Drosha regulates gene expression independently of RNA cleavage function.

scientific article published on 19 December 2013

Drosha regulates gene expression independently of RNA cleavage function. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CELREP.2013.11.032
P932PMC publication ID3898267
P698PubMed publication ID24360955
P5875ResearchGate publication ID259447590

P50authorNicholas Jarvis ProudfootQ21166845
Eduardo EyrasQ30503190
Javier CaceresQ43165847
Mireya PlassQ56501770
Sara MaciasQ61117481
P2093author name stringNatalia Gromak
Martin Dienstbier
P2860cites workThe nuclear RNase III Drosha initiates microRNA processingQ24295234
Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAsQ24302072
Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent terminationQ24307617
The Microprocessor complex mediates the genesis of microRNAsQ24312976
The FHA domain proteins DAWDLE in Arabidopsis and SNIP1 in humans act in small RNA biogenesisQ24314338
Human 5' --> 3' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sitesQ24317135
Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferationQ24317359
The Drosha-DGCR8 complex in primary microRNA processingQ24318603
RNA exosome depletion reveals transcription upstream of active human promotersQ24321777
SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genesQ24323701
Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme DroshaQ24557506
MicroRNAs: target recognition and regulatory functionsQ24609584
Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcriptionQ24646744
Processing of intronic microRNAsQ24677011
Nuclear export of microRNA precursorsQ27860686
Role for a bidentate ribonuclease in the initiation step of RNA interferenceQ27860832
Posttranscriptional regulation of microRNA biogenesis in animalsQ28282519
The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesisQ28297566
CLIP: construction of cDNA libraries for high-throughput sequencing from RNAs cross-linked to proteins in vivoQ33416241
Ars2 regulates both miRNA- and siRNA- dependent silencing and suppresses RNA virus infection in DrosophilaQ33486941
Diverse endonucleolytic cleavage sites in the mammalian transcriptome depend upon microRNAs, Drosha, and additional nucleasesQ34038435
Canonical and alternate functions of the microRNA biogenesis machinery.Q34102263
Beyond secondary structure: primary-sequence determinants license pri-miRNA hairpins for processing.Q34328115
Primary microRNA transcripts are processed co-transcriptionally.Q34931030
Expanding the role of Drosha to the regulation of viral gene expressionQ35090908
DGCR8 HITS-CLIP reveals novel functions for the MicroprocessorQ36233919
Microprocessor, Setx, Xrn2, and Rrp6 co-operate to induce premature termination of transcription by RNAPII.Q36679818
The splicing factor SC35 has an active role in transcriptional elongationQ36952048
Genome-wide identification of targets of the drosha-pasha/DGCR8 complexQ37142093
Posttranscriptional crossregulation between Drosha and DGCR8.Q37188339
The DEAD box RNA helicases p68 (Ddx5) and p72 (Ddx17): novel transcriptional co-regulators.Q37217745
Two cap-binding proteins CBP20 and CBP80 are involved in processing primary MicroRNAsQ37292978
Coupled RNA processing and transcription of intergenic primary microRNAsQ37374749
Transcription regulation through promoter-proximal pausing of RNA polymerase II.Q39442921
The 3'-end of the human beta-actin gene enhances activity of the beta-actin expression vector system: construction of improved vectorsQ41057998
Chromatin structure is implicated in "late" elongation checkpoints on the U2 snRNA and beta-actin genesQ42068307
Chromatin-associated RNA interference components contribute to transcriptional regulation in DrosophilaQ42721062
Post-transcriptional control of DGCR8 expression by the MicroprocessorQ43123531
Autoregulation of polypyrimidine tract binding protein by alternative splicing leading to nonsense-mediated decayQ44734157
Evolutionary trends of GC/AT distribution patterns in promotersQ48058356
Tissue-specific histone modification and transcription factor binding in alpha globin gene expression.Q53026451
The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18aQ64462273
P433issue6
P304page(s)1499-1510
P577publication date2013-12-19
P1433published inCell ReportsQ5058165
P1476titleDrosha regulates gene expression independently of RNA cleavage function
P478volume5

Reverse relations

cites work (P2860)
Q39442714A framework for understanding the roles of miRNAs in animal development
Q38770496Alternative splicing affects the subcellular localization of Drosha
Q27013994Cross talk between spliceosome and microprocessor defines the fate of pre-mRNA
Q38791696DICER, DROSHA and DNA damage response RNAs are necessary for the secondary recruitment of DNA damage response factors
Q91891000DNA methylation directs microRNA biogenesis in mammalian cells
Q42801411DROSHA targets its own transcript to modulate alternative splicing
Q64073356Deregulation of Drosha in the pathogenesis of hereditary hemorrhagic telangiectasia
Q40466317Drosha controls dendritic cell development by cleaving messenger RNAs encoding inhibitors of myelopoiesis.
Q48117535Drosha cuts the tethers of myelopoiesis
Q49549364Drosha drives the formation of DNA:RNA hybrids around DNA break sites to facilitate DNA repair.
Q33553039Drosha promotes splicing of a pre-microRNA-like alternative exon
Q36284788Drosophila Dicer-2 has an RNA interference-independent function that modulates Toll immune signaling.
Q49682613Emerging roles of DROSHA beyond primary microRNA processing.
Q58862336From “Cellular” RNA to “Smart” RNA: Multiple Roles of RNA in Genome Stability and Beyond
Q34224353Germ cell-specific targeting of DICER or DGCR8 reveals a novel role for endo-siRNAs in the progression of mammalian spermatogenesis and male fertility
Q41809522HP1BP3, a Chromatin Retention Factor for Co-transcriptional MicroRNA Processing
Q48232072Inactivating mutations in Drosha mediate vascular abnormalities similar to hereditary hemorrhagic telangiectasia.
Q38715102MicroRNA-independent functions of DGCR8 are essential for neocortical development and TBR1 expression.
Q42133796Microprocessor Recruitment to Elongating RNA Polymerase II Is Required for Differential Expression of MicroRNAs
Q35823164Microprocessor mediates transcriptional termination of long noncoding RNA transcripts hosting microRNAs
Q58778010Microprocessor-dependent processing of splice site overlapping microRNA exons does not result in changes in alternative splicing
Q26776102Non-Coding RNA: Sequence-Specific Guide for Chromatin Modification and DNA Damage Signaling
Q42216487Oleic Acid Induces MiR-7 Processing through Remodeling of Pri-MiR-7/Protein Complex
Q98784955Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells
Q48328245RNA fate determination through cotranscriptional adenosine methylation and microprocessor binding
Q35781273RNA interference machinery-mediated gene regulation in mouse adult neural stem cells
Q58692167Regulating gene expression in animals through RNA endonucleolytic cleavage
Q51102304Super-Enhancer-Mediated RNA Processing Revealed by Integrative MicroRNA Network Analysis.
Q38504335Swiss army knives: non-canonical functions of nuclear Drosha and Dicer
Q39914513Tat-dependent production of an HIV-1 TAR-encoded miRNA-like small RNA.
Q39149348The emerging role of RNAs in DNA damage repair
Q50914831The evidence for a microRNA product of human DROSHA gene.
Q36080312The role of Dicer1 in the male reproductive tract
Q38809329miR-497 inhibits epithelial mesenchymal transition in breast carcinoma by targeting Slug