063
Cortical ablation induces a spreading calcium-dependent, secondary pathogenesis which can be reduced by inhibiting calpainQ48266661
Structure and physiological function of calpainsQ24530607
Calpain: novel family members, activation, and physiologic functionQ28273311
Molecular mode of action of a covalently inhibiting peptidomimetic on the human calpain protease coreQ28596594
Synthesis and calpain inhibitory activity of alpha-ketoamides with 2,3-methanoleucine stereoisomers at the P2 positionQ31585865
A survey of calpain inhibitorsQ34060656
Calpains and diseaseQ36156260
Developments in the design and synthesis of calpain inhibitors.Q36324430
p53-dependent cell cycle arrest induced by N-acetyl-L-leucinyl-L-leucinyl-L-norleucinal in platelet-derived growth factor-stimulated human fibroblastsQ37297319
Calcium-activated neutral protease (calpain) system: structure, function, and regulationQ37767409
Calcium-activated neutral proteinases as regulators of cellular function. Implications for Alzheimer's disease pathogenesisQ38327364
Calpain inhibition: an overview of its therapeutic potentialQ40592886
Calpain: new perspectives in molecular diversity and physiological-pathological involvement.Q40694801
Calpain inhibitor 1 activates p53-dependent apoptosis in tumor cell lines.Q41740427
Calpain inhibition by alpha-ketoamide and cyclic hemiacetal inhibitors revealed by X-ray crystallography.Q42688028
Regulation of cyclin D1 by calpain proteaseQ42834597
Peptidyl aldehyde inhibitors of calpain incorporating P2-proline mimeticsQ44345391
P433issue17
P407language of work or nameEnglishQ1860
P304page(s)4806-4808
P577publication date2008-07-27
P1433published inBioorganic & Medicinal Chemistry LettersQ2709483
P1476titleSynthesis and calpain inhibitory activity of peptidomimetic compounds with constrained amino acids at the P2 position
P478volume18

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cites work (P2860)
Q37857282Calpain inhibitors: a survey of compounds reported in the patent and scientific literature
Q36469004Development of α-helical calpain probes by mimicking a natural protein-protein interaction
Q33500422Discrete proteolysis of neuronal calcium sensor-1 (NCS-1) by mu-calpain disrupts calcium binding
Q88628745NCS-1 is a regulator of calcium signaling in health and disease
Q34194374Peptidyl alpha-ketoamides with nucleobases, methylpiperazine, and dimethylaminoalkyl substituents as calpain inhibitors

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