Zebrafish gbx1 refines the midbrain-hindbrain boundary border and mediates the Wnt8 posteriorization signal

scientific article published on 2 April 2009

Zebrafish gbx1 refines the midbrain-hindbrain boundary border and mediates the Wnt8 posteriorization signal is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1032007276
P356DOI10.1186/1749-8104-4-12
P932PMC publication ID2674439
P698PubMed publication ID19341460
P5875ResearchGate publication ID24253051

P50authorMichael BrandQ50583632
P2093author name stringMuriel Rhinn
Klaus Lun
Michaela Geffarth
Reiner Ahrendt
P2860cites workA vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryoQ24564561
Cell determination boundaries as organizing regions for secondary embryonic fieldsQ28274615
The caudal limit of Otx2 gene expression as a marker of the midbrain/hindbrain boundary: a study using in situ hybridisation and chick/quail homotopic graftsQ28302345
Regionalisation of anterior neuroectoderm and its competence in responding to forebrain and midbrain inducing activities depend on mutual antagonism between OTX2 and GBX2Q28586025
Effective targeted gene 'knockdown' in zebrafishQ29547445
Expression of a zebrafish caudal homeobox gene correlates with the establishment of posterior cell lineages at gastrulationQ30986355
Positioning the isthmic organizer where Otx2 and Gbx2meet.Q33927269
Otx2, Gbx2 and Fgf8 interact to position and maintain a mid-hindbrain organizerQ34076850
The midbrain--hindbrain boundary organizer.Q34141435
Neural plate patterning: upstream and downstream of the isthmic organizerQ34185965
Early anterior/posterior patterning of the midbrain and cerebellumQ34345487
Cloning of the zebrafish krox-20 gene (krx-20) and its expression during hindbrain developmentQ34362663
Specification of the anterior hindbrain and establishment of a normal mid/hindbrain organizer is dependent on Gbx2 gene functionQ34434576
Divide et Impera--the midbrain-hindbrain boundary and its organizerQ35947525
A zebrafish engrailed-like homeobox sequence expressed during embryogenesisQ36415998
Expression of wnt10a in the central nervous system of developing zebrafish.Q36764933
Expression pattern of two otx genes suggests a role in specifying anterior body structures in zebrafish.Q36797827
Developmental regulation of zebrafish MyoD in wild-type, no tail and spadetail embryosQ38287447
The Sp1-related transcription factors sp5 and sp5-like act downstream of Wnt/beta-catenin signaling in mesoderm and neuroectoderm patterning.Q38514669
Wnt1 and wnt10b function redundantly at the zebrafish midbrain-hindbrain boundaryQ38521067
Zebrafish wnt8 encodes two wnt8 proteins on a bicistronic transcript and is required for mesoderm and neurectoderm patterning.Q38523908
Direct regulation of the Xenopus engrailed-2 promoter by the Wnt signaling pathway, and a molecular screen for Wnt-responsive genes, confirm a role for Wnt signaling during neural patterning in Xenopus.Q38527333
Zebrafishwnt8andwnt8bshare a common activity but are involved in distinct developmental pathwaysQ38531729
cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genesQ40633690
Spiel-ohne-grenzen/pou2 mediates regional competence to respond to Fgf8 during zebrafish early neural development.Q40657976
Otx2 can activate the isthmic organizer genetic network in the Xenopus embryoQ40672250
Early anteroposterior division of the presumptive neurectoderm in XenopusQ40702301
The caudal limit of Otx2 expression positions the isthmic organizerQ40928475
Order and coherence in the fate map of the zebrafish nervous systemQ40976641
Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulation.Q40995595
Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification.Q41046046
Engrailed, Wnt and Pax genes regulate midbrain--hindbrain developmentQ41064646
Early mesencephalon/metencephalon patterning and development of the cerebellumQ41724283
Regional cell movement and tissue patterning in the zebrafish embryo revealed by fate mapping with caged fluoresceinQ41743027
Expression of the zebrafish paired box gene pax[zf-b] during early neurogenesisQ41818633
Ace/Fgf8 is required for forebrain commissure formation and patterning of the telencephalon.Q42488388
Wnt8 is required in lateral mesendodermal precursors for neural posteriorization in vivo.Q43744674
Otx2 and Gbx2 are required for refinement and not induction of mid-hindbrain gene expression.Q43826745
gbx2 Homeobox gene is required for the maintenance of the isthmic region in the zebrafish embryonic brain.Q44632595
Interaction of Wnt and caudal-related genes in zebrafish posterior body formationQ45263246
Midbrain development induced by FGF8 in the chick embryo.Q46013905
Specification of the hindbrain fate in the zebrafish.Q46101694
Specification of the Zebrafish Nervous System by Nonaxial SignalsQ46905446
Regulatory gene expression boundaries demarcate sites of neuronal differentiation in the embryonic zebrafish forebrainQ47073096
Engrailed and Fgf8 act synergistically to maintain the boundary between diencephalon and mesencephalonQ47073461
Positioning of the midbrain-hindbrain boundary organizer through global posteriorization of the neuroectoderm mediated by Wnt8 signalingQ47073539
Differential expression of two zebrafish emx homeoprotein mRNAs in the developing brainQ47073636
Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesisQ47073664
A series of no isthmus (noi) alleles of the zebrafish pax2.1 gene reveals multiple signaling events in development of the midbrain-hindbrain boundaryQ47073721
Analysis of Wnt8 for neural posteriorizing factor by identifying Frizzled 8c and Frizzled 9 as functional receptors for Wnt8.Q47073727
valentino: a zebrafish gene required for normal hindbrain segmentation.Q47073916
Expression of two zebrafish homologues of the murine Six3 gene demarcates the initial eye primordiaQ48037954
Zebrafish hox genes: expression in the hindbrain region of wild-type and mutants of the segmentation gene, valentino.Q48041265
Ectopic expression of Hoxa-1 in the zebrafish alters the fate of the mandibular arch neural crest and phenocopies a retinoic acid-induced phenotypeQ48065965
Sequence and expression pattern of the Stra7 (Gbx-2) homeobox-containing gene induced by retinoic acid in P19 embryonal carcinoma cellsQ48068766
A role for Gbx2 in repression of Otx2 and positioning the mid/hindbrain organizerQ48110711
Cell autonomous and non-cell autonomous functions of Otx2 in patterning the rostral brain.Q48118664
Regeneration of isthmic tissue is the result of a specific and direct interaction between rhombomere 1 and midbrain.Q48130782
Coordinate embryonic expression of three zebrafish engrailed genesQ48146193
Fgf8 and Gbx2 induction concomitant with Otx2 repression is correlated with midbrain-hindbrain fate of caudal prosencephalonQ48182728
Cloning, expression and relationship of zebrafish gbx1 and gbx2 genes to Fgf signalingQ48203653
Isolation and expression of the homeobox gene Gbx1 during mouse developmentQ48208107
Sustained interactive Wnt and FGF signaling is required to maintain isthmic identityQ48229313
Gbx2 interacts with Otx2 and patterns the anterior-posterior axis during gastrulation in XenopusQ48685519
Induction of a mesencephalic phenotype in the 2-day-old chick prosencephalon is preceded by the early expression of the homeobox gene en.Q48717668
Neuroepithelial co-expression of Gbx2 and Otx2 precedes Fgf8 expression in the isthmic organizerQ48964505
EN and GBX2 play essential roles downstream of FGF8 in patterning the mouse mid/hindbrain regionQ49141522
Cloning and embryonic expression analysis of the mouse Gbx1 gene.Q52104313
Interaction between Otx2 and Gbx2 defines the organizing center for the optic tectum.Q52170383
Forebrain and midbrain regions are deleted in Otx2−/− mutants due to a defective anterior neuroectoderm specification during gastrulationQ54602798
A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brainQ70910667
Xenopus embryos regulate the nuclear localization of XMyoDQ72718764
Expression of Otx homeodomain proteins induces cell aggregation in developing zebrafish embryosQ73959518
P921main subjectDanio rerioQ169444
Gastrulation brain homeobox 1Q29825330
Wingless-type MMTV integration site family, member 8aQ29830803
P304page(s)12
P577publication date2009-04-02
P1433published inNeural DevelopmentQ15761981
P1476titleZebrafish gbx1 refines the midbrain-hindbrain boundary border and mediates the Wnt8 posteriorization signal
P478volume4

Reverse relations

cites work (P2860)
Q37892502Brain regionalization: of signaling centers and boundaries
Q41979847Cerebellar development in the absence of Gbx function in zebrafish
Q47866746Comprehensive analysis of target genes in zebrafish embryos reveals gbx2 involvement in neurogenesis
Q38004616Development and evolution of cerebellar neural circuits
Q37838909Development of the cerebellum and cerebellar neural circuits
Q27334410Dynamic association with donor cell filopodia and lipid-modification are essential features of Wnt8a during patterning of the zebrafish neuroectoderm
Q28587839Elongation factor 1 alpha1 and genes associated with Usher syndromes are downstream targets of GBX2
Q34167636Evolutionarily conserved function of Gbx2 in anterior hindbrain development
Q39282682Evolutionary mechanisms that generate morphology and neural-circuit diversity of the cerebellum.
Q48270370Identification and expression analysis of the zebrafish homologs of the ceramide synthase gene family
Q37783809Making senses development of vertebrate cranial placodes
Q41222022Midbrain-Hindbrain Boundary Morphogenesis: At the Intersection of Wnt and Fgf Signaling
Q27026327Neural crest induction at the neural plate border in vertebrates
Q27022400Neurogenesis in zebrafish - from embryo to adult
Q50504353Patterning, morphogenesis, and neurogenesis of zebrafish cranial sensory placodes.
Q37958896Specification and regionalisation of the neural plate border.
Q21129150The evolutionary and genetic origins of consciousness in the Cambrian Period over 500 million years ago
Q29347277The homeodomain factor Gbx1 is required for locomotion and cell specification in the dorsal spinal cord
Q38025839The peripheral sensory nervous system in the vertebrate head: a gene regulatory perspective
Q95831978The ubiquitin-conjugating enzyme UBE2K determines neurogenic potential through histone H3 in human embryonic stem cells
Q33952203Toxicological assessment of trace β-diketone antibiotic mixtures on zebrafish (Danio rerio) by proteomic analysis
Q91537063Wnt signaling regulates neural plate patterning in distinct temporal phases with dynamic transcriptional outputs
Q39930689vox homeobox gene: a novel regulator of midbrain-hindbrain boundary development in medaka fish?

Search more.