Cytotoxic effects of streptozotocin and N-nitrosomethylurea on the pancreatic B cells with special regard to the role of nicotinamide-adenine dinucleotide

scientific article published on June 1974

Cytotoxic effects of streptozotocin and N-nitrosomethylurea on the pancreatic B cells with special regard to the role of nicotinamide-adenine dinucleotide is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1042/BJ1400487
P932PMC publication ID1168026
P698PubMed publication ID4374939
P5875ResearchGate publication ID18790914

P50authorClaes HellerströmQ62560677
P2093author name stringGunnarsson R
Berne C
P2860cites workDrugs producing diabetes through damage of the insulin secreting cellsQ28247851
Potassium ions and the secretion of insulin by islets of Langerhans incubated in vitroQ41869324
Effect of phenylpyruvate on enzymes involved in fatty acid synthesis in rat brainQ42248288
The rate of breakdown of methyl methanesulphonate, dimethyl sulphate and N-methyl-N-nitrosourea in the ratQ42937374
Immunoassay of insulin with insulin-antibody precipitateQ42961363
The bioelectrical properties of pancreatic islet cells: effects of diabetogenic agentsQ43706394
Streptozotocin diabetes: time course of irreversible B-cell damage; further observations on prevention by nicotinamideQ44217133
Streptozotocin diabetes in the mouse and guinea pig.Q46672033
The quantitative histochemistry of the brain; histological sampling.Q51345360
The use of nicotinamide to modify the toxicity of streptozotocin diabetes without loss of antitumor activity.Q53709539
Significance of streptozotocin induced nicotinamide-adenine-dinucleotide (NAD) degradation in mouse pancreatic islets.Q53720022
Glucose and alloxan interactions in the pancreatic islets.Q54064249
The Effects of Streptozotocin on Glucose Oxidation by Isolated Islets of LangerhansQ54114183
Studies on the ability of compounds to block the diabetogenic activity of streptozotocin.Q54384812
Increased Circulating Insulin-like Activity in Obese-Hyperglycæmic MiceQ59084324
Estimation of Steam-Volatile N-Nitrosamines in Foods at the 1 µg/kg LevelQ59094062
Streptozotocin: depression of mouse liver pyridine nucleotidesQ68582371
Reversal of streptozotocin diabetes with nicotinamideQ68590302
Pyridine nucleotide depletion in pancreatic islets associated with streptozotocin-induced diabetesQ68644058
Streptozotocin diabetes--further studies on the mechanism of depression of nicotinamide adenine dinucleotide concentrations in mouse pancreatic islets and liverQ68673917
Photokinetic micro assay based on dehydrogenase reactions and bacterial luciferaseQ68754932
Photokinetic assay of NADH and NADPH in microdissected tissue samplesQ68768845
Pentose cycle in isolated islets during glucose-stimulated insulin releaseQ69917034
Letter: Diabetogenic nitrosamines?Q70006811
Effects of Carbohydrates on the Oxygen Consumption of Isolated Pancreatic Islets of MiceQ71208156
Structure of streptozotocinQ72353904
Metabolic, nutritional and endocrine studies of the hereditary obesity-diabetes syndrome of mice and mechanism of its developmentQ72994756
Studies on the methods of staining the islet cells of the pancreasQ75874888
A simple method for in vitro metabolic studies using small volumes of tissue and mediumQ76484060
SELECTIVE INDUCTION OF MALIGNANT TUMORS IN THE BRAIN AND SPINAL CORD OF RATS BY N-METHYL-N-NITROSOUREAQ78242950
Studies of tissue permeability. V. The penetration and phosphorylation of 2-deoxyglucose in the rat diaphragmQ78478266
The occurrence of argyrophil cells in the islets of Langerhans of American obese-hyperglycaemic miceQ78876473
Pancreatic islets in mice with the obese-hyperglycemic syndrome: lack of effect of carbutamideQ79249114
Acute effects of alloxan on the metabolism and insulin secretion of the pancreatic B-cellQ93754091
P433issue3
P407language of work or nameEnglishQ1860
P1104number of pages8
P304page(s)487-494
P577publication date1974-06-01
P1433published inBiochemical JournalQ864221
P1476titleCytotoxic effects of streptozotocin and N-nitrosomethylurea on the pancreatic B cells with special regard to the role of nicotinamide-adenine dinucleotide
P478volume140

Reverse relations

cites work (P2860)
Q72515117Adrenergic receptors and the onset of streptozotocin-induced diabetes in mice
Q43924770An ultrastructural study of pancreatic islet cell destruction by n-nitrosomethylurea
Q70530784Autonomic neuropathy in the streptozotocin diabetic rat
Q39769035Autoradiographic study of the distribution and cellular uptake of (14C)-streptozotocin in the rat
Q37361139Cardiac metabolism in a new rat model of type 2 diabetes using high-fat diet with low dose streptozotocin.
Q40124837Diabetes Mellitus Associated with Autonomic and Peripheral Neuropathy after Vacor Rodenticide Poisoning: A Review
Q39737657Diabetogenic effects of n-nitrosomethylurea in the chinese hamster
Q31115333Differentiating between effects of streptozotocin per se and subsequent hyperglycemia on renal function and metabolism in the streptozotocin-diabetic rat model
Q39779540Effect of l-methyl-l-nitrosourea and streptozotocin on glucose-induced insulin secretion by isolated islets of Langerhans
Q39788727Effects of streptozotocin in vitro on proinsulin biosynthesis, insulin release and ATP content of isolated rat islets of Langerhans
Q38716420Function and metabolism of pancreatic beta-cells maintained in culture following experimentally induced damage
Q36249802In vivo imaging of immuno-spin trapped radicals with molecular magnetic resonance imaging in a diabetic mouse model
Q66904743Influence of anoxia on glucose metabolism in pancreatic islets: Lack of correlation between fructose-1,6-diphosphate and apparent glycolytic flux
Q41344890Mitochondrial changes and associated alterations induced in mice by streptozotocin administered in vivo and in vitro
Q34165030N-3-pyridylmethyl-N'-p-nitrophenylurea ocular toxicity in man and an animal model
Q47814324Neuroprotective Activities of Saffron and Crocin
Q40632082Nicotinamide treatment in the prevention of insulin-dependent diabetes mellitus.
Q35617525Pancreatic B cells possess defense mechanisms against cell-specific toxicity
Q66921615Pesticidal diabetes
Q40276647Poly(ADP-ribose) levels in carcinogen-treated cells
Q37181314Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes
Q69980051Protective effect of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase, against streptozotocin-induced diabetes
Q66899987Specific uptake of labelled N-Nitrosomethylurea in the pancreatic islets of Chinese hamsters
Q72802230Streptozotocin, but not alloxan, induces DNA repair synthesis in mouse pancreatic islets in vitro
Q67532971Studies on pancreatic islet accumulation and cytotoxicity of N-nitrosomethylurea in the cynomolgus monkey
Q43829603The Swedish Childhood Diabetes Study--a multivariate analysis of risk determinants for diabetes in different age groups
Q40188118The effect of gamma radiation and neocarzinostatin of NAD and ATP levels in mouse leukaemia cells
Q70252321The effects of intermittent insulin therapy on the autonomic neuropathy in the streptozotocin diabetic rat
Q28320066The fate of [14C]streptozotocin in nicotinamide-pretreated mice: Observations on pancreatic islet radioactivity and urinary N1-[methyl-14C]nicotinamide-excretion
Q38692426The role of chemicals in the etiology of diabetes mellitus
Q39296188The stimulus--secretion coupling 4-methyl-2-oxopentanoate-induced insulin release
Q71046984Unscheduled synthesis of DNA and poly(ADP‐ribose) in human fibroblasts following DNA damage
Q67512405Uptake of labelled-n-nitrosomethylurea in the pancreatic islets

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