SRPK1 inhibition in prostate cancer: A novel anti-angiogenic treatment through modulation of VEGF alternative splicing

scientific article published on 16 March 2016

SRPK1 inhibition in prostate cancer: A novel anti-angiogenic treatment through modulation of VEGF alternative splicing is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.PHRS.2016.03.013
P932PMC publication ID4876767
P698PubMed publication ID26995304

P2093author name stringSebastian Oltean
Athina Mavrou
P2860cites workHallmarks of Cancer: The Next GenerationQ22252312
ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicingQ24321530
Metastatic castration-resistant prostate cancer: new therapies, novel combination strategies and implications for immunotherapyQ26825053
Resistance and escape from antiangiogenesis therapy: clinical implications and future strategiesQ27016629
Cancer statistics, 2015Q27860576
Alternative isoform regulation in human tissue transcriptomesQ27861118
Serine-arginine protein kinase 1 (SRPK1) inhibition as a potential novel targeted therapeutic strategy in prostate cancerQ28251240
Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencingQ29547470
Phase II trial of docetaxel, bevacizumab, lenalidomide and prednisone in patients with metastatic castration-resistant prostate cancer.Q33429309
Nova regulates brain-specific splicing to shape the synapseQ34436585
Abnormal expression of the pre-mRNA splicing regulators SRSF1, SRSF2, SRPK1 and SRPK2 in non small cell lung carcinomaQ34447216
Alternative mRNA transcription, processing, and translation: insights from RNA sequencingQ34461131
SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA miceQ34478749
The spliceosome is a therapeutic vulnerability in MYC-driven cancerQ34492012
Elevated expression of the serine-arginine protein kinase 1 gene in ovarian cancer and its role in Cisplatin cytotoxicity in vitroQ34510663
Motor neuron disease. SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophyQ35221624
Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinantQ35408783
Tumor angiogenesis correlates with metastasis in invasive prostate carcinomaQ35833169
Randomized, double-blind, placebo-controlled phase III trial comparing docetaxel and prednisone with or without bevacizumab in men with metastatic castration-resistant prostate cancer: CALGB 90401.Q36058291
Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacyQ36089148
Serine-arginine protein kinase 1 (SRPK1), a determinant of angiogenesis, is upregulated in prostate cancer and correlates with disease stage and invasionQ36577277
Novel therapies for the treatment of advanced prostate cancerQ36665708
VEGF-A splicing: the key to anti-angiogenic therapeutics?Q37035757
SRPK1 Dissimilarly Impacts on the Growth, Metastasis, Chemosensitivity and Angiogenesis of Glioma in Normoxic and Hypoxic ConditionsQ37347529
Prostate cancer progression after androgen deprivation therapy: mechanisms of castrate resistance and novel therapeutic approachesQ37537958
Angiogenesis and anti-angiogenic therapy in prostate cancer.Q38078609
Hallmarks of alternative splicing in cancerQ38171229
The alternative splicing side of cancer.Q38198391
MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesisQ38299040
Antiangiogenic therapy in oncology: current status and future directionsQ38725587
The crucial role of SRPK1 in TGF-β-induced proliferation and apoptosis in the esophageal squamous cell carcinomasQ38861204
WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicingQ39427761
An ESRP-regulated splicing programme is abrogated during the epithelial-mesenchymal transitionQ39667327
Modulators of alternative splicing as novel therapeutics in cancerQ41904460
Vascular endothelial growth factor and basic fibroblast growth factor urine levels as predictors of outcome in hormone-refractory prostate cancer patients: a cancer and leukemia group B studyQ43566256
VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, is down-regulated in renal cell carcinomaQ44068637
SRPK1 contributes to malignancy of hepatocellular carcinoma through a possible mechanism involving PI3K/Akt.Q44206065
RBM24 is a major regulator of muscle-specific alternative splicingQ51049428
Plasma levels of vascular endothelial growth factor are increased in patients with metastatic prostate cancerQ60156367
Serine-arginine protein kinase 1 overexpression is associated with tumorigenic imbalance in mitogen-activated protein kinase pathways in breast, colonic, and pancreatic carcinomasQ79856279
P921main subjectangiogenesis inhibitorQ574834
alternative mRNA splicing, via spliceosomeQ21114084
P304page(s)276-281
P577publication date2016-03-16
P1433published inPharmacological ResearchQ15724622
P1476titleSRPK1 inhibition in prostate cancer: A novel anti-angiogenic treatment through modulation of VEGF alternative splicing
P478volume107

Reverse relations

cites work (P2860)
Q45056589Anti-Tumorigenic Potential of a Novel Orlistat-AICAR Combination in Prostate Cancer Cells
Q39223617RNA splicing and splicing regulator changes in prostate cancer pathology
Q57467861Role of alternative splicing of VEGF-A in the development of atherosclerosis
Q61450687SOX2 knockdown inhibits the migration and invasion of basal cell carcinoma cells by targeting the SRPK1-mediated PI3K/AKT signaling pathway
Q60300790SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4
Q42365311Serine-arginine protein kinase 1 (SRPK1) is elevated in gastric cancer and plays oncogenic functions
Q92446657Targeting Angiogenesis in Prostate Cancer
Q55128284Targeting Splicing in Prostate Cancer.

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