The MAP kinase Slt2 is involved in vacuolar function and actin remodeling in Saccharomyces cerevisiae mutants affected by endogenous oxidative stress

scientific article published on 16 August 2013

The MAP kinase Slt2 is involved in vacuolar function and actin remodeling in Saccharomyces cerevisiae mutants affected by endogenous oxidative stress is …
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scholarly articleQ13442814

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P356DOI10.1128/AEM.01692-13
P932PMC publication ID3811184
P698PubMed publication ID23956390

P2093author name stringLuis Serrano
Maria Angeles de la Torre-Ruiz
Nuria Pujol-Carrion
Mima I Petkova
P2860cites workCdc42p and Rho1p are sequentially activated and mechanistically linked to vacuole membrane fusionQ82977294
Two proteins from Saccharomyces cerevisiae: Pfy1 and Pkc1, play a dual role in activating actin polymerization and in increasing cell viability in the adaptive response to oxidative stressQ84572825
The fungal vacuole: composition, function, and biogenesisQ24634743
Battles with iron: manganese in oxidative stress protectionQ27025367
Subcellular localization of Aft1 transcription factor responds to iron status in Saccharomyces cerevisiaeQ27931033
Regulation of the cell integrity pathway by rapamycin-sensitive TOR function in budding yeast.Q27931199
A family of genes required for maintenance of cell wall integrity and for the stress response in Saccharomyces cerevisiaeQ27931403
Glutaredoxins Grx3 and Grx4 regulate nuclear localisation of Aft1 and the oxidative stress response in Saccharomyces cerevisiae.Q27932221
Dominant mutations in a gene encoding a putative protein kinase (BCK1) bypass the requirement for a Saccharomyces cerevisiae protein kinase C homologQ27933556
Grx5 glutaredoxin plays a central role in protection against protein oxidative damage in Saccharomyces cerevisiaeQ27933647
Pkc1 and the upstream elements of the cell integrity pathway in Saccharomyces cerevisiae, Rom2 and Mtl1, are required for cellular responses to oxidative stressQ27933664
Isolation and characterization of PEP3, a gene required for vacuolar biogenesis in Saccharomyces cerevisiaeQ27934122
Lysosomal (vacuolar) proteinases of yeast are essential catalysts for protein degradation, differentiation, and cell survivalQ27934404
Grx5 is a mitochondrial glutaredoxin required for the activity of iron/sulfur enzymesQ27934525
Saccharomyces cerevisiae mutants altered in vacuole function are defective in copper detoxification and iron-responsive gene transcriptionQ27934640
Role of glutaredoxin-3 and glutaredoxin-4 in the iron regulation of the Aft1 transcriptional activator in Saccharomyces cerevisiaeQ27934787
MKK1 and MKK2, which encode Saccharomyces cerevisiae mitogen-activated protein kinase-kinase homologs, function in the pathway mediated by protein kinase CQ27935137
Rom2p, the Rho1 GTP/GDP exchange factor of Saccharomyces cerevisiae, can mediate stress responses via the Ras-cAMP pathway.Q27935188
Iron-regulated DNA binding by the AFT1 protein controls the iron regulon in yeast.Q27936505
Glutaredoxins Grx4 and Grx3 of Saccharomyces cerevisiae play a role in actin dynamics through their Trx domains, which contributes to oxidative stress resistance.Q27936690
Fusion of docked membranes requires the armadillo repeat protein Vac8pQ27937772
Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolasesQ27937990
Mtl1 is required to activate general stress response through Tor1 and Ras2 inhibition under conditions of glucose starvation and oxidative stressQ27939306
Cell wall stress depolarizes cell growth via hyperactivation of RHO1.Q27939544
Saccharomyces cerevisiae mid2p is a potential cell wall stress sensor and upstream activator of the PKC1-MPK1 cell integrity pathwayQ27939724
A new vital stain for visualizing vacuolar membrane dynamics and endocytosis in yeastQ28131611
Calcium-sensitive cls mutants of Saccharomyces cerevisiae showing a Pet- phenotype are ascribable to defects of vacuolar membrane H(+)-ATPase activityQ28270365
Copper and iron are the limiting factors for growth of the yeast Saccharomyces cerevisiae in an alkaline environment.Q30753892
Disruption of genes encoding subunits of yeast vacuolar H(+)-ATPase causes conditional lethalityQ33568063
Genetic dissection of a mitochondria-vacuole signaling pathway in yeast reveals a link between chronic oxidative stress and vacuolar iron transportQ33795931
Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiaeQ33893822
Yeast vacuoles and membrane fusion pathwaysQ34086175
Adaptive response of the yeast Saccharomyces cerevisiae to reactive oxygen species: defences, damage and deathQ34122742
Asymmetric inheritance of oxidatively damaged proteins during cytokinesisQ34180285
Oxidative stress and signal transduction in Saccharomyces cerevisiae: insights into ageing, apoptosis and diseases.Q34419264
The Rho1 GTPase acts together with a vacuolar glutathione S-conjugate transporter to protect yeast cells from oxidative stressQ35221468
Organelle assembly in yeast: characterization of yeast mutants defective in vacuolar biogenesis and protein sortingQ36219420
The vacuolar kinase Yck3 maintains organelle fragmentation by regulating the HOPS tethering complexQ36321361
Remodeling of organelle-bound actin is required for yeast vacuole fusionQ36325643
The where, when, and how of organelle acidification by the yeast vacuolar H+-ATPaseQ36416690
Loss of vacuolar H+-ATPase (V-ATPase) activity in yeast generates an iron deprivation signal that is moderated by induction of the peroxiredoxin TSA2.Q36779673
Monothiol glutaredoxins: a common domain for multiple functions.Q36784368
Protein oxidation, repair mechanisms and proteolysis in Saccharomyces cerevisiaeQ36823887
Yeast vacuole fusion: a model system for eukaryotic endomembrane dynamicsQ36968956
The yeast lysosome-like vacuole: endpoint and crossroadsQ37266848
Regulation of Vps4 ATPase activity by ESCRT-III.Q37368267
How budding yeast sense and transduce the oxidative stress signal and the impact in cell growth and morphogenesisQ37828604
Cdc42p is activated during vacuole membrane fusion in a sterol-dependent subreaction of primingQ39538510
Proteinases, proteolysis and biological control in the yeast Saccharomyces cerevisiaeQ39845149
New actin mutants allow further characterization of the nucleotide binding cleft and drug binding sitesQ41644315
A protein kinase gene complements the lytic phenotype of Saccharomyces cerevisiae lyt2 mutants.Q42619371
The Cln3 cyclin is down-regulated by translational repression and degradation during the G1 arrest caused by nitrogen deprivation in budding yeastQ42633982
Analysis of Saccharomyces cerevisiae proteins induced by peroxide and superoxide stress.Q52511609
Mtl1 O-mannosylation mediated by both Pmt1 and Pmt2 is important for cell survival under oxidative conditions and TOR blockade.Q54485399
Iron storage in Saccharomyces cerevisiaeQ68133891
Identification of the disulfide-linked peptide in irreversibly sickled cell beta-actinQ71010214
Oxidative stress and iron are implicated in fragmenting vacuoles of Saccharomyces cerevisiae lacking Cu,Zn-superoxide dismutaseQ72993751
Stimulation of actin polymerization by vacuoles via Cdc42p-dependent signalingQ80860112
Pkc1 and actin polymerisation activities play a role in ribosomal gene repression associated with secretion impairment caused by oxidative stressQ82554456
P433issue20
P407language of work or nameEnglishQ1860
P921main subjectSaccharomyces cerevisiaeQ719725
P304page(s)6459-6471
P577publication date2013-08-16
P1433published inApplied and Environmental MicrobiologyQ4781593
P1476titleThe MAP kinase Slt2 is involved in vacuolar function and actin remodeling in Saccharomyces cerevisiae mutants affected by endogenous oxidative stress
P478volume79